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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Mini-Review Article

The Natural Sweetener Stevia: An Updated Review on its Phytochemistry, Health Benefits, and Anti-diabetic Study

Author(s): Shraddha Patel and Archana Navale*

Volume 20, Issue 2, 2024

Published on: 09 June, 2023

Article ID: e010523216398 Pages: 11

DOI: 10.2174/1573399819666230501210803

Price: $65

Abstract

Stevia rebaudiana Bertoni is one of the significant high qualities of non-caloric sugar substitute sweetener plants against diabetes disease. Diabetes mellitus is one of the most common metabolic diseases caused by insulin secretion defects, insulin resistance in peripheral tissues, or both. Stevia rebaudiana is a perennial shrub of the Compositae family that is grown in several places around the world. It contains a plethora of different bioactive constituents which are responsible for several activities and sweetness. This sweetness is due to the presence of steviol glycosides which is 100-300 times sweeter than sucrose. Furthermore, stevia reduces oxidative stress, lowering the risk of diabetes. Its leaves have been used to control and treat diabetes and a variety of other metabolic diseases. This review summarizes the history, bioactive constituents of S. rebaudiana extract, pharmacology, anti-diabetic activity, and its application, especially in food supplements.

[1]
Lemus-Mondaca R, Ah-Hen K, Vega-Gálvez A, Honores C, Moraga NO. Stevia rebaudiana leaves: Effect of drying process temperature on bioactive components, antioxidant capacity and natural sweeteners. Plant Foods Hum Nutr 2016; 71(1): 49-56.
[http://dx.doi.org/10.1007/s11130-015-0524-3] [PMID: 26650384]
[2]
Shivanna N, Naika M, Khanum F, Kaul VK. Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. J Diabetes Compl 2013; 27(2): 103-13.
[http://dx.doi.org/10.1016/j.jdiacomp.2012.10.001] [PMID: 23140911]
[3]
Lasekan O, Naidu RM. Changes in the volatile constituents of the leaves of Stevia rebaudiana Bertoni caused by diferent drying procedures. J Food Agric Environ 2013; 11(3): 190-4.
[4]
Lemus-Mondaca R, Vega-Gálvez A, Zura-Bravo L, Ah-Hen K. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chem 2012; 132(3): 1121-32.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.140] [PMID: 29243591]
[5]
Preethi D, Sridhar TM, Josthna P, Naidu CV. Studies on antibacterial activity, phytochemical analysis of Stevia rebaudiana (Bert.). An important calorie free biosweetner. J Ecobiotechnol 2011; 3(7): 5-10.
[6]
Singh SD, Rao GP. Stevia: The herbal sugar of 21st century. Sugar Tech 2005; 7(1): 17-24.
[http://dx.doi.org/10.1007/BF02942413]
[7]
Wölwer-Rieck U. The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: A review. J Agric Food Chem 2012; 60(4): 886-95.
[http://dx.doi.org/10.1021/jf2044907] [PMID: 22250765]
[8]
Patel A, Pasha TY, Modi A. Synthesis and Biological Evaluation of 4-Aryl substituted -2-(5-carboxylicacid-1, 6-dihydro)-2-thiophenylethylene-6-oxopyrimidine as Protein Tyrosine Phosphatase (PTP-1B) Inhibitors. Int J Pharm Tech Res 2015; 8(8): 136-43.
[9]
Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37 (Suppl. 1): S81-90.
[http://dx.doi.org/10.2337/dc14-S081] [PMID: 24357215]
[10]
Patel AD, Pasha TY, Lunagariya P, Shah U, Bhambharoliya T, Tripathi RKP. A library of thiazolidin‐4‐one derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors: An attempt to discover novel antidiabetic agents. ChemMedChem 2020; 15(13): 1229-42.
[http://dx.doi.org/10.1002/cmdc.202000055] [PMID: 32390300]
[11]
Panchal II, Sen DJ, Patel AD, et al. Molecular docking, synthesis and biological evaluation of sulphonylureas/guanidine derivatives as promising antidiabetic agent. Curr Drug Discov Technol 2018; 15(4): 315-25.
[http://dx.doi.org/10.2174/1570163814666171002102904] [PMID: 28969569]
[12]
Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3(11): e442.
[http://dx.doi.org/10.1371/journal.pmed.0030442] [PMID: 17132052]
[13]
Saeedi P, Salpea P, Karuranga S, et al. Mortality attributable to diabetes in 20-79 years old adults, 2019 estimates: Results from the international diabetes federation diabetes atlas. J Diabetes Res 2020; 162: 108086.
[14]
Ali MK, Pearson-Stuttard J, Selvin E, Gregg EW. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia 2022; 65(1): 3-13.
[http://dx.doi.org/10.1007/s00125-021-05585-2] [PMID: 34837505]
[15]
Gregory GA, Robinson TIG, Linklater SE, et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: A modelling study. Lancet Diabetes Endocrinol 2022; 10(10): 741-60.
[http://dx.doi.org/10.1016/S2213-8587(22)00218-2] [PMID: 36113507]
[16]
Li G, Zhang P, Wang J, et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: A 20-year follow-up study. Lancet 2008; 371(9626): 1783-9.
[http://dx.doi.org/10.1016/S0140-6736(08)60766-7] [PMID: 18502303]
[17]
Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial. Lancet 2009; 373(9681): 2125-35.
[http://dx.doi.org/10.1016/S0140-6736(09)60953-3] [PMID: 19501900]
[18]
Lebovitz HE. Thiazolidinediones: The forgotten diabetes medications. Curr Diab Rep 2019; 19(12): 151-64.
[http://dx.doi.org/10.1007/s11892-019-1270-y] [PMID: 31776781]
[19]
Jan SA, Shinwari ZK, Malik M, Ilyas M. Antioxidant and anticancer activities of Brassica rapa: A review. MOJ Biol Med 2018; 3(5): 175-8.
[20]
Shinwari ZK, Jan SA, Khalil AT, et al. Identifcation and phylogenetic analysis of selected medicinal plant species from Pakistan: DNA barcoding approach. Pak J Bot 2018; 50(2): 553-60.
[21]
Ullah I, Wakeel A, Shinwari ZK, Jan SA, Khalil AT, Ali M. Antibacterial and antifungal activity of Isatis tinctoria L. using micro-plate method. Pak J Bot 2017; 49(5): 1949-57.
[22]
Carrera-Lanestosa A, Coral-Martínez T, Ruíz-Ciau D, Moguel-Ordoñez Y, Segura-Campos MR. Phenolic compounds and major steviol glucosides by HPLC-DAD-RP and in vitro evaluation of the biological activity of aqueous and ethanolic extracts of leaves and stems: S. rebaudiana Bertoni (creole variety INIFAP C01). Int J Food Prop 2020; 23(1): 199-212.
[http://dx.doi.org/10.1080/10942912.2020.1716789]
[23]
Myint K, Wu K, Xia Y, et al. Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties. J Food Sci 2020; 85(2): 240-8.
[http://dx.doi.org/10.1111/1750-3841.15017] [PMID: 31990038]
[24]
Talevi A. Potential medicinal effects and applications of stevia constituents. Phytochem Rev 2022; 21(1): 161-78.
[http://dx.doi.org/10.1007/s11101-021-09753-5]
[25]
Ilias N, Hamzah H, Ismail IS, Mohidin TBM, Idris MF, Ajat M. An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases. Biomed Pharmacother 2021; 143: 112207.
[http://dx.doi.org/10.1016/j.biopha.2021.112207] [PMID: 34563950]
[26]
Mirzaei AR, Shakoory-Moghadam V. Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes. Cell Mol Biomed Rep 2022; 2(2): 64-73.
[PMID: 35815189]
[27]
Samuel P, Ayoob KT, Magnuson BA, et al. Stevia leaf to stevia sweetener: Exploring its science, benefits, and future potential. J Nutr 2018; 148(7): 1186S-205S.
[http://dx.doi.org/10.1093/jn/nxy102] [PMID: 29982648]
[28]
Rojas E, Bermúdez V, Motlaghzadeh Y, et al. Stevia rebaudiana Bertoni and its effects in human disease: Emphasizing its role in inflammation, atherosclerosis and metabolic syndrome. Curr Nutr Rep 2018; 7(3): 161-70.
[http://dx.doi.org/10.1007/s13668-018-0228-z] [PMID: 29995279]
[29]
Ruiz-Ruiz JC, Moguel-Ordoñez YB, Matus-Basto AJ, Segura-Campos MR. Nutritional, amylolytic enzymes inhibition and antioxidant properties of bread incorporated with Stevia rebaudiana. Int J Food Sci Nutr 2015; 66(6): 649-56.
[http://dx.doi.org/10.3109/09637486.2015.1077785] [PMID: 26299814]
[30]
Yadav SK, Guleria P. Steviol glycosides from Stevia: Biosynthesis pathway review and their application in foods and medicine. Crit Rev Food Sci Nutr 2012; 52(11): 988-98.
[http://dx.doi.org/10.1080/10408398.2010.519447] [PMID: 22823347]
[31]
Momtazi-Borojeni AA, Esmaeili SA, Abdollahi E, Sahebkar A. A review on the pharmacology and toxicology of steviol glycosides extracted from Stevia rebaudiana. Curr Pharm Des 2017; 23(11): 1616-22.
[http://dx.doi.org/10.2174/1381612822666161021142835] [PMID: 27784241]
[32]
Šic Žlabur J, Voća S, Dobričević N, Ježek D, Bosiljkov T, Brnčić M. Stevia rebaudiana Bertoni-A review of nutritional and biochemical properties of natural sweetener. ACS Agric Conspec Sci 2013; 78(1): 25-30.
[33]
Jan SA, Habib N, Shinwari ZK, Ali M, Ali N. The anti-diabetic activities of natural sweetener plant Stevia: An updated review. SN Applied Sciences 2021; 3(4): 517.
[http://dx.doi.org/10.1007/s42452-021-04519-2]
[34]
Ramesh K, Singh V, Megeji NW. Cultivation of Stevia [Stevia rebaudiana (Bert.) Bertoni]: A comprehensive review. Adv Agron 2006; 89: 137-77.
[http://dx.doi.org/10.1016/S0065-2113(05)89003-0]
[35]
Carakostas MC, Curry LL, Boileau AC, Brusick DJ. Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food Chem Toxicol 2008; 46(7): S1-S10.
[http://dx.doi.org/10.1016/j.fct.2008.05.003] [PMID: 18555576]
[36]
Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Regul Toxicol Pharmacol 2008; 51(1): 37-41.
[http://dx.doi.org/10.1016/j.yrtph.2008.02.006] [PMID: 18397817]
[37]
Zaman N, Crosson M, Whitehurst T, Barrette E, Henderson J, Rajchel D. Llewellyn’s 2015 herbal almanac: herbs for growing and gathering, cooking and crafts, health and beauty, history, myth and lore. Woodbury: Llewellyn Publications 2015.
[38]
How did Stevia get mainstream? BBC News Magazine 2022. Available from: https://www.bbc.com/news/magazine-22758059
[39]
Center for Food Safety and Applied Nutrition (CFSAN) 2008. Available From: https://www.fda.gov/about-fda/fda-organization/center-food-safety-and-applied-nutrition-cfsan
[40]
Prakash I, Dubois GE, Clos JF, Wilkens KL, Fosdick LE. Development of rebiana, a natural, non-caloric sweetener Food Chem Toxicol 2008; 46(7): S75YS82.
[http://dx.doi.org/10.1016/j.fct.2008.05.004]
[41]
Thiyagarajan M, Venkatachalam P. Large scale in vitro propagation of Stevia rebaudiana (bert) for commercial application: Pharmaceutically important and antidiabetic medicinal herb. Ind Crops Prod 2012; 37(1): 111-7.
[http://dx.doi.org/10.1016/j.indcrop.2011.10.037]
[42]
Borgo J, Laurella LC, Martini F, Catalán CAN, Sülsen VP. Stevia genus: Phytochemistry and biological activities update. Molecules 2021; 26(9): 2733.
[http://dx.doi.org/10.3390/molecules26092733] [PMID: 34066562]
[43]
Sülsen V, Martino V. Overview. Sesquiterpene Lactones Advances in Their Chemistry and Biological Aspects. Cham, Switzerland: Springer 2018; pp. 3-17.
[http://dx.doi.org/10.1007/978-3-319-78274-4_1]
[44]
Mishra N. An Analysis of antidiabetic activity of Stevia rebaudiana extract on diabetic patient. J Nat Sci Res 2011; 1(3): 1-9.
[45]
Goyal SK, Samsher , Goyal RK. Stevia rebaudiana a bio-sweetener: A review. Int J Food Sci Nutr 2010; 61(1): 1-10.
[http://dx.doi.org/10.3109/09637480903193049] [PMID: 19961353]
[46]
Ahmad J, Khan I, Blundell R, Azzopardi J, Mahomoodally MF. Stevia rebaudiana Bertoni.: An updated review of its health benefits, industrial applications and safety. Trends Food Sci Technol 2020; 100(100): 177-89.
[http://dx.doi.org/10.1016/j.tifs.2020.04.030]
[47]
Uhler B, Yang Z. Rebaudioside A and other unreported steviol glycoside isomers found in the sweet tea (Rubus suavissimis) leaf. Phytochem Lett 2018; 28(11): 93-7.
[http://dx.doi.org/10.1016/j.phytol.2018.09.003]
[48]
Jayaraman S, Manoharan MS, Illanchezian S. In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Trop J Pharm Res 2008; 7(4): 1143-9.
[http://dx.doi.org/10.4314/tjpr.v7i4.14700]
[49]
Milani PG, Formigoni M, Dacome AS, Benossi L, Costa CMD, Costa SCD. New seminal variety of Stevia rebaudiana: Obtaining fractions with high antioxidant potential of leaves. An Acad Bras Cienc 2017; 89(3): 1841-50.
[http://dx.doi.org/10.1590/0001-3765201720170174] [PMID: 28876399]
[50]
Sheeja R, Lawrence B. Phytochemical screening of the leaves of Stevia rebaudiana, Bertoni. Int J Curr Microbiol Appl Sci 2015; 4(3): 344-7.
[51]
Abou-Arab AE, Abou-Arab AA, Abu-Salem MF. Physico-chemical assessment of natural sweeteners steviosides produced from Stevia rebaudiana Bertoni plant. Afr J Food Sci 2010; 4(5): 269-81.
[52]
Komissarenko N, Derkach A, Kovalyov I, Bublik N. Diterpene glycosides and phenylpropanoids of Stevia rebaudiana Bertoni. Rast Res 1994; 1(2): 53-64.
[53]
Tadhani M, Subhash R. Preliminary studies on Stevia rebaudiana leaves: Proximal composition, mineral analysis and phytochemical screening. J Med Sci Res 2006; 6(3): 321-6.
[54]
He J, Zhu NL, Kong J, et al. A newly discovered phenylethanoid glycoside from Stevia rebaudiana Bertoni affects insulin secretion in rat INS-1 Islet β cells. Molecules 2019; 24(22): 4178.
[http://dx.doi.org/10.3390/molecules24224178] [PMID: 31752141]
[55]
Peteliuk V, Rybchuk L, Bayliak M, Storey KB, Lushchak O. Natural sweetener Stevia rebaudiana: Functionalities, health benefits and potential risks. EXCLI J 2021; 20(20): 1412-30.
[PMID: 34803554]
[56]
Khiraoui A, Bakha M, Amchra F, et al. Nutritional and biochemical properties of natural sweeteners of six cultivars of Stevia rebaudiana Bertoni leaves grown in Morocco. J Environ Sci (China) 2017; 8(3): 1015-22.
[57]
Atteh J, Onagbesan O, Tona K, Buyse J, Decuypere E, Geuns J. Potential use of Stevia rebaudiana in animal feeds. Arch Zootec 2011; 60(229): 133-6.
[http://dx.doi.org/10.21071/az.v60i229.4697]
[58]
Assi AA, Abd El-hamid DH, Abdel-Rahman MS, Ashry EE, AI Bayoumi S, Ahmed AM. A The potential efficacy of Stevia extract, Glimepiride and their combination in treating diabetic rats: A novel strategy in therapy of Type 2 diabetes mellitus. Egypt J Basic Clin Pharmacol 2020; 10: 1-15.
[http://dx.doi.org/10.32527/2020/101455]
[59]
Ahmad U, Ahmad RS. Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Complement Altern Med 2018; 18(1): 179-90.
[http://dx.doi.org/10.1186/s12906-018-2245-2] [PMID: 29890969]
[60]
Wang T, Guo M, Song X, et al. Stevioside plays an anti-inflammatory role by regulating the NF-κB and MAPK pathways in S. aureus-infected mouse mammary glands. Inflammation 2014; 37(5): 1837-46.
[http://dx.doi.org/10.1007/s10753-014-9915-0] [PMID: 24858724]
[61]
Fengyang L, Yunhe F, Bo L, et al. Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cells. Inflammation 2012; 35(5): 1669-75.
[http://dx.doi.org/10.1007/s10753-012-9483-0] [PMID: 22644339]
[62]
Chen TH, Chen SC, Chan P, Chu YL, Yang HY, Cheng JT. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med 2005; 71(2): 108-13.
[http://dx.doi.org/10.1055/s-2005-837775] [PMID: 15729617]
[63]
Prata C, Zambonin L, Rizzo B, et al. Glycosides from Stevia rebaudiana Bertoni possess insulin-mimetic and antioxidant activities in rat cardiac fibroblasts. Oxid Med Cell Longev 2017; 2017(2017): 1-13.
[http://dx.doi.org/10.1155/2017/3724545] [PMID: 28947927]
[64]
Das S, Istiak A, Hazra P, Habiba U, Bhuiyan M, Rafiq K. Efects of crystal derived from Stevia rebaudiana leaves on Alloxan induced type-1 diabetic mice. Br J Pharm Res 2017; 17(2): 1-11.
[http://dx.doi.org/10.9734/BJPR/2017/33740]
[65]
Assaei R, Mokarram P, Dastghaib S, et al. Hypoglycemic effect of aquatic extract of stevia in pancreas of diabetic rats: PPARgamma-dependent regulation or antioxidant potential. Avicenna J Med Biotechnol 2016; 8(2): 65-74.
[PMID: 27141265]
[66]
Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004; 53(1): 73-6.
[http://dx.doi.org/10.1016/j.metabol.2003.07.013] [PMID: 14681845]
[67]
Bhasker S, Madhav H, Chinnamma M. Molecular evidence of insulinomimetic property exhibited by steviol and stevioside in diabetes induced L6 and 3T3L1 cells. Phytomedicine 2015; 22(11): 1037-44.
[http://dx.doi.org/10.1016/j.phymed.2015.07.007] [PMID: 26407946]
[68]
Boonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric 2013; 93(15): 3820-5.
[http://dx.doi.org/10.1002/jsfa.6287] [PMID: 23794454]
[69]
Tao Z, Shi A, Zhao J. Epidemiological perspectives of diabetes. Cell Biochem Biophys 2015; 73(1): 181-5.
[http://dx.doi.org/10.1007/s12013-015-0598-4] [PMID: 25711186]
[70]
Vaiserman A, Lushchak O. Developmental origins of type 2 diabetes: Focus on epigenetics. Ageing Res Rev 2019; 55: 100957.
[http://dx.doi.org/10.1016/j.arr.2019.100957] [PMID: 31473332]
[71]
Vaiserman A, Lushchak O. Prenatal malnutrition-induced epigenetic dysregulation as a risk factor for type 2 diabetes. Int J Genomics 2019; 2019: 1-11.
[http://dx.doi.org/10.1155/2019/3821409] [PMID: 30944826]
[72]
Jeppesen PB, Gregersen S, Rolfsen SED, et al. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism 2003; 52(3): 372-8.
[http://dx.doi.org/10.1053/meta.2003.50058] [PMID: 12647278]
[73]
Gogia A, Agarwal PK. Metabolic syndrome. Indian J Med Sci 2006; 60(2): 72-81.
[http://dx.doi.org/10.4103/0019-5359.19918] [PMID: 16505579]
[74]
Dutta P, Razu M, Alam M, Awal M, Mostofa M. Comparative efficacy of aqueous extract of Stevia Rebaudiana Bertoni) leaves and metformin hydrochloride (Comet®) in streptozotocin induced diabetes mellitus in rats. Int J Biol Res 2010; 2(8): 17-22.
[75]
Sumon MH, Mostofa M, Jahan MS, Kayesh MEH, Haque MA. Comparative efficacy of powdered form of stevia (Stevia rebaudiana leaves and glimepiride in induced diabetic rats. Bangladesh J Vet Med 1970; 6(2): 211-5.
[http://dx.doi.org/10.3329/bjvm.v6i2.2338]
[76]
Hossain MS, Alam MB, Asadujjaman M, Islam MM, Rahman MA, Islam MA. Antihyperglycemic and antihyperlipidemic effects of different fractions of Stevia rebaudiana leaves in alloxan induced diabetic rats. Int J Pharm Sci Res 2011; 2(7): 1722-9.
[77]
Sharma R, Yadav R, Manivannan E. Study of effect of Stevia rebaudiana bertoni on oxidative stress in type-2 diabetic rat models. Biomed Aging Pathol 2012; 2(3): 126-31.
[http://dx.doi.org/10.1016/j.biomag.2012.07.001]
[78]
Singh S, Garg V, Yadav D. Antihyperglycemic and antioxidative ability of Stevia rebaudiana (Bertoni) leaves in diabetes induced mice. Int J Pharm Pharm Sci 2013; 5(2): 297-302.
[79]
Aranda-González I, Barbosa-Martín E, Toraya-Avilés R, Segura-Campos M, Moguel-Ordoñez Y, Betancur-Ancona D. [Safety assessment of Stevia rebaudiana bertoni grown in southeastern Mexico as food sweetener]. Nutr Hosp 2014; 30(3): 594-601.
[PMID: 25238836]
[80]
Geuns JM, Buyse J, Vankeirsbilck A, Temme EH. Metabolism of stevioside by healthy subjects. Exp Biol Med (Maywood) 2007; 232(1): 164-73.
[PMID: 17202597]
[81]
Curi R, Alvarez M, Bazotte RB, Botion LM, Godoy JL, Bracht A. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Braz J Med Biol Res 1986; 19(6): 771-4.
[PMID: 3651629]
[82]
Anton SD, Martin CK, Han H, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite 2010; 55(1): 37-43.
[http://dx.doi.org/10.1016/j.appet.2010.03.009] [PMID: 20303371]
[83]
Maki KC, Curry LL, Reeves MS, et al. Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. Food Chem Toxicol 2008; 46(7) (Suppl. 7): S47-53. a
[http://dx.doi.org/10.1016/j.fct.2008.05.007] [PMID: 18555575]
[84]
Ritu M, Nandini J. Nutritional composition of Stevia rebaudiana, a sweet herb, and its hypoglycaemic and hypolipidaemic effect on patients with non-insulin dependent diabetes mellitus. J Sci Food Agric 2016; 96(12): 4231-4.
[http://dx.doi.org/10.1002/jsfa.7627] [PMID: 26781312]
[85]
Lohner S, Toews I, Meerpohl JJ. Health outcomes of non-nutritive sweeteners: Analysis of the research landscape. Nutr J 2017; 16(1): 55-76.
[http://dx.doi.org/10.1186/s12937-017-0278-x] [PMID: 28886707]
[86]
Urban JD, Carakostas MC, Taylor SL. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 2015; 75: 71-8.
[http://dx.doi.org/10.1016/j.fct.2014.11.011] [PMID: 25449199]
[87]
Planas GM, Kuć J. Contraceptive properties of Stevia rebaudiana. Science 1968; 162(3857): 1007.
[http://dx.doi.org/10.1126/science.162.3857.1007.a] [PMID: 5698837]
[88]
Roy BK, Kujur RS, Singh V, et al. Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacognosy Res 2010; 2(4): 258-63.
[http://dx.doi.org/10.4103/0974-8490.69128] [PMID: 21808578]
[89]
Nikiforov AI, Rihner MO, Eapen AK, Thomas JA. Metabolism and toxicity studies supporting the safety of rebaudioside D. Int J Toxicol 2013; 32(4): 261-73.
[http://dx.doi.org/10.1177/1091581813492828] [PMID: 23766392]
[90]
Uçar A, Yılmaz S, Yılmaz Ş, Kılıç MS. A research on the genotoxicity of stevia in human lymphocytes. Drug Chem Toxicol 2018; 41(2): 221-4.
[http://dx.doi.org/10.1080/01480545.2017.1349135] [PMID: 28738695]
[91]
Vargas Jentzsch P, Torrico-Vallejos S, Mendieta-Brito S, Ramos LA, Ciobotă V. Detection of counterfeit stevia products using a handheld Raman spectrometer. Vib Spectrosc 2016; 83: 126-31.
[http://dx.doi.org/10.1016/j.vibspec.2016.01.015]
[92]
Mathur S, Bulchandan N, Parihar S, Shekhawat GS. Critical review on steviol glycosides: pharmacological, toxicological and therapeutic aspects of high potency zero caloric sweetener. Int J Pharmacol 2017; 13(7): 916-28.
[http://dx.doi.org/10.3923/ijp.2017.916.928]
[93]
Zhang Q, Yang H, Li Y, Liu H, Jia X. Toxicological evaluation of ethanolic extract from Stevia rebaudiana Bertoni leaves: Genotoxicity and subchronic oral toxicity. Regul Toxicol Pharmacol 2017; 86: 253-9.
[http://dx.doi.org/10.1016/j.yrtph.2017.03.021] [PMID: 28351677]
[94]
Victoria AJ, Felix CO. Optimisation of wheat-sprouted soybean flour bread using response surface methodology. Afr J Biotechnol 2009; 8(22): 6364-73.
[http://dx.doi.org/10.5897/AJB09.707]
[95]
Chupeerach C, Yothakulsiri C, Chamchan R, et al. The efect of coconut jelly with natural sweeteners Stevia (Stevia rebaudiana Bertoni) replacement on blood glucose, insulin, and C-peptide responses. Recent Pat Food Nutr Agric 2018; 9(2): 127-33.
[http://dx.doi.org/10.2174/2212798410666180717163852] [PMID: 30019656]
[96]
A review on natural sweetener plant–Stevia having medicinal and commercial importance. Agronomski glasnik: Glasilo Hrvatskog agronomskog društva 2011; 73(1-2): 75-9.
[97]
Luo X, Arcot J, Gill T, Louie JCY, Rangan A. A review of food reformulation of baked products to reduce added sugar intake. Trends Food Sci Technol 2019; 86: 412-25.
[http://dx.doi.org/10.1016/j.tifs.2019.02.051]
[98]
Li XE, Lopetcharat K, Drake MA. Parents’ and children’s acceptance of skim chocolate milks sweetened by monk fruit and stevia leaf extracts. J Food Sci 2015; 80(5): S1083-92.
[http://dx.doi.org/10.1111/1750-3841.12835] [PMID: 25847181]
[99]
Lisak K, Jeličić I, Tratnik L, Božanić R. Influence of sweetener stevia on the quality of strawberry flavoured fresh yoghurt. Mljekarstvo 2011; 61(3): 220-5.
[100]
Góngora Salazar VA, Vázquez Encalada S, Corona Cruz A, Segura Campos MR. Stevia rebaudiana: A sweetener and potential bioactive ingredient in the development of functional cookies. J Funct Foods 2018; 44: 183-90.
[http://dx.doi.org/10.1016/j.jff.2018.03.007]
[101]
Vatankhah M, Garavand F, Mohammadi B, Elhamirad A. Quality attributes of reduced-sugar Iranian traditional sweet bread containing stevioside. J Food Meas Charact 2017; 11(3): 1233-9.
[http://dx.doi.org/10.1007/s11694-017-9500-y]
[102]
Ahouei MH, Pourahmad R, Moghari AA. Improvement of physical and sensory properties of whipping cream by replacing sucrose with rebaudioside A, isomalt and maltodextrin. Food Sci Technol (Campinas) 2019; 39(1): 170-5.
[http://dx.doi.org/10.1590/fst.41917]
[103]
M. Incorporation of bael (Aegle marmelos L.) pulp and stevia (Stevia rebaudiana) powder in value added sweet products. Curr J Appl Sci Technol 2019; 38(2): 1.
[104]
Parpinello GP, Versari A, Castellari M, Galassi S. Stevioside as a replacement of sucrose in peach juice: Sensory evaluation. J Sens Stud 2001; 16(5): 471-84.
[http://dx.doi.org/10.1111/j.1745-459X.2001.tb00314.x]
[105]
Šic Žlabur J, Dobričević N, Galić A, Pliestić S, Voća S. The influence of natural sweetener Stevia rebaudiana Bertoni) on bioactive compounds content in chokeberry juice. J Food Process Preserv 2018; 42(1): e13406.
[http://dx.doi.org/10.1111/jfpp.13406]
[106]
Andersen BV, Mielby LH, Viemose I, Bredie WLP, Hyldig G. Integration of the sensory experience and post-ingestive measures for understanding food satisfaction. A case study on sucrose replacement by Stevia rebaudiana and addition of beta glucan in fruit drinks. Food Qual Prefer 2017; 58: 76-84.
[http://dx.doi.org/10.1016/j.foodqual.2017.01.005]
[107]
Hossain F, Islam MT, Islam MA, Akhta S. Cultivation and uses of stevia (Stevia rebaudiana Bertoni): A review. Afr J Food Agric Nutr Dev 2017; 17(4): 12745-57.
[http://dx.doi.org/10.18697/ajfand.80.16595]
[108]
Hong J, Chen L, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside counteracts the α-cell hypersecretion caused by long-term palmitate exposure. Am J Physiol Endocrinol Metab 2006; 290(3): E416-22.
[http://dx.doi.org/10.1152/ajpendo.00331.2005] [PMID: 16204336]
[109]
Matsukubo T, Takazoe I. Sucrose substitutes and their role in caries prevention. Int Dent J 2006; 56(3): 119-30.
[http://dx.doi.org/10.1111/j.1875-595X.2006.tb00083.x] [PMID: 16826877]
[110]
Geuns JMC. Stevioside. Phytochemistry 2003; 64(5): 913-21.
[http://dx.doi.org/10.1016/S0031-9422(03)00426-6] [PMID: 14561506]
[111]
Jeppesen PB, Rolfsen SED, Agger A, et al. Can stevioside in combination with a soy-based dietary supplement be a new useful treatment of type 2 diabetes? An in vivo study in the diabetic goto-kakizaki rat. Rev Diabet Stud 2006; 3(4): 189-99.
[http://dx.doi.org/10.1900/RDS.2006.3.189] [PMID: 17487343]
[112]
Ruiz-Ruiz JC, Moguel-Ordoñez YB, Matus-Basto AJ, Segura-Campos MR. Antidiabetic and antioxidant activity of Stevia rebaudiana extracts (Var. Morita) and their incorporation into a potential functional bread. J Food Sci Technol 2015; 52(12): 7894-903.
[http://dx.doi.org/10.1007/s13197-015-1883-3] [PMID: 26604361]
[113]
Mayasari NR, Susetyowati , Wahyuningsih MSH, Probosuseno . Antidiabetic efect of Rosella-Stevia tea on prediabetic women in Yogyakarta, Indonesia. J Am Coll Nutr 2018; 37(5): 1-7.
[http://dx.doi.org/10.1080/07315724.2017.1400927] [PMID: 29425471]
[114]
Mohd-Radzman NH, Ismail WIW, Adam Z, Jaapar SS, Adam A. Potential Roles of Stevia rebaudiana Bertoni in abrogating insulin resistance and diabetes: A review. Evid Based Complement Alternat Med 2013; 2013: 1-10.
[http://dx.doi.org/10.1155/2013/718049] [PMID: 24324517]
[115]
Chowdhury AI, Rahanur Alam M, Raihan MM, Rahman T, Islam S, Halima O. Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta‐analysis of preclinical studies. Food Sci Nutr 2022; 10(9): 2868-78.
[http://dx.doi.org/10.1002/fsn3.2904] [PMID: 36171777]

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