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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Mini-Review Article

Phytosomal Drug Delivery System: A Detailed Study

Author(s): Srikala Kamireddy*, S. Sangeetha and Sreya Kosanam

Volume 10, Issue 4, 2024

Published on: 07 July, 2023

Article ID: e310523217507 Pages: 8

DOI: 10.2174/2215083810666230531163053

Price: $65

Abstract

Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies.

[1]
Awasthi R, Kulkarni GT, Pawar VK. Phytosomes: An approach to increase the bioavailability of plant extracts. Int J Pharm Pharm Sci 2011; 3(2): 1-3.
[2]
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: Food sources and bioavailability. Am J Clin Nutr 2004; 79(5): 727-47.
[http://dx.doi.org/10.1093/ajcn/79.5.727] [PMID: 15113710]
[3]
Bombardelli E, Spelta M. Phospholipid-polyphenol complexes: A new concept in skin care ingredients. Cosmetics and toiletries 1991; 106(3): 69-76.
[4]
Lu M, Qiu Q, Luo X, et al. Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents. Asian J Pharm Sci 2019; 14(3): 265-74.
[5]
Kidd PM. Bioavailability and activity of phytosome complexes from botanical polyphenols: The silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev 2009; 14(3): 226-46.
[PMID: 19803548]
[6]
What Are Polyphenols? Types, Benefits, and Food Sources. Available from: https://www.healthline.com/nutrition/polyphenols
[7]
Tan Q, Liu S, Chen X, et al. Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability. AAPS PharmSciTech 2012; 13(2): 534-47.
[http://dx.doi.org/10.1208/s12249-012-9772-9] [PMID: 22454136]
[8]
Parry MJ, Alakoskela JMI, Khandelia H, et al. High-affinity small molecule-phospholipid complex formation: Binding of siramesine to phosphatidic acid. J Am Chem Soc 2008; 130(39): 12953-60.
[http://dx.doi.org/10.1021/ja800516w] [PMID: 18767848]
[9]
Ghanbarzadeh B, Babazadeh A, Hamishehkar H. Nano-phytosome as a potential food-grade delivery system. Food Biosci 2016; 15: 126-35.
[http://dx.doi.org/10.1016/j.fbio.2016.07.006]
[10]
Li J, Wang X, Zhang T, et al. A review on phospholipids and their main applications in drug delivery systems. Asian J Pharma Sci 2015; 10(2): 81-98.
[11]
Xiao Y, Song Y, Chen Z, Ping Q. The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm 2006; 307(1): 77-82.
[12]
Semalty A. Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: A critical and meta-analysis. Expert Opin Drug Deliv 2014; 11(8): 1255-72.
[http://dx.doi.org/10.1517/17425247.2014.916271] [PMID: 24909802]
[13]
Tripathy S, Patel DK, Barob L, Naira SK. A review on phytosomes, their characterization, advancement & potential for transdermal application. J Drug Deliv Ther 2013; 3(3): 147-52.
[http://dx.doi.org/10.22270/jddt.v3i3.508]
[14]
Chauhan NS, Rajan GB. GopalakrishnaPhytosomes: A potential phyto-phospholipid carriers for herbal drug delivery. J Pharm Res 2009; 2(7): 1267-70.
[15]
Abdelkader H, Longman M, Alany R, Pierscionek B. Phytosome-hyaluronic acid systems for ocular delivery of L-carnosine. Int J Nanomedicine 2016; 11: 2815-27.
[http://dx.doi.org/10.2147/IJN.S104774] [PMID: 27366062]
[16]
Bombardelli E. Phytosome: New cosmetic delivery system. Boll Chim Farm 1991; 130(11): 431-8.
[PMID: 1809296]
[17]
Bombardelli E, Spelta M. Phospholipid, polyphenol complexes a new concept in skin care ingredients. Cosm and Toil 1991; 106(3): 69-76.
[18]
Zhang J, Tang Q, Xu X, Li N. Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery. Int J Pharm 2013; 448(1): 168-74.
[http://dx.doi.org/10.1016/j.ijpharm.2013.03.021] [PMID: 23524117]
[19]
Singh RP, Gangadharappa H, Kenganora M. Phytosome loaded novel herbal drug delivery system: A review. Int Res J Pharm 2016; 7: 15-21.
[http://dx.doi.org/10.7897/2230-8407.07656]
[20]
Shan L, Tan QY, Hong W, Hong L, Zhang JQ. Preparation, characterization and in vitro anti-tumor activities of evodiamine phospholipids complex. Chung Kuo Yao Hsueh Tsa Chih 2012; 47(7): 517-23.
[21]
Yu F, Li Y, Chen Q, et al. Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency. Eur J Pharm Biopharm 2016; 103: 136-48.
[http://dx.doi.org/10.1016/j.ejpb.2016.03.019] [PMID: 27020531]
[22]
Kumar S, Baldi A, Sharma DK. Phytosomes: A modernistic approach for novel herbal drug delivery-enhancing bioavailability and revealing endless frontier of phytopharmaceuticals. J Dev Drugs 2009; 8(1): 1-8.
[23]
He N, Zhang L, Zhu F, Rui K, Yuan MQ, Qin H. Formulation of self-nanoemulsifying drug delivery systems for insulin-soybean lecithin complex. Huaxi Yaoxue Zazhi 2010; 25(4): 396-9.
[24]
Sanjay J, Champalal D, Neelesh M. Physicochemical characterization and determination of free radical scavenging activity of rutin-phospholipid complex. Int J Pharm Sci Res 2012; 3(3): 909-13.
[25]
Mazumder A, Dwivedi A, du Preez JL, du Plessis J. In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. Int J Pharm 2016; 498(1-2): 283-93.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.027] [PMID: 26706438]
[26]
Singh D, Rawat MSM, Semalty A, Semalty M. Chrysophanol–phospholipid complex. J Therm Anal Calorim 2013; 111(3): 2069-77.
[http://dx.doi.org/10.1007/s10973-012-2448-6]
[27]
Kumar S, Ashish B, Dinesh KS. Phytosomes: A modernistic approach for novel herbal drug delivery - enhancing bioavailability and revealing endless frontier of phytopharmaceuticals. J Dev Drugs 2020; 9(2): 195.
[28]
Freag MS, Elnaggar YS, Abdallah OY. Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: Optimization and ex vivo permeation. Int J Nanomedicine 2013; 8: 2385-97.
[PMID: 23861584]
[29]
Magistretti MJ. BombardelliEzio: Pharmaceutical compositions containing flavanolignans and phospholipids. Transmission electron microscopy 1997; 187: 125-33.
[30]
Pandey S, Patel K. Phytosomes: Technical revolution in phytomedicine. Int J Pharm Tech Res 2010; 2: 627-31.
[31]
Sharma S, Sikarwar M. Phytosome- a review. Plant Indica 2005; 1: 1-3.
[32]
Pathan RA, Bhandari U. Preparation & characterization of embelin–phospholipid complex as effective drug delivery tool. J Incl Phenom Macrocycl 2011; 69(1–2): 139-47.
[33]
Kumar A, Kumar B, Singh SK, Kaur B, Singh S. A review on phytosomes: Novel approach for herbal phytochemicals. Asian J Pharm Clin Res 2017; 10(10): 41-7.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20424]
[34]
Nagpal N, Arora M, Swami G. Rageeb, Kapoor R. Designing of a phytosome dosage form with Tecomella undulata as a novel drug delivery for better utilization. Pak J Pharm Sci 2016; 29(4): 1231-5.
[PMID: 27393436]
[35]
Xu K, Liu B, Ma Y, et al. Physicochemical properties and antioxidant activities of luteolin-phospholipid complex. Molecules 2009; 14(9): 3486-93.
[http://dx.doi.org/10.3390/molecules14093486] [PMID: 19783938]
[36]
Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs. liposomes. Biomaterials 2000; 21(18): 1879-85.
[http://dx.doi.org/10.1016/S0142-9612(00)00063-6] [PMID: 10919691]
[37]
Hao H, Jia Y, Han R, Amp PIA. Phytosomes: An effective approach to enhance the oral bioavailability of active constituents extracted from plants. J Chin Pharm Sci 2013; 22(5): 385-92.
[http://dx.doi.org/10.5246/jcps.2013.05.056]
[38]
Das MK, Kalita B. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application J. J Appl Pharm Sci 2014; 4(10): 51-7.
[http://dx.doi.org/10.7324/JAPS.2014.401010]
[39]
Parihar SK, Bhowmick M, Kumar R, Dubey BK. Soft Malleable vesicles tailored for enhanced delivery of active agents through the skin: An update. Int J Pharm Sci Res 2013; 4(1): 172-80.
[40]
Lu M, Qiu Q, Luo X, et al. Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents. Asian J Pharm 2019; 14(3): 265-74.
[http://dx.doi.org/10.1016/j.ajps.2018.05.011] [PMID: 32104457]
[41]
El-Menshawe S, Ali A, Rabeh M, Khalil N. Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: An approach for acceptable level of evidence of an effective novel herbal weight loss product. Int J Nanomedicine 2018; 13: 307-18.
[http://dx.doi.org/10.2147/IJN.S153429] [PMID: 29391791]
[42]
Pande SD, Wagh AS, Bhagure LB, Patil SG, Deshmukh AR. Preparation and evaluation of phytosomes of pomegrane peels. Research. J Pharm Technol 2015; 8(4): 416-22.
[43]
Rathee S, Kamboj A. Optimization and development of antidiabetic phytosomes by the Box–Behnken design. J Liposome Res 2018; 28(2): 161-72.
[http://dx.doi.org/10.1080/08982104.2017.1311913] [PMID: 28337938]
[44]
Sahu AN, Sharma S. Development, characterization, and evaluation of hepatoprotective effect of Abutilon indicum and Piper longum phytosomes. Pharmacognosy Res 2016; 8(1): 29-36.
[http://dx.doi.org/10.4103/0974-8490.171102] [PMID: 26941533]
[45]
Jeevanajyothi B, Regalatha P. Development and in vitro evaluation of phytosomes of naringin. Asian J Pharm Clin Res 2019; 12(9): 252-6.
[46]
Manral K, Singhak SV, Huang Y. Development and characterization of morin loaded phytosomes for its anti-oxidant activity. J Drug Deliv Ther 2019; 9(4): 30-6.
[47]
Hou Z, Li Y, Huang Y, et al. Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery. Mol Pharm 2013; 10(1): 90-101.
[http://dx.doi.org/10.1021/mp300489p] [PMID: 23194396]
[48]
Moscarella S, Giusti A, Marra F, et al. Therapeutic and antilipoperoxidant effects of silybin-phosphatidylcholine complex in chronic liver disease: Preliminary results. Curr Ther Res Clin Exp 1993; 53(1): 98-102.
[http://dx.doi.org/10.1016/S0011-393X(05)80160-2]
[49]
Gilardini L, Pasqualinotto L, Di Pierro F, Risso P, Invitti C. Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: A randomized placebo-controlled study. BMC Complement Altern Med 2016; 16(1): 233.
[http://dx.doi.org/10.1186/s12906-016-1214-x] [PMID: 27450231]
[50]
Sonam S, Alakh NS. Development, characterization, and evaluation of hepatoprotective effect of abutilon indicum and piper longum. Phytosomes Pharmacogn Res 2016; 8(1): 29-36.
[http://dx.doi.org/10.4103/0974-8490.171102]
[51]
Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A. Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 2017; 85: 102-12.
[http://dx.doi.org/10.1016/j.biopha.2016.11.098] [PMID: 27930973]
[52]
Loguercio C, Festi D. Silybin and the liver: From basic research to clinical practice. World J Gastroenterol 2011; 17(18): 2288-301.
[http://dx.doi.org/10.3748/wjg.v17.i18.2288] [PMID: 21633595]
[53]
Furey A, Tassell MC, Kingston R, Gilroy D, Lehane M. Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease. Pharmacogn Rev 2010; 4(7): 32-41.
[http://dx.doi.org/10.4103/0973-7847.65324] [PMID: 22228939]
[54]
Park JH, Jang JS, Kim KS, Hong JT. Anti-inflammatory effect of Centellaasiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. Phytomedicine 2018; 43: 110-9.
[http://dx.doi.org/10.1016/j.phymed.2018.04.013] [PMID: 29747743]
[55]
Naik SR, Pilgaonkar VW, Panda VS. Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain. Phytother Res 2006; 20(11): 1013-6.
[http://dx.doi.org/10.1002/ptr.1976] [PMID: 16909446]
[56]
Kesarwani K, Gupta R, Mukerjee A. Bioavailability enhancers of herbal origin: An overview. Asian Pac J Trop Biomed 2013; 3(4): 253-66.
[http://dx.doi.org/10.1016/S2221-1691(13)60060-X] [PMID: 23620848]
[57]
Bombardelli E, Spelta M. Phospholipid-polyphenol complexes: A new concept in skin care ingredients. Cosmet Toiletries 1991; 106(3): 69-76.

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