Stress, Environment and Early Psychosis

Lida-Alkisti      Xenaki; Stefanos      Dimitrakopoulos; Mirjana      Selakovic; Nikos      Stefanis
doi:10.2174/1570159X21666230817153631
Abstract

Existing literature provides extended evidence of the close relationship between stress dysregulation, environmental insults, and psychosis onset. Early stress can sensitize genetically vulnerable individuals to future stress, modifying their risk for developing psychotic phenomena. Neurobiological substrate of the aberrant stress response to hypothalamic-pituitary-adrenal axis dysregulation, disrupted inflammation processes, oxidative stress increase, gut dysbiosis, and altered brain signaling, provides mechanistic links between environmental risk factors and the development of psychotic symptoms. Early-life and later-life exposures may act directly, accumulatively, and repeatedly during critical neurodevelopmental time windows. Environmental hazards, such as pre- and perinatal complications, traumatic experiences, psychosocial stressors, and cannabis use might negatively intervene with brain developmental trajectories and disturb the balance of important stress systems, which act together with recent life events to push the individual over the threshold for the manifestation of psychosis. The current review presents the dynamic and complex relationship between stress, environment, and psychosis onset, attempting to provide an insight into potentially modifiable factors, enhancing resilience and possibly influencing individual psychosis liability.
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[1]
Stilo, S.A.; Murray, R.M. Non-genetic factors in schizophrenia. Curr. Psychiatry Rep.,  2019, 21(10), 100.
 [http://dx.doi.org/10.1007/s11920-019-1091-3] [PMID:  31522306]

[2]
Murray, R.M.; Vassos, E. Nature, nurture, and the polygenic risk score for schizophrenia. Schizophr. Bull.,  2020, 46(6), 1363-1365.
 [http://dx.doi.org/10.1093/schbul/sbaa119] [PMID:  32829401]

[3]
van Os, J.; Kenis, G.; Rutten, B.P.F. The environment and schizophrenia. Nature,  2010, 468(7321), 203-212.
 [http://dx.doi.org/10.1038/nature09563] [PMID:  21068828]

[4]
Radua, J.; Ramella-Cravaro, V.; Ioannidis, J.P.A.; Reichenberg, A.; Phiphopthatsanee, N.; Amir, T.; Yenn Thoo, H.; Oliver, D.; Davies, C.; Morgan, C.; McGuire, P.; Murray, R.M.; Fusar-Poli, P. What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry,  2018, 17(1), 49-66.
 [http://dx.doi.org/10.1002/wps.20490] [PMID:  29352556]

[5]
Belbasis, L.; Köhler, C.A.; Stefanis, N.; Stubbs, B.; van Os, J.; Vieta, E.; Seeman, M.V.; Arango, C.; Carvalho, A.F.; Evangelou, E. Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: An umbrella review of meta-analyses. Acta Psychiatr. Scand.,  2018, 137(2), 88-97.
 [http://dx.doi.org/10.1111/acps.12847] [PMID:  29288491]

[6]
Varese, F.; Smeets, F.; Drukker, M.; Lieverse, R.; Lataster, T.; Viechtbauer, W.; Read, J.; van Os, J.; Bentall, R.P. Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr. Bull.,  2012, 38(4), 661-671.
 [http://dx.doi.org/10.1093/schbul/sbs050] [PMID:  22461484]

[7]
McGrath, J.J.; McLaughlin, K.A.; Saha, S.; Aguilar-Gaxiola, S.; Al-Hamzawi, A.; Alonso, J.; Bruffaerts, R.; de Girolamo, G.; de Jonge, P.; Esan, O.; Florescu, S.; Gureje, O.; Haro, J.M.; Hu, C.; Karam, E.G.; Kovess-Masfety, V.; Lee, S.; Lepine, J.P.; Lim, C.C.W.; Medina-Mora, M.E.; Mneimneh, Z.; Pennell, B.E.; Piazza, M.; Posada-Villa, J.; Sampson, N.; Viana, M.C.; Xavier, M.; Bromet, E.J.; Kendler, K.S.; Kessler, R.C. The association between childhood adversities and subsequent first onset of psychotic experiences: A cross-national analysis of 23 998 respondents from 17 countries. Psychol. Med.,  2017, 47(7), 1230-1245.
 [http://dx.doi.org/10.1017/S0033291716003263] [PMID:  28065209]

[8]
Jaaro-Peled, H.; Sawa, A. Neurodevelopmental factors in schizophrenia. Psychiatr. Clin. North Am.,  2020, 43(2), 263-274.
 [http://dx.doi.org/10.1016/j.psc.2020.02.010] [PMID:  32439021]

[9]
Wahbeh, M.H.; Avramopoulos, D. Gene-environment interactions in schizophrenia: A literature review. Genes,  2021, 12(12), 1850.
 [http://dx.doi.org/10.3390/genes12121850] [PMID:  34946799]

[10]
Pries, L.K.; Guloksuz, S.; ten Have, M.; de Graaf, R.; van Dorsselaer, S.; Gunther, N.; Rauschenberg, C.; Reininghaus, U.; Radhakrishnan, R.; Bak, M.; Rutten, B.P.F.; van Os, J. Evidence that environmental and familial risks for psychosis additively impact a multidimensional subthreshold psychosis syndrome. Schizophr. Bull.,  2018, 44(4), 710-719.
 [http://dx.doi.org/10.1093/schbul/sby051] [PMID:  29701807]

[11]
Hassan, A.N.; De Luca, V. The effect of lifetime adversities on resistance to antipsychotic treatment in schizophrenia patients. Schizophr. Res.,  2015, 161(2-3), 496-500.
 [http://dx.doi.org/10.1016/j.schres.2014.10.048] [PMID:  25468176]

[12]
Misiak, B.; Frydecka, D. A history of childhood trauma and response to treatment with antipsychotics in first-episode schizophrenia patients. J. Nerv. Ment. Dis.,  2016, 204(10), 787-792.
 [http://dx.doi.org/10.1097/NMD.0000000000000567] [PMID:  27441460]

[13]
Loewy, R.L.; Corey, S.; Amirfathi, F.; Dabit, S.; Fulford, D.; Pearson, R.; Hua, J.P.Y.; Schlosser, D.; Stuart, B.K.; Mathalon, D.H.; Vinogradov, S. Childhood trauma and clinical high risk for psychosis. Schizophr. Res.,  2019, 205, 10-14.
 [http://dx.doi.org/10.1016/j.schres.2018.05.003] [PMID:  29779964]

[14]
Murray, R.M.; Mondelli, V.; Stilo, S.A.; Trotta, A.; Sideli, L.; Ajnakina, O.; Ferraro, L.; Vassos, E.; Iyegbe, C.; Schoeler, T.; Bhattacharyya, S.; Marques, T.R.; Dazzan, P.; Lopez-Morinigo, J.; Colizzi, M.; O’Connor, J.; Falcone, M.A.; Quattrone, D.; Rodriguez, V.; Tripoli, G.; La Barbera, D.; La Cascia, C.; Alameda, L.; Trotta, G.; Morgan, C.; Gaughran, F.; David, A.; Di Forti, M. The influence of risk factors on the onset and outcome of psychosis: What we learned from the GAP study. Schizophr. Res.,  2020, 225, 63-68.
 [http://dx.doi.org/10.1016/j.schres.2020.01.011] [PMID:  32037203]

[15]
Babenko, O.; Kovalchuk, I.; Metz, G.A.S. Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health. Neurosci. Biobehav. Rev.,  2015, 48, 70-91.
 [http://dx.doi.org/10.1016/j.neubiorev.2014.11.013] [PMID:  25464029]

[16]
Misiak, B.; Krefft, M.; Bielawski, T.; Moustafa, A.A. Sąsiadek, M.M.; Frydecka, D. Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings. Neurosci. Biobehav. Rev.,  2017, 75, 393-406.
 [http://dx.doi.org/10.1016/j.neubiorev.2017.02.015] [PMID:  28216171]

[17]
Corcoran, C.; Walker, E.; Huot, R.; Mittal, V.; Tessner, K.; Kestler, L.; Malaspina, D. The stress cascade and schizophrenia: Etiology and onset. Schizophr. Bull.,  2003, 29(4), 671-692.
 [http://dx.doi.org/10.1093/oxfordjournals.schbul.a007038] [PMID:  14989406]

[18]
van Winkel, R.; Stefanis, N.C.; Myin-Germeys, I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr. Bull.,  2008, 34(6), 1095-1105.
 [http://dx.doi.org/10.1093/schbul/sbn101] [PMID:  18718885]

[19]
Gianfrancesco, O.; Bubb, V.J.; Quinn, J.P. Treating the “E” in “G × E”: Trauma-informed approaches and psychological therapy interventions in psychosis. Front. Psychiatry,  2019, 10, 9.
 [http://dx.doi.org/10.3389/fpsyt.2019.00009] [PMID:  30761022]

[20]
Lardinois, M.; Lataster, T.; Mengelers, R.; Van Os, J.; Myin-Germeys, I. Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatr. Scand.,  2011, 123(1), 28-35.
 [http://dx.doi.org/10.1111/j.1600-0447.2010.01594.x] [PMID:  20712824]

[21]
Read, J.; Fosse, R.; Moskowitz, A.; Perry, B. The traumagenic neurodevelopmental model of psychosis revisited. Neuropsychiatry,  2014, 4(1), 65-79.
 [http://dx.doi.org/10.2217/npy.13.89]

[22]
Howes, O.D.; Murray, R.M. Schizophrenia: An integrated sociodevelopmental-cognitive model. Lancet,  2014, 383(9929), 1677-1687.
 [http://dx.doi.org/10.1016/S0140-6736(13)62036-X] [PMID:  24315522]

[23]
Pruessner, M.; Cullen, A.E.; Aas, M.; Walker, E.F. The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities. Neurosci. Biobehav. Rev.,  2017, 73, 191-218.
 [http://dx.doi.org/10.1016/j.neubiorev.2016.12.013] [PMID:  27993603]

[24]
Vargas, T.; Conley, R.E.; Mittal, V.A. Chronic stress, structural exposures and neurobiological mechanisms: A stimulation, discrepancy and deprivation model of psychosis. Int. Rev. Neurobiol.,  2020, 152, 41-69.
 [http://dx.doi.org/10.1016/bs.irn.2019.11.004] [PMID:  32451000]

[25]
de Kloet, E.R.; Sibug, R.M.; Helmerhorst, F.M.; Schmidt, M. Stress, genes and the mechanism of programming the brain for later life. Neurosci. Biobehav. Rev.,  2005, 29(2), 271-281.
 [http://dx.doi.org/10.1016/j.neubiorev.2004.10.008] [PMID:  15811498]

[26]
DeRosse, P.; Barber, A.D. Overlapping neurobiological substrates for early-life stress and resilience to psychosis. Biol. Psychiatry Cogn. Neurosci. Neuroimaging,  2021, 6(2), 144-153.
 [http://dx.doi.org/10.1016/j.bpsc.2020.09.003] [PMID:  33097471]

[27]
Ciufolini, S.; Gayer-Anderson, C.; Fisher, H.L.; Marques, T.R.; Taylor, H.; Di Forti, M.; Zunszain, P.; Morgan, C.; Murray, R.M.; Pariante, C.M.; Dazzan, P.; Mondelli, V. Cortisol awakening response is decreased in patients with first-episode psychosis and increased in healthy controls with a history of severe childhood abuse. Schizophr. Res.,  2019, 205, 38-44.
 [http://dx.doi.org/10.1016/j.schres.2018.05.002] [PMID:  29776641]

[28]
Aas, M.; Dazzan, P.; Mondelli, V.; Toulopoulou, T.; Reichenberg, A.; Di Forti, M.; Fisher, H.L.; Handley, R.; Hepgul, N.; Marques, T.; Miorelli, A.; Taylor, H.; Russo, M.; Wiffen, B.; Papadopoulos, A.; Aitchison, K.J.; Morgan, C.; Murray, R.M.; Pariante, C.M. Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychol. Med.,  2011, 41(3), 463-476.
 [http://dx.doi.org/10.1017/S0033291710001170] [PMID:  20529412]

[29]
Aas, M.; Dazzan, P.; Mondelli, V.; Melle, I.; Murray, R.M.; Pariante, C.M. A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation. Front. Psychiatry,  2014, 4, 182.
 [http://dx.doi.org/10.3389/fpsyt.2013.00182] [PMID:  24409157]

[30]
Reniers, R.L.E.P.; Garner, B.; Phassouliotis, C.; Phillips, L.J.; Markulev, C.; Pantelis, C.; Bendall, S.; McGorry, P.D.; Wood, S.J. The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment. Psychiatry Res. Neuroimaging,  2015, 231(2), 111-119.
 [http://dx.doi.org/10.1016/j.pscychresns.2014.11.004] [PMID:  25492856]

[31]
Valli, I.; Crossley, N.A.; Day, F.; Stone, J.; Tognin, S.; Mondelli, V.; Howes, O.; Valmaggia, L.; Pariante, C.; McGuire, P. HPA-axis function and grey matter volume reductions: Imaging the diathesis-stress model in individuals at ultra-high risk of psychosis. Transl. Psychiatry,  2016, 6(5), e797.
 [http://dx.doi.org/10.1038/tp.2016.68] [PMID:  27138796]

[32]
Daskalakis, N.P.; Binder, E.B. Schizophrenia in the spectrum of gene-stress interactions: The FKBP5 example. Schizophr. Bull.,  2015, 41(2), 323-329.
 [http://dx.doi.org/10.1093/schbul/sbu189] [PMID:  25592294]

[33]
Howes, O.; McCutcheon, R.; Stone, J. Glutamate and dopamine in schizophrenia: An update for the 21st century. J. Psychopharmacol.,  2015, 29(2), 97-115.
 [http://dx.doi.org/10.1177/0269881114563634] [PMID:  25586400]

[34]
Nordholm, D.; Krogh, J.; Mondelli, V.; Dazzan, P.; Pariante, C.; Nordentoft, M. Pituitary gland volume in patients with schizophrenia, subjects at ultra high-risk of developing psychosis and healthy controls: A systematic review and meta-analysis. Psychoneuroendocrinology,  2013, 38(11), 2394-2404.
 [http://dx.doi.org/10.1016/j.psyneuen.2013.06.030] [PMID:  23890984]

[35]
Saunders, T.S.; Mondelli, V.; Cullen, A.E. Pituitary volume in individuals at elevated risk for psychosis: A systematic review and meta-analysis. Schizophr. Res.,  2019, 213, 23-31.
 [http://dx.doi.org/10.1016/j.schres.2018.12.026] [PMID:  30600112]

[36]
Poletti, S.; Mazza, E.; Bollettini, I.; Locatelli, C.; Cavallaro, R.; Smeraldi, E.; Benedetti, F. Adverse childhood experiences influence white matter microstructure in patients with schizophrenia. Psychiatry Res. Neuroimaging,  2015, 234(1), 35-43.
 [http://dx.doi.org/10.1016/j.pscychresns.2015.08.003] [PMID:  26341951]

[37]
Herringa, R.J.; Birn, R.M.; Ruttle, P.L.; Burghy, C.A.; Stodola, D.E.; Davidson, R.J.; Essex, M.J. Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence. Proc. Natl. Acad. Sci. USA,  2013, 110(47), 19119-19124.
 [http://dx.doi.org/10.1073/pnas.1310766110] [PMID:  24191026]

[38]
Sinclair, D.; Fillman, S.G.; Webster, M.J.; Weickert, C.S. Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness. Sci. Rep.,  2013, 3(1), 3539.
 [http://dx.doi.org/10.1038/srep03539] [PMID:  24345775]

[39]
Mondelli, V.; Dazzan, P.; Hepgul, N.; Di Forti, M.; Aas, M.; D’Albenzio, A.; Di Nicola, M.; Fisher, H.; Handley, R.; Marques, T.R.; Morgan, C.; Navari, S.; Taylor, H.; Papadopoulos, A.; Aitchison, K.J.; Murray, R.M.; Pariante, C.M. Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: The role of stress and of antipsychotic treatment. Schizophr. Res.,  2010, 116(2-3), 234-242.
 [http://dx.doi.org/10.1016/j.schres.2009.08.013] [PMID:  19751968]

[40]
Popoli, M.; Yan, Z.; McEwen, B.S.; Sanacora, G. The stressed synapse: The impact of stress and glucocorticoids on glutamate transmission. Nat. Rev. Neurosci.,  2012, 13(1), 22-37.
 [http://dx.doi.org/10.1038/nrn3138] [PMID:  22127301]

[41]
Girshkin, L.; Matheson, S.L.; Shepherd, A.M.; Green, M.J. Morning cortisol levels in schizophrenia and bipolar disorder: A meta-analysis. Psychoneuroendocrinology,  2014, 49, 187-206.
 [http://dx.doi.org/10.1016/j.psyneuen.2014.07.013] [PMID:  25108162]

[42]
Zorn, J.V.; Schür, R.R.; Boks, M.P.; Kahn, R.S.; Joëls, M.; Vinkers, C.H. Cortisol stress reactivity across psychiatric disorders: A systematic review and meta-analysis. Psychoneuroendocrinology,  2017, 77, 25-36.
 [http://dx.doi.org/10.1016/j.psyneuen.2016.11.036] [PMID:  28012291]

[43]
Berger, M.; Kraeuter, A.K.; Romanik, D.; Malouf, P.; Amminger, G.P.; Sarnyai, Z. Cortisol awakening response in patients with psychosis: Systematic review and meta-analysis. Neurosci. Biobehav. Rev.,  2016, 68, 157-166.
 [http://dx.doi.org/10.1016/j.neubiorev.2016.05.027] [PMID:  27229759]

[44]
Dauvermann, M.R.; Donohoe, G. Cortisol stress response in psychosis from the high-risk to the chronic stage: A systematic review. Ir. J. Psychol. Med.,  2019, 36(4), 305-315.
 [http://dx.doi.org/10.1017/ipm.2019.27] [PMID:  31317845]

[45]
Misiak, B.; Pruessner, M.; Samochowiec, J. Wiśniewski, M.; Reginia, A.; Stańczykiewicz, B. A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals. Front. Neuroendocrinol.,  2021, 62(100930), 100930.
 [http://dx.doi.org/10.1016/j.yfrne.2021.100930] [PMID:  34171354]

[46]
de Kloet, E.R. Hormones, brain and stress. Endocr. Regul.,  2003, 37(2), 51-68.
 [PMID:  12932191]

[47]
Holtzman, C.W.; Trotman, H.D.; Goulding, S.M.; Ryan, A.T.; MacDonald, A.N.; Shapiro, D.I.; Brasfield, J.L.; Walker, E.F. Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience,  2013, 249, 172-191.
 [http://dx.doi.org/10.1016/j.neuroscience.2012.12.017] [PMID:  23298853]

[48]
Khandaker, G.M.; Cousins, L.; Deakin, J.; Lennox, B.R.; Yolken, R.; Jones, P.B. Inflammation and immunity in schizophrenia: Implications for pathophysiology and treatment. Lancet Psychiatry,  2015, 2(3), 258-270.
 [http://dx.doi.org/10.1016/S2215-0366(14)00122-9] [PMID:  26359903]

[49]
Fraguas, D.; Díaz-Caneja, C.M.; Ayora, M.; Hernández-Álvarez, F.; Rodríguez-Quiroga, A.; Recio, S.; Leza, J.C.; Arango, C. Oxidative stress and inflammation in first-episode psychosis: A systematic review and meta-analysis. Schizophr. Bull.,  2019, 45(4), 742-751.
 [http://dx.doi.org/10.1093/schbul/sby125] [PMID:  30169868]

[50]
Misiak, B.; Łoniewski, I.; Marlicz, W.; Frydecka, D.; Szulc, A.; Rudzki, L.; Samochowiec, J. The HPA axis dysregulation in severe	mental illness: Can we shift the blame to gut microbiota? Prog. Neuropsychopharmacol. Biol. Psychiatry,  2020, 102(109951), 109951.
 [http://dx.doi.org/10.1016/j.pnpbp.2020.109951] [PMID:  32335265]

[51]
Rohleder, N. Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom. Med.,  2014, 76(3), 181-189.
 [http://dx.doi.org/10.1097/PSY.0000000000000049] [PMID:  24608036]

[52]
Goldsmith, D.R.; Rapaport, M.H.; Miller, B.J. A meta-analysis of blood cytokine network alterations in psychiatric patients: Comparisons between schizophrenia, bipolar disorder and depression. Mol. Psychiatry,  2016, 21(12), 1696-1709.
 [http://dx.doi.org/10.1038/mp.2016.3] [PMID:  26903267]

[53]
Marcinowicz, P. Więdłocha, M.; Zborowska, N.; Dębowska, W.; Podwalski, P.; Misiak, B.; Tyburski, E.; Szulc, A. A meta-analysis of the influence of antipsychotics on cytokines levels in first episode psychosis. J. Clin. Med.,  2021, 10(11), 2488.
 [http://dx.doi.org/10.3390/jcm10112488] [PMID:  34199832]

[54]
Upthegrove, R.; Khandaker, G.M. Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia. Curr. Top. Behav. Neurosci.,  2019, 44, 49-66.
 [http://dx.doi.org/10.1007/7854_2018_88] [PMID:  31115797]

[55]
Miller, B.J.; Buckley, P.; Seabolt, W.; Mellor, A.; Kirkpatrick, B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol. Psychiatry,  2011, 70(7), 663-671.
 [http://dx.doi.org/10.1016/j.biopsych.2011.04.013] [PMID:  21641581]

[56]
Dunleavy, C.; Elsworthy, R.J.; Upthegrove, R.; Wood, S.J.; Aldred, S. Inflammation in first‐episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta‐analysis. Acta Psychiatr. Scand.,  2022, 146(1), 6-20.
 [http://dx.doi.org/10.1111/acps.13416] [PMID:  35202480]

[57]
Laskaris, L.; Mancuso, S.; Shannon Weickert, C.; Zalesky, A.; Chana, G.; Wannan, C.; Bousman, C.; Baune, B.T.; McGorry, P.; Pantelis, C.; Cropley, V.L. Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder. Brain Behav. Immun.,  2021, 95, 299-309.
 [http://dx.doi.org/10.1016/j.bbi.2021.04.002] [PMID:  33838248]

[58]
Hoang, D.; Xu, Y.; Lutz, O.; Bannai, D.; Zeng, V.; Bishop, J.R.; Keshavan, M.; Lizano, P. Inflammatory subtypes in antipsychotic-naïve first-episode schizophrenia are associated with altered brain morphology and topological organization. Brain Behav. Immun.,  2022, 100, 297-308.
 [http://dx.doi.org/10.1016/j.bbi.2021.11.019] [PMID:  34875344]

[59]
Schizophrenia Working Group of the Psychiatric Genomics Consortium Biological insights from 108 schizophrenia-associated genetic loci. Nature,  2014, 511(7510), 421-427.
 [http://dx.doi.org/10.1038/nature13595] [PMID:  25056061]

[60]
Mostaid, M.S.; Dimitrakopoulos, S.; Wannan, C.; Cropley, V.; Weickert, C.S.; Everall, I.P.; Pantelis, C.; Bousman, C.A. An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure. Schizophr. Res.,  2019, 204, 201-205.
 [http://dx.doi.org/10.1016/j.schres.2018.09.008] [PMID:  30220520]

[61]
Misiak, B.; Bartoli, F.; Carrà, G. Stańczykiewicz, B.; Gładka, A.; Frydecka, D.; Samochowiec, J.; Jarosz, K.; Hadryś T.; Miller, B.J. Immune-inflammatory markers and psychosis risk: A systematic review and meta-analysis. Psychoneuroendocrinology,  2021, 127(105200), 105200.
 [http://dx.doi.org/10.1016/j.psyneuen.2021.105200] [PMID:  33740587]

[62]
Khandaker, G.M.; Pearson, R.M.; Zammit, S.; Lewis, G.; Jones, P.B. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: A population-based longitudinal study. JAMA Psychiatry,  2014, 71(10), 1121-1128.
 [http://dx.doi.org/10.1001/jamapsychiatry.2014.1332] [PMID:  25133871]

[63]
Baumeister, D.; Akhtar, R.; Ciufolini, S.; Pariante, C.M.; Mondelli, V. Childhood trauma and adulthood inflammation: A meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol. Psychiatry,  2016, 21(5), 642-649.
 [http://dx.doi.org/10.1038/mp.2015.67] [PMID:  26033244]

[64]
Khandaker, G.M.; Zimbron, J.; Lewis, G.; Jones, P.B. Prenatal maternal infection, neurodevelopment and adult schizophrenia: A systematic review of population-based studies. Psychol. Med.,  2013, 43(2), 239-257.
 [http://dx.doi.org/10.1017/S0033291712000736] [PMID:  22717193]

[65]
Cannon, M.; Clarke, M.C.; Cotter, D.R. Priming the brain for psychosis: Maternal inflammation during fetal development and the risk of later psychiatric disorder. Am. J. Psychiatry,  2014, 171(9), 901-905.
 [http://dx.doi.org/10.1176/appi.ajp.2014.14060749] [PMID:  25178744]

[66]
Radhakrishnan, R.; Kaser, M.; Guloksuz, S. The link between the immune system, environment, and psychosis. Schizophr. Bull.,  2017, 43(4), 693-697.
 [http://dx.doi.org/10.1093/schbul/sbx057] [PMID:  28969353]

[67]
Howes, O.D.; McCutcheon, R. Inflammation and the neural diathesis-stress hypothesis of schizophrenia: A reconceptualization. Transl. Psychiatry,  2017, 7(2), e1024-e1024.
 [http://dx.doi.org/10.1038/tp.2016.278] [PMID:  28170004]

[68]
Di Biase, M.A.; Zalesky, A.; O’keefe, G.; Laskaris, L.; Baune, B.T.; Weickert, C.S.; Olver, J.; McGorry, P.D.; Amminger, G.P.; Nelson, B.; Scott, A.M.; Hickie, I.; Banati, R.; Turkheimer, F.; Yaqub, M.; Everall, I.P.; Pantelis, C.; Cropley, V. PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia. Transl. Psychiatry,  2017, 7(8), e1225-e1225.
 [http://dx.doi.org/10.1038/tp.2017.193] [PMID:  28850113]

[69]
Murray, A.J.; Rogers, J.C.; Katshu, M.Z.U.H.; Liddle, P.F.; Upthegrove, R. Oxidative stress and the pathophysiology and symptom profile of schizophrenia spectrum disorders. Front. Psychiatry,  2021, 12, 703452.
 [http://dx.doi.org/10.3389/fpsyt.2021.703452] [PMID:  34366935]

[70]
Flatow, J.; Buckley, P.; Miller, B.J. Meta-analysis of oxidative stress in schizophrenia. Biol. Psychiatry,  2013, 74(6), 400-409.
 [http://dx.doi.org/10.1016/j.biopsych.2013.03.018] [PMID:  23683390]

[71]
Fraguas, D.; Díaz-Caneja, C.M.; Rodríguez-Quiroga, A.; Arango, C. Oxidative stress and inflammation in early onset first episode psychosis: A systematic review and meta-analysis. Int. J. Neuropsychopharmacol.,  2017, 20(6), 435-444.
 [http://dx.doi.org/10.1093/ijnp/pyx015] [PMID:  28575316]

[72]
Ventriglio, A.; Bellomo, A.; Donato, F.; Iris, B.; Giovanna, V.; Dario, D.S.; Edwige, C.; Pettorruso, M.; Perna, G.; Valchera, A.; De Berardis, D. Oxidative stress in the early stage of psychosis. Curr. Top. Med. Chem.,  2021, 21(16), 1457-1470.
 [http://dx.doi.org/10.2174/1568026621666210701105839] [PMID:  34218786]

[73]
Fraguas, D.; Gonzalez-Pinto, A.; Micó, J.A.; Reig, S.; Parellada, M.; Martínez-Cengotitabengoa, M.; Castro-Fornieles, J.; Rapado-Castro, M.; Baeza, I.; Janssen, J.; Desco, M.; Leza, J.C.; Arango, C. Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study. Schizophr. Res.,  2012, 137(1-3), 58-65.
 [http://dx.doi.org/10.1016/j.schres.2012.01.040] [PMID:  22365149]

[74]
Alameda, L.; Fournier, M.; Khadimallah, I.; Griffa, A.; Cleusix, M.; Jenni, R.; Ferrari, C.; Klauser, P.; Baumann, P.S.; Cuenod, M.; Hagmann, P.; Conus, P.; Do, K.Q. Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis. Proc. Natl. Acad. Sci. USA,  2018, 115(49), 12495-12500.
 [http://dx.doi.org/10.1073/pnas.1812821115] [PMID:  30455310]

[75]
McGorry, P.D.; Nelson, B.; Markulev, C.; Yuen, H.P.; Schäfer, M.R.; Mossaheb, N.; Schlögelhofer, M.; Smesny, S.; Hickie, I.B.; Berger, G.E.; Chen, E.Y.H.; de Haan, L.; Nieman, D.H.; Nordentoft, M.; Riecher-Rössler, A.; Verma, S.; Thompson, A.; Yung, A.R.; Amminger, G.P. Effect of ω-3 polyunsaturated fatty acids in young people at ultrahigh risk for psychotic disorders: The NEURAPRO randomized clinical trial: The NEURAPRO randomized clinical trial. JAMA Psychiatry,  2017, 74(1), 19-27.
 [http://dx.doi.org/10.1001/jamapsychiatry.2016.2902] [PMID:  27893018]

[76]
Green, M.J.; Matheson, S.L.; Shepherd, A.; Weickert, C.S.; Carr, V.J. Brain-derived neurotrophic factor levels in schizophrenia: A systematic review with meta-analysis. Mol. Psychiatry,  2011, 16(9), 960-972.
 [http://dx.doi.org/10.1038/mp.2010.88] [PMID:  20733577]

[77]
Singh, S.; Roy, D.; Marzouk, T.; Zhang, J.P. Peripheral blood levels of brain-derived neurotrophic factor in patients with first episode psychosis: A systematic review and meta-analysis. Brain Sci.,  2022, 12(4), 414.
 [http://dx.doi.org/10.3390/brainsci12040414] [PMID:  35447946]

[78]
Yee, J.Y.; Lee, T.S.; Lee, J. Levels of serum brain-derived neurotropic factor in individuals at ultra-high risk for psychosis—findings from the longitudinal youth at risk study (LYRIKS). Int. J. Neuropsychopharmacol.,  2018, 21(8), 734-739.
 [http://dx.doi.org/10.1093/ijnp/pyy036] [PMID:  29584866]

[79]
Heitz, U.; Papmeyer, M.; Studerus, E.; Egloff, L.; Ittig, S.; Andreou, C.; Vogel, T.; Borgwardt, S.; Graf, M.; Eckert, A.; Riecher-Rössler, A. Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients. World J. Biol. Psychiatry,  2019, 20(7), 545-554.
 [http://dx.doi.org/10.1080/15622975.2018.1462532] [PMID:  29938562]

[80]
Misiak, B.; Stramecki, F. Gawęda, Ł Prochwicz, K.; Sąsiadek, M.M.; Moustafa, A.A.; Frydecka, D. Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: A systematic review. Mol. Neurobiol.,  2018, 55(6), 5075-5100.
 [http://dx.doi.org/10.1007/s12035-017-0708-y] [PMID:  28822116]

[81]
De Picker, L.J.; Morrens, M.; Chance, S.A.; Boche, D. Microglia and brain plasticity in acute psychosis and schizophrenia illness course: A meta-review. Front. Psychiatry,  2017, 8, 238.
 [http://dx.doi.org/10.3389/fpsyt.2017.00238] [PMID:  29201010]

[82]
Lynch, S.V.; Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med.,  2016, 375(24), 2369-2379.
 [http://dx.doi.org/10.1056/NEJMra1600266] [PMID:  27974040]

[83]
Severance, E.G.; Prandovszky, E.; Castiglione, J.; Yolken, R.H. Gastroenterology issues in schizophrenia: Why the gut matters. Curr. Psychiatry Rep.,  2015, 17(5), 27.
 [http://dx.doi.org/10.1007/s11920-015-0574-0] [PMID:  25773227]

[84]
Dash, S.; Syed, Y.A.; Khan, M.R. Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders. Front. Cell Dev. Biol.,  2022, 10, 880544.
 [http://dx.doi.org/10.3389/fcell.2022.880544] [PMID:  35493075]

[85]
Rogers, G.B.; Keating, D.J.; Young, R.L.; Wong, M-L.; Licinio, J.; Wesselingh, S. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol. Psychiatry,  2016, 21(6), 738-748.
 [http://dx.doi.org/10.1038/mp.2016.50] [PMID:  27090305]

[86]
Hoffman, K.W.; Lee, J.J.; Corcoran, C.M.; Kimhy, D.; Kranz, T.M.; Malaspina, D. Considering the microbiome in stress-related and neurodevelopmental trajectories to schizophrenia. Front. Psychiatry,  2020, 11, 629.
 [http://dx.doi.org/10.3389/fpsyt.2020.00629] [PMID:  32719625]

[87]
Wan, X.; Eguchi, A.; Qu, Y.; Yang, Y.; Chang, L.; Shan, J.; Mori, C.; Hashimoto, K. Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence. Eur. Arch. Psychiatry Clin. Neurosci.,  2022, 272(7), 1297-1309.
 [http://dx.doi.org/10.1007/s00406-022-01437-1] [PMID:  35666299]

[88]
Nguyen, T.T.; Kosciolek, T.; Maldonado, Y.; Daly, R.E.; Martin, A.S.; McDonald, D.; Knight, R.; Jeste, D.V. Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects. Schizophr. Res.,  2019, 204, 23-29.
 [http://dx.doi.org/10.1016/j.schres.2018.09.014] [PMID:  30268819]

[89]
Zhang, X.; Pan, L.; Zhang, Z.; Zhou, Y.; Jiang, H.; Ruan, B. Analysis of gut mycobiota in first-episode, drug-naïve Chinese patients with schizophrenia: A pilot study. Behav. Brain Res.,  2020, 379(112374), 112374.
 [http://dx.doi.org/10.1016/j.bbr.2019.112374] [PMID:  31759045]

[90]
He, Y.; Kosciolek, T.; Tang, J.; Zhou, Y.; Li, Z.; Ma, X.; Zhu, Q.; Yuan, N.; Yuan, L.; Li, C.; Jin, K.; Knight, R.; Tsuang, M.T.; Chen, X. Gut microbiome and magnetic resonance spectroscopy study of subjects at ultra-high risk for psychosis may support the membrane hypothesis. Eur. Psychiatry,  2018, 53, 37-45.
 [http://dx.doi.org/10.1016/j.eurpsy.2018.05.011] [PMID:  29870894]

[91]
Li, S.; Song, J.; Ke, P.; Kong, L.; Lei, B.; Zhou, J.; Huang, Y.; Li, H.; Li, G.; Chen, J.; Li, X.; Xiang, Z.; Ning, Y.; Wu, F.; Wu, K. The gut microbiome is associated with brain structure and function in schizophrenia. Sci. Rep.,  2021, 11(1), 9743.
 [http://dx.doi.org/10.1038/s41598-021-89166-8] [PMID:  33963227]

[92]
Socała, K.; Doboszewska, U.; Szopa, A.; Serefko, A.; Włodarczyk, M.; Zielińska, A.; Poleszak, E.; Fichna, J.; Wlaź P. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacol. Res.,  2021, 172(105840), 105840.
 [http://dx.doi.org/10.1016/j.phrs.2021.105840] [PMID:  34450312]

[93]
Tsamakis, K.; Galinaki, S.; Alevyzakis, E.; Hortis, I.; Tsiptsios, D.; Kollintza, E.; Kympouropoulos, S.; Triantafyllou, K.; Smyrnis, N.; Rizos, E. Gut microbiome: A brief review on its role in schizophrenia and first episode of psychosis. Microorganisms,  2022, 10(6), 1121.
 [http://dx.doi.org/10.3390/microorganisms10061121] [PMID:  35744639]

[94]
Samochowiec, J.; Misiak, B. Gut microbiota and microbiome in schizophrenia. Curr. Opin. Psychiatry,  2021, 34(5), 503-507.
 [http://dx.doi.org/10.1097/YCO.0000000000000733] [PMID:  34155149]

[95]
Murray, N.; Al Khalaf, S.; Kaulmann, D.; Lonergan, E.; Cryan, J.F.; Clarke, G. Compositional and functional alterations in the oral and gut microbiota in patients with psychosis or schizophrenia: A systematic review. HRB open res,  2021, 4, 108.

[96]
Howes, O.D.; McCutcheon, R.; Owen, M.J.; Murray, R.M. The role of genes, stress, and dopamine in the development of schizophrenia. Biol. Psychiatry,  2017, 81(1), 9-20.
 [http://dx.doi.org/10.1016/j.biopsych.2016.07.014] [PMID:  27720198]

[97]
McCutcheon, R.A.; Krystal, J.H.; Howes, O.D. Dopamine and glutamate in schizophrenia: Biology, symptoms and treatment. World Psychiatry,  2020, 19(1), 15-33.
 [http://dx.doi.org/10.1002/wps.20693] [PMID:  31922684]

[98]
Fernandez-Espejo, E.; Viveros, M.P.; Núñez, L.; Ellenbroek, B.A.; Rodriguez de Fonseca, F. Role of cannabis and endocannabinoids in the genesis of schizophrenia. Psychopharmacology,  2009, 206(4), 531-549.
 [http://dx.doi.org/10.1007/s00213-009-1612-6] [PMID:  19629449]

[99]
Hill, M.N.; Patel, S.; Campolongo, P.; Tasker, J.G.; Wotjak, C.T.; Bains, J.S. Functional interactions between stress and the endocannabinoid system: From synaptic signaling to behavioral output. J. Neurosci.,  2010, 30(45), 14980-14986.
 [http://dx.doi.org/10.1523/JNEUROSCI.4283-10.2010] [PMID:  21068301]

[100]
Castelli, M.P.; Paola, P.A.; D’Agostino, A.; Pibiri, F.; Perra, S.; Gessa, G.L.; Maccarrone, M.; Pistis, M. Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2. Eur. J. Pharmacol.,  2007, 573(1-3), 11-19.
 [http://dx.doi.org/10.1016/j.ejphar.2007.06.047] [PMID:  17644084]

[101]
Lutz, B.; Marsicano, G.; Maldonado, R.; Hillard, C.J. The endocannabinoid system in guarding against fear, anxiety and stress. Nat. Rev. Neurosci.,  2015, 16(12), 705-718.
 [http://dx.doi.org/10.1038/nrn4036] [PMID:  26585799]

[102]
Fusar-Poli, P.; Tantardini, M.; De Simone, S.; Ramella-Cravaro, V.; Oliver, D.; Kingdon, J.; Kotlicka-Antczak, M.; Valmaggia, L.; Lee, J.; Millan, M.J.; Galderisi, S.; Balottin, U.; Ricca, V.; McGuire, P. Deconstructing vulnerability for psychosis: Meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur. Psychiatry,  2017, 40, 65-75.
 [http://dx.doi.org/10.1016/j.eurpsy.2016.09.003] [PMID:  27992836]

[103]
Dean, K.; Murray, R.M. Environmental risk factors for psychosis. Dialogues Clin. Neurosci.,  2005, 7(1), 69-80.
 [http://dx.doi.org/10.31887/DCNS.2005.7.1/kdean] [PMID:  16060597]

[104]
De Matteis, T.; D’Andrea, G.; Lal, J.; Berardi, D.; Tarricone, I. The impact of peri-natal stress on psychosis risk: Results from the Bo-FEP incidence study. BMC Res. Notes,  2020, 13(1), 153.
 [http://dx.doi.org/10.1186/s13104-020-04992-9] [PMID:  32178713]

[105]
Brasso, C.; Giordano, B.; Badino, C.; Bellino, S.; Bozzatello, P.; Montemagni, C.; Rocca, P. Primary psychosis: Risk and protective factors and early detection of the onset. Diagnostics,  2021, 11(11), 2146.
 [http://dx.doi.org/10.3390/diagnostics11112146] [PMID:  34829493]

[106]
Lopez-Castroman, J.; Gómez, D.D.; Belloso, J.J.C.; Fernandez-Navarro, P.; Perez-Rodriguez, M.M.; Villamor, I.B.; Navarrete, F.F.; Ginestar, C.M.; Currier, D.; Torres, M.R.; Navio-Acosta, M.; Saiz-Ruiz, J.; Jimenez-Arriero, M.A.; Baca-Garcia, E. Differences in maternal and paternal age between Schizophrenia and other psychiatric disorders. Schizophr. Res.,  2010, 116(2-3), 184-190.
 [http://dx.doi.org/10.1016/j.schres.2009.11.006] [PMID:  19945257]

[107]
Nosarti, C.; Reichenberg, A.; Murray, R.M.; Cnattingius, S.; Lambe, M.P.; Yin, L.; MacCabe, J.; Rifkin, L.; Hultman, C.M. Preterm birth and psychiatric disorders in young adult life. Arch. Gen. Psychiatry,  2012, 69(6), E1-E8.
 [http://dx.doi.org/10.1001/archgenpsychiatry.2011.1374] [PMID:  22660967]

[108]
Davies, C.; Segre, G.; Estradé, A.; Radua, J.; De Micheli, A.; Provenzani, U.; Oliver, D.; Salazar de Pablo, G.; Ramella-Cravaro, V.; Besozzi, M.; Dazzan, P.; Miele, M.; Caputo, G.; Spallarossa, C.; Crossland, G.; Ilyas, A.; Spada, G.; Politi, P.; Murray, R.M.; McGuire, P.; Fusar-Poli, P. Prenatal and perinatal risk and protective factors for psychosis: A systematic review and meta-analysis. Lancet Psychiatry,  2020, 7(5), 399-410.
 [http://dx.doi.org/10.1016/S2215-0366(20)30057-2] [PMID:  32220288]

[109]
Haukka, J.K.; Suvisaari, J.; Lönnqvist, J. Family structure and risk factors for schizophrenia: Case-sibling study. BMC Psychiatry,  2004, 4(1), 41.
 [http://dx.doi.org/10.1186/1471-244X-4-41] [PMID:  15566576]

[110]
Kollias, C.; Dimitrakopoulos, S.; Xenaki, L.A.; Stefanis, N.; Papageorgiou, C. Evidence of advanced parental age linked to sporadic schizophrenia. Psychiatriki,  2019, 30(1), 24-31.
 [http://dx.doi.org/10.22365/jpsych.2019.301.24] [PMID:  31115351]

[111]
Schürhoff, F.; Pignon, B.; Lajnef, M.; Denis, R.; Rutten, B.; Morgan, C.; Murray, R.M.; Leboyer, M.; van Os, J.; Szöke, A. Psychotic experiences are associated with paternal age but not with delayed fatherhood in a large, multinational, community sample. Schizophr. Bull.,  2020, 46(5), 1327-1334.
 [http://dx.doi.org/10.1093/schbul/sbz142] [PMID:  32049353]

[112]
Arango, C.; Dragioti, E.; Solmi, M.; Cortese, S.; Domschke, K.; Murray, R.M.; Jones, P.B.; Uher, R.; Carvalho, A.F.; Reichenberg, A.; Shin, J.I.I.; Andreassen, O.A.; Correll, C.U.; Fusar-Poli, P. Risk and protective factors for mental disorders beyond genetics: an evidence‐based atlas. World Psychiatry,  2021, 20(3), 417-436.
 [http://dx.doi.org/10.1002/wps.20894] [PMID:  34505386]

[113]
Ellegren, H. Characteristics, causes and evolutionary consequences of male-biased mutation. Proc. Biol. Sci.,  2007, 274(1606), 1-10.
 [http://dx.doi.org/10.1098/rspb.2006.3720] [PMID:  17134994]

[114]
Petersen, L.; Mortensen, P.B.; Pedersen, C.B. Paternal age at birth of first child and risk of schizophrenia. Am. J. Psychiatry,  2011, 168(1), 82-88.
 [http://dx.doi.org/10.1176/appi.ajp.2010.10020252] [PMID:  20952457]

[115]
Ek, M.; Wicks, S.; Svensson, A.C.; Idring, S.; Dalman, C. Advancing paternal age and schizophrenia: The impact of delayed fatherhood. Schizophr. Bull.,  2015, 41(3), 708-714.
 [http://dx.doi.org/10.1093/schbul/sbu154] [PMID:  25378438]

[116]
Escott-Price, V.; Smith, D.J.; Kendall, K.; Ward, J.; Kirov, G.; Owen, M.J.; Walters, J.; O’Donovan, M.C. Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort. Psychol. Med.,  2019, 49(15), 2499-2504.
 [http://dx.doi.org/10.1017/S0033291718000454] [PMID:  29501066]

[117]
Carter, J.W.; Schulsinger, F.; Parnas, J.; Cannon, T.; Mednick, S.A. A multivariate prediction model of schizophrenia. Schizophr. Bull.,  2002, 28(4), 649-682.
 [http://dx.doi.org/10.1093/oxfordjournals.schbul.a006971] [PMID:  12795497]

[118]
Corcoran, C.; Perrin, M.; Harlap, S.; Deutsch, L.; Fennig, S.; Manor, O.; Nahon, D.; Kimhy, D.; Malaspina, D.; Susser, E. Effect of socioeconomic status and parents’ education at birth on risk of schizophrenia in offspring. Soc. Psychiatry Psychiatr. Epidemiol.,  2009, 44(4), 265-271.
 [http://dx.doi.org/10.1007/s00127-008-0439-5] [PMID:  18836884]

[119]
Veling, W.; Pot-Kolder, R.; Counotte, J.; van Os, J.; van der Gaag, M. Environmental social stress, paranoia and psychosis liability: A virtual reality study. Schizophr. Bull.,  2016, 42(6), 1363-1371.
 [http://dx.doi.org/10.1093/schbul/sbw031] [PMID:  27038469]

[120]
Coid, J.W.; Zhang, Y.; Sun, H.; Yu, H.; Wei, W.; Li, X.; Lv, Q.; Tang, W.; Wang, Q.; Deng, W.; Guo, W.; Zhao, L.; Ma, X.; Meng, Y.; Li, M.; Wang, H.; Chen, T.; Li, T. Impact of urban birth and upbringing on expression of psychosis in a Chinese undergraduate population. BMC Psychiatry,  2021, 21(1), 493.
 [http://dx.doi.org/10.1186/s12888-021-03475-w] [PMID:  34625040]

[121]
Ursini, G.; Punzi, G.; Chen, Q.; Marenco, S.; Robinson, J.F.; Porcelli, A.; Hamilton, E.G.; Mitjans, M.; Maddalena, G.; Begemann, M.; Seidel, J.; Yanamori, H.; Jaffe, A.E.; Berman, K.F.; Egan, M.F.; Straub, R.E.; Colantuoni, C.; Blasi, G.; Hashimoto, R.; Rujescu, D.; Ehrenreich, H.; Bertolino, A.; Weinberger, D.R. Convergence of placenta biology and genetic risk for schizophrenia. Nat. Med.,  2018, 24(6), 792-801.
 [http://dx.doi.org/10.1038/s41591-018-0021-y] [PMID:  29808008]

[122]
Rubio-Abadal, E.; Ochoa, S.; Barajas, A.; Baños, I.; Dolz, M.; Sanchez, B.; Del Cacho, N.; Carlson, J.; Huerta-Ramos, E.; Usall, J. Birth weight and obstetric complications determine age at onset in first episode of psychosis. J. Psychiatr. Res.,  2015, 65, 108-114.
 [http://dx.doi.org/10.1016/j.jpsychires.2015.03.018] [PMID:  25890850]

[123]
Brown, A.S.; Begg, M.D.; Gravenstein, S.; Schaefer, C.A.; Wyatt, R.J.; Bresnahan, M.; Babulas, V.P.; Susser, E.S. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch. Gen. Psychiatry,  2004, 61(8), 774-780.
 [http://dx.doi.org/10.1001/archpsyc.61.8.774] [PMID:  15289276]

[124]
Canetta, S.; Sourander, A.; Surcel, H.M.; Hinkka-Yli-Salomäki, S.; Leiviskä, J.; Kellendonk, C.; McKeague, I.W.; Brown, A.S. Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort. Am. J. Psychiatry,  2014, 171(9), 960-968.
 [http://dx.doi.org/10.1176/appi.ajp.2014.13121579] [PMID:  24969261]

[125]
Anglin, D.M.; Ereshefsky, S.; Klaunig, M.J.; Bridgwater, M.A.; Niendam, T.A.; Ellman, L.M.; DeVylder, J.; Thayer, G.; Bolden, K.; Musket, C.W.; Grattan, R.E.; Lincoln, S.H.; Schiffman, J.; Lipner, E.; Bachman, P.; Corcoran, C.M.; Mota, N.B.; van der Ven, E. From womb to neighborhood: A racial analysis of social determinants of psychosis in the United States. Am. J. Psychiatry,  2021, 178(7), 599-610.
 [http://dx.doi.org/10.1176/appi.ajp.2020.20071091] [PMID:  33934608]

[126]
Vassos, E.; Kou, J.; Tosato, S.; Maxwell, J.; Dennison, C.A.; Legge, S.E.; Walters, J.T.R.; Owen, M.J.; O’Donovan, M.C.; Breen, G.; Lewis, C.M.; Sullivan, P.F.; Hultman, C.; Ruggeri, M.; Walshe, M.; Bramon, E.; Bergen, S.E.; Murray, R.M. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophr. Bull.,  2022, 48(1), 20-26.
 [http://dx.doi.org/10.1093/schbul/sbab052] [PMID:  33987677]

[127]
Mittal, V.A.; Ellman, L.M.; Cannon, T.D. Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications. Schizophr. Bull.,  2008, 34(6), 1083-1094.
 [http://dx.doi.org/10.1093/schbul/sbn080] [PMID:  18635675]

[128]
Zwicker, A.; Denovan-Wright, E.M.; Uher, R. Gene-environment interplay in the etiology of psychosis. Psychol. Med.,  2018, 48(12), 1925-1936.
 [http://dx.doi.org/10.1017/S003329171700383X] [PMID:  29334044]

[129]
Kinney, D.K. Prenatal stress and risk for schizophrenia. Int. J. Ment. Health,  2000, 29(4), 62-72.
 [http://dx.doi.org/10.1080/00207411.2000.11449503]

[130]
Sørensen, H.J.; Mortensen, E.L.; Reinisch, J.M.; Mednick, S.A. Association between prenatal exposure to bacterial infection and risk of schizophrenia. Schizophr. Bull.,  2009, 35(3), 631-637.
 [http://dx.doi.org/10.1093/schbul/sbn121] [PMID:  18832344]

[131]
Mortensen, P.B.; Pedersen, C.B.; Hougaard, D.M.; Nørgaard-Petersen, B.; Mors, O.; Børglum, A.D.; Yolken, R.H. A danish national birth cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring. Schizophr. Res.,  2010, 122(1-3), 257-263.
 [http://dx.doi.org/10.1016/j.schres.2010.06.010] [PMID:  20598509]

[132]
Buka, S.L.; Tsuang, M.T.; Torrey, E.F.; Klebanoff, M.A.; Bernstein, D.; Yolken, R.H. Maternal infections and subsequent psychosis among offspring. Arch. Gen. Psychiatry,  2001, 58(11), 1032-1037.
 [http://dx.doi.org/10.1001/archpsyc.58.11.1032] [PMID:  11695949]

[133]
Brown, A.S.; Derkits, E.J. Prenatal infection and schizophrenia: A review of epidemiologic and translational studies. Am. J. Psychiatry,  2010, 167(3), 261-280.
 [http://dx.doi.org/10.1176/appi.ajp.2009.09030361] [PMID:  20123911]

[134]
Babulas, V.; Factor-Litvak, P.; Goetz, R.; Schaefer, C.A.; Brown, A.S. Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. Am. J. Psychiatry,  2006, 163(5), 927-929.
 [http://dx.doi.org/10.1176/ajp.2006.163.5.927] [PMID:  16648337]

[135]
Selten, J.P.; Termorshuizen, F. The serological evidence for maternal influenza as risk factor for psychosis in offspring is insufficient: critical review and meta-analysis. Schizophr. Res.,  2017, 183, 2-9.
 [http://dx.doi.org/10.1016/j.schres.2016.11.006] [PMID:  27856157]

[136]
Sideli, L.; Murray, R.M.; Schimmenti, A.; Corso, M.; La Barbera, D.; Trotta, A.; Fisher, H.L. Childhood adversity and psychosis: A systematic review of bio-psycho-social mediators and moderators. Psychol. Med.,  2020, 50(11), 1761-1782.
 [http://dx.doi.org/10.1017/S0033291720002172] [PMID:  32624020]

[137]
Kessler, R.C.; McLaughlin, K.A.; Green, J.G.; Gruber, M.J.; Sampson, N.A.; Zaslavsky, A.M.; Aguilar-Gaxiola, S.; Alhamzawi, A.O.; Alonso, J.; Angermeyer, M.; Benjet, C.; Bromet, E.; Chatterji, S.; de Girolamo, G.; Demyttenaere, K.; Fayyad, J.; Florescu, S.; Gal, G.; Gureje, O.; Haro, J.M.; Hu, C.; Karam, E.G.; Kawakami, N.; Lee, S.; Lépine, J.P.; Ormel, J.; Posada-Villa, J.; Sagar, R.; Tsang, A.; Üstün, T.B.; Vassilev, S.; Viana, M.C.; Williams, D.R. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br. J. Psychiatry,  2010, 197(5), 378-385.
 [http://dx.doi.org/10.1192/bjp.bp.110.080499] [PMID:  21037215]

[138]
Setién-Suero, E.; Suárez-Pinilla, P.; Ferro, A.; Tabarés-Seisdedos, R.; Crespo-Facorro, B.; Ayesa-Arriola, R. Childhood trauma and substance use underlying psychosis: A systematic review. Eur. J. Psychotraumatol.,  2020, 11(1), 1748342.
 [http://dx.doi.org/10.1080/20008198.2020.1748342] [PMID:  32373286]

[139]
Thompson, J.L.; Kelly, M.; Kimhy, D.; Harkavy-Friedman, J.M.; Khan, S.; Messinger, J.W.; Schobel, S.; Goetz, R.; Malaspina, D.; Corcoran, C. Childhood trauma and prodromal symptoms among individuals at clinical high risk for psychosis. Schizophr. Res.,  2009, 108(1-3), 176-181.
 [http://dx.doi.org/10.1016/j.schres.2008.12.005] [PMID:  19174322]

[140]
Stowkowy, J.; Liu, L.; Cadenhead, K.S.; Cannon, T.D.; Cornblatt, B.A.; McGlashan, T.H.; Perkins, D.O.; Seidman, L.J.; Tsuang, M.T.; Walker, E.F.; Woods, S.W.; Bearden, C.E.; Mathalon, D.H.; Addington, J. Early traumatic experiences, perceived discrimination and conversion to psychosis in those at clinical high risk for psychosis. Soc. Psychiatry Psychiatr. Epidemiol.,  2016, 51(4), 497-503.
 [http://dx.doi.org/10.1007/s00127-016-1182-y] [PMID:  26851943]

[141]
Strauss, G.P.; Raugh, I.M.; Mittal, V.A.; Gibb, B.E.; Coles, M.E. Bullying victimization and perpetration in a community sample of youth with psychotic like experiences. Schizophr. Res.,  2018, 195, 534-536.
 [http://dx.doi.org/10.1016/j.schres.2017.08.056] [PMID:  28888357]

[142]
Vargas, T.; Damme, K.S.F.; Mittal, V.A. Bullying victimization in typically developing and clinical high risk (CHR) adolescents: A multimodal imaging study. Schizophr. Res.,  2019, 213, 40-47.
 [http://dx.doi.org/10.1016/j.schres.2018.11.017] [PMID:  30528926]

[143]
Barzilay, R.; Calkins, M.E.; Moore, T.M.; Wolf, D.H.; Satterthwaite, T.D.; Cobb, S.J.; Jones, J.D.; Benton, T.D.; Gur, R.C.; Gur, R.E. Association between traumatic stress load, psychopathology, and cognition in the Philadelphia Neurodevelopmental Cohort. Psychol. Med.,  2019, 49(2), 325-334.
 [http://dx.doi.org/10.1017/S0033291718000880] [PMID:  29655375]

[144]
Ered, A.; Ellman, L.M. Specificity of childhood trauma type and attenuated positive symptoms in a non-clinical sample. J. Clin. Med.,  2019, 8(10), 1537.
 [http://dx.doi.org/10.3390/jcm8101537] [PMID:  31557792]

[145]
Stickley, A.; Waldman, K.; Sumiyoshi, T.; Narita, Z.; Shirama, A.; Shin, J.I.; Oh, H. Childhood physical neglect and psychotic experiences: Findings from the National Comorbidity Survey Replication. Early Interv. Psychiatry,  2021, 15(2), 256-262.
 [http://dx.doi.org/10.1111/eip.12932] [PMID:  32048480]

[146]
Bonoldi, I.; Simeone, E.; Rocchetti, M.; Codjoe, L.; Rossi, G.; Gambi, F.; Balottin, U.; Caverzasi, E.; Politi, P.; Fusar-Poli, P. Prevalence of self-reported childhood abuse in psychosis: A meta-analysis of retrospective studies. Psychiatry Res.,  2013, 210(1), 8-15.
 [http://dx.doi.org/10.1016/j.psychres.2013.05.003] [PMID:  23790604]

[147]
Rosenberg, S.D.; Lu, W.; Mueser, K.T.; Jankowski, M.K.; Cournos, F. Correlates of adverse childhood events among adults with schizophrenia spectrum disorders. Psychiatr. Serv.,  2007, 58(2), 245-253.
 [http://dx.doi.org/10.1176/ps.2007.58.2.245] [PMID:  17287383]

[148]
Stanton, K.J.; Denietolis, B.; Goodwin, B.J.; Dvir, Y. Childhood trauma and psychosis. Child Adolesc. Psychiatr. Clin. N. Am.,  2020, 29(1), 115-129.
 [http://dx.doi.org/10.1016/j.chc.2019.08.004] [PMID:  31708041]

[149]
Pastore, A.; de Girolamo, G.; Tafuri, S.; Tomasicchio, A.; Margari, F. Traumatic experiences in childhood and adolescence: A meta-analysis of prospective studies assessing risk for psychosis. Eur. Child Adolesc. Psychiatry,  2022, 31(2), 215-228.
 [http://dx.doi.org/10.1007/s00787-020-01574-9] [PMID:  32577908]

[150]
Hailes, H.P.; Yu, R.; Danese, A.; Fazel, S. Long-term outcomes of childhood sexual abuse: An umbrella review. Lancet Psychiatry,  2019, 6(10), 830-839.
 [http://dx.doi.org/10.1016/S2215-0366(19)30286-X] [PMID:  31519507]

[151]
Ayerbe, L.; Pérez-Piñar, M.; Foguet-Boreu, Q.; Ayis, S. Psychosis in children of separated parents: A systematic review and meta-analysis. Eur. Psychiatry,  2020, 63(1), e3.
 [http://dx.doi.org/10.1192/j.eurpsy.2019.15] [PMID:  32093793]

[152]
Shin, S.H. Need for and actual use of mental health service by adolescents in the child welfare system. Child. Youth Serv. Rev.,  2005, 27(10), 1071-1083.
 [http://dx.doi.org/10.1016/j.childyouth.2004.12.027]

[153]
AbdelMalik, P.; Husted, J.; Chow, E.W.C.; Bassett, A.S. Childhood head injury and expression of schizophrenia in multiply affected families. Arch. Gen. Psychiatry,  2003, 60(3), 231-236.
 [http://dx.doi.org/10.1001/archpsyc.60.3.231] [PMID:  12622655]

[154]
Nielsen, A.S.; Mortensen, P.B.; O’Callaghan, E.; Mors, O.; Ewald, H. Is head injury a risk factor for schizophrenia? Schizophr. Res.,  2002, 55(1-2), 93-98.
 [http://dx.doi.org/10.1016/S0920-9964(01)00205-5] [PMID:  11955968]

[155]
Wilcox, J.A.; Nasrallah, H.A. Childhood head trauma and psychosis. Psychiatry Res.,  1987, 21(4), 303-306.
 [http://dx.doi.org/10.1016/0165-1781(87)90013-8] [PMID:  3628613]

[156]
David, A.S.; Prince, M. Psychosis following head injury: A critical review. J. Neurol. Neurosurg. Psychiatry,  2005, 76(Suppl. 1), i53-i60.
 [http://dx.doi.org/10.1136/jnnp.2004.060475]

[157]
Read, J.; Perry, B.D.; Moskowitz, A.; Connolly, J. The contribution of early traumatic events to schizophrenia in some patients: A traumagenic neurodevelopmental model. Psychiatry,  2001, 64(4), 319-345.
 [http://dx.doi.org/10.1521/psyc.64.4.319.18602] [PMID:  11822210]

[158]
Dvir, Y.; Ford, J.D.; Hill, M.; Frazier, J.A. Childhood maltreatment, emotional dysregulation, and psychiatric comorbidities. Harv. Rev. Psychiatry,  2014, 22(3), 149-161.
 [http://dx.doi.org/10.1097/HRP.0000000000000014] [PMID:  24704784]

[159]
Kramer, I.; Simons, C.J.P.; Wigman, J.T.W.; Collip, D.; Jacobs, N.; Derom, C.; Thiery, E.; van Os, J.; Myin-Germeys, I.; Wichers, M. Time-lagged moment-to-moment interplay between negative affect and paranoia: New insights in the affective pathway to psychosis. Schizophr. Bull.,  2014, 40(2), 278-286.
 [http://dx.doi.org/10.1093/schbul/sbs194] [PMID:  23407984]

[160]
van Rossum, I.; Dominguez, M.G.; Lieb, R.; Wittchen, H.U.; van Os, J. Affective dysregulation and reality distortion: A 10-year prospective study of their association and clinical relevance. Schizophr. Bull.,  2011, 37(3), 561-571.
 [http://dx.doi.org/10.1093/schbul/sbp101] [PMID:  19793794]

[161]
Lataster, T.; Collip, D.; Lardinois, M.; Van Os, J.; Myin-Germeys, I. Evidence for a familial correlation between increased reactivity to stress and positive psychotic symptoms. Acta Psychiatr. Scand.,  2010, 122(5), 395-404.
 [http://dx.doi.org/10.1111/j.1600-0447.2010.01566.x] [PMID:  20491716]

[162]
Pries, L.K.; Dal Ferro, G.A.; van Os, J.; Delespaul, P.; Kenis, G.; Lin, B.D.; Luykx, J.J.; Richards, A.L.; Akdede, B.; Binbay, T. Altınyazar, V.; Yalınçetin, B.; Gümüş-Akay, G.; Cihan, B.; Soygür, H.; Ulaş H.; Şahin Cankurtaran, E.; Ulusoy Kaymak, S.; Mihaljevic, M.M.; Andric Petrovic, S.; Mirjanic, T.; Bernardo, M.; Mezquida, G.; Amoretti, S.; Bobes, J.; Saiz, P.A.; García-Portilla, M.P.; Sanjuan, J.; Aguilar, E.J.; Santos, J.L.; Jiménez-López, E.; Arrojo, M.; Carracedo, A.; López, G.; González-Peñas, J.; Parellada, M.; Maric, N.P.; Atbaşoğlu, C.; Ucok, A.; Alptekin, K.; Can Saka, M.; Arango, C.; O’Donovan, M.; Tosato, S.; Rutten, B.P.F.; Guloksuz, S. Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum. Epidemiol. Psychiatr. Sci.,  2020, 29, e182.
 [http://dx.doi.org/10.1017/S2045796020000943] [PMID:  33200977]

[163]
Shevlin, M.; Houston, J.E.; Dorahy, M.J.; Adamson, G. Cumulative traumas and psychosis: An analysis of the national comorbidity survey and the British Psychiatric Morbidity Survey. Schizophr. Bull.,  2007, 34(1), 193-199.
 [http://dx.doi.org/10.1093/schbul/sbm069] [PMID:  17586579]

[164]
DeCamp, W.; Zaykowski, H. Developmental victimology. Int. Rev. Victimology,  2015, 21(3), 255-272.
 [http://dx.doi.org/10.1177/0269758015591722]

[165]
van Nierop, M.; van Os, J.; Gunther, N.; van Zelst, C.; de Graaf, R.; ten Have, M.; van Dorsselaer, S.; Bak, M.; Myin-Germeys, I.; van Winkel, R. Does social defeat mediate the association between childhood trauma and psychosis? Evidence from the NEMESIS-2 Study. Acta Psychiatr. Scand.,  2014, 129(6), 467-476.
 [http://dx.doi.org/10.1111/acps.12212] [PMID:  24571736]

[166]
Gevonden, M.J.; Selten, J.P.; Myin-Germeys, I.; de Graaf, R.; ten Have, M.; van Dorsselaer, S.; van Os, J.; Veling, W. Sexual minority status and psychotic symptoms: Findings from the Netherlands Mental Health Survey and Incidence Studies (NEMESIS). Psychol. Med.,  2014, 44(2), 421-433.
 [http://dx.doi.org/10.1017/S0033291713000718] [PMID:  23710972]

[167]
Guloksuz, S.; van Nierop, M.; Lieb, R.; van Winkel, R.; Wittchen, H.U.; van Os, J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychol. Med.,  2015, 45(11), 2389-2401.
 [http://dx.doi.org/10.1017/S0033291715000380] [PMID:  25804288]

[168]
Sigurdardottir, S.; Halldorsdottir, S.; Bender, S.S. Consequences of childhood sexual abuse for health and well-being: Gender similarities and differences. Scand. J. Public Health,  2014, 42(3), 278-286.
 [http://dx.doi.org/10.1177/1403494813514645] [PMID:  24345814]

[169]
Maynard, T.M.; Sikich, L.; Lieberman, J.A.; LaMantia, A.S. Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia. Schizophr. Bull.,  2001, 27(3), 457-476.
 [http://dx.doi.org/10.1093/oxfordjournals.schbul.a006887] [PMID:  11596847]

[170]
Daskalakis, N.P.; Bagot, R.C.; Parker, K.J.; Vinkers, C.H.; de Kloet, E.R. The three-hit concept of vulnerability and resilience: Toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology,  2013, 38(9), 1858-1873.
 [http://dx.doi.org/10.1016/j.psyneuen.2013.06.008] [PMID:  23838101]

[171]
McLaughlin, K.A.; Sheridan, M.A.; Lambert, H.K. Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience. Neurosci. Biobehav. Rev.,  2014, 47, 578-591.
 [http://dx.doi.org/10.1016/j.neubiorev.2014.10.012] [PMID:  25454359]

[172]
Colich, N.L.; Rosen, M.L.; Williams, E.S.; McLaughlin, K.A. Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis. Psychol. Bull.,  2020, 146(9), 721-764.
 [http://dx.doi.org/10.1037/bul0000270] [PMID:  32744840]

[173]
Saxton, K.; Chyu, L. Early life adversity increases the salience of later life stress: an investigation of interactive effects in the PSID. J. Dev. Orig. Health Dis.,  2020, 11(1), 25-36.
 [http://dx.doi.org/10.1017/S2040174419000308] [PMID:  31221227]

[174]
Tsai, N.; Jaeggi, S.M.; Eccles, J.S.; Atherton, O.E.; Robins, R.W. Predicting late adolescent anxiety from early adolescent environmental stress exposure: Cognitive control as mediator. Front. Psychol.,  2020, 11, 1838.
 [http://dx.doi.org/10.3389/fpsyg.2020.01838] [PMID:  32849080]

[175]
Ellis, B.J.; Del Giudice, M. Beyond allostatic load: Rethinking the	role of stress in regulating human development. Dev. Psychopathol.,  2014, 26(1), 1-20.
 [http://dx.doi.org/10.1017/S0954579413000849] [PMID:  24280315]

[176]
van Os, J.; Guloksuz, S.; Vijn, T.W.; Hafkenscheid, A.; Delespaul, P. The evidence‐based group‐level symptom‐reduction model as the organizing principle for mental health care: time for change? World Psychiatry,  2019, 18(1), 88-96.
 [http://dx.doi.org/10.1002/wps.20609] [PMID:  30600612]

[177]
Stilo, S.A.; Gayer-Anderson, C.; Beards, S.; Hubbard, K.; Onyejiaka, A.; Keraite, A.; Borges, S.; Mondelli, V.; Dazzan, P.; Pariante, C.; Di Forti, M.; Murray, R.M.; Morgan, C. Further evidence of a cumulative effect of social disadvantage on risk of psychosis. Psychol. Med.,  2017, 47(5), 913-924.
 [http://dx.doi.org/10.1017/S0033291716002993] [PMID:  27916012]

[178]
Byrne, M.; Agerbo, E.; Eaton, W.W.; Mortensen, P.B. Parental socio-economic status and risk of first admission with schizophrenia. Soc. Psychiatry Psychiatr. Epidemiol.,  2004, 39(2), 87-96.
 [http://dx.doi.org/10.1007/s00127-004-0715-y] [PMID:  15052389]

[179]
Kwok, W. Is there evidence that social class at birth increases risk of psychosis? A systematic review. Int. J. Soc. Psychiatry,  2014, 60(8), 801-808.
 [http://dx.doi.org/10.1177/0020764014524737] [PMID:  24608029]

[180]
Lochner, K.; Kawachi, I.; Kennedy, B.P. Social capital: A guide to its measurement. Health Place,  1999, 5(4), 259-270.
 [http://dx.doi.org/10.1016/S1353-8292(99)00016-7] [PMID:  10984580]

[181]
Kirkbride, J.B.; Boydell, J.; Ploubidis, G.B.; Morgan, C.; Dazzan, P.; McKenzie, K.; Murray, R.M.; Jones, P.B. Testing the association between the incidence of schizophrenia and social capital in an urban area. Psychol. Med.,  2008, 38(8), 1083-1094.
 [http://dx.doi.org/10.1017/S0033291707002085] [PMID:  17988420]

[182]
Pignon, B.; Lajnef, M.; Kirkbride, J.B.; Peyre, H.; Ferchiou, A.; Richard, J.R.; Baudin, G.; Tosato, S.; Jongsma, H.; de Haan, L.; Tarricone, I.; Bernardo, M.; Velthorst, E.; Braca, M.; Arango, C.; Arrojo, M.; Bobes, J.; Del-Ben, C.M.; Di Forti, M.; Gayer-Anderson, C.; Jones, P.B.; La Cascia, C.; Lasalvia, A.; Menezes, P.R.; Quattrone, D.; Sanjuán, J.; Selten, J.P.; Tortelli, A.; Llorca, P.M.; van Os, J.; Rutten, B.P.F.; Murray, R.M.; Morgan, C.; Leboyer, M.; Szöke, A.; Schürhoff, F. The independent effects of psychosocial stressors on subclinical psychosis: Findings from the multinational EU-GEI study. Schizophr. Bull.,  2021, 47(6), 1674-1684.
 [http://dx.doi.org/10.1093/schbul/sbab060] [PMID:  34009318]

[183]
Selten, J.P.; Cantor-Graae, E. Social defeat: Risk factor for schizophrenia? Br. J. Psychiatry,  2005, 187(2), 101-102.
 [http://dx.doi.org/10.1192/bjp.187.2.101] [PMID:  16055818]

[184]
Selten, J.P.; van der Ven, E.; Rutten, B.P.F.; Cantor-Graae, E. The social defeat hypothesis of schizophrenia: an update. Schizophr. Bull.,  2013, 39(6), 1180-1186.
 [http://dx.doi.org/10.1093/schbul/sbt134] [PMID:  24062592]

[185]
Selten, J.P. The social defeat hypothesis of schizophrenia is more topical than ever. Reply to Schalbroeck. Psychol. Med.,  2021, 1-2, 1-2.
 [http://dx.doi.org/10.1017/S0033291720005176] [PMID:  33431105]

[186]
Selten, J.P.; Booij, J.; Buwalda, B.; Meyer-Lindenberg, A. Biological mechanisms whereby social exclusion may contribute to the etiology of psychosis: A narrative review. Schizophr. Bull.,  2017, 43(2), sbw180.
 [http://dx.doi.org/10.1093/schbul/sbw180] [PMID:  28053019]

[187]
Fett, A.K.J.; Lemmers-Jansen, I.L.J.; Krabbendam, L. Psychosis and urbanicity. Curr. Opin. Psychiatry,  2019, 32(3), 232-241.
 [http://dx.doi.org/10.1097/YCO.0000000000000486] [PMID:  30724751]

[188]
Vassos, E.; Pedersen, C.B.; Murray, R.M.; Collier, D.A.; Lewis, C.M. Meta-analysis of the association of urbanicity with schizophrenia. Schizophr. Bull.,  2012, 38(6), 1118-1123.
 [http://dx.doi.org/10.1093/schbul/sbs096] [PMID:  23015685]

[189]
Pedersen, C.B.; Mortensen, P.B. Are the cause(s) responsible for urban-rural differences in schizophrenia risk rooted in families or in individuals? Am. J. Epidemiol.,  2006, 163(11), 971-978.
 [http://dx.doi.org/10.1093/aje/kwj169] [PMID:  16675535]

[190]
March, D.; Hatch, S.L.; Morgan, C.; Kirkbride, J.B.; Bresnahan, M.; Fearon, P.; Susser, E. Psychosis and Place. Epidemiol. Rev.,  2008, 30(1), 84-100.
 [http://dx.doi.org/10.1093/epirev/mxn006] [PMID:  18669521]

[191]
DeVylder, J.E.; Kelleher, I.; Lalane, M.; Oh, H.; Link, B.G.; Koyanagi, A. Association of urbanicity with psychosis in low- and middle-income countries. JAMA Psychiatry,  2018, 75(7), 678-686.
 [http://dx.doi.org/10.1001/jamapsychiatry.2018.0577] [PMID:  29799917]

[192]
Van Os, J. Does the urban environment cause psychosis? Br. J. Psychiatry,  2004, 184(4), 287-288.
 [http://dx.doi.org/10.1192/bjp.184.4.287] [PMID:  15056569]

[193]
Cantor-Graae, E.; Selten, J.P. Schizophrenia and migration: A meta-analysis and review. Am. J. Psychiatry,  2005, 162(1), 12-24.
 [http://dx.doi.org/10.1176/appi.ajp.162.1.12] [PMID:  15625195]

[194]
Selten, J.P.; van der Ven, E.; Termorshuizen, F. Migration and psychosis: A meta-analysis of incidence studies. Psychol. Med.,  2020, 50(2), 303-313.
 [http://dx.doi.org/10.1017/S0033291719000035] [PMID:  30722795]

[195]
Bourque, F.; van der Ven, E.; Malla, A. A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychol. Med.,  2011, 41(5), 897-910.
 [http://dx.doi.org/10.1017/S0033291710001406] [PMID:  20663257]

[196]
Tortelli, A.; Errazuriz, A.; Croudace, T.; Morgan, C.; Murray, R.M.; Jones, P.B.; Szoke, A.; Kirkbride, J.B. Schizophrenia and other psychotic disorders in Caribbean-born migrants and their descendants in England: systematic review and meta-analysis of incidence rates, 1950-2013. Soc. Psychiatry Psychiatr. Epidemiol.,  2015, 50(7), 1039-1055.
 [http://dx.doi.org/10.1007/s00127-015-1021-6] [PMID:  25660551]

[197]
Hutchinson, G.; Takei, N.; Fahy, T.A.; Bhugra, D.; Gilvarry, C.; Moran, P.; Mallett, R.; Sham, P.; Leff, J.; Murray, R.M. Morbid risk of schizophrenia in first-degree relatives of white and African-Caribbean patients with psychosis. Br. J. Psychiatry,  1996, 169(6), 776-780.
 [http://dx.doi.org/10.1192/bjp.169.6.776] [PMID:  8968638]

[198]
Bhugra, D.; Hilwig, M.; Hossein, B.; Marceau, H.; Neehall, J.; Leff, J.; Mallett, R.; Der, G. First-contact incidence rates of schizophrenia in Trinidad and one-year follow-up. Br. J. Psychiatry,  1996, 169(5), 587-592.
 [http://dx.doi.org/10.1192/bjp.169.5.587] [PMID:  8932887]

[199]
Jongsma, H.E.; Gayer-Anderson, C.; Tarricone, I.; Velthorst, E.; van der Ven, E.; Quattrone, D.; di Forti, M.; Menezes, P.R.; Del-Ben, C.M.; Arango, C.; Lasalvia, A.; Berardi, D.; La Cascia, C.; Bobes, J.; Bernardo, M.; Sanjuán, J.; Santos, J.L.; Arrojo, M.; de Haan, L.; Tortelli, A.; Szöke, A.; Murray, R.M.; Rutten, B.P.; van Os, J.; Morgan, C.; Jones, P.B.; Kirkbride, J.B. Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: Results from the EU-GEI case-control study. Psychol. Med.,  2021, 51(9), 1536-1548.
 [http://dx.doi.org/10.1017/S003329172000029X] [PMID:  32122439]

[200]
Boydell, J.; van Os, J.; McKenzie, K.; Allardyce, J.; Goel, R.; McCreadie, R.G.; Murray, R.M. Incidence of schizophrenia in ethnic minorities in London: ecological study into interactions with environment. BMJ,  2001, 323(7325), 1336-1338.
 [http://dx.doi.org/10.1136/bmj.323.7325.1336] [PMID:  11739218]

[201]
Veling, W.; Susser, E.; van Os, J.; Mackenbach, J.P.; Selten, J.P.; Hoek, H.W. Ethnic density of neighborhoods and incidence of psychotic disorders among immigrants. Am. J. Psychiatry,  2008, 165(1), 66-73.
 [http://dx.doi.org/10.1176/appi.ajp.2007.07030423] [PMID:  18086750]

[202]
Baker, S.J.; Jackson, M.; Jongsma, H.; Saville, C.W.N. The ethnic density effect in psychosis: A systematic review and multilevel meta-analysis. Br. J. Psychiatry,  2021, 219(6), 632-643.
 [http://dx.doi.org/10.1192/bjp.2021.96] [PMID:  35048877]

[203]
Egerton, A.; Howes, O.D.; Houle, S.; McKenzie, K.; Valmaggia, L.R.; Bagby, M.R.; Tseng, H.H.; Bloomfield, M.A.P.; Kenk, M.; Bhattacharyya, S.; Suridjan, I.; Chaddock, C.A.; Winton-Brown, T.T.; Allen, P.; Rusjan, P.; Remington, G.; Meyer-Lindenberg, A.; McGuire, P.K.; Mizrahi, R. Elevated striatal dopamine function in immigrants and their children: A risk mechanism for psychosis. Schizophr. Bull.,  2017, 43(2), sbw181.
 [http://dx.doi.org/10.1093/schbul/sbw181] [PMID:  28057720]

[204]
Squires, E.C.; McClure, H.H.; Martinez, C.R., Jr; Eddy, J.M.; Jiménez, R.A.; Isiordia, L.E.; Snodgrass, J.J. Diurnal cortisol rhythms among Latino immigrants in Oregon, USA. J. Physiol. Anthropol.,  2012, 31(1), 19.
 [http://dx.doi.org/10.1186/1880-6805-31-19] [PMID:  22738123]

[205]
Morgan, C.; Charalambides, M.; Hutchinson, G.; Murray, R.M. Migration, ethnicity, and psychosis: Toward a sociodevelopmental model. Schizophr. Bull.,  2010, 36(4), 655-664.
 [http://dx.doi.org/10.1093/schbul/sbq051] [PMID:  20513653]

[206]
Sara, G.E.; Large, M.M.; Matheson, S.L.; Burgess, P.M.; Malhi, G.S.; Whiteford, H.A.; Hall, W.D. Stimulant use disorders in people with psychosis: A meta-analysis of rate and factors affecting variation. Aust. N. Z. J. Psychiatry,  2015, 49(2), 106-117.
 [http://dx.doi.org/10.1177/0004867414561526] [PMID:  25518844]

[207]
Di Forti, M.; Marconi, A.; Carra, E.; Fraietta, S.; Trotta, A.; Bonomo, M.; Bianconi, F.; Gardner-Sood, P.; O’Connor, J.; Russo, M.; Stilo, S.A.; Marques, T.R.; Mondelli, V.; Dazzan, P.; Pariante, C.; David, A.S.; Gaughran, F.; Atakan, Z.; Iyegbe, C.; Powell, J.; Morgan, C.; Lynskey, M.; Murray, R.M. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study. Lancet Psychiatry,  2015, 2(3), 233-238.
 [http://dx.doi.org/10.1016/S2215-0366(14)00117-5] [PMID:  26359901]

[208]
Marconi, A.; Di Forti, M.; Lewis, C.M.; Murray, R.M.; Vassos, E. Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophr. Bull.,  2016, 42(5), 1262-1269.
 [http://dx.doi.org/10.1093/schbul/sbw003] [PMID:  26884547]

[209]
Di Forti, M.; Quattrone, D.; Freeman, T.P.; Tripoli, G.; Gayer-Anderson, C.; Quigley, H.; Rodriguez, V.; Jongsma, H.E.; Ferraro, L.; La Cascia, C.; La Barbera, D.; Tarricone, I.; Berardi, D.; Szöke, A.; Arango, C.; Tortelli, A.; Velthorst, E.; Bernardo, M.; Del-Ben, C.M.; Menezes, P.R.; Selten, J.P.; Jones, P.B.; Kirkbride, J.B.; Rutten, B.P.F.; de Haan, L.; Sham, P.C.; van Os, J.; Lewis, C.M.; Lynskey, M.; Morgan, C.; Murray, R.M.; Amoretti, S.; Arrojo, M.; Baudin, G.; Beards, S.; Bernardo, M.; Bobes, J.; Bonetto, C.; Cabrera, B.; Carracedo, A.; Charpeaud, T.; Costas, J.; Cristofalo, D.; Cuadrado, P.; Díaz-Caneja, C.M.; Ferchiou, A.; Franke, N.; Frijda, F.; García, B.E.; Garcia-Portilla, P.; González, E.; Hubbard, K.; Jamain, S.; Jiménez-López, E.; Leboyer, M.; López, M.G.; Lorente-Rovira, E.; Marcelino, L.C.; Marrazzo, G.; Martínez, C.; Matteis, M.; Messchaart, E.; Moltó, M.D.; Nacher, J.; Olmeda, M.S.; Parellada, M.; González, P.J.; Pignon, B.; Rapado, M.; Richard, J-R.; Rodríguez, S.J.J.; Roldán Díaz, L.; Ruggeri, M.; Sáiz, P.A.; Sánchez, E.; Sanjuán, J.; Sartorio, C.; Schürhoff, F.; Seminerio, F.; Shuhama, R.; Sideli, L.; Stilo, S.A.; Termorshuizen, F.; Tosato, S.; Tronche, A-M.; van Dam, D.; van der Ven, E. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): A multicentre case-control study. Lancet Psychiatry,  2019, 6(5), 427-436.
 [http://dx.doi.org/10.1016/S2215-0366(19)30048-3] [PMID:  30902669]

[210]
Large, M.; Sharma, S.; Compton, M.T.; Slade, T.; Nielssen, O. Cannabis use and earlier onset of psychosis: a systematic meta-analysis. Arch. Gen. Psychiatry,  2011, 68(6), 555-561.
 [http://dx.doi.org/10.1001/archgenpsychiatry.2011.5] [PMID:  21300939]

[211]
Stefanis, N.C.; Dragovic, M.; Power, B.D.; Jablensky, A.; Castle, D.; Morgan, V.A. The effect of drug use on the age at onset of psychotic disorders in an Australian cohort. Schizophr. Res.,  2014, 156(2-3), 211-216.
 [http://dx.doi.org/10.1016/j.schres.2014.04.003] [PMID:  24831390]

[212]
Di Forti, M.; Sallis, H.; Allegri, F.; Trotta, A.; Ferraro, L.; Stilo, S.A.; Marconi, A.; La Cascia, C.; Reis, M.T.; Pariante, C.; Dazzan, P.; Mondelli, V.; Paparelli, A.; Kolliakou, A.; Prata, D.; Gaughran, F.; David, A.S.; Morgan, C.; Stahl, D.; Khondoker, M.; MacCabe, J.H.; Murray, R.M. Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users. Schizophr. Bull.,  2014, 40(6), 1509-1517.
 [http://dx.doi.org/10.1093/schbul/sbt181] [PMID:  24345517]

[213]
Stefanis, N.C.; Dragovic, M.; Power, B.D.; Jablensky, A.; Castle, D.; Morgan, V.A. Age at initiation of cannabis use predicts age at onset of psychosis: the 7- to 8-year trend. Schizophr. Bull.,  2013, 39(2), 251-254.
 [http://dx.doi.org/10.1093/schbul/sbs188] [PMID:  23314189]

[214]
Murray, R.M.; Englund, A.; Abi-Dargham, A.; Lewis, D.A.; Di Forti, M.; Davies, C.; Sherif, M.; McGuire, P.; D’Souza, D.C. Cannabis-associated psychosis: Neural substrate and clinical impact. Neuropharmacology,  2017, 124, 89-104.
 [http://dx.doi.org/10.1016/j.neuropharm.2017.06.018] [PMID:  28634109]

[215]
Power, R.A.; Verweij, K.J.H.; Zuhair, M.; Montgomery, G.W.; Henders, A.K.; Heath, A.C.; Madden, P A F.; Medland, S.E.; Wray, N.R.; Martin, N.G. Genetic predisposition to schizophrenia associated with increased use of cannabis. Mol. Psychiatry,  2014, 19(11), 1201-1204.
 [http://dx.doi.org/10.1038/mp.2014.51] [PMID:  24957864]

[216]
Guloksuz, S.; Pries, L.K.; Delespaul, P.; Kenis, G.; Luykx, J.J.; Lin, B.D.; Richards, A.L.; Akdede, B.; Binbay, T. Altınyazar, V.; Yalınçetin, B.; Gümüş-Akay, G.; Cihan, B.; Soygür, H.; Ulaş H.; Cankurtaran, E.; Kaymak, S.U.; Mihaljevic, M.M.; Petrovic, S.A.; Mirjanic, T.; Bernardo, M.; Cabrera, B.; Bobes, J.; Saiz, P.A.; García-Portilla, M.P.; Sanjuan, J.; Aguilar, E.J.; Santos, J.L.; Jiménez-López, E.; Arrojo, M.; Carracedo, A.; López, G.; González-Peñas, J.; Parellada, M.; Maric, N.P.; Atbaşog˘lu, C.; Ucok, A.; Alptekin, K.; Saka, M.C.; Arango, C.; O’Donovan, M.; Rutten, B.P.F.; van Os, J.; Alizadeh, B.Z.; van Amelsvoort, T.; van Beveren, N.J.; Bruggeman, R.; Cahn, W.; de Haan, L.; Delespaul, P.; Luykx, J.J.; Myin-Germeys, I.; van Winkel, R.; van Os, J. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry,  2019, 18(2), 173-182.
 [http://dx.doi.org/10.1002/wps.20629] [PMID:  31059627]

[217]
Kolliakou, A.; Castle, D.; Sallis, H.; Joseph, C.; O’Connor, J.; Wiffen, B.; Gayer-Anderson, C.; McQueen, G.; Taylor, H.; Bonaccorso, S.; Gaughran, F.; Smith, S.; Greenwood, K.; Murray, R.M.; Di Forti, M.; Atakan, Z.; Ismail, K. Reasons for cannabis use in first-episode psychosis: Does strength of endorsement change over 12 months? Eur. Psychiatry,  2015, 30(1), 152-159.
 [http://dx.doi.org/10.1016/j.eurpsy.2014.10.007] [PMID:  25541346]

[218]
Murray, R.M.; Mehta, M.; Di Forti, M. Different dopaminergic abnormalities underlie cannabis dependence and cannabis-induced psychosis. Biol. Psychiatry,  2014, 75(6), 430-431.
 [http://dx.doi.org/10.1016/j.biopsych.2014.01.011] [PMID:  24560431]

[219]
Jacobson, M.R.; Watts, J.J.; Boileau, I.; Tong, J.; Mizrahi, R. A systematic review of phytocannabinoid exposure on the endocannabinoid system: Implications for psychosis. Eur. Neuropsychopharmacol.,  2019, 29(3), 330-348.
 [http://dx.doi.org/10.1016/j.euroneuro.2018.12.014] [PMID:  30635160]

[220]
Mizrahi, R. Social stress and psychosis risk: Common neurochemical substrates? Neuropsychopharmacology,  2016, 41(3), 666-674.
 [http://dx.doi.org/10.1038/npp.2015.274] [PMID:  26346639]

[221]
Steinberg, H.R.; Durell, J. A stressful social situation as a precipitant of schizophrenic symptoms: An epidemiological study. Br. J. Psychiatry,  1968, 114(514), 1097-1105.
 [http://dx.doi.org/10.1192/bjp.114.514.1097] [PMID:  5684658]

[222]
Brown, G.W.; Birley, J.L.T. Crises and life changes and the onset of schizophrenia. J. Health Soc. Behav.,  1968, 9(3), 203-214.
 [http://dx.doi.org/10.2307/2948405] [PMID:  5676853]

[223]
Raune, D.; Kuipers, E.; Bebbington, P. Stressful and intrusive life events preceding first episode psychosis. Epidemiol. Psichiatr. Soc.,  2009, 18(3), 221-228.
 [http://dx.doi.org/10.1017/S1121189X00000506] [PMID:  20034200]

[224]
Dimitrakopoulos, S.; Vitoratou, S.; Mougiakos, T.; Bogeas, N.; Giotakos, O.; van Os, J.; Stefanis, N.C. Steinberg and Durell (1968) revisited: Increased rates of First Episode Psychosis following military induction in Greek Army Recruits. Psychol. Med.,  2018, 48(5), 728-736.
 [http://dx.doi.org/10.1017/S0033291717002276] [PMID:  28826418]

[225]
Beards, S.; Gayer-Anderson, C.; Borges, S.; Dewey, M.E.; Fisher, H.L.; Morgan, C. Life events and psychosis: A review and meta-analysis. Schizophr. Bull.,  2013, 39(4), 740-747.
 [http://dx.doi.org/10.1093/schbul/sbt065] [PMID:  23671196]

[226]
Garety, P.A.; Kuipers, E.; Fowler, D.; Freeman, D.; Bebbington, P.E. A cognitive model of the positive symptoms of psychosis. Psychol. Med.,  2001, 31(2), 189-195.
 [http://dx.doi.org/10.1017/S0033291701003312] [PMID:  11232907]

[227]
Beards, S.; Fisher, H.L.; Gayer-Anderson, C.; Hubbard, K.; Reininghaus, U.; Craig, T.J.; Di Forti, M.; Mondelli, V.; Pariante, C.; Dazzan, P.; Murray, R.; Morgan, C. Threatening life events and difficulties and psychotic disorder. Schizophr. Bull.,  2020, 46(4), 814-822.
 [http://dx.doi.org/10.1093/schbul/sbaa005] [PMID:  32047940]

[228]
Myers, B.; McLaughlin, K.A.; Wang, S.; Blanco, C.; Stein, D.J. Associations between childhood adversity, adult stressful life events, and past-year drug use disorders in the National Epidemiological Study of Alcohol and Related Conditions (NESARC). Psychol. Addict. Behav.,  2014, 28(4), 1117-1126.
 [http://dx.doi.org/10.1037/a0037459] [PMID:  25134042]

[229]
Myin-Germeys, I.; Krabbendam, L.; Delespaul, P.A.E.G.; Van Os, J. Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress? Psychol. Med.,  2003, 33(2), 327-333.
 [http://dx.doi.org/10.1017/S0033291702006785] [PMID:  12622311]

[230]
Myin-Germeys, I.; van Os, J. Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis. Clin. Psychol. Rev.,  2007, 27(4), 409-424.
 [http://dx.doi.org/10.1016/j.cpr.2006.09.005] [PMID:  17222489]

[231]
Chasiropoulou, C.; Siouti, N.; Mougiakos, T.; Dimitrakopoulos, S. The diathesis-stress model in the emergence of major psychiatric disorders during military service. Psychiatriki,  2020, 30(4), 291-298.
 [http://dx.doi.org/10.22365/jpsych.2019.304.291] [PMID:  32283532]

[232]
Rauschenberg, C.; Schulte-Strathaus, J.C.C.; van Os, J.; Goedhart, M.; Schieveld, J.N.M.; Reininghaus, U. Negative life events and stress sensitivity in youth’s daily life: An ecological momentary assessment study. Soc. Psychiatry Psychiatr. Epidemiol.,  2022, 57(8), 1641-1657.
 [http://dx.doi.org/10.1007/s00127-022-02276-0] [PMID:  35467134]

[233]
Pries, L.K.; van Os, J.; ten Have, M.; de Graaf, R.; van Dorsselaer, S.; Bak, M.; Lin, B.D.; van Eijk, K.R.; Kenis, G.; Richards, A.; O’Donovan, M.C.; Luykx, J.J.; Rutten, B.P.F.; Guloksuz, S. Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia. JAMA Psychiatry,  2020, 77(12), 1296-1304.
 [http://dx.doi.org/10.1001/jamapsychiatry.2020.2304] [PMID:  32805017]

[234]
Jones, S.R.; Fernyhough, C. A new look at the neural diathesis-stress model of schizophrenia: The primacy of social-evaluative and uncontrollable situations. Schizophr. Bull.,  2007, 33(5), 1171-1177.
 [http://dx.doi.org/10.1093/schbul/sbl058] [PMID:  17105966]

[235]
Fusar-Poli, L.; Rutten, B.P.F.; van Os, J.; Aguglia, E.; Guloksuz, S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: Hope or hype? Int. Rev. Psychiatry,  2022, •••, 1-13.
 [http://dx.doi.org/10.1080/09540261.2022.2101352]

[236]
Padmanabhan, J.L.; Shah, J.L.; Tandon, N.; Keshavan, M.S. The “polyenviromic risk score”: Aggregating environmental risk factors predicts conversion to psychosis in familial high-risk subjects. Schizophr. Res.,  2017, 181, 17-22.
 [http://dx.doi.org/10.1016/j.schres.2016.10.014] [PMID:  28029515]

[237]
Vassos, E.; Sham, P.; Kempton, M.; Trotta, A.; Stilo, S.A.; Gayer-Anderson, C.; Di Forti, M.; Lewis, C.M.; Murray, R.M.; Morgan, C. The Maudsley environmental risk score for psychosis. Psychol. Med.,  2020, 50(13), 2213-2220.
 [http://dx.doi.org/10.1017/S0033291719002319] [PMID:  31535606]

[238]
Pries, L.K.; Lage-Castellanos, A.; Delespaul, P.; Kenis, G.; Luykx, J.J.; Lin, B.D.; Richards, A.L.; Akdede, B.; Binbay, T.; Altinyazar, V.; Yalinçetin, B. Gümüş-Akay, G.; Cihan, B.; Soygür, H.; Ulaş H.; Cankurtaran, E.Ş Kaymak, S.U.; Mihaljevic, M.M.; Petrovic, S.A.; Mirjanic, T.; Bernardo, M.; Cabrera, B.; Bobes, J.; Saiz, P.A.; García-Portilla, M.P.; Sanjuan, J.; Aguilar, E.J.; Santos, J.L.; Jiménez-López, E.; Arrojo, M.; Carracedo, A.; López, G.; González-Peñas, J.; Parellada, M.; Maric, N.P.; Atbaşoğlu, C.; Ucok, A.; Alptekin, K.; Saka, M.C.; Alizadeh, B.Z.; van Amelsvoort, T.; Bruggeman, R.; Cahn, W.; de Haan, L.; Luykx, J.J.; van Winkel, R.; Rutten, B.P.F.; van Os, J.; Arango, C.; O’Donovan, M.; Rutten, B.P.F.; van Os, J.; Guloksuz, S. Estimating exposome score for schizophrenia using predictive modeling approach in two independent samples: The results from the EUGEI study. Schizophr. Bull.,  2019, 45(5), 960-965.
 [http://dx.doi.org/10.1093/schbul/sbz054] [PMID:  31508804]

[239]
Pries, L.K.; Erzin, G.; van Os, J.; ten Have, M.; de Graaf, R.; van Dorsselaer, S.; Bak, M.; Rutten, B.P.F.; Guloksuz, S. Predictive performance of exposome score for schizophrenia in the general population. Schizophr. Bull.,  2021, 47(2), 277-283.
 [http://dx.doi.org/10.1093/schbul/sbaa170] [PMID:  33215211]

[240]
Erzin, G.; Pries, L.K.; Dimitrakopoulos, S.; Ralli, I.; Xenaki, L.A.; Soldatos, R.F.; Vlachos, I.; Selakovic, M.; Foteli, S.; Kosteletos, I.; Nianiakas, N.; Mantonakis, L.; Rizos, E.; Kollias, K.; Van Os, J.; Guloksuz, S.; Stefanis, N. Association between exposome score for schizophrenia and functioning in first-episode psychosis: results from the Athens first-episode psychosis research study. Psychol. Med.,  2021, 1-10.
 [http://dx.doi.org/10.1017/S0033291721004542] [PMID:  34789350]

[241]
Vaucher, J.; Keating, B.J.; Lasserre, A.M.; Gan, W.; Lyall, D.M.; Ward, J.; Smith, D.J.; Pell, J.P.; Sattar, N.; Paré, G.; Holmes, M.V. Cannabis use and risk of schizophrenia: A Mendelian randomization study. Mol. Psychiatry,  2018, 23(5), 1287-1292.
 [http://dx.doi.org/10.1038/mp.2016.252] [PMID:  28115737]

[242]
Lin, B.D.; Pries, L.K.; Sarac, H.S.; van Os, J.; Rutten, B.P.F.; Luykx, J.; Guloksuz, S. Nongenetic factors associated with psychotic experiences among UK Biobank participants. JAMA Psychiatry,  2022, 79(9), 857-868.
 [http://dx.doi.org/10.1001/jamapsychiatry.2022.1655] [PMID:  35857297]

[243]
Gage, S.H.; Jones, H.J.; Burgess, S.; Bowden, J.; Davey Smith, G.; Zammit, S.; Munafò, M.R. Assessing causality in associations between cannabis use and schizophrenia risk: A two-sample Mendelian randomization study. Psychol. Med.,  2017, 47(5), 971-980.
 [http://dx.doi.org/10.1017/S0033291716003172] [PMID:  27928975]

[244]
Rutter, M. Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. Br. J. Psychiatry,  1985, 147(6), 598-611.
 [http://dx.doi.org/10.1192/bjp.147.6.598] [PMID:  3830321]

[245]
McGrath, J.; Brown, A.; St Clair, D. Prevention and schizophrenia-the role of dietary factors. Schizophr. Bull.,  2011, 37(2), 272-283.
 [http://dx.doi.org/10.1093/schbul/sbq121] [PMID:  20974747]

[246]
Tienari, P.; Wynne, L.C.; Sorri, A.; Lahti, I.; Läksy, K.; Moring, J.; Naarala, M.; Nieminen, P.; Wahlberg, K.E. Genotype-environment interaction in schizophrenia-spectrum disorder. Br. J. Psychiatry,  2004, 184(3), 216-222.
 [http://dx.doi.org/10.1192/bjp.184.3.216] [PMID:  14990519]

[247]
O’Brien, M.P.; Gordon, J.L.; Bearden, C.E.; Lopez, S.R.; Kopelowicz, A.; Cannon, T.D. Positive family environment predicts improvement in symptoms and social functioning among adolescents at imminent risk for onset of psychosis. Schizophr. Res.,  2006, 81(2-3), 269-275.
 [http://dx.doi.org/10.1016/j.schres.2005.10.005] [PMID:  16309893]

[248]
Achterhof, R.; Schneider, M.; Kirtley, O.J.; Wampers, M.; Decoster, J.; Derom, C.; De Hert, M.; Guloksuz, S.; Jacobs, N.; Menne-Lothmann, C.; Rutten, B.P.F.; Thiery, E.; van Os, J.; van Winkel, R.; Wichers, M.; Myin-Germeys, I. Be(com)ing social: Daily-life social interactions and parental bonding. Dev. Psychol.,  2022, 58(4), 792-805.
 [http://dx.doi.org/10.1037/dev0001315] [PMID:  35343722]

[249]
Kuranova, A.; Booij, S.H.; de Jonge, P.; Jeronimus, B.; Lin, A.; Wardenaar, K.J.; Wichers, M.; Wigman, J.T.W. Don’t worry, be happy: Protective factors to buffer against distress associated with psychotic experiences. Schizophr. Res.,  2020, 223, 79-86.
 [http://dx.doi.org/10.1016/j.schres.2020.05.019] [PMID:  32473933]

[250]
Crush, E.; Arseneault, L.; Moffitt, T.E.; Danese, A.; Caspi, A.; Jaffee, S.R.; Matthews, T.; Fisher, H.L. Protective factors for psychotic experiences amongst adolescents exposed to multiple forms of victimization. J. Psychiatr. Res.,  2018, 104, 32-38.
 [http://dx.doi.org/10.1016/j.jpsychires.2018.06.011] [PMID:  29929082]

[251]
Oliver, D.; Reilly, T.J.; Baccaredda Boy, O.; Petros, N.; Davies, C.; Borgwardt, S.; McGuire, P.; Fusar-Poli, P. What causes the onset of psychosis in individuals at clinical high risk? A meta-analysis of risk and protective factors. Schizophr. Bull.,  2020, 46(1), 110-120.
 [http://dx.doi.org/10.1093/schbul/sbz039] [PMID:  31219164]

[252]
Turley, D.; Drake, R.; Killackey, E.; Yung, A.R. Perceived stress and psychosis: The effect of perceived stress on psychotic‐like experiences in a community sample of adolescents. Early Interv. Psychiatry,  2019, 13(6), 1465-1469.
 [http://dx.doi.org/10.1111/eip.12795] [PMID:  30712294]

[253]
Ered, A.; Gibson, L.E.; Maxwell, S.D.; Cooper, S.; Ellman, L.M. Coping as a mediator of stress and psychotic-like experiences. Eur. Psychiatry,  2017, 43, 9-13.
 [http://dx.doi.org/10.1016/j.eurpsy.2017.01.327] [PMID:  28365470]

[254]
Taylor, S.E.; Stanton, A.L. Coping resources, coping processes, and mental health. Annu. Rev. Clin. Psychol.,  2007, 3(1), 377-401.
 [http://dx.doi.org/10.1146/annurev.clinpsy.3.022806.091520] [PMID:  17716061]

[255]
Cohen, S.; Kamarck, T.; Mermelstein, R. A global measure of perceived stress. J. Health Soc. Behav.,  1983, 24(4), 385-396.
 [http://dx.doi.org/10.2307/2136404] [PMID:  6668417]

[256]
Jalbrzikowski, M.; Sugar, C.A.; Zinberg, J.; Bachman, P.; Cannon, T.D.; Bearden, C.E. Coping styles of individuals at clinical high risk for developing psychosis. Early Interv. Psychiatry,  2014, 8(1), 68-76.
 [http://dx.doi.org/10.1111/eip.12005] [PMID:  23164368]

[257]
Cotton, S.M.; McCann, T.V.; Gleeson, J.F.; Crisp, K.; Murphy, B.P.; Lubman, D.I. Coping strategies in carers of young people with a first episode of psychosis. Schizophr. Res.,  2013, 146(1-3), 118-124.
 [http://dx.doi.org/10.1016/j.schres.2013.02.008] [PMID:  23490761]

[258]
DeVylder, J.E.; Ben-David, S.; Kimhy, D.; Corcoran, C.M. Attributional style among youth at clinical risk for psychosis. Early Interv. Psychiatry,  2013, 7(1), 84-88.
 [http://dx.doi.org/10.1111/j.1751-7893.2012.00347.x] [PMID:  22390315]

[259]
Reininghaus, U.; Kempton, M.J.; Valmaggia, L.; Craig, T.K.J.; Garety, P.; Onyejiaka, A.; Gayer-Anderson, C.; So, S.H.; Hubbard, K.; Beards, S.; Dazzan, P.; Pariante, C.; Mondelli, V.; Fisher, H.L.; Mills, J.G.; Viechtbauer, W.; McGuire, P.; van Os, J.; Murray, R.M.; Wykes, T.; Myin-Germeys, I.; Morgan, C. Stress sensitivity, aberrant salience, and threat anticipation in early psychosis: An experience sampling study. Schizophr. Bull.,  2016, 42(3), 712-722.
 [http://dx.doi.org/10.1093/schbul/sbv190] [PMID:  26834027]

[260]
Xenaki, L.A.; Stefanatou, P.; Ralli, E.; Hatzimanolis, A.; Dimitrakopoulos, S.; Soldatos, R.F.; Vlachos, I.I.; Selakovic, M.; Foteli, S.; Kosteletos, I.; Nianiakas, N.; Ntigridaki, A.; Triantafyllou, T.F.; Voulgaraki, M.; Mantonakis, L.; Tsapas, A.; Bozikas, V.P.; Kollias, K.; Stefanis, N.C. The relationship between early symptom severity, improvement and remission in first episode psychosis with jumping to conclusions. Schizophr. Res.,  2022, 240, 24-30.
 [http://dx.doi.org/10.1016/j.schres.2021.11.039] [PMID:  34915248]

[261]
Prasko, J.; Holubova, M.; Hruby, R.; Latalova, K.; Kamaradova, D.; Marackova, M.; Slepecky, M.; Gubova, T. Coping strategies and self-stigma in patients with schizophrenia-spectrum disorders. Patient Prefer. Adherence,  2016, 10, 1151-1158.
 [http://dx.doi.org/10.2147/PPA.S106437] [PMID:  27445463]

[262]
Mian, L.; Lattanzi, G.M.; Tognin, S. Coping strategies in individuals at ultra-high risk of psychosis: A systematic review. Early Interv. Psychiatry,  2018, 12(4), 525-534.
 [http://dx.doi.org/10.1111/eip.12492] [PMID:  29761632]

[263]
Behrouian, M.; Ramezani, T.; Dehghan, M.; Sabahi, A.; Ebrahimnejad Zarandi, B. The effect of the emotion regulation training on the resilience of caregivers of patients with schizophrenia: a parallel randomized controlled trial. BMC Psychol.,  2021, 9(1), 39.
 [http://dx.doi.org/10.1186/s40359-021-00542-5] [PMID:  33653410]

[264]
Stramecki, F.; Kotowicz, K.; Piotrowski, P. Beszłej, J.A.; Rymaszewska, J.; Samochowiec, J.; Samochowiec, A.; Moustafa, A.A.; Jabłoński, M.; Podwalski, P.; Waszczuk, K.; Wroński, M.; Misiak, B. Coping styles and symptomatic manifestation of first-episode psychosis: Focus on cognitive performance. Psychiatry Res.,  2019, 272, 246-251.
 [http://dx.doi.org/10.1016/j.psychres.2018.12.083] [PMID:  30590279]

[265]
Bozikas, V.; Parlapani, E. Resilience in patients with psychotic disorder. Psychiatriki,  2016, 27(1), 13-16.
 [PMID:  27110878]

[266]
Steger, M.F. Meaning in life is a fundamental protective factor in the context of psychopathology. World Psychiatry,  2022, 21(3), 389-390.
 [http://dx.doi.org/10.1002/wps.20916] [PMID:  36073697]

[267]
Rapoport, J.L.; Giedd, J.N.; Gogtay, N. Neurodevelopmental model of schizophrenia: Update 2012. Mol. Psychiatry,  2012, 17(12), 1228-1238.
 [http://dx.doi.org/10.1038/mp.2012.23] [PMID:  22488257]

[268]
Kochunov, P.; Hong, L.E. Neurodevelopmental and neurodegenerative models of schizophrenia: White matter at the center stage. Schizophr. Bull.,  2014, 40(4), 721-728.
 [http://dx.doi.org/10.1093/schbul/sbu070] [PMID:  24870447]

[269]
Broerman, R. Diathesis-Stress Model.In:Encyclopedia of Personality and Individual Differences; Zeigler-Hill, V.; Shackelford, T., Eds.; Springer: Cham, 2018, pp. 1-3.
 [http://dx.doi.org/10.1007/978-3-319-28099-8_891-1]

[270]
Stroud, C.B. The stress sensitization model.In:The Oxford handbook of stress and mental health; Harkness, K.L.; Hayden, E.P., Eds.; Oxford University Press: Oxford, 2020, pp. 349-370.

[271]
Moran, P.; Stokes, J.; Marr, J.; Bock, G.; Desbonnet, L.; Waddington, J.; O’Tuathaigh, C. Gene × Environment interactions in schizophrenia: Evidence from genetic mouse models. Neural Plast.,  2016, 2016, 1-23.
 [http://dx.doi.org/10.1155/2016/2173748] [PMID:  27725886]

[272]
Mas, S.; Boloc, D.; Rodríguez, N.; Mezquida, G.; Amoretti, S.; Cuesta, M.J.; González-Peñas, J.; García-Alcón, A.; Lobo, A.; González-Pinto, A.; Corripio, I.; Vieta, E.; Castro-Fornieles, J.; Mané, A.; Saiz-Ruiz, J.; Gassó, P.; Bioque, M.; Bernardo, M. Examining gene-environment interactions using aggregate scores in a first-episode psychosis cohort. Schizophr. Bull.,  2020, 46(4), 1019-1025.
 [http://dx.doi.org/10.1093/schbul/sbaa012] [PMID:  32083289]

[273]
Pardiñas, A.F.; Holmans, P.; Pocklington, A.J.; Escott-Price, V.; Ripke, S.; Carrera, N.; Legge, S.E.; Bishop, S.; Cameron, D.; Hamshere, M.L.; Han, J.; Hubbard, L.; Lynham, A.; Mantripragada, K.; Rees, E.; MacCabe, J.H.; McCarroll, S.A.; Baune, B.T.; Breen, G.; Byrne, E.M.; Dannlowski, U.; Eley, T.C.; Hayward, C.; Martin, N.G.; McIntosh, A.M.; Plomin, R.; Porteous, D.J.; Wray, N.R.; Caballero, A.; Geschwind, D.H.; Huckins, L.M.; Ruderfer, D.M.; Santiago, E.; Sklar, P.; Stahl, E.A.; Won, H.; Agerbo, E.; Als, T.D.; Andreassen, O.A.; Bækvad-Hansen, M.; Mortensen, P.B.; Pedersen, C.B.; Børglum, A.D.; Bybjerg-Grauholm, J.; Djurovic, S.; Durmishi, N.; Pedersen, M.G.; Golimbet, V.; Grove, J.; Hougaard, D.M.; Mattheisen, M.; Molden, E.; Mors, O.; Nordentoft, M.; Pejovic-Milovancevic, M.; Sigurdsson, E.; Silagadze, T.; Hansen, C.S.; Stefansson, K.; Stefansson, H.; Steinberg, S.; Tosato, S.; Werge, T.; Collier, D.A.; Rujescu, D.; Kirov, G.; Owen, M.J.; O’Donovan, M.C.; Walters, J.T.R. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat. Genet.,  2018, 50(3), 381-389.
 [http://dx.doi.org/10.1038/s41588-018-0059-2] [PMID:  29483656]

[274]
Guloksuz, S.; van Os, J.; Rutten, B.P.F. The exposome paradigm and the complexities of environmental research in psychiatry. JAMA Psychiatry,  2018, 75(10), 985-986.
 [http://dx.doi.org/10.1001/jamapsychiatry.2018.1211] [PMID:  29874362]

[275]
Robinson, N.; Bergen, S.E. Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: Current knowledge and future directions. Front. Genet.,  2021, 12, 686666.
 [http://dx.doi.org/10.3389/fgene.2021.686666] [PMID:  34262598]

[276]
Kendler, K.S.; Gardner, C.O. Interpretation of interactions: Guide for the perplexed. Br. J. Psychiatry,  2010, 197(3), 170-171.
 [http://dx.doi.org/10.1192/bjp.bp.110.081331] [PMID:  20807958]

[277]
McAllister, K.; Mechanic, L.E.; Amos, C.; Aschard, H.; Blair, I.A.; Chatterjee, N.; Conti, D.; Gauderman, W.J.; Hsu, L.; Hutter, C.M.; Jankowska, M.M.; Kerr, J.; Kraft, P.; Montgomery, S.B.; Mukherjee, B.; Papanicolaou, G.J.; Patel, C.J.; Ritchie, M.D.; Ritz, B.R.; Thomas, D.C.; Wei, P.; Witte, J.S. Current challenges and new opportunities for gene-environment interaction studies of complex diseases. Am. J. Epidemiol.,  2017, 186(7), 753-761.
 [http://dx.doi.org/10.1093/aje/kwx227] [PMID:  28978193]

[278]
Pinckaers, F.M.E.; Rotee, I.L.M.; Nwosu, C.V.; Krolinski, P.; Smeets, A.P.W.; Gülöksüz, S.; de Jong, L.; Vaessen, T.S.J.; Damen, T.; Uittenboogaard, A.; Schäfer, A.T.; Menne-Lothmann, C.; Decoster, J.; van Winkel, R.; Collip, D.; Delespaul, P.; De Hert, M.; Derom, C.; Thiery, E.; Jacobs, N.; Wichers, M.; Rutten, B.P.F.; van Os, J.; Drukker, M. Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. Soc. Psychiatry Psychiatr. Epidemiol.,  2019, 54(9), 1045-1054.
 [http://dx.doi.org/10.1007/s00127-019-01711-z] [PMID:  31209522]

[279]
Domingue, B.; Trejo, S.; Armstrong-Carter, E.; Tucker-Drob, E. Interactions between polygenic scores and environments: Methodological and conceptual challenges. Sociol. Sci.,  2020, 7, 365-386.
 [http://dx.doi.org/10.15195/v7.a19] [PMID:  36091972]

[280]
Lewis, D.A.; Curley, A.A.; Glausier, J.R.; Volk, D.W. Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci.,  2012, 35(1), 57-67.
 [http://dx.doi.org/10.1016/j.tins.2011.10.004] [PMID:  22154068]

[281]
Guloksuz, S.; Rutten, B.P.F.; Pries, L.K.; ten Have, M.; de Graaf, R.; van Dorsselaer, S.; Klingenberg, B.; van Os, J.; Ioannidis, J.P.A. The complexities of evaluating the exposome in psychiatry: A data-driven illustration of challenges and some propositions for amendments. Schizophr. Bull.,  2018, 44(6), 1175-1179.
 [http://dx.doi.org/10.1093/schbul/sby118] [PMID:  30169883]

[282]
Uher, R.; Zwicker, A. Etiology in psychiatry: Embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry,  2017, 16(2), 121-129.
 [http://dx.doi.org/10.1002/wps.20436] [PMID:  28498595]
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DOI https://dx.doi.org/10.2174/1570159X21666230817153631	Print ISSN 1570-159X
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