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Current Bioactive Compounds

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Review Article

Impact of Phytomolecules with Nanotechnology on the Treatment of Inflammation

Author(s): Sonia Singh*, Bhupesh C. Semwal, Himanshu Sharma and Divya Sharma

Volume 19, Issue 10, 2023

Published on: 28 August, 2023

Article ID: e070823219471 Pages: 27

DOI: 10.2174/1573407219666230807150030

Price: $65

Abstract

Inflammation is a part of the biological response of body tissues against harmful stimuli, such as damaged cells, pathogens, irradiations, and toxic compounds. Numerous treatments, including anti-inflammatory drugs that treat the condition of inflammation, are available for its management. Because of the severe adverse effects associated with synthetic medications, phytotherapy may be a promising and effective approach to treating inflammation. The therapeutic potential of herbs is due to their capacity to target a variety of inflammatory mediators, including chemokines, cytokines, nitric oxide, lipoxygenase, nuclear factor kappa-B, and arachidonic acid. Furthermore, nanomedicine may be a valuable and effective formulation approach for overcoming the drawbacks of phytoconstituents, such as their low bioavailability, high first-pass metabolism, and poor stability. The current manuscript provides a thorough description of many phytoconstituents and herbal plants that have great potential for treating inflammation-related diseases, as well as information on their limitations, drug formulations, and regulatory issues.

Graphical Abstract

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