Login Register Cart 0
Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Case Report

18F-Fluorodeoxyglucose PET/CT and MRI Imaging Characteristics of Monomorphic Epitheliotropic Intestinal T-cell Lymphoma: A Case Report

Author(s): Xiaoying Zhang, Simin Liu, Ying Liu, Zhongwei Lv and Jianshe Yang*

Volume 20, 2024

Published on: 18 July, 2023

Article ID: e010623217539 Pages: 5

DOI: 10.2174/1573405620666230601111844

Price: $65

Abstract

Background: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, rapidly progressive, primary intestinal T-cell lymphoma. The most common site of occurrence is on the small intestine. The prognosis of MEITL is extremely poor due to delayed diagnosis and lack of targeted therapy.

Case Summary: A case of MEITL involving the entire small bowel, part of the colon, rectum, mesenteric lymph nodes, and liver is herein reported. We are presenting the 18F-FDG PET/CT features of MEITL, which showed all involved lesions with increased FDG activity. The MRI and pathological characteristics of MEITL were also described. Furthermore, some malignant diseases and benign diseases should be considered in the differential diagnosis.

Conclusion: Based on the lesions with a high accumulation of FDG, our case shows the involved extent of MEITL, which is helpful for biopsy and treatment option decisions. We expect more could know about this disease and make an early diagnosis to improve the outcomes of MEITL.

[1]
Chan TSY, Lee E, Khong PL, Tse EWC, Kwong YL. Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma. Hematology 2018; 23(1): 10-6.
[http://dx.doi.org/10.1080/10245332.2017.1335979] [PMID: 28581364]
[2]
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016; 127(20): 2375-90.
[http://dx.doi.org/10.1182/blood-2016-01-643569] [PMID: 26980727]
[3]
Qian L, Yan M, Zhang W, et al. Prognostic value of interim 18F-FDG PET/CT in T-cell lymphomas. Leuk Lymphoma 2020; 61(4): 927-33.
[http://dx.doi.org/10.1080/10428194.2019.1697815] [PMID: 31795794]
[4]
Gurion R, Bernstine H, Domachevsky L, et al. Utility of PET-CT for evaluation of patients with peripheral T-cell Lymphoma. Clin Lymphoma Myeloma Leuk 2018; 18(10): 687-91.
[http://dx.doi.org/10.1016/j.clml.2018.06.022] [PMID: 30017596]
[5]
Hoffmann M, Vogelsang H, Kletter K, Zettinig G, Chott A, Raderer M. 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) for assessment of enteropathy-type T cell lymphoma. Gut 2003; 52(3): 347-51.
[http://dx.doi.org/10.1136/gut.52.3.347] [PMID: 12584214]
[6]
Hadithi M, Mallant M, Oudejans J, van Waesberghe JH, Mulder CJ, Comans EF. 18F-FDG PET versus CT for the detection of enteropathy-associated T-cell lymphoma in refractory celiac disease J Nucl Med 2006; 47(10): 1622-7.
[7]
Suzuki Y, Minemura H, Tomita H, et al. Monomorphic epitheliotropic intestinal T-cell Lymphoma involving the lung and brain: A rare case study. Intern Med 2020; 59(20): 2559-63.
[http://dx.doi.org/10.2169/internalmedicine.4710-20] [PMID: 32641648]
[8]
Li C, He Y. (18)F-FDG PET/CT findings in a rare monomorphic epitheliotropic intestinal T cell lymphoma. Eur J Nucl Med Mol Imaging 2020.
[PMID: 32632459]
[9]
Delabie J, Holte H, Vose JM, et al. Enteropathy-associated T-cell lymphoma: Clinical and histological findings from the international peripheral T-cell lymphoma project. Blood 2011; 118(1): 148-55.
[http://dx.doi.org/10.1182/blood-2011-02-335216] [PMID: 21566094]
[10]
Ferreri AJM, Zinzani PL, Govi S, Pileri SA. Enteropathy-associated T-cell lymphoma. Crit Rev Oncol Hematol 2011; 79(1): 84-90.
[http://dx.doi.org/10.1016/j.critrevonc.2010.06.006] [PMID: 20655757]
[11]
Li C, He Y. 18F-FDG PET/CT findings in a rare monomorphic epitheliotropic intestinal T cell lymphoma. Eur J Nucl Med Mol Imaging 2021; 48(2): 649-50.
[http://dx.doi.org/10.1007/s00259-020-04939-z] [PMID: 32632459]
[12]
Chan WKS, Au WY, Wong CYO, et al. Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas. Clin Nucl Med 2010; 35(8): 571-5.
[http://dx.doi.org/10.1097/RLU.0b013e3181e4dcbf] [PMID: 20631501]
[13]
Chandesris MO, Malamut G, Verkarre V, et al. Enteropathy-associated T-cell lymphoma: A review on clinical presentation, diagnosis, therapeutic strategies and perspectives. Gastroenterol Clin Biol 2010; 34(11): 590-605.
[http://dx.doi.org/10.1016/j.gcb.2010.09.008] [PMID: 21050687]
[14]
Gentille C, Qin Q, Barbieri A, Sai Ravi P, Iyer S. Use of PEG-asparaginase in monomorphic epitheliotropic intestinal T-cell lymphoma, a disease with diagnostic and therapeutic challenges. Ecancermedicalscience 2017; 11: 771.
[http://dx.doi.org/10.3332/ecancer.2017.771] [PMID: 29062389]
[15]
Di Sabatino A, Biagi F, Gobbi PG, Corazza GR. How I treat enteropathy-associated T-cell lymphoma. Blood 2012; 119(11): 2458-68.
[http://dx.doi.org/10.1182/blood-2011-10-385559] [PMID: 22271451]
[16]
van Vliet C, Spagnolo DV. T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: Review and update. Pathology 2020; 52(1): 128-41.
[http://dx.doi.org/10.1016/j.pathol.2019.10.001] [PMID: 31727264]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy