Clinical Case of a Combination of Endocrine, Metabolic, and Mental
Pathologies: Hypopituitarism Associated with Organic Personality Disorder

Basheer   Abdullah   Marzoog

doi:10.2174/0250688204666230417092226

Abstract

Background: Psychiatric disorders are difficult to assess, diagnose, and treat in most cases. The present case describes an extremely rare psychological disorder in combination with metabolic and endocrine insufficiency.

Case Presentation: The condition of a 7-year-old child with inherited psychopathology from his father was found to be aggravated by his mother's alcoholism. The child was delivered in emergency from a primigravida/primipara mother due to preeclampsia and premature membrane rupture. The examinations involved clinical signs and symptoms and instrumental and laboratory findings. All laboratory results were compared with the normal range of the local laboratory. The results of the examination showed pronounced impairment in learning and controlling behavior, and communication, as well as moderate impairment in orientation.

Disscussion: The future consequences and complications are poorly understood. Management guidelines for such complicated cases are underdeveloped.

Conclusion: The child was managed by diet correction, potassium iodide and hormone replacement therapy, calcium supplement, nootropics with 2 courses per year, examination by a urologist and pediatric endocrinologist 2 times a year, and hospitalization after 6 months of treatment.

[1]
Butler C, Zeman AZ. Neurological syndromes which can be mistaken for psychiatric conditions. J Neurol Neurosurg Psychiatry  2005; 76(Suppl 1): i31-8.
 [http://dx.doi.org/10.1136/jnnp.2004.060459] [PMID: 15718219]

[2]
Yu JY, Pearl PL. Metabolic causes of epileptic encephalopathy. Epilepsy Res Treat  2013; 2013: 1-20.
 [http://dx.doi.org/10.1155/2013/124934] [PMID: 23762547]

[3]
Stepien KM. Hormonal dysfunction in adult patients affected with inherited metabolic disorders. J Mother Child  2020; 24(2): 21-31.

[4]
Welte-Santana CA, Macedo de Queiroz AF, Merola Fontoura N, et al. Atypical cognitive dysfunction due to brain damage: A case report. Eur Psychiatry  2016; 33(S1): S536-6.
 [http://dx.doi.org/10.1016/j.eurpsy.2016.01.1984]

[5]
Ghosh A. Endocrine, metabolic, nutritional, and toxic disorders leading to dementia. Ann Indian Acad Neurol  2010; 13(6): 63.
 [http://dx.doi.org/10.4103/0972-2327.74247] [PMID: 21369420]

[6]
Reblin M, Uchino BN. Social and emotional support and its implication for health. Curr Opin Psychiatry  2008; 21(2): 201-5.
 [http://dx.doi.org/10.1097/YCO.0b013e3282f3ad89] [PMID: 18332671]

[7]
Ngai SS, Cheung CK, Mo J, et al. Mediating effects of emotional support reception and provision on the relationship between group interaction and psychological well-being: A study of young patients. Int J Environ Res Public Health  2021; 18(22): 12110.
 [http://dx.doi.org/10.3390/ijerph182212110] [PMID: 34831863]

[8]
Hopkins SE, Somoza A, Gilbert DL. Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine disease. J Child Neurol  2010; 25(6): 752-6.
 [http://dx.doi.org/10.1177/0883073809343313] [PMID: 19815814]

[9]
Massin P, Dubois-Laforgue D, Meas T, et al. Retinal and renal complications in patients with a mutation of mitochondrial DNA at position 3,243 (maternally inherited diabetes and deafness). A case–control study. Diabetologia  2008; 51(9): 1664-70.
 [http://dx.doi.org/10.1007/s00125-008-1073-1] [PMID: 18581092]

[10]
Bruno C, Minetti C, Tang Y, et al. Primary adrenal insufficiency in a child with a mitochondrial DNA deletion. J Inherit Metab Dis  1998; 21(2): 155-61.
 [http://dx.doi.org/10.1023/A:1005347826664] [PMID: 9584267]

[11]
Coman D, McGill J, MacDonald R, et al. Congenital disorder of glycosylation type 1a: Three siblings with a mild neurological phenotype. J Clin Neurosci  2007; 14(7): 668-72.
 [http://dx.doi.org/10.1016/j.jocn.2006.04.008] [PMID: 17451957]

[12]
Kristiansson B, Stibler H, Wide L. Gonadal function and glycoprotein hormones in the carbohydrate-deficient glycoprotein (CDG) syndrome. Acta Paediatr  1995; 84(6): 655-9.
 [http://dx.doi.org/10.1111/j.1651-2227.1995.tb13720.x] [PMID: 7670249]

[13]
Valenti L, Varenna M, Fracanzani AL, Rossi V, Fargion S, Sinigaglia L. Association between iron overload and osteoporosis in patients with hereditary hemochromatosis. Osteoporos Int  2009; 20(4): 549-55.
 [http://dx.doi.org/10.1007/s00198-008-0701-4] [PMID: 18661088]

[14]
McDermott JH, Walsh CH. Hypogonadism in hereditary hemochromatosis. J Clin Endocrinol Metab  2005; 90(4): 2451-5.
 [http://dx.doi.org/10.1210/jc.2004-0980] [PMID: 15657376]

[15]
Gordon CM, Ackerman KE, Berga SL, et al. Functional hypothalamic amenorrhea: An endocrine society clinical practice guideline. J Clin Endocrinol Metab  2017; 102(5): 1413-39.
 [http://dx.doi.org/10.1210/jc.2017-00131] [PMID: 28368518]

[16]
Guyatt GH, Schünemann HJ, Djulbegovic B, Akl EA. Guideline panels should not GRADE good practice statements. J Clin Epidemiol  2015; 68(5): 597-600.
 [http://dx.doi.org/10.1016/j.jclinepi.2014.12.011] [PMID: 25660962]

Rights & Permissions Print Cite

Journal Information

For Authors

For Editors

For Reviewers

Explore Articles

For Visitors

DOI https://dx.doi.org/10.2174/0250688204666230417092226	Print ISSN 0250-6882
Publisher Name Bentham Science Publisher	Online ISSN 0250-6882

New Emirates Medical Journal

Clinical Case of a Combination of Endocrine, Metabolic, and Mental Pathologies: Hypopituitarism Associated with Organic Personality Disorder

Abstract Play Pause

Related Journals

Related Books

Abstract