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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Aging and Diabetic Kidney Disease: Emerging Pathogenetic Mechanisms and Clinical Implications

Author(s): Yi Chen, Yashpal S. Kanwar, Xueqin Chen and Ming Zhan*

Volume 31, Issue 6, 2024

Published on: 14 July, 2023

Page: [697 - 725] Pages: 29

DOI: 10.2174/0929867330666230621112215

Price: $65

Abstract

Diabetic kidney disease (DKD) is one of the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. With the overpowering trend of aging, the prevalence of DKD in the elderly is progressively increasing. Genetic factors, abnormal glucose metabolism, inflammation, mitochondrial dysregulation, and oxidative stress all contribute to the development of DKD. Conceivably, during aging, these pathobiological processes are likely to be intensified, and this would further exacerbate the deterioration of renal functions in elderly patients, ultimately leading to ESRD. Currently, the pathogenesis of DKD in the elderly is not very well-understood. This study describes an appraisal of the relationship between diabetic nephropathy and aging while discussing the structural and functional changes in the aged kidney, the impact of related mechanisms on the outcome of DKD, and the latest advances in targeted therapies.

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