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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Mini-Review Article

Dietary, Herbal and Nutritional Interventions for Managing Rheumatoid Arthritis: A Review

Author(s): Aanchal Verma, Nandini Dubey, Anant Agrawal and Ahsas Goyal*

Volume 25, Issue 2, 2024

Published on: 10 August, 2023

Page: [125 - 132] Pages: 8

DOI: 10.2174/1389201024666230807155529

Price: $65

Abstract

Rheumatoid Arthritis (RA) is a systemic, inflammatory disease that affects joints and leads to progressive cartilage and bone deterioration. The susceptibility to RA is determined by genetic and environmental factors. Recently, many efforts have been undertaken to develop natural compounds capable of reducing the symptoms of RA to avoid the negative effects of the current anti-inflammatory drugs. Interestingly, substantial data has revealed that nutritional, and herbal supplements may be effective adjuvants in reducing the symptoms of RA by influencing the pathogenic inflammatory processes. In this context, various kinds of food, phenolic substances, spices like ginger, and turmeric, several vitamins, and probiotics are reported to control the activity of inflammatory molecules implicated in the pathophysiology of RA and therefore, have proved successful in slowing the course of this arthritic illness. Therefore, the goal of this review article is to compile various findings on RA that have revealed illuminating information about the antiinflammatory, antioxidant, analgesic, immunomodulatory, and bone erosion-preventing properties of nutritional, and herbal components. Conclusively, this review concentrates on natural ingredients that may enhance overall well-being, promote health, and lessen the risk of RA.

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Graphical Abstract

[1]
Gabriel, S.E.; Michaud, K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res. Ther., 2009, 11(3), 229.
[http://dx.doi.org/10.1186/ar2669] [PMID: 19519924]
[2]
Heidari, B. Rheumatoid Arthritis: Early diagnosis and treatment outcomes. Caspian J. Intern. Med., 2011, 2(1), 161-170.
[PMID: 24024009]
[3]
Alamanos, Y.; Drosos, A. Epidemiology of adult rheumatoid arthritis. Autoimmun. Rev., 2005, 4(3), 130-136.
[http://dx.doi.org/10.1016/j.autrev.2004.09.002] [PMID: 15823498]
[4]
Myasoedova, E.; Crowson, C.S.; Kremers, H.M.; Therneau, T.M.; Gabriel, S.E. Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955-2007. Arthritis Rheum., 2010, 62(6), 1576-1582.
[http://dx.doi.org/10.1002/art.27425] [PMID: 20191579]
[5]
Arayssi, T.; Harfouche, M.; Darzi, A.; Al Emadi, S.; Alnaqbi, A. K.; Badsha, H.; Al Balushi, F.; Dib, C.; Elzorkany, B.; Halabi, H.; Hammoudeh, M.; Hazer, W.; Masri, B.; Merashli, M.; Omair, M.; Salloum, N.; Uthman, I.; Zahirovic, S.; Ziade, N.; Bannuru, R.R.; McAlindon, T.; Nomier, M.A.; Singh, J.A.; Christensen, R.; Tugwell, P.; Schünemann, H.; Akl, E.A. Recommendations for the management of rheumatoid arthritis in the eastern mediterranean region: An adolopment of the 2015 American College of Rheumatology guidelines. Clin. Rheumatol., 2018, 37(11), 2947-2959.
[http://dx.doi.org/10.1007/s10067-018-4245-5] [PMID: 30097896]
[6]
Handa, R.; Rao, U.R.K.; Lewis, J.F.M.; Rambhad, G.; Shiff, S.; Ghia, C.J. Literature review of rheumatoid arthritis in India. Int. J. Rheum. Dis., 2016, 19(5), 440-451.
[http://dx.doi.org/10.1111/1756-185X.12621] [PMID: 26171649]
[7]
Finckh, A.; Gilbert, B.; Hodkinson, B.; Bae, S.C.; Thomas, R.; Deane, K.D.; Alpizar-Rodriguez, D.; Lauper, K. Global epidemiology of rheumatoid arthritis. Nat. Rev. Rheumatol., 2022, 18(10), 591-602.
[PMID: 36068354]
[8]
Cojocaru, M.; Cojocaru, I.M.; Silosi, I.; Vrabie, C.D.; Tanasescu, R. Extra-articular manifestations in rheumatoid arthritis. Maedica (Buchar.), 2010, 5(4), 286-291.
[PMID: 21977172]
[9]
Lindhardsen, J.; Ahlehoff, O.; Gislason, G.H.; Madsen, O.R.; Olesen, J.B.; Torp-Pedersen, C.; Hansen, P.R. The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: A Danish nationwide cohort study. Ann. Rheum. Dis., 2011, 70(6), 929-934.
[http://dx.doi.org/10.1136/ard.2010.143396] [PMID: 21389043]
[10]
Aletaha, D.; Smolen, J.S. Diagnosis and management of rheumatoid arthritis: A review. JAMA, 2018, 320(13), 1360-1372.
[http://dx.doi.org/10.1001/jama.2018.13103] [PMID: 30285183]
[11]
Akiyama, M.; Kaneko, Y. Pathogenesis, clinical features, and treatment strategy for rheumatoid arthritis-associated interstitial lung disease. Autoimmun. Rev., 2022, 21(5), 103056.
[http://dx.doi.org/10.1016/j.autrev.2022.103056] [PMID: 35121155]
[12]
Chehade, L.; Jaafar, Z.A.; El Masri, D.; Zmerly, H.; Kreidieh, D.; Tannir, H.; Itani, L.; El Ghoch, M. Lifestyle modification in rheumatoid arthritis: Dietary and physical activity recommendations based on evidence. Curr. Rheumatol. Rev., 2019, 15(3), 209-214.
[http://dx.doi.org/10.2174/1573397115666190121135940] [PMID: 30666911]
[13]
Soeken, K.L.; Miller, S.A.; Ernst, E. Herbal medicines for the treatment of rheumatoid arthritis: A systematic review. Br. J. Rheumatol., 2003, 42(5), 652-659.
[http://dx.doi.org/10.1093/rheumatology/keg183] [PMID: 12709541]
[14]
Dragos, D.; Gilca, M.; Gaman, L.; Vlad, A.; Iosif, L.; Stoian, I.; Lupescu, O. Phytomedicine in joint disorders. Nutrients, 2017, 9(1), 70.
[http://dx.doi.org/10.3390/nu9010070] [PMID: 28275210]
[15]
Pedersen, M.; Stripp, C.; Klarlund, M.; Olsen, S.F.; Tjønneland, A.M.; Frisch, M. Diet and risk of rheumatoid arthritis in a prospective cohort. J. Rheumatol., 2005, 32(7), 1249-1252.
[PMID: 15996059]
[16]
Philippou, E.; Nikiphorou, E. Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis. Autoimmun. Rev., 2018, 17(11), 1074-1077.
[http://dx.doi.org/10.1016/j.autrev.2018.05.009] [PMID: 30213695]
[17]
Alwarith, J.; Kahleova, H.; Rembert, E.; Yonas, W.; Dort, S.; Calcagno, M.; Burgess, N.; Crosby, L.; Barnard, N.D. Nutrition interventions in rheumatoid arthritis: The potential use of plant-based diets. A review. Front. Nutr., 2019, 6, 141.
[http://dx.doi.org/10.3389/fnut.2019.00141] [PMID: 31552259]
[18]
Umar, S.; Umar, K.; Sarwar, A.H.M.G.; Khan, A.; Ahmad, N.; Ahmad, S.; Katiyar, C.K.; Husain, S.A.; Khan, H.A. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine, 2014, 21(6), 847-856.
[http://dx.doi.org/10.1016/j.phymed.2014.02.001] [PMID: 24667331]
[19]
Akhtar, N.; Miller, M.J.S.; Haqqi, T.M. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC Complement. Altern. Med., 2011, 11(1), 66.
[http://dx.doi.org/10.1186/1472-6882-11-66] [PMID: 21854562]
[20]
Choy, E. Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology, 2012, 51(Suppl. 5), v3-v11.
[http://dx.doi.org/10.1093/rheumatology/kes113] [PMID: 22718924]
[21]
Byng-Maddick, R.; Ehrenstein, M.R. The impact of biological therapy on regulatory T cells in rheumatoid arthritis. Rheumatology, 2015, 54(5), 768-775.
[http://dx.doi.org/10.1093/rheumatology/keu487] [PMID: 25667434]
[22]
Smolen, J.S.; Aletaha, D.; Barton, A.; Burmester, G.R.; Emery, P.; Firestein, G.S.; Kavanaugh, A.; McInnes, I.B.; Solomon, D.H.; Strand, V.; Yamamoto, K. Rheumatoid arthritis. Nat. Rev. Dis. Primers, 2018, 4(1), 18001.
[http://dx.doi.org/10.1038/nrdp.2018.1] [PMID: 29417936]
[23]
Chen, Z.; Bozec, A.; Ramming, A.; Schett, G. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat. Rev. Rheumatol., 2019, 15(1), 9-17.
[http://dx.doi.org/10.1038/s41584-018-0109-2] [PMID: 30341437]
[24]
Bach-Faig, A.; Berry, E.M.; Lairon, D.; Reguant, J.; Trichopoulou, A.; Dernini, S.; Medina, F.X.; Battino, M.; Belahsen, R.; Miranda, G.; Serra-Majem, L. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr., 2011, 14(12A), 2274-2284.
[http://dx.doi.org/10.1017/S1368980011002515] [PMID: 22166184]
[25]
Vallverdú-Queralt, A.; Regueiro, J.; Martínez-Huélamo, M.; Rinaldi Alvarenga, J.F.; Leal, L.N.; Lamuela-Raventos, R.M. A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chem., 2014, 154, 299-307.
[http://dx.doi.org/10.1016/j.foodchem.2013.12.106] [PMID: 24518346]
[26]
Dinu, M.; Pagliai, G.; Casini, A.; Sofi, F. Mediterranean diet and multiple health outcomes: An umbrella review of meta-analyses of observational studies and randomised trials. Eur. J. Clin. Nutr., 2018, 72(1), 30-43.
[http://dx.doi.org/10.1038/ejcn.2017.58] [PMID: 28488692]
[27]
Matsumoto, Y.; Sugioka, Y.; Tada, M.; Okano, T.; Mamoto, K.; Inui, K.; Habu, D.; Koike, T. Monounsaturated fatty acids might be key factors in the mediterranean diet that suppress rheumatoid arthritis disease activity: The TOMORROW study. Clin. Nutr., 2018, 37(2), 675-680.
[http://dx.doi.org/10.1016/j.clnu.2017.02.011] [PMID: 28285975]
[28]
McKellar, G.; Morrison, E.; McEntegart, A.; Hampson, R.; Tierney, A.; Mackle, G.; Scoular, J.; Scott, J.A.; Capell, H.A. A pilot study of a Mediterranean-type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow. Ann. Rheum. Dis., 2007, 66(9), 1239-1243.
[http://dx.doi.org/10.1136/ard.2006.065151] [PMID: 17613557]
[29]
Oliviero, F.; Spinella, P.; Fiocco, U.; Ramonda, R.; Sfriso, P.; Punzi, L. How the Mediterranean diet and some of its components modulate inflammatory pathways in arthritis. Swiss Med. Wkly., 2015, 145, w14190.
[http://dx.doi.org/10.4414/smw.2015.14190] [PMID: 26523418]
[30]
Philippou, E. The glycemic index: Applications in practice; CRC Press: Nicosia, Cyprus; London, UK, 2016.
[http://dx.doi.org/10.1201/9781315371764]
[31]
Papandreou, P.; Gioxari, A.; Daskalou, E.; Grammatikopoulou, M.G.; Skouroliakou, M.; Bogdanos, D.P. Mediterranean diet and physical activity nudges versus usual care in women with rheumatoid arthritis: Results from the MADEIRA randomized controlled trial. Nutrients, 2023, 15(3), 676.
[http://dx.doi.org/10.3390/nu15030676] [PMID: 36771382]
[32]
Lozada-Mellado, M.; Llorente, L.; Hinojosa-Azaola, A.; García-Morales, J.M.; Ogata-Medel, M.; Alcocer-Varela, J.; Pineda-Juárez, J.A.; Castillo-Martínez, L. Comparison of the impacts of a dynamic exercise program vs. a Mediterranean diet on serum cytokine concentrations in women with rheumatoid arthritis. A secondary analysis of a randomized clinical trial. Front. Nutr., 2022, 9, 834824.
[http://dx.doi.org/10.3389/fnut.2022.834824] [PMID: 35548581]
[33]
Sadeghi, A.; Tabatabaiee, M.; Mousavi, M.A.; Mousavi, S.N.; Abdollahi Sabet, S.; Jalili, N. Dietary pattern or weight loss: Which one is more important to reduce disease activity score in patients with rheumatoid arthritis? A randomized feeding trial. Int. J. Clin. Pract., 2022, 2022, 1-6.
[http://dx.doi.org/10.1155/2022/6004916] [PMID: 35685522]
[34]
Holst-Jensen, S.E.; Pfeiffer-Jensen, M.; Monsrud, M.; Tarp, U.; Buus, A.; Hessov, I.; Thorling, E.; Stengaard-Pedersen, K. Treatment of rheumatoid arthritis with a peptide diet: A randomized, controlled trial. Scand. J. Rheumatol., 1998, 27(5), 329-336.
[http://dx.doi.org/10.1080/03009749850154339] [PMID: 9808394]
[35]
Podas, T.; Nightingale, J.M.D.; Oldham, R.; Roy, S.; Sheehan, N.J.; Mayberry, J.F. Is rheumatoid arthritis a disease that starts in the intestine? A pilot study comparing an elemental diet with oral prednisolone. Postgrad. Med. J., 2007, 83(976), 128-131.
[http://dx.doi.org/10.1136/pgmj.2006.050245] [PMID: 17308218]
[36]
Kavanagh, R.; Workman, E.; Nash, P.; Smith, M.; Hazleman, B.L.; Hunter, J.O. The effects of elemental diet and subsequent food reintroduction on rheumatoid arthritis. Rheumatology, 1995, 34(3), 270-273.
[http://dx.doi.org/10.1093/rheumatology/34.3.270] [PMID: 7728405]
[37]
Serhan, C.N.; Chiang, N.; Dalli, J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin. Immunol., 2015, 27(3), 200-215.
[http://dx.doi.org/10.1016/j.smim.2015.03.004] [PMID: 25857211]
[38]
Müller, H.; de Toledo, F.W.; Resch, K.L. Fasting followed by vegetarian diet in patients with rheumatoid arthritis: A systematic review. Scand. J. Rheumatol., 2001, 30(1), 1-10.
[http://dx.doi.org/10.1080/030097401750065256] [PMID: 11252685]
[39]
Newman, J.C.; Verdin, E. Ketone bodies as signaling metabolites. Trends Endocrinol. Metab., 2014, 25(1), 42-52.
[http://dx.doi.org/10.1016/j.tem.2013.09.002] [PMID: 24140022]
[40]
Youm, Y.H.; Nguyen, K.Y.; Grant, R.W.; Goldberg, E.L.; Bodogai, M.; Kim, D.; D’Agostino, D.; Planavsky, N.; Lupfer, C.; Kanneganti, T.D.; Kang, S.; Horvath, T.L.; Fahmy, T.M.; Crawford, P.A.; Biragyn, A.; Alnemri, E.; Dixit, V.D. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med., 2015, 21(3), 263-269.
[http://dx.doi.org/10.1038/nm.3804] [PMID: 25686106]
[41]
Vandanmagsar, B.; Youm, Y.H.; Ravussin, A.; Galgani, J.E.; Stadler, K.; Mynatt, R.L.; Ravussin, E.; Stephens, J.M.; Dixit, V.D. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med., 2011, 17(2), 179-188.
[http://dx.doi.org/10.1038/nm.2279] [PMID: 21217695]
[42]
Ravussin, E.; Redman, L.M.; Rochon, J.; Das, S.K.; Fontana, L.; Kraus, W.E.; Romashkan, S.; Williamson, D.A.; Meydani, S.N.; Villareal, D.T.; Smith, S.R.; Stein, R.I.; Scott, T.M.; Stewart, T.M.; Saltzman, E.; Klein, S.; Bhapkar, M.; Martin, C.K.; Gilhooly, C.H.; Holloszy, J.O.; Hadley, E.C.; Roberts, S.B. A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity. J. Gerontol. A Biol. Sci. Med. Sci., 2015, 70(9), 1097-1104.
[http://dx.doi.org/10.1093/gerona/glv057] [PMID: 26187233]
[43]
Murti, Y.; Agrawal, K.K.; Semwal, B.C.; Gupta, J.; Gupta, R. A review on novel herbal drug delivery system and its application. Curr. Tradit. Med., 2023, 9(2), e280422204154.
[http://dx.doi.org/10.2174/2215083808666220428092638]
[44]
Agrawal, K.K.; Murti, Y. Tangeretin: A biologically potential citrus flavone. Curr. Tradit. Med., 2022, 8(4), 31-41.
[45]
Ahuja, A.; Singh, S. Impact of the current scenario and future perspectives for the management of oral diseases: Remarkable contribution of herbs in dentistry. Antiinfect. Agents, 2022, 20(5), e050422203119.
[http://dx.doi.org/10.2174/2211352520666220405124929]
[46]
Scalbert, A.; Manach, C.; Morand, C.; Rémésy, C.; Jiménez, L. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr., 2005, 45(4), 287-306.
[http://dx.doi.org/10.1080/1040869059096] [PMID: 16047496]
[47]
Kataoka, H.; Kono, H.; Patel, Z.; Rock, K.L.; Rock, K.L. Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses. PLoS One, 2014, 9(8), e104741.
[http://dx.doi.org/10.1371/journal.pone.0104741] [PMID: 25127469]
[48]
Rahman, M.M.; Rahaman, M.S.; Islam, M.R.; Rahman, F.; Mithi, F.M.; Alqahtani, T.; Almikhlafi, M.A.; Alghamdi, S.Q.; Alruwaili, A.S.; Hossain, M.S.; Ahmed, M.; Das, R.; Emran, T.B.; Uddin, M.S. Role of phenolic compounds in human disease: Current knowledge and future prospects. Molecules, 2021, 27(1), 233.
[http://dx.doi.org/10.3390/molecules27010233] [PMID: 35011465]
[49]
Sharma, D.; Chaubey, P.; Suvarna, V. Role of natural products in alleviation of rheumatoid arthritis—A review. J. Food Biochem., 2021, 45(4), e13673.
[http://dx.doi.org/10.1111/jfbc.13673] [PMID: 33624882]
[50]
Al-Nahain, A.; Jahan, R.; Rahmatullah, M. Zingiber officinale: A potential plant against rheumatoid arthritis. Arthritis, 2014, 2014, 1-8.
[http://dx.doi.org/10.1155/2014/159089] [PMID: 24982806]
[51]
Aryaeian, N.; Shahram, F.; Mahmoudi, M.; Tavakoli, H.; Yousefi, B.; Arablou, T.; Jafari Karegar, S. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active rheumatoid arthritis. Gene, 2019, 698, 179-185.
[http://dx.doi.org/10.1016/j.gene.2019.01.048] [PMID: 30844477]
[52]
Grzanna, R.; Lindmark, L.; Frondoza, C.G. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J. Med. Food, 2005, 8(2), 125-132.
[http://dx.doi.org/10.1089/jmf.2005.8.125] [PMID: 16117603]
[53]
Ojewole, J.A.O. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (roscoe) rhizomes (zingiberaceae) in mice and rats. Phytother. Res., 2006, 20(9), 764-772.
[http://dx.doi.org/10.1002/ptr.1952] [PMID: 16807883]
[54]
Ahsas, G.; Verma, A.; Agrawal, N.; Pathak, S. Ayurvedic herbs and spices: A promising approach for the treatment of COVID-19. Nat. Prod. J., 2022, 13(3), e200522205091.
[55]
Chin, K.Y. The spice for joint inflammation: Anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des. Devel. Ther., 2016, 10, 3029-3042.
[http://dx.doi.org/10.2147/DDDT.S117432] [PMID: 27703331]
[56]
Shep, D.; Khanwelkar, C.; Gade, P.; Karad, S. Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis. Medicine, 2020, 99(16), e19723.
[http://dx.doi.org/10.1097/MD.0000000000019723] [PMID: 32311961]
[57]
Deodhar, S.D.; Sethi, R.; Srimal, R.C. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J. Med. Res., 1980, 71, 632-634.
[PMID: 7390600]
[58]
Zheng, Z.; Sun, Y.; Liu, Z.; Zhang, M.; Li, C.; Cai, H. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des. Devel. Ther., 2015, 9, 4931-4942.
[PMID: 26345159]
[59]
Roberts, K.T. The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J. Med. Food, 2011, 14(12), 1485-1489.
[http://dx.doi.org/10.1089/jmf.2011.0002] [PMID: 21861724]
[60]
Singh, D.; Aggarwal, A.; Maurya, R.; Naik, S. Withania somnifera inhibits NF-κB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother. Res., 2007, 21(10), 905-913.
[http://dx.doi.org/10.1002/ptr.2180] [PMID: 17562568]
[61]
Ganesan, K.; Sehgal, P.K.; Mandal, A.B.; Sayeed, S. Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Appl. Biochem. Biotechnol., 2011, 165(3-4), 1075-1091.
[http://dx.doi.org/10.1007/s12010-011-9326-8] [PMID: 21789568]
[62]
Gupta, A.; Singh, S. Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats. Pharm. Biol., 2014, 52(3), 308-320.
[http://dx.doi.org/10.3109/13880209.2013.835325] [PMID: 24188460]
[63]
Khan, M.A.; Ahmed, R.S.; Chandra, N.; Arora, V.K.; Ali, A. In vivo, extract from Withaniasomnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Antiinflamm. Antiallergy Agents Med. Chem., 2019, 18(1), 55-70.
[http://dx.doi.org/10.2174/1871523017666181116092934] [PMID: 30444203]
[64]
Baliga, M.S.; Mane, P.P.; Nallemgera, J.T.; Thilakchand, K.R.; Kalekhan, F. Chapter 5 - dietary spices in the prevention of rheumatoid arthritis: Past, present, and future. In: Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults; Academic Press, 2015; p. 41-49.
[65]
Al-Okbi, S.Y. Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis. Toxicol. Ind. Health, 2014, 30(8), 738-749.
[http://dx.doi.org/10.1177/0748233712462468] [PMID: 23104728]
[66]
Gheita, T.A.; Kenawy, S.A. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: A placebo controlled study. Phytother. Res., 2012, 26(8), 1246-1248.
[http://dx.doi.org/10.1002/ptr.3679] [PMID: 22162258]
[67]
Chanda, D.; Shanker, K.; Pal, A.; Luqman, S.; Bawankule, D.U.; Mani, D.; Darokar, M.P. Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats. J. Toxicol. Sci., 2009, 34(1), 99-108.
[http://dx.doi.org/10.2131/jts.34.99] [PMID: 19182439]
[68]
Aslam, M.M.; John, P.; Bhatti, A.; Jahangir, S.; Kamboh, M.I. Vitamin D as a principal factor in mediating rheumatoid arthritis-derived immune response. BioMed Res. Int., 2019, 2019, 1-12.
[http://dx.doi.org/10.1155/2019/3494937] [PMID: 31205940]
[69]
Muscogiuri, G.; Mitri, J.; Mathieu, C.; Badenhoop, K.; Tamer, G.; Orio, F.; Mezza, T.; Vieth, R.; Colao, A.; Pittas, A. Mechanisms in endocrinology: Vitamin D as a potential contributor in endocrine health and disease. Eur. J. Endocrinol., 2014, 171(3), R101-R110.
[http://dx.doi.org/10.1530/EJE-14-0158] [PMID: 24872497]
[70]
Bellan, M.; Sainaghi, P.P.; Pirisi, M. Role of vitamin D in rheumatoid arthritis. Adv. Exp. Med. Biol., 2017, 996, 155-168.
[http://dx.doi.org/10.1007/978-3-319-56017-5_13] [PMID: 29124698]
[71]
Cantorna, M.T.; Hayes, C.E.; DeLuca, H.F. 1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J. Nutr., 1998, 128(1), 68-72.
[http://dx.doi.org/10.1093/jn/128.1.68] [PMID: 9430604]
[72]
Bogaczewicz, J.; Sysa-Jedrzejowska, A.; Arkuszewska, C.; Zabek, J.; Kontny, E.; McCauliffe, D.P.; Wozniacka, A. Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters. Lupus, 2012, 21(5), 477-484.
[http://dx.doi.org/10.1177/0961203311427549] [PMID: 22065093]
[73]
Luo, J.; Wen, H.; Guo, H.; Cai, Q.; Li, S.; Li, X. 1,25-dihydroxyvitamin D3 inhibits the RANKL pathway and impacts on the production of pathway-associated cytokines in early rheumatoid arthritis. BioMed Res. Int., 2013, 2013, 1-9.
[http://dx.doi.org/10.1155/2013/101805] [PMID: 23710436]
[74]
Salesi, M.; Farajzadegan, Z. Efficacy of Vitamin D in patients with active rheumatoid arthritis receiving methotrexate therapy. Rheumatol. Int., 2012, 32(7), 2129-2133.
[http://dx.doi.org/10.1007/s00296-011-1944-5] [PMID: 21523344]
[75]
Cerhan, J.R.; Saag, K.G.; Merlino, L.A.; Mikuls, T.R.; Criswell, L.A. Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am. J. Epidemiol., 2003, 157(4), 345-354.
[http://dx.doi.org/10.1093/aje/kwf205] [PMID: 12578805]
[76]
Mahajan, A.; Tandon, V.R. Antioxidants and rheumatoid arthritis. J. Indian Rheumatol. Assoc., 2004, 12, 139-142.
[77]
Bandt, M.D.; Grossin, M.; Driss, F.; Pincemail, J.; Babin-Chevaye, C.; Pasquier, C. Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis. Arthritis Rheum., 2002, 46(2), 522-532.
[http://dx.doi.org/10.1002/art.10085] [PMID: 11840456]
[78]
Dai, W.; Qi, C.; Wang, S. Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats. Biomed. Pharmacother., 2018, 105, 835-840.
[http://dx.doi.org/10.1016/j.biopha.2018.05.136] [PMID: 30021375]
[79]
Aqaeinezhad Rudbane, S.M.; Rahmdel, S.; Abdollahzadeh, S.M.; Zare, M.; Bazrafshan, A.; Mazloomi, S.M. The efficacy of probiotic supplementation in rheumatoid arthritis: A meta-analysis of randomized, controlled trials. Inflammopharmacology, 2018, 26(1), 67-76.
[http://dx.doi.org/10.1007/s10787-017-0436-y] [PMID: 29302905]
[80]
Wang, P.; Tao, J.H.; Pan, H.F. Probiotic bacteria: A viable adjuvant therapy for relieving symptoms of rheumatoid arthritis. Inflammopharmacology, 2016, 24(5), 189-196.
[http://dx.doi.org/10.1007/s10787-016-0277-0] [PMID: 27581587]
[81]
Vaghef-Mehrabany, E.; Alipour, B.; Homayouni-Rad, A.; Sharif, S.K.; Asghari-Jafarabadi, M.; Zavvari, S. Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis. Nutrition, 2014, 30(4), 430-435.
[http://dx.doi.org/10.1016/j.nut.2013.09.007] [PMID: 24355439]
[82]
Alipour, B.; Homayouni-Rad, A.; Vaghef-Mehrabany, E.; Sharif, S.K.; Vaghef-Mehrabany, L.; Asghari-Jafarabadi, M.; Nakhjavani, M.R.; Mohtadi-Nia, J. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: A randomized double-blind clinical trial. Int. J. Rheum. Dis., 2014, 17(5), 519-527.
[PMID: 24673738]
[83]
Khandpur, S.; Malhotra, A.K.; Bhatia, V.; Gupta, S.; Sharma, V.K.; Mishra, R.; Arora, N.K. Chronic arsenic toxicity from Ayurvedic medicines. Int. J. Dermatol., 2008, 47(6), 618-621.
[http://dx.doi.org/10.1111/j.1365-4632.2008.03475.x] [PMID: 18477160]
[84]
Bolan, S.; Kunhikrishnan, A.; Seshadri, B.; Choppala, G.; Naidu, R.; Bolan, N.S.; Ok, Y.S.; Zhang, M.; Li, C.G.; Li, F.; Noller, B.; Kirkham, M.B. Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines. Environ. Int., 2017, 108, 103-118.
[http://dx.doi.org/10.1016/j.envint.2017.08.005] [PMID: 28843139]

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