Login Register Cart 0
Generic placeholder image

Current Neurovascular Research

Editor-in-Chief

ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Association of Blood Lipid Profile Components with White Matter Hyperintensity Burden in Cerebral Small Vessel Disease

Author(s): Shanshan Li, Yunchao Wang, Lulu Yu, Yuan Gao, Yinghao Yang, Hanghang Zhu, Lu An, Wenxin Yuan, Jinghao Wu, Ce Zong, Yuming Xu* and Yusheng Li*

Volume 20, Issue 2, 2023

Published on: 12 July, 2023

Page: [175 - 182] Pages: 8

DOI: 10.2174/1567202620666230524155702

Price: $65

Abstract

Background: Cerebral small vessel disease (CSVD) refers to a common cerebrovascular disease and white matter hyperintensities (WMHs) constitute a typical feature of CSVD. However, there has not been a large number of studies investigating the relationship between lipid profile components and WMHs.

Methods: Altogether, 1019 patients with CSVD were enrolled at the First Affiliated Hospital of Zhengzhou University between April 2016 to December 2021. Baseline data were collected for all patients, including demographic characteristics and clinical data. WMH volumes were evaluated by two experienced neurologists using the MRIcro software. Multivariate regression analysis was used to investigate the relationship among the severity of WMHs, blood lipids and common risk factors.

Results: Altogether, 1019 patients with CSVD were enrolled, including 255 in the severe WMH group and 764 in the mild WMH group. After including age, sex and blood lipids to construct a multivariate logistic regression equation, we observed that the severity of WMHs was independently predicted by low-density lipoprotein (LDL), homocysteine level and history of cerebral infarction.

Conclusion: We used WMH volume, a highly accurate measure, to assess its relationship with lipid profiles. The WMH volume increased with a decrease in LDL. This relationship was more significant, especially among the subgroups of patients aged <70 years and men. Patients with cerebral infarction and higher homocysteine levels were more likely to have higher WMH volumes. Our study has provided a reference for clinical diagnosis and therapy, especially for discussing the role of blood lipid profiles in the pathophysiology of CSVD.

« Previous Next »
[1]
Litak J, Mazurek M, Kulesza B, et al. Cerebral small vessel disease. Int J Mol Sci 2020; 21(24): 9729.
[http://dx.doi.org/10.3390/ijms21249729] [PMID: 33419271]
[2]
Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF. CNS small vessel disease. Neurology 2019; 92(24): 1146-56.
[http://dx.doi.org/10.1212/WNL.0000000000007654] [PMID: 31142635]
[3]
Kuller LH, Longstreth WT Jr, Arnold AM, Bernick C, Bryan RN, Beauchamp NJ Jr. White matter hyperintensity on cranial magnetic resonance imaging: A predictor of stroke. Stroke 2004; 35(8): 1821-5.
[http://dx.doi.org/10.1161/01.STR.0000132193.35955.69] [PMID: 15178824]
[4]
Neumann-Haefelin T, Hoelig S, Berkefeld J, et al. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke 2006; 37(10): 2463-6.
[http://dx.doi.org/10.1161/01.STR.0000239321.53203.ea] [PMID: 16931786]
[5]
Stewart R, de Groot JC, Breteler MMB. Cerebral white matter lesions and subjective cognitive dysfunction: The Rotterdam Scan Study. Neurology 2001; 57(11): 2149.
[http://dx.doi.org/10.1212/WNL.57.11.2149] [PMID: 11739854]
[6]
Prins ND, van Dijk EJ, den Heijer T, et al. Cerebral white matter lesions and the risk of dementia. Arch Neurol 2004; 61(10): 1531-4.
[http://dx.doi.org/10.1001/archneur.61.10.1531] [PMID: 15477506]
[7]
Liao D, Cooper L, Cai J, et al. The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: The ARIC Study. Neuroepidemiology 1997; 16(3): 149-62.
[http://dx.doi.org/10.1159/000368814] [PMID: 9159770]
[8]
Leeuw FD. Hypertension and cerebral white matter lesions in a prospective cohort study. Oxford, UK: Oxford University Press 2002.
[http://dx.doi.org/10.1093/brain/awf077]
[9]
Jimenez-Conde J, Biffi A, Rahman R, et al. Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke. Stroke 2010; 41(3): 437-42.
[http://dx.doi.org/10.1161/STROKEAHA.109.563502] [PMID: 20133919]
[10]
Ohwaki K, Yano E, Tamura A, Inoue T, Saito I. Hypercholesterolemia is associated with a lower risk of cerebral ischemic small vessel disease detected on brain checkups. Clin Neurol Neurosurg 2013; 115(6): 669-72.
[http://dx.doi.org/10.1016/j.clineuro.2012.07.025] [PMID: 22884863]
[11]
Khan U, Porteous L, Hassan A, Markus HS. Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry 2006; 78(7): 702-6.
[http://dx.doi.org/10.1136/jnnp.2006.103549] [PMID: 17210627]
[12]
Ichikawa H, Mukai M, Ohno H, Shimizu Y, Itaya K, Kawamura M. Deep white matter hyperintensities, decreased serum low-density lipoprotein, and dilative large arteriopathy. J Stroke Cerebrovasc Dis 2012; 21(3): 225-30.
[http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2010.07.002] [PMID: 20880719]
[13]
Longstreth WT Jr, Arnold AM, Beauchamp NJ Jr, et al. Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: The cardiovascular health study. Stroke 2005; 36(1): 56-61.
[http://dx.doi.org/10.1161/01.STR.0000149625.99732.69] [PMID: 15569873]
[14]
Schilling S, Tzourio C, Dufouil C, et al. Plasma lipids and cerebral small vessel disease. Neurology 2014; 83(20): 1844-52.
[http://dx.doi.org/10.1212/WNL.0000000000000980] [PMID: 25320101]
[15]
Willey JZ, Gardener H, Moon YP, et al. Lipid profile components and subclinical cerebrovascular disease in the northern Manhattan study. Cerebrovasc Dis 2014; 37(6): 423-30.
[http://dx.doi.org/10.1159/000362920] [PMID: 25034465]
[16]
Duan D, Shen L, Cui C, Shu T, Zheng J. Association between Low-density lipoprotein cholesterol and occipital periventricular hyperintensities in a group of Chinese patients: An observational study. Lipids Health Dis 2017; 16(1): 48.
[http://dx.doi.org/10.1186/s12944-017-0436-3] [PMID: 28241772]
[17]
Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 1987; 149(2): 351-6.
[http://dx.doi.org/10.2214/ajr.149.2.351] [PMID: 3496763]
[18]
van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988; 19(5): 604-7.
[http://dx.doi.org/10.1161/01.STR.19.5.604] [PMID: 3363593]
[19]
Rorden C, Karnath HO, Bonilha L. Improving lesion-symptom mapping. J Cogn Neurosci 2007; 19(7): 1081-8.
[http://dx.doi.org/10.1162/jocn.2007.19.7.1081] [PMID: 17583985]
[20]
Goldstein MR, Mascitelli L. Regarding long-term statin therapy: Are we trading stronger hearts for weaker brains? Med Hypotheses 2014; 83(3): 346-51.
[http://dx.doi.org/10.1016/j.mehy.2014.06.010] [PMID: 24986644]
[21]
Duan D, Congyang L, Lin S, et al. Regional gray matter atrophy coexistent with occipital periventricular white matter hyper intensities. Front Aging Neurosci 2016; 8: 214.
[http://dx.doi.org/10.3389/fnagi.2016.00214]
[22]
Sliz E, Shin J, Ahmad S, et al. Circulating metabolome and white matter hyperintensities in women and men. Circulation 2022; 145(14): 1040-52.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.121.056892] [PMID: 35050683]
[23]
Anagnostis P, Stevenson JC, Crook D, Johnston DG, Godsland IF. Effects of gender, age and menopausal status on serum apolipoprotein concentrations. Clin Endocrinol 2016; 85(5): 733-40.
[http://dx.doi.org/10.1111/cen.13085] [PMID: 27086565]
[24]
Anagnostis P, Stevenson JC, Crook D, Johnston DG, Godsland IF. Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions. Maturitas 2015; 81(1): 62-8.
[http://dx.doi.org/10.1016/j.maturitas.2015.02.262] [PMID: 25804951]
[25]
Berg G, Mesch V, Boero L, et al. Lipid and lipoprotein profile in menopausal transition. Effects of hormones, age and fat distribution. Horm Metab Res 2004; 36(4): 215-20.
[http://dx.doi.org/10.1055/s-2004-814450] [PMID: 15114519]
[26]
Lohner V, Pehlivan G, Sanroma G, et al. Relation between sex, menopause, and white matter hyperintensities. Neurology 2022; 99(9): e935-43.
[http://dx.doi.org/10.1212/WNL.0000000000200782] [PMID: 35768207]
[27]
Mauch DH, Nägler K, Schumacher S, et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001; 294(5545): 1354-7.
[http://dx.doi.org/10.1126/science.294.5545.1354] [PMID: 11701931]
[28]
Soljanlahti S, Autti T, Lauerma K, et al. Familial hypercholesterolemia patients treated with statins at no increased risk for intracranial vascular lesions despite increased cholesterol burden and extracranial atherosclerosis. Stroke 2005; 36(7): 1572-4.
[http://dx.doi.org/10.1161/01.STR.0000169920.64180.fa] [PMID: 15933262]
[29]
Smith JA, Turner ST, Sun YV, et al. Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study. BMC Med Genomics 2009; 2(1): 16.
[http://dx.doi.org/10.1186/1755-8794-2-16] [PMID: 19351393]
[30]
Dietschy JM, Turley SD. Cholesterol metabolism in the brain. Curr Opin Lipidol 2001; 12(2): 105-12.
[http://dx.doi.org/10.1097/00041433-200104000-00003] [PMID: 11264981]
[31]
Goritz C, Mauch DH, Pfrieger FW, Goritz C, Mauch DH. Pfrieger FWMultiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol Cell Neurosci 29:190-201. Mol Cell Neurosci 2005; 29: 190-201.
[http://dx.doi.org/10.1016/j.mcn.2005.02.006] [PMID: 15911344]
[32]
Vogt NM, Hunt JFV, Ma Y, et al. Effects of simvastatin on white matter integrity in healthy middle‐aged adults. Ann Clin Transl Neurol 2021; 8(8): 1656-67.
[http://dx.doi.org/10.1002/acn3.51421] [PMID: 34275209]
[33]
Austin MA, Edwards KL, McNeely MJ, et al. Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans. Diabetes 2004; 53(4): 1166-9.
[http://dx.doi.org/10.2337/diabetes.53.4.1166] [PMID: 15047637]
[34]
Atwood LD, Wolf PA, Heard-Costa NL, et al. Genetic variation in white matter hyperintensity volume in the Framingham Study. Stroke 2004; 35(7): 1609-13.
[http://dx.doi.org/10.1161/01.STR.0000129643.77045.10] [PMID: 15143299]
[35]
ten Dam VH, van den Heuvel DMJ, van Buchem MA, et al. Effect of pravastatin on cerebral infarcts and white matter lesions. Neurology 2005; 64(10): 1807-9.
[http://dx.doi.org/10.1212/01.WNL.0000161844.00797.73] [PMID: 15911821]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy