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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Synthesis of Dendrimer Conjugates with Naproxen and their Anticancer Activity

Author(s): Irving Osiel Castillo-Rodríguez, Teresa Ramírez-Ápan and Marcos Martínez-García*

Volume 27, Issue 6, 2023

Published on: 13 July, 2023

Page: [540 - 545] Pages: 6

DOI: 10.2174/1385272827666230605160243

Price: $65

Abstract

Here we report the easy synthesis of dendrimer conjugates with four and eight naproxen moieties at the periphery. The synthesis involved two steps protection-deprotection sequence joined with triethylene glycol. A comparison was made between the cytotoxicity of dendron-naproxen conjugates and that of G1.0 G2.0 dendrimer-naproxen conjugates. Cytotoxicity studies showed that dendron conjugates were toxic towards all cancer cell lines studied, and their toxicity was significantly lower than that of dendrimer conjugates. However, dendrimer conjugates showed higher cytotoxicity and selectivity against K-562 and SKLU- 1 than dendron conjugates.

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