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Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Editorial

Biological Importance and Therapeutic Potential of Delicaflavone against Cancerous Disorders: A Rare Naturally Occurring Biflavonoids of Selaginella Species

Author(s): Dinesh Kumar Patel*

Volume 10, Issue 5, 2024

Published on: 17 July, 2023

Article ID: e080623217785 Pages: 3

DOI: 10.2174/2215083810666230608104601

Price: $65

[1]
Patel K, Jain A, Patel DK. Medicinal significance, pharmacological activities, and analytical aspects of anthocyanidins ‘delphinidin’: A concise report. J Acute Dis 2013; 2(3): 169-78.
[http://dx.doi.org/10.1016/S2221-6189(13)60123-7]
[2]
Patel K, Gadewar M, Tahilyani V, Patel DK. A review on pharmacological and analytical aspects of diosmetin: A concise report. Chin J Integr Med 2013; 19(10): 792-800.
[http://dx.doi.org/10.1007/s11655-013-1595-3] [PMID: 24092244]
[3]
Patel DK, Patel K, Duraiswamy B, Dhanabal SP. Phytochemical analysis and standardization of Strychnos nux-vomica extract through HPTLC techniques. Asian Pac J Trop Dis 2012; 2: S56-60.
[http://dx.doi.org/10.1016/S2222-1808(12)60124-8]
[4]
Patel DK. Therapeutic potential of a bioactive flavonoids glycitin from glycine max: A review on medicinal importance, pharmacological activities and analytical aspects. Curr Tradit Med 2023; 9(2): e130522204766.
[http://dx.doi.org/10.2174/2215083808666220513143957]
[5]
Patel DK, Patel K. An overview of medicinal importance, pharmacological activities and analytical aspects of Fraxin from Cortex fraxinus. Curr Tradit Med 2023; 9(5): e190922208921.
[http://dx.doi.org/10.2174/2215083808666220919114652]
[6]
Jang GH, Kim HW, Lee MK, et al. Characterization and quantification of flavonoid glycosides in the Prunus genus by UPLC-DAD-QTOF/MS. Saudi J Biol Sci 2018; 25(8): 1622-31.
[http://dx.doi.org/10.1016/j.sjbs.2016.08.001] [PMID: 30591779]
[7]
Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules 2016; 21(5): 559.
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[8]
Patel DK. Biological importance of a biflavonoid ‘Bilobetin’ in the medicine: Medicinal importance, pharmacological activities and analytical aspects. Infect Disord Drug Targets 2022; 22(5): 22-30.
[PMID: 35319397]
[9]
Xu J, Yang L, Wang R, Zeng K, Fan B, Zhao Z. The biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella uncinata and their antihyperglycemic action. Fitoterapia 2019; 137: 104255.
[http://dx.doi.org/10.1016/j.fitote.2019.104255] [PMID: 31271785]
[10]
Chen B, Wang X, Zhang Y, et al. Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion. Drug Deliv 2020; 27(1): 309-22.
[http://dx.doi.org/10.1080/10717544.2020.1716876] [PMID: 32037895]
[11]
Demehin AA, Thamnarak W, Lamtha T, et al. Siamenflavones A-C, three undescribed biflavonoids from Selaginella siamensis Hieron. and biflavonoids from spike mosses as EGFR inhibitor. Phytochemistry 2022; 203: 113374.
[http://dx.doi.org/10.1016/j.phytochem.2022.113374] [PMID: 35964804]
[12]
Sui Y, Yao H, Li S, et al. Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway. J Mol Med 2017; 95(3): 311-22.
[http://dx.doi.org/10.1007/s00109-016-1487-z] [PMID: 27838742]
[13]
Sui Y, Li S, Shi P, et al. Ethyl acetate extract from Selaginella doederleinii Hieron inhibits the growth of human lung cancer cells A549 via caspase-dependent apoptosis pathway. J Ethnopharmacol 2016; 190: 261-71.
[http://dx.doi.org/10.1016/j.jep.2016.06.029] [PMID: 27292193]
[14]
Chen B, Wang X, Zou Y, et al. Simultaneous quantification of five biflavonoids in rat plasma by LC-ESI–MS/MS and its application to a comparatively pharmacokinetic study of Selaginella doederleinii Hieron extract in rats. J Pharm Biomed Anal 2018; 149: 80-8.
[http://dx.doi.org/10.1016/j.jpba.2017.10.028] [PMID: 29101819]
[15]
Goossens JF, Goossens L, Bailly C. Hinokiflavone and related C–O–C-Type Biflavonoids as anti-cancer compounds: Properties and mechanism of action. Nat Prod Bioprospect 2021; 11(4): 365-77.
[http://dx.doi.org/10.1007/s13659-021-00298-w] [PMID: 33534099]
[16]
Yao W, Lin Z, Shi P, et al. Delicaflavone induces ROS-mediated apoptosis and inhibits PI3K/AKT/mTOR and Ras/MEK/Erk signaling pathways in colorectal cancer cells. Biochem Pharmacol 2020; 171: 113680.
[http://dx.doi.org/10.1016/j.bcp.2019.113680] [PMID: 31669234]
[17]
Li S, Li Z, Li H, et al. Synthesis, biological evaluation, pharmacokinetic studies and molecular docking of 4′′′-acetyl-delicaflavone as antitumor agents. Bioorg Chem 2022; 120: 105638.
[http://dx.doi.org/10.1016/j.bioorg.2022.105638] [PMID: 35121550]
[18]
Xu D, Wang X, Huang D, et al. Disclosing targets and pharmacological mechanisms of total bioflavonoids extracted from Selaginella doederleinii against non-small cell lung cancer by combination of network pharmacology and proteomics. J Ethnopharmacol 2022; 286: 114836.
[http://dx.doi.org/10.1016/j.jep.2021.114836] [PMID: 34793885]
[19]
Yao W, Lin Z, Wang G, et al. Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells. Phytomedicine 2019; 62: 152973.
[http://dx.doi.org/10.1016/j.phymed.2019.152973] [PMID: 31177019]
[20]
Li L, You W, Wang X, et al. Delicaflavone reactivates anti-tumor immune responses by abrogating monocytic myeloid cell-mediated immunosuppression. Phytomedicine 2023; 108: 154508.
[http://dx.doi.org/10.1016/j.phymed.2022.154508] [PMID: 36332384]
[21]
Menezes JCJMDS, Diederich MF. Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies. Pharmacol Res 2021; 167: 105525.
[http://dx.doi.org/10.1016/j.phrs.2021.105525] [PMID: 33667686]
[22]
Wang X, Chen B, Xu D, Li Z, Sui Y, Lin X. Delicaflavone reverses Cisplatin Resistance via Endoplasmic Reticulum stress signaling pathway in non-small cell lung cancer cells. OncoTargets Ther 2020; 13: 10315-22.
[http://dx.doi.org/10.2147/OTT.S255586] [PMID: 33116611]
[23]
Wang X, Xu D, Chen B, et al. Delicaflavone represses lung cancer growth by activating antitumor immune response through N6-Methyladenosine transferases and oxidative stress. Oxid Med Cell Longev 2022; 2022: 1-16.
[http://dx.doi.org/10.1155/2022/8619275] [PMID: 35979397]
[24]
Chen B, Luo H, Chen W, et al. Pharmacokinetics, tissue distribution, and human serum albumin binding properties of delicaflavone, a novel anti-tumor candidate. Front Pharmacol 2021; 12: 761884.
[http://dx.doi.org/10.3389/fphar.2021.761884] [PMID: 34867382]

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