Login Register Cart 0
Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Relationship of the Characteristic Imaging Findings of Breast Cancer with Molecular Subtypes in Young Women

Author(s): Emirhan Temel*, Eda Elverici, Engin Sarı, Arzu Özsoy, Mutlu Akbaş Doğan and Sezer Kulaçoğlu

Volume 20, 2024

Published on: 06 September, 2023

Article ID: e210723218990 Pages: 8

DOI: 10.2174/1573405620666230721124048

Price: $65

Abstract

Background: The characteristic imaging findings of breast cancer in young women are not yet fully understood. It causes a delay in diagnosis by mixing with benign findings.

Objective: To evaluate the relationship between the imaging and histopathological features of breast cancer in women aged under 40 years.

Methods: In our center, 537 suspicious lesions were detected in a total of 15,223 adult female patients under 40 years who were evaluated by breast ultrasonography (US). As a result of the mammographic, histopathological, and immunohistochemical analysis, 101 lesions meeting the study criteria were included in the sample.

Results: The luminal subtypes of breast cancer mostly visualized as irregularly shaped spiculated lesions with calcification and architectural distortion mammography and presented as masses that were sometimes accompanied by increased echogenicity in the surrounding tissue on US. The human epidermal growth factor receptor 2 (HER2) enriched subtypes mostly had microlobulated or indistinct margins with heterogeneous echoes accompanied by high calcification on mammography. The triple-negative (TN) subtypes generally appeared as microlobulated lesions with angular or indistinct margins, hypo echogenicity, posterior enhancement or shadowing, and vascularization.

Conclusion: Some radiological features of breast cancer in young women were found to be associated with molecular subtypes similar to other age groups in the literature. However, unlike other age groups, the incidences of the HER2-enriched subtype presenting with only calcification, TN subtypes presenting with circumscribed masses, and calcification were found to be low among the young women in our study.

[1]
Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. CA Cancer J Clin 2022; 72(6): 524-41.
[http://dx.doi.org/10.3322/caac.21754] [PMID: 36190501]
[2]
Cathcart-Rake EJ, Ruddy KJ, Bleyer A, Johnson RH. breast cancer in adolescent and young adult women under the age of 40 years. JCO Oncol Pract 2021; 17(6): 305-13.
[http://dx.doi.org/10.1200/OP.20.00793] [PMID: 33449828]
[3]
Lee SK, Kim SW, Yu JH, et al. Is the high proportion of young age at breast cancer onset a unique feature of asian breast cancer? Breast Cancer Res Treat 2019; 173(1): 189-99.
[http://dx.doi.org/10.1007/s10549-018-4947-z] [PMID: 30238275]
[4]
Najjar H, Easson A. Age at diagnosis of breast cancer in arab nations. Int J Surg 2010; 8(6): 448-52.
[http://dx.doi.org/10.1016/j.ijsu.2010.05.012] [PMID: 20601253]
[5]
Kheirelseid EAH, Boggs JME, Curran C, et al. Younger age as a prognostic indicator in breast cancer: A cohort study. BMC Cancer 2011; 11(1): 383.
[http://dx.doi.org/10.1186/1471-2407-11-383] [PMID: 21871129]
[6]
WHO. Breast cancer fact and figures. American Cancer Society,. Inc 2017.
[7]
Nasim Z, Girtain C, Gupta V, Patel I, Hossain MA. Breast cancer incidence and behavior in younger patients: A study from the surveillance, epidemiology and end results database. World J Oncol 2020; 11(3): 88-97.
[http://dx.doi.org/10.14740/wjon1278] [PMID: 32494315]
[8]
Anders CK, Fan C, Parker JS, et al. Breast carcinomas arising at a young age: Unique biology or a surrogate for aggressive intrinsic subtypes? J Clin Oncol 2011; 29(1): e18-20.
[http://dx.doi.org/10.1200/JCO.2010.28.9199] [PMID: 21115855]
[9]
Han W, Kim SW, Ae Park I, et al. Young age: An independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer 2004; 4(1): 82.
[http://dx.doi.org/10.1186/1471-2407-4-82] [PMID: 15546499]
[10]
Anders CK, Hsu DS, Broadwater G, et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 2008; 26(20): 3324-30.
[http://dx.doi.org/10.1200/JCO.2007.14.2471] [PMID: 18612148]
[11]
Sun X, Liu J, Ji H, Yang M, Lu Y. Clinicopathological characteristics and prognosis of breast cancer in young women: A single center study in a developing country. Cancer Manag Res 2021; 13: 1601-7.
[http://dx.doi.org/10.2147/CMAR.S299066] [PMID: 33628050]
[12]
Fredholm H, Magnusson K, Lindström LS, et al. Breast cancer in young women and prognosis: How important are proliferation markers? Eur J Cancer 2017; 84: 278-89.
[http://dx.doi.org/10.1016/j.ejca.2017.07.044] [PMID: 28844016]
[13]
Hu X, Myers KS, Oluyemi ET, Philip M, Azizi A, Ambinder EB. Presentation and characteristics of breast cancer in young women under age 40. Breast Cancer Res Treat 2021; 186(1): 209-17.
[http://dx.doi.org/10.1007/s10549-020-06000-x] [PMID: 33136248]
[14]
Lehman CD, Lee CI, Loving VA, Portillo MS, Peacock S, DeMartini WB. Accuracy and value of breast ultrasound for primary imaging evaluation of symptomatic women 30-39 years of age. AJR Am J Roentgenol 2012; 199(5): 1169-77.
[http://dx.doi.org/10.2214/AJR.12.8842] [PMID: 23096195]
[15]
Bullier B, MacGrogan G, Bonnefoi H, et al. Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. Eur Radiol 2013; 23(12): 3237-45.
[http://dx.doi.org/10.1007/s00330-013-2966-z] [PMID: 23918218]
[16]
Cardoso F, Loibl S, Pagani O, et al. The european society of breast cancer specialists recommendations for the management of young women with breast cancer. Eur J Cancer 2012; 48(18): 3355-77.
[http://dx.doi.org/10.1016/j.ejca.2012.10.004] [PMID: 23116682]
[17]
Desreux JAC. Breast cancer screening in young women. Eur J Obstet Gynecol Reprod Biol 2018; 230: 208-11.
[http://dx.doi.org/10.1016/j.ejogrb.2018.05.018] [PMID: 29804884]
[18]
Elizabeth Hammond MH, Hayes DF, Dowsett M, et al. American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Unabridged Version 2010.
[19]
Cheang MCU, Chia SK, Voduc D, et al. Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 2009; 101(10): 736-50.
[http://dx.doi.org/10.1093/jnci/djp082] [PMID: 19436038]
[20]
Collins LC, Marotti JD, Gelber S, et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat 2012; 131(3): 1061-6.
[http://dx.doi.org/10.1007/s10549-011-1872-9] [PMID: 22080245]
[21]
Tang LC, Jin X, Yang HY, et al. Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in china. BMC Cancer 2015; 15(1): 201.
[http://dx.doi.org/10.1186/s12885-015-1207-z] [PMID: 25885213]
[22]
Huang J, Lin Q, Cui C, et al. Correlation between imaging features and molecular subtypes of breast cancer in young women (≤30 years old). Jpn J Radiol 2020; 38(11): 1062-74.
[http://dx.doi.org/10.1007/s11604-020-01001-8] [PMID: 32562180]
[23]
An YY, Kim SH, Kang BJ, Park CS, Jung NY, Kim JY. Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes. Eur J Radiol 2015; 84(10): 1894-902.
[http://dx.doi.org/10.1016/j.ejrad.2015.07.002] [PMID: 26198117]
[24]
Broberg A, Glas U, Gustafsson SA, Hellström L, Somell A. Relationship between mammographic pattern and estrogen receptor content in breast cancer. Breast Cancer Res Treat 1983; 3(2): 201-7.
[http://dx.doi.org/10.1007/BF01803562] [PMID: 6616077]
[25]
Santiago D, Eugênio G, Souza JA, et al. Breast cancer diagnosed before the 40 years :Imaging findings and correlation with histology and molecular subtype 2017; 1-7.
[26]
Sardanelli F, Giuseppetti GM, Panizza P, et al. Sensitivity of MRI versus mammography for detecting foci of multifocal, multicentric breast cancer in Fatty and dense breasts using the whole-breast pathologic examination as a gold standard. AJR Am J Roentgenol 2004; 183(4): 1149-57.
[http://dx.doi.org/10.2214/ajr.183.4.1831149] [PMID: 15385322]
[27]
Redmond CE, Healy GM, Murphy CF, O’Doherty A, Foster A. The use of ultrasonography and digital mammography in women under 40 years with symptomatic breast cancer: a 7-year Irish experience. Irish J Med Sci 2016; 186: 63-7.
[28]
Kim J, Jang M, Kim SM, et al. Clinicopathological and imaging features of breast cancer in korean women under 40 years of age. J Korean Soc Radiol 2017; 76(6): 375.
[http://dx.doi.org/10.3348/jksr.2017.76.6.375]
[29]
Au-Yong ITH, Evans AJ, Taneja S, et al. Sonographic correlations with the new molecular classification of invasive breast cancer. Eur Radiol 2009; 19(10): 2342-8.
[http://dx.doi.org/10.1007/s00330-009-1418-2] [PMID: 19440719]
[30]
Ian TWM, Tan EY, Chotai N. Role of mammogram and ultrasound imaging in predicting breast cancer subtypes in screening and symptomatic patients. World J Clin Oncol 2021; 12(9): 808-22.
[http://dx.doi.org/10.5306/wjco.v12.i9.808] [PMID: 34631444]
[31]
Kim MY, Choi N. Mammographic and ultrasonographic features of triple-negative breast cancer: A comparison with other breast cancer subtypes. Acta Radiol 2013; 54(8): 889-94.
[http://dx.doi.org/10.1177/0284185113488580] [PMID: 23761558]
[32]
Ozmen V, Ozmen T, Dogru V. Breast cancer in turkey; an analysis of 20.000 patients with breast cancer. Eur J Breast Heal 2019; 15(4): 276.
[http://dx.doi.org/10.5152/ejbh.2019.4890]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy