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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

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Research Article

One-pot Synthesis of Some New Betulinic Acid Derivatives with Cytotoxicity Against Human Pancreatic Cancer Cells

Author(s): Muhammad Shaiq Ali*, Ghafoor Ahmed, Huma Rasheed, Samiya Kainat, Itrat Fatima and Azra Akbar

Volume 20, Issue 2, 2024

Published on: 04 October, 2023

Article ID: e050723218451 Pages: 7

DOI: 10.2174/1573407219666230705160027

Price: $65

Abstract

Background: One-pot synthesis of new and biologically important betulinic acid derivatives has been designed and efficiently achieved in this work.

Methods: The utilization of the carboxylic and hydroxyl moieties of betulinic acid has resulted in the development of a one-pot strategy towards the synthesis of some target compounds.

Results: One-pot synthesis of new betulinic acid derivatives 3-9 has been achieved in moderate to high yields by way of esterification of the carboxylic functionality with a variety of alkylating agents. These were fully characterized by spectroscopic techniques.

Conclusion: The synthesized new derivatives of betulinic acid were screened for their cytotoxic effect against human pancreatic cancer cells.

Graphical Abstract

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