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Current Materials Science

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ISSN (Print): 2666-1454
ISSN (Online): 2666-1462

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Review Article

Review on Hydrogel Based Systems and their use in Drug Delivery for Wound Healing & Wound Management

Author(s): Meet A. Jayswal*, Priyanka Ahlawat and Ashaben Patel

Volume 17, Issue 4, 2024

Published on: 24 July, 2023

Page: [336 - 357] Pages: 22

DOI: 10.2174/2666145417666230710165247

Price: $65

Abstract

The largest organ of the human body, the skin, shields the body from the outside environment. Despite having a great capacity for regeneration, major skin abnormalities cannot heal on their own and must be covered with artificial skin. In recent years, significant advancements have been achieved in the area of skin tissue engineering to create novel skin replacements. Because of their porous as well as moisturized polymeric structural composition, hydrogels are one of the choices with the greatest ability to imitate the natural skin microenvironment. Naturally derived polymers, synthesized polymers, polymerizable synthetic monomolecules, as well as mixtures of natural and synthesized polymers, can all be used to create hydrogels. They can be used to assist in the regeneration as well as repair of the wounded dermis, epidermis or else both by dressing various wounds permanently or temporarily. Hydrogels possess distinct properties like lightweight, stretchable, biocompatible, and biodegradable; they have the potential to be incorporated as flexible solutions for the care of chronic wounds. Additionally, these characteristics make hydrogels appropriate for use in the pharmaceutical and medical industries. Physical, chemical, and hybrid bonding are all involved in the creation of hydrogels. Several processes, including solution casting, solution mixing, bulk crosslinking polymerization, the free radical mechanism, radiation therapy, and the development of interpenetrating networks, are used to create the bonding. This review primarily focuses on the type of wounds with phases in wound healing and the many kinds of hydrogels based on cross-linking, ionic charge, physical properties, source etc., and it also describes potential fabrication techniques for hydrogel design in biomedical applications, drug delivery as well as wound management hydrogel systems. Hydrogel-based systems for wound recovery and management are described, as well as current research & future prospective of hydrogel-based drug delivery systems in wound healing for topical applications.

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[1]
Paxton S, Peckham M, Knibbs A, Paxton S, Knibbs A, Peckham M. The Leeds Histology Guide. 2003. Available from: https://www.histology.leeds.ac.uk
[2]
Bahram M, Mohseni N, Moghtader M. An introduction to hydrogels and some recent applicationsEmerging Concepts in Analysis and Applications of Hydrogels. London: IntechOpen Limited 2016.
[http://dx.doi.org/10.5772/64301]
[3]
Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin Wound Healing: An Update on the Current Knowledge and Concepts. Eur Surg Res 2017; 58(1-2): 81-94.
[http://dx.doi.org/10.1159/000454919] [PMID: 27974711]
[4]
How Wounds Heal: The 4 Main Phases of Wound Healing | Shield HealthCare. Available from: http://www.shieldhealthcare.com/community/popular/2015/12/18/how-wounds-heal-the-4-main-phases-of-wound-healing/
[5]
Metcalfe AD, Ferguson MWJ. Tissue engineering of replacement skin: The crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. Available from: https://royalsocietypublishing.org/
[http://dx.doi.org/10.1098/rsif.2006.0179]
[6]
Kolarsick PAJ, Kolarsick MA, Goodwin C. Anatomy and Physiology of the Skin. J Dermatol Nurses Assoc 2011; 3(4): 203-13.
[http://dx.doi.org/10.1097/JDN.0b013e3182274a98]
[7]
Sathiyaseelan A, Shajahan A, Kalaichelvan PT, Kaviyarasan V. Fungal chitosan based nanocomposites sponges-An alternative medicine for wound dressing. 2017. Available from: https://europepmc.org/article/med/28373049] [http://dx.doi.org/10.1016/j.ijbiomac.2017.03.188
[8]
Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. 2022. Available From: http://www.un.org/
[http://dx.doi.org/10.1111/j.1365-2133.2010.09804.x]
[9]
Patel S, Srivastava S, Singh MR, Singh D. Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomed Pharmacother 2019; 112: 108615.
[http://dx.doi.org/10.1016/j.biopha.2019.108615] [PMID: 30784919]
[10]
Aderibigbe BA, Buyana B. Alginate in Wound Dressings. Pharmaceutics 2018; 10(2): 42.
[http://dx.doi.org/10.3390/pharmaceutics10020042]
[11]
Alven S, Nqoro X, Aderibigbe BA. Polymer-based materials loaded with curcumin for wound healing applications. Polymers 2020; 12(10): 2286.
[http://dx.doi.org/10.3390/polym12102286] [PMID: 33036130]
[12]
Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P. A review on wound dressings with an emphasis on electrospun nano-fibrous polymeric bandages. Polym Adv Technol 2010; 21(2): 77-95.
[http://dx.doi.org/10.1002/pat.1625]
[13]
Zuliani-Alvarez L, Midwood KS. Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing. Adv Wound Care 2015; 4(5): 273.
[14]
Fayaz AM, Balaji K, Girilal M, Yadav R, Kalaichelvan PT, Venketesan R. Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: A study against gram-positive and gram-negative bacteria. 2010. Available from: https://austinpublishinggroup.com/nanomedicine-nanotechnology/fulltext/ajnn-v5-id1056.php
[http://dx.doi.org/10.1016/j.nano.2009.04.006]
[15]
Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care 2015; 4(9): 560.
[http://dx.doi.org/10.1089/wound.2015.0635]
[16]
Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomedicine 2015; 11(6): 1551-73. https://europepmc.org/article/med/25804415
[http://dx.doi.org/10.1016/j.nano.2015.03.002] [PMID: 25804415]
[17]
Mihai MM, Dima MB, Dima B, Holban AM. Nanomaterials for wound healing and infection control. Materials 2019; 12(13)
[http://dx.doi.org/10.3390/ma12132176]
[18]
Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res 2010; 89(3): 219-29. https://journals.sagepub.com/doi/abs/10.1177/0022034509359125
[http://dx.doi.org/10.1177/0022034509359125] [PMID: 20139336]
[19]
Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol 2015; 173(2): 370-8.
[http://dx.doi.org/10.1111/bjd.13954] [PMID: 26175283]
[20]
Rajendran NK, Kumar SSD, Houreld NN, Abrahamse H. A review on nanoparticle based treatment for wound healing. J Drug Deliv Sci Technol 2018; 44(2): 421-30.
[21]
Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chin Med Assoc 2018; 81(2): 94-101.
[http://dx.doi.org/10.1016/j.jcma.2017.11.002] [PMID: 29169897]
[22]
Wang W, Lu KJ, Yu CH, Huang QL, Du YZ. Nano-drug delivery systems in wound treatment and skin regeneration. J Nanobiotechnology 2019; 2019
[23]
Wichterle O, Lím D. Hydrophilic Gels for Biological Use. 1960. Available from: https://www.nature.com/articles/185117a0
[http://dx.doi.org/10.1038/185117a0]
[24]
Silva AKA, Richard C, Bessodes M, Scherman D, Merten OW. Growth factor delivery approaches in hydrogels. Biomacromolecules 2009; 10(1): 9-18.
[25]
Ullah F, Othman MBH, Javed F, Ahmad Z, Akil HM. Classification, processing and application of hydrogels: A review. Mater Sci Eng C 2015; 57: 414-33.
[http://dx.doi.org/10.1016/j.msec.2015.07.053] [PMID: 26354282]
[26]
Akhtar MF, Hanif M, Ranjha NM. Methods of synthesis of hydrogels … A review. Saudi Pharm J 2016; 24(5): 554-9.
[http://dx.doi.org/10.1016/j.jsps.2015.03.022] [PMID: 27752227]
[27]
Boucard N, Viton C, Domard A. New aspects of the formation of physical hydrogels of chitosan in a hydroalcoholic medium. Biomacromolecules 2005; 6(6): 3227-37. https://www.researchgate.net/publication/7484193_New_Aspects_of_the_Formation_of_Physical_Hydrogels_of_Chitosan_in_a_Hydroalcoholic_Medium
[http://dx.doi.org/10.1021/bm050653d] [PMID: 16283750]
[28]
Berger J, Reist M, Mayer JM, Felt O, Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004; 57(1): 35-52. https://europepmc.org/article/med/14729079
[http://dx.doi.org/10.1016/S0939-6411(03)00160-7] [PMID: 14729079]
[29]
Umamaheswari RB, Jain P, Jain NK. Hydrogel - A novel drug delivery system. Indian Drugs 2002; 39(5): 243-56.
[30]
Hoare TR, Kohane DS. Hydrogels in drug delivery: Progress and challenges. Polymer (Guildf) 2008; 49(8): 1993-2007.
[http://dx.doi.org/10.1016/j.polymer.2008.01.027]
[31]
Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res 2015; 6(2): 105-21.
[http://dx.doi.org/10.1016/j.jare.2013.07.006] [PMID: 25750745]
[32]
Mohana Raju K, Padmanabha Raju M. Synthesis of novel superabsorbing copolymers for agricultural and horticultural applications. Polym Int 2001; 50(8): 946-51.
[http://dx.doi.org/10.1002/pi.721]
[33]
Hisao T, Yasunor T. Production process for highly water absorbable polymer. US-4525527-A, 2022.
[34]
Chen J, Zhao Y. Relationship between water absorbency and reaction conditions in aqueous solution polymerization of polyacrylate superabsorbents. J Appl Polym Sci 2001; 75(6): 808-14.
[35]
Kiatkamjornwong S. Sci Asia 2007; 33(s1): 039.
[http://dx.doi.org/10.2306/scienceasia1513-1874.2007.33(s1).039]
[36]
Weerasundara L, Gabriele B, Figoli A, Ok YS, Bundschuh J. Hydrogels: Novel materials for contaminant removal in water—A review. Crit Rev Environ Sci Technol 2021; 51(17): 1970-2014.
[http://dx.doi.org/10.1080/10643389.2020.1776055]
[37]
Ogata T, Nagayoshi K, Nagasako T, Kurihara S, Nonaka T. Synthesis of hydrogel beads having phosphinic acid groups and its ad-sorption ability for lanthanide ions. React Funct Polym 2006; 66(6): 625-33.
[http://dx.doi.org/10.1016/j.reactfunctpolym.2005.10.015]
[38]
Hunkeler D. Synthesis and characterization of high molecular weight water-soluble polymers. Polym Int 1992; 27(1): 23-33.
[http://dx.doi.org/10.1002/pi.4990270105]
[39]
Watanabe N, Hosoya Y, Tamura A, Kosuge H. Characteristics of water-absorbent polymer emulsions. 1993. Available from: https://www.google.com/search?q=Watanabe+N%2C+Hosoya+Y%2C+Tamura+A%2C+Kosuge+H.+Characteristics+of+water-absorbent+polymer+emulsions.+Polym+Int+19 93%3B30%3A525–31.&oq=Watanabe+N%2C+Hosoya+ Y%2C+Tamura+A%2C+Kosuge+H.+Characteristics+of+water-absorbent+polymer+emulsions.+Polym+Int+1993% 3B30%3A525–31.&aqs=chrome.69i57.6642j0j7&sourceid =chrome&ie=UTF-8
[http://dx.doi.org/10.1002/pi.4990300417]
[40]
Development of a Multi-Component Fertilizing Hydrogel with Relevant Techno-Economic Indicator 2022. Available from: https://www.researchgate.net/publication/268338583_Development_of_a_Multi-Component_Fertilizing_Hydrogel_with_Relevant_Techno-Economic_Indicators
[41]
Qunyi T, Ganwei Z. Rapid synthesis of a superabsorbent from a saponified starch and acrylonitrile/AMPS graft copolymers. Carbohydr Polym 2005; 62(1): 74-9.
[http://dx.doi.org/10.1016/j.carbpol.2005.07.016]
[42]
Radiation induced superabsorbent hydrogels. Acrylamide/itaconic acid copolymers. Macromol Mater Eng 2001; 286(1): 34-42.
[43]
Ajji Z, Mirjalili G, Alkhatab A, Dada H. Use of electron beam for the production of hydrogel dressings. Radiat Phys Chem 2008; 77(2): 200-2.
[http://dx.doi.org/10.1016/j.radphyschem.2007.05.016]
[44]
Marrale M, D’errico F. Hydrogels for three-dimensional ionizing-radiation dosimetry. Gels 2021; 7(2): 74.
[http://dx.doi.org/10.3390/gels7020074]
[45]
Tabata Y. Biomaterials for tissue engineering applications and current updates in the field: A comprehensive review. AAPS PharmSciTech 20022 23: 267.
[46]
Shantha KL, Harding DRK. Synthesis and evaluation of sucrose-containing polymeric hydrogels for oral drug delivery. J Appl Polym Sci 2002; 84(14): 2597-604.
[http://dx.doi.org/10.1002/app.10378]
[47]
Tsihlis ND, Murar J, Kapadia MR, Ahanchi SS, Oustwani CS, Saavedra JE. Hydrogels: Methods of Preparation. J Vasc Surg 2010; 51(5): 1248-59.
[http://dx.doi.org/10.1016/j.jvs.2009.12.028] [PMID: 20223627]
[48]
Shoukat H, Buksh K, Noreen S, Pervaiz F, Maqbool I. Hydrogels as potential drug-delivery systems: Network design and applications. Ther Deliv 2021; 12(5): 375-96.
[http://dx.doi.org/10.4155/tde-2020-0114] [PMID: 33792360]
[49]
Bellich B, D’Agostino I, Semeraro S, Gamini A, Cesàro A. “The Good, the Bad and the Ugly” of Chitosans. Mar Drugs 2016; 14(5): 99.
[http://dx.doi.org/10.3390/md14050099] [PMID: 27196916]
[50]
Bhatia S, Bhatia S. NNatural Polymers vs Synthetic Polymer Natural Polymer Drug Delivery Systems. London: Springer Nature 2016; pp. 95-118.
[http://dx.doi.org/10.1007/978-3-319-41129-3_3]
[51]
Salehi-Nik N, Rad MR, Nazeman P, Khojasteh A. Polymers for oral and dental tissue engineeringBiomaterials for Oral and Dental Tissue Engineering Sawston. Woodhead Publishing 2017; pp. 25-46.
[http://dx.doi.org/10.1016/B978-0-08-100961-1.00003-7]
[52]
Firlar I, Altunbek M, McCarthy C, Ramalingam M, Camci-Unal G. Functional Hydrogels for Treatment of Chronic Wounds. Gels 2022; 8(2): 127.
[http://dx.doi.org/10.3390/gels8020127] [PMID: 35200508]
[53]
Pourshahrestani S, Zeimaran E, Kadri NA, Mutlu N, Boccaccini AR. Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing. Adv Healthc Mater 2020; 9(20): 2000905.
[http://dx.doi.org/10.1002/adhm.202000905] [PMID: 32940025]
[54]
Chen T, Chen Y, Rehman HU, et al. Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing. ACS Appl Mater Interfaces 2018; 10(39): 33523-31.
[http://dx.doi.org/10.1021/acsami.8b10064] [PMID: 30204399]
[55]
Wang H, Xu Z, Zhao M, Liu G, Wu J. Advances of hydrogel dressings in diabetic wounds. Biomater Sci 2021; 9(5): 1530-46.
[http://dx.doi.org/10.1039/D0BM01747G] [PMID: 33433534]
[56]
Wang T, Chen L, Shen T, Wu D. Preparation and properties of a novel thermo-sensitive hydrogel based on chitosan/ hydroxypropyl methylcellulose/glycerol. Int J Biol Macromol 2016; 93(Pt A): 775-82.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.09.038] [PMID: 27640090]
[57]
Díaz A, Puiggalí J, Puiggalí J. Hydrogels for biomedical applications: Cellulose, chitosan, and protein/peptide derivatives. Gels 2017; 3(3): 27.
[http://dx.doi.org/10.3390/gels3030027] [PMID: 30920524]
[58]
Shao C, Meng L, Wang M, et al. Mimicking dynamic adhesiveness and strain stiffening behavior of biological tissues in tough and self-healable cellulose nanocomposite hydrogels. ACS Appl Mater Interfaces 2019; 11(6)
[59]
Zu Y, Zhang Y, Zhao X, et al. Preparation and characterization of chitosan–polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin. Int J Biol Macromol 2012; 50(1): 82-7. https://www.researchgate.net/publication/51735705_Preparation_and_characterization_of_chitosanpolyvinyl_alcohol_blend_hydrogels_for_the_controlled_release_of_nano-insulin
[http://dx.doi.org/10.1016/j.ijbiomac.2011.10.006] [PMID: 22020189]
[60]
Nam J, Byun E, Shim H, et al. A Hydrogel-Based Ultrasonic Backscattering Wireless Biochemical Sensing. Front Bioeng Biotechnol 2020; 8: 596370.
[http://dx.doi.org/10.3389/fbioe.2020.596370] [PMID: 33330426]
[61]
Li J, Weber E, Guth-Gundel S, et al. Tough composite hydrogels with high loading and local release of biological drugs. Adv Heal Mater 2018; 7(9)
[http://dx.doi.org/10.1002/adhm.201701393]
[62]
Daly AC, Riley L, Segura T, Burdick JA. Hydrogel microparticles for biomedical applications. Nat Rev Mater 2019; 5(1): 20-43.
[http://dx.doi.org/10.1038/s41578-019-0148-6] [PMID: 34123409]
[63]
Wei J, Wan F, Zhang P, et al. Bioprocess-inspired synthesis of printable, self-healing mineral hydrogels for rapidly responsive, wearable ionic skin. Chem Eng J 2021; 424: 130549.
[http://dx.doi.org/10.1016/j.cej.2021.130549]
[64]
Xu K, Lu Y, Takei K. Multifunctional skin‐inspired flexible sensor systems for wearable electronics. Adv Mater Tech. 2019.
[65]
Yang Y, Gao W. Wearable and flexible electronics for continuous molecular monitoring. Chem Soc Rev 2019; 48(6): 1465-91.
[66]
Moura LIF, Dias AMA, Carvalho E, de Sousa HC. Recent advances on the development of wound dressings for diabetic foot ulcer treatment-A review. Acta Biomater 2013; 9(7): 7093-114.
[http://dx.doi.org/10.1016/j.actbio.2013.03.033] [PMID: 23542233]
[67]
Koivukangas V, Annala AP, Salmela PI, Oikarinen A. Delayed restoration of epidermal barrier function after suction blister injury in patients with diabetes mellitus. Diabet Med 1999; 16(7): 563-7.
[http://dx.doi.org/10.1046/j.1464-5491.1999.00117.x] [PMID: 10445831]
[68]
Malone-Povolny MJ, Maloney SE, Schoenfisch MH. Nitric Oxide Therapy for Diabetic Wound Healing. Adv Healthc Mater 2019; 8(12): 1801210.
[http://dx.doi.org/10.1002/adhm.201801210] [PMID: 30645055]
[69]
Wang T, Rong F, Tang Y, et al. Targeted polymer-based antibiotic delivery system: A promising option for treating bacterial infections via macromolecular approaches. Prog Polym Sci 2021; 116: 101389.
[70]
Da Silva L, Carvalho E, Cruz MT. Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing. 2010. Available from: https://www.tandfonline.com/doi/abs/10.1517/14712598.2010.515207
[http://dx.doi.org/10.1517/14712598.2010.515207]
[71]
Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005; 366(9498): 1736-43.
[http://dx.doi.org/10.1016/S0140-6736(05)67700-8] [PMID: 16291068]
[72]
Winter GD. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 1962; 193(4812): 293-4.
[http://dx.doi.org/10.1038/193293a0] [PMID: 14007593]
[73]
Bullock AJ, Pickavance P, Haddow DB, Rimmer S, MacNeil S. Development of a calcium-chelating hydrogel for treatment of superficial burns and scalds. 2009. Available from: https://www.futuremedicine.com/doi/10.2217/rme.09.67
[74]
Xu Z, Han S, Gu Z, Wu J. Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing. Adv Healthc Mater 2020; 9(5): 1901502. https://europepmc.org/article/med/31977162
[http://dx.doi.org/10.1002/adhm.201901502] [PMID: 31977162]
[75]
Pang Q, Lou D, Li S, et al. Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treat-ment of Infected Wounds. Adv Sci (Weinh) 2020; 7(6): 1902673. https://www.researchgate.net/publication/338519344_Smart_Flexible_Electronics-Integrated_Wound_Dressing_for_ Real-Time_Monitoring_and_On-Demand_Treatment_of_ Infected_Wounds
[http://dx.doi.org/10.1002/advs.201902673] [PMID: 32195091]
[76]
Krishnamoorthy M, Hakobyan S, Ramstedt M, Gautrot JE. Surface-initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. Chem Rev 2014; 114(21): 10976-1026.
[http://dx.doi.org/10.1021/cr500252u] [PMID: 25353708]
[77]
Khan MI, Paul P, Behera SK, Jena B, Tripathy SK, Stålsby Lundborg C. To decipher the antibacterial mechanism and promotion of wound healing activity by hydrogels embedded with biogenic Ag@ZnO core-shell nanocomposites. Chem Eng J 2020; 417: 128025.
[78]
Lu S, Zhang X, Tang Z, et al. Mussel-inspired blue-light-activated cellulose-based adhesive hydrogel with fast gelation, rapid haemo-stasis and antibacterial property for wound healing. Chem Eng J 2021; 417: 129329.
[http://dx.doi.org/10.1016/j.cej.2021.129329]
[79]
Kaur R, Liu S. Antibacterial surface design - Contact kill. Prog Surf Sci 2019; 91(3): 136-53.
[80]
Liu Y, Li F, Guo Z, et al. Silver nanoparticle-embedded hydrogel as a photothermal platform for combating bacterial infections. Chem Eng J 2020; 382: 122990.
[http://dx.doi.org/10.1016/j.cej.2019.122990]
[81]
Li S, Zeng J, Yin D, et al. Synergic fabrication of titanium dioxide incorporation into heparin-polyvinyl alcohol nanocomposite: Enhanced in vitro antibacterial activity and care of in vivo burn injury. Mater Res Express 2021; 8(8): 085012.
[http://dx.doi.org/10.1088/2053-1591/abe1fb]
[82]
Zhou L, Ren M, Zeng T, Wang W, et al. STET2-interacting long noncoding RNA promotes active DNA demethylation of the MMP-9 promoter in diabetic wound healing. Cell Death Dis 2019; 10(11): 813.
[83]
Losi P, Briganti E, Errico C, et al. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Acta Biomater 2013; 9(8): 7814-21. https://europepmc.org/article/med/23603001
[http://dx.doi.org/10.1016/j.actbio.2013.04.019] [PMID: 23603001]
[84]
Bennett NT, Schultz GS. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am J Surg 1993; 166(1): 74-81.
[http://dx.doi.org/10.1016/S0002-9610(05)80589-6] [PMID: 8392302]
[85]
Dai T, Kharkwal GB, Tanaka M, Huang YY, Bil de Arce VJ, Hamblin MR. Animal models of external traumatic wound infections. 2011. Available from: https://www.tandfonline.com/doi/abs/10.4161/viru.2.4.16840
[http://dx.doi.org/10.4161/viru.2.4.16840]
[86]
Adhirajan N, Shanmugasundaram N, Babu M. Gelatin microspheres cross-linked with EDC as a drug delivery system for doxycyline: Development and characterization. J Microencapsul 2007; 24(7): 647-59.
[87]
Van Vlierberghe S, Dubruel P, Schacht E. Effect of cryogenic treatment on the rheological properties of gelatin hydrogels. J Bioact Compat Polym 2010; 25(5): 498-512.
[http://dx.doi.org/10.1177/0883911510377254]
[88]
Shi M, Zhang H, Song T, et al. Sustainable Dual Release of Antibiotic and Growth Factor from pH-Responsive Uniform Alginate Composite Microparticles to Enhance Wound Healing. 2019. Available from: https://www.researchgate.net/publication/333476338_Sustainable_Dual_Release_of_Antibiotic_and_Growth_Factor _from_pH-Responsive_Uniform_Alginate_Composite_ Microparticles_to_Enhance_Wound_Healing
[http://dx.doi.org/10.1021/acsami.9b04750]
[89]
Rong F, Tang Y, Wang T, et al. Nitric oxide-releasing polymeric materials for antimicrobial applications: A review. 2019. Available From: https://pubmed.ncbi.nlm.nih.gov/31731704/
[http://dx.doi.org/10.3390/antiox8110556]
[90]
Joseph CA, McCarthy CW, Tyo AG, et al. Development of an Injectable Nitric Oxide Releasing Poly(ethylene) Glycol-Fibrin Adhesive Hydrogel. ACS Biomater Sci Eng 2019; 5(2): 959-69.
[http://dx.doi.org/10.1021/acsbiomaterials.8b01331] [PMID: 31650030]
[91]
Barraud N, Kelso M, Rice S, Kjelleberg S. Nitric oxide: A key mediator of biofilm dispersal with applications in infectious diseases. Curr Pharm Des 2014; 21(1): 31-42.
[http://dx.doi.org/10.2174/1381612820666140905112822] [PMID: 25189865]
[92]
Zhang X, Tan B, Wu Y, Zhang M, Liao J. A review on hydrogels with photothermal effect in wound healing and bone tissue engineering. Polymers 2021; 13(13): 2100.
[http://dx.doi.org/10.3390/polym13132100] [PMID: 34202237]
[93]
Oh JY, Bao Z, Oh JY, Bao Z. Second skin enabled by advanced electronics. Adv Sci 2019; 6(11): 1900186.
[http://dx.doi.org/10.1002/advs.201900186] [PMID: 31179225]
[94]
Ghosal K, Chakraborty D, Roychowdhury V, Ghosh S, Dutta S. Recent advancement of functional hydrogels toward diabetic wound management. ACS Omega 2022; 7(48): 43364-80.
[http://dx.doi.org/10.1021/acsomega.2c05538]
[95]
Zou W, Chen Y, Zhang X, et al. Cytocompatible chitosan based multi-network hydrogels with antimicrobial, cell anti-adhesive and mechanical properties. Carbohydr Polym 2018; 202: 246-57.
[http://dx.doi.org/10.1016/j.carbpol.2018.08.124] [PMID: 30286998]
[96]
Thi PL, Lee Y, Tran DL, et al. In situ forming and reactive oxygen species-scavenging gelatin hydrogels for enhancing wound healing efficacy. Acta Biomater 2020; 103: 142-52.
[http://dx.doi.org/10.1016/j.actbio.2019.12.009] [PMID: 31846801]
[97]
Golledge J, Fernando M, Lazzarini P, Najafi BG, Armstrong D. The potential role of sensors, wearables and telehealth in the remote management of diabetes-related foot disease. Sensors 2020; 20(16): 4527.
[http://dx.doi.org/10.3390/s20164527] [PMID: 32823514]
[98]
Niu Y, Liu H, He R, Luo M, Shu M, Xu F. Environmentally Compatible Wearable Electronics Based on Ionically Conductive Organohydrogels for Health Monitoring with Thermal Compatibility, Anti‐Dehydration, and Underwater Adhesion. Small 2021; 17(24): 2101151.
[http://dx.doi.org/10.1002/smll.202101151] [PMID: 34013638]
[99]
Liu H, Li M, Ouyang C, Lu TJ, Li F, Xu F. Biofriendly, Stretchable, and Reusable Hydrogel Electronics as Wearable Force Sensors. Small 2018; 14(38): 1801711.
[100]
Fallahi H, Zhang J, Phan HP, Nguyen NT. Flexible microfluidics: Fundamentals, recent developments, and applications. Micromachines 2019; 10(12): 830.
[http://dx.doi.org/10.3390/mi10120830] [PMID: 31795397]
[101]
Sempionatto JR, Lin M, Yin L. An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers. Nat Biomed Eng 2021; 5: 737-48.
[102]
Song J, Zhang Y, Yin Chan S, et al. Hydrogel-based flexible materials for diabetes diagnosis, treatment, and management. npj Flex Electron 2021; 5: 26.
[http://dx.doi.org/10.1038/s41528-021-00122-y]
[103]
Bordbar-Khiabani A, Gasik M. Smart hydrogels for advanced drug delivery systems. Int J Mol Sci 2022; 23(7): 3665.
[http://dx.doi.org/10.3390/ijms23073665] [PMID: 35409025]
[104]
Bustamante-Torres M, Romero-Fierro D, Arcentales-Vera B, Palomino K, Magaña H, Bucio E. Hydrogels classification according to the physical or chemical interactions and as stimuli-sensitive materials. Gels 2021; 7(4): 182.
[http://dx.doi.org/10.3390/gels7040182] [PMID: 34842654]
[105]
Zubik K, Singhsa P, Wang Y, Manuspiya H, Narain R. Thermo-responsive poly (N-isopropylacrylamide)-cellulose nanocrystals hybrid hydrogels for wound dressing. Polymers 2017; 9(12): 119.
[http://dx.doi.org/10.3390/polym9040119] [PMID: 30970798]
[106]
Park SH, Shin HS, Park SN. A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin. Carbohydr Polym 2018; 200: 341-52.
[http://dx.doi.org/10.1016/j.carbpol.2018.08.011] [PMID: 30177174]
[107]
Al-Aribe K, Knopf GK, Bassi AS. Photo-responsive hydrogel for controlling flow on a microfluidic chip. Int Soc Opt Photonics 2006; 6343: 63432R.
[http://dx.doi.org/10.1117/12.707765]
[108]
Li Z, Li Y, Chen C, Cheng Y. Magnetic-responsive hydrogels: From strategic design to biomedical applications. J Control Release 2021; 335: 541-56.
[http://dx.doi.org/10.1016/j.jconrel.2021.06.003] [PMID: 34097923]
[109]
Ha JH, Shin HH, Choi HW, et al. Electro-responsive hydrogel-based microfluidic actuator platform for photothermal therapy. Lab Chip 2020; 20(18): 3354-64.
[http://dx.doi.org/10.1039/D0LC00458H] [PMID: 32749424]
[110]
Aswathy SH, Narendrakumar U, Manjubala I. Commercial hydrogels for biomedical applications. Heliyon 2020; 6(4): e03719.
[http://dx.doi.org/10.1016/j.heliyon.2020.e03719] [PMID: 32280802]
[111]
Zhang A, Liu Y, Qin D, Sun M, Wang T, Chen X. Research status of self-healing hydrogel for wound management: A review. Int J Biol Macromol 2020; 164: 2108-23.
[http://dx.doi.org/10.1016/j.ijbiomac.2020.08.109] [PMID: 32798548]
[112]
Hebeish A, Sharaf S. Novel nanocomposite hydrogel for wound dressing and other medical applications. RSC Advances 2015; 5(125): 103036-46.
[http://dx.doi.org/10.1039/C5RA07076G]
[113]
Amirian J, Zeng Y, Shekh MI, et al. In-situ crosslinked hydrogel based on amidated pectin/oxidized chitosan as potential wound dressing for skin repairing. Carbohydr Polym 2021; 251: 117005.
[http://dx.doi.org/10.1016/j.carbpol.2020.117005] [PMID: 33142572]
[114]
Turner JG, White LR, Estrela P, et al. Hydrogel‐Forming Microneedles: Current Advancements and Future Trends. Macromol Biosci 2021; 21(2): 2000307.
[http://dx.doi.org/10.1002/mabi.202000307] [PMID: 33241641]
[115]
Xeroudaki M, Thangavelu M, Lennikov A, et al. A porous collagen-based hydrogel and implantation method for corneal stromal re-generation and sustained local drug delivery 2020. Available from: https://www.nature.com/articles/s41598-020-73730-9] [http://dx.doi.org/10.1038/s41598-020-73730-9
[116]
Kolimi P, Narala S, Nyavanandi D, Youssef AAA, Dudhipala N. Innovative treatment strategies to accelerate wound healing: Trajectory and recent advancements. Cells 2022; 11(15): 2439.
[http://dx.doi.org/10.3390/cells11152439] [PMID: 35954282]

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