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Research Article

Intestinal Anti-inflammatory Effects of Linum usitatissimum Alkaloid on Experimental Ulcerative Colitis in BALB/c Mice

Author(s): Noureddine Bribi*, Mohamed Sofiane Merakeb and Hania Boudaoud-Ouahmed

Volume 19, Issue 8, 2023

Published on: 15 May, 2023

Article ID: e170423215930 Pages: 6

DOI: 10.2174/1573407219666230417112912

Price: $65

Abstract

Introduction: There is growing interest in alternative therapies for managing inflammatory bowel disorders (IBD) that offer efficacy and a suitable safety profile. The present study aimed to evaluate the intestinal anti-inflammatory effect of the alkaloid extract of Linum usitatissimum (ALU) on the acetic acid (AA) experimental model of colitis.

Methods: For in vivo experiments, an 8-day 5% acetic acid administration protocol was used in BALB/c mice to induce colitis. The intestinal anti-inflammatory effect of oral ALU (12.5, 25, and 50mg/kg) was evaluated after 8 days. Colon damage was evaluated macroscopically (colon weight/ colon length), and the histological alterations were also assessed.

Results: ALU treatment significantly reduced signs of intestinal inflammation compared to the Acetic acid control mice, confirmed by histological examination.

Conclusion: These results suggest that the total alkaloid extract from Linum usitatissimum seeds has potent intestinal anti-inflammatory properties and may be a promising treatment for ulcerative colitis.

Graphical Abstract

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