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Current Protein & Peptide Science

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Review Article

Literature Review on Crotalus durissus terrificus Toxins: From a Perspective of Structural Biology and Therapeutic Applications

Author(s): Jamile Mariano Macedo*, Anderson Maciel de Lima, Anderson Makoto Kayano, Mateus Farias Souza, Iolanda da Silva Oliveira, Ana Fidelina Gomez Garay, Anderson Maciel Rocha, Juliana Pavan Zuliani and Andreimar Martins Soares*

Volume 24, Issue 7, 2023

Published on: 20 July, 2023

Page: [536 - 550] Pages: 15

DOI: 10.2174/1389203724666230607105355

Price: $65

Abstract

Background: The venom of Crotalus durissus terrificus, as well as its fractions, has intrigued research groups worldwide who are working to isolate, characterize, and find possible biotechnological applications. A number of studies have elucidated that these fractions and their derivatives possess pharmacological properties, which can enable the development of new drug prototypes with anti-inflammatory, antinociceptive, antitumor, antiviral, and antiparasitic applications.

Objective: This review presents a systematic study on Crotalus durissus terrificus, the most notable crotalid subspecies in South America, focusing on the composition, toxicological mechanisms, structural aspects, and applications of the main venom toxins (convulxin, gyroxin, crotamine, crotoxin, and their subunits).

Conclusion: The authors have found that research on this snake and its toxins is still an area of focus, despite that almost a century has passed since the isolation of crotoxin. Several applications of these proteins in the development of novel drugs and bioactive substances have also been demonstrated.

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Graphical Abstract

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