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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Mini-Review Article

Guggul: Potency and Mechanistic Insight for Tremendous Therapeutic Benefit

Author(s): Shikha Srivastava*

Volume 10, Issue 3, 2024

Published on: 18 May, 2023

Article ID: e130423215759 Pages: 9

DOI: 10.2174/2215083810666230413094344

Price: $65

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Abstract

Commiphoramukul being a treasure to phytochemicals, are of great medicinal value. The plant, composed of flavonoids, phytosterols and terpenes, possesses antimicrobial, antiinflammatory, antioxidant and anticancerous properties with wide therapeutic activities. The active ingredient in plants include ketosteroids, E and Z guggulsterone, ellagic acid, myrrhanols B, myrrhanonesA, myrrhanoes B, guggulsterone-I, guggulsterone-II, guggulsterone-III. Various phytochemicals in plants play a very vital role in treating acute to chronic diseases, such as rheumatoid arthritis, atherosclerosis, inflammatory gastric disorders, hyperlipidemia, cancer, ageing, and for cosmetic purposes too. The present chapter aims to update mankind with the profound phytochemical constituents present in plants and their pharmacological application.

[1]
Tomar R, Kaur G, Sannd R, Singh H, Sarkar B. A review on guggulu formulations used in Ayurveda. Annals Ayurvedic Med 2014; 3: 96-113.
[2]
Sastry VV. History of Guggulu based on Ayurvedic literature. Bull Indian Inst Hist Med Hyderabad 1976; 6(2): 102-16.
[PMID: 11610476]
[3]
Bhatia A, Bharti SK, Tripathi T, et al. Metabolic profiling of Commiphora wightii (guggul) reveals a potential source for pharmaceuticals and nutraceuticals. Phytochemistry 2015; 110: 29-36.
[http://dx.doi.org/10.1016/j.phytochem.2014.12.016] [PMID: 25561401]
[4]
Ansari SH, Bhatt D. A concise test book of Pharmacognossy Birla Publications. 2016; pp. 126-7. Available from: https://www.researchgate.net/scientific-contributions/SH-Ansari-2006964207
[5]
Verma R, Jakhar ML, Kumar R, Nath A. In vitro propagation of medicinal plant Guggul: A review. J Pharmacogn Phytochem 2017; 6(4): 559-63.
[6]
Sarup P, Bala S, Kamboj S. Pharmacology and phytochemistry of oleo-gum resin of Commiphorawightii (Guggulu). Scientifica 2015; 2015: 138039.
[http://dx.doi.org/10.1155/2015/138039] [PMID: 26587309]
[7]
Ulbricht C, Basch E, Szapary P, et al. Guggul for hyperlipidemia: A review by the Natural Standard Research Collaboration. Complement Ther Med 2005; 13(4): 279-90.
[http://dx.doi.org/10.1016/j.ctim.2005.08.003] [PMID: 16338199]
[8]
Jasuja N D, Choudhary J, Sharma P, Sharma N, Joshi S C. A review on bioactive compounds and medicinal uses of Commiphoramukul. J Plant Sci 2012; 7(4): 113-37.
[9]
Sharma B, Salunke R, Srivastava S, Majumder C, Roy P. Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol 2009; 47(10): 2631-9.
[http://dx.doi.org/10.1016/j.fct.2009.07.021] [PMID: 19635521]
[10]
Manchope MF, Casagrande R, Verri WA Jr. Naringenin: An analgesic and anti-inflammatory citrus flavanone. Oncotarget 2017; 8(3): 3766-7.
[http://dx.doi.org/10.18632/oncotarget.14084] [PMID: 28030851]
[11]
Wang J, Xing H, Qin X, Ren Q, Yang J, Li L. Pharmacological effects and mechanisms of muscone. J Ethnopharmacol 2020; 262: 113120.
[http://dx.doi.org/10.1016/j.jep.2020.113120] [PMID: 32668321]
[12]
Vayalil PK, Kuttan G, Kuttan R. Rasayanas: Evidence for the concept of prevention of diseases. Am J Chin Med 2002; 30(1): 155-71.
[http://dx.doi.org/10.1142/S0192415X02000168] [PMID: 12067090]
[13]
Shishodia S, Azu N, Rosenzweig JA, Jackson DA. Guggulsterone for chemoprevention of cancer. Curr Pharm Des 2016; 22(3): 294-306.
[http://dx.doi.org/10.2174/1381612822666151112153117] [PMID: 26561056]
[14]
Macha MA, Matta A, Chauhan SS, Siu KWM, Ralhan R. 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells. BMC Cancer 2010; 10(1): 655.
[http://dx.doi.org/10.1186/1471-2407-10-655] [PMID: 21118500]
[15]
Bhat AA, Prabhu KS, Kuttikrishnan S, et al. Potential therapeutic targets of Guggulsterone in cancer. Nutr Metab 2017; 14(1): 23.
[http://dx.doi.org/10.1186/s12986-017-0180-8] [PMID: 28261317]
[16]
Yamada T, Sugimoto K. Guggulsterone and its role in chronic diseases. Drug Discovery from Mother Nature. Cham: Springer 2016; pp. 329-61.
[http://dx.doi.org/10.1007/978-3-319-41342-6_15]
[17]
Panda S, Kar A. Gugulu (Commiphora mukul) induces triiodothyronine production: Possible involvement of lipid peroxidation. Life Sci 1999; 65(12): PL137-41.
[http://dx.doi.org/10.1016/S0024-3205(99)00369-0] [PMID: 10503949]
[18]
Chander R, Rizvi F, Khanna AK, Pratap R. Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study. Indian J Clin Biochem 2003; 18(2): 71-9.
[http://dx.doi.org/10.1007/BF02867370] [PMID: 23105395]
[19]
Magin PJ, Adams J, Pond CD, Smith W. Topical and oral CAM in acne: A review of the empirical evidence and a consideration of its context. Complement Ther Med 2006; 14(1): 62-76.
[http://dx.doi.org/10.1016/j.ctim.2005.10.007] [PMID: 16473756]
[20]
Thappa DM, Dogra J. Nodulocystic acne: Oral gugulipid versus tetracycline. J Dermatol 1994; 21(10): 729-31.
[http://dx.doi.org/10.1111/j.1346-8138.1994.tb03277.x] [PMID: 7798429]
[21]
Siddiqui MZ, Thomas M, Prasad N. Physicochemical characterization and antioxidant activity of essential oils of guggul (Commiphora wightii) collected from Madhya Pradesh. Indian J Pharm Sci 2013; 75(3): 368-72.
[http://dx.doi.org/10.4103/0250-474X.117422] [PMID: 24082356]
[22]
Kunnumakkara AB, Banik K, Bordoloi D, et al. Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases. Front Pharmacol 2018; 9: 686.
[http://dx.doi.org/10.3389/fphar.2018.00686] [PMID: 30127736]
[23]
El-Mekkawy S, Meselhy MR, Nkobole N, Lall N. Three new α-glucosidase inhibitors from guggul, the oleogum resin of Commiphora wightii. Nat Prod Res 2013; 27(2): 146-54.
[http://dx.doi.org/10.1080/14786419.2012.662651] [PMID: 22376270]
[24]
Sotoudeh R, Hadjzadeh MA, Gholamnezhad Z, Aghaei A. The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats. Avicenna J Phytomed 2019; 9(5): 454-64.
[PMID: 31516859]
[25]
Khan MB, Chavan R, Sathe N. Commiphora mukul Engl.–“Divya”: A Review. Ayurlog. Nat J Res Ayurved Sci 2015; 3(2): 1-12.
[26]
Rout OP, Acharya R, Mishra SK. Oleogum resin Guggulu: A review of the medicinal evidence for its therapeutic properties. Int J Res Ayurveda Pharm 2012; 3: 15-21.
[27]
Preethi L, Ganamurali N, Dhanasekaran D, Sabarathinam S. Therapeutic use of Guggulsterone in COVID-19 induced obesity (COVIBESITY) and significant role in immunomodulatory effect. Obes Med 2021; 24: 100346.
[http://dx.doi.org/10.1016/j.obmed.2021.100346] [PMID: 33942025]
[28]
Gulati K, Ray A, Debnath PK, Bhattacharya SK. Immunomodulatory Indian medicinal plants. J Nat Rem 2002; 2(2): 121-31.
[29]
De León EJ, Olmedo DA, Solís PN, Gupta MP, Terencio MC. Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo. Planta Med 2002; 68(12): 1128-31.
[http://dx.doi.org/10.1055/s-2002-36355] [PMID: 12494343]
[30]
Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes. J Med Food 2009; 12(4): 846-53.
[http://dx.doi.org/10.1089/jmf.2008.0158] [PMID: 19735186]
[31]
(a) Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J American Acad Dermatol 2017; 52(3): 533-4.;
(b) Rastogi S. Urticarial rashes following guggulu intake: A case report. J Ayurveda Integr Med 2017; 8(3): 205-6.
[32]
Deng R. Therapeutic effects of guggul and its constituent guggulsterone: Cardiovascular benefits. Cardiovasc Drug Rev 2007; 0(0): 071116234914002.
[http://dx.doi.org/10.1111/j.1527-3466.2007.00023.x] [PMID: 18078436]
[33]
Saeed MA, Sabir AW. Irritant potential of some constituents from oleo-gum-resin of Commiphora myrrha. Fitoterapia 2004; 75(1): 81-4.
[http://dx.doi.org/10.1016/j.fitote.2003.08.010] [PMID: 14693226]
[34]
Soni V, Swarnkar PL, Tyagi V, Pareek LK. Variation in E- and Z-guggulsterones of Commiphora wightii. S Afr J Bot 2010; 76(3): 421-4.
[http://dx.doi.org/10.1016/j.sajb.2009.10.004]
[35]
Taru P, Abhyankar M, Undale V, Bhosale A. Acute and subacute toxicity studies on Shodhana processed guggul. Int J Pharm Sci Res 2013; 4: 796-9.
[36]
Dave V, Yadav R B, Gupta S. Formulation and evaluation of orally dispersible tablets of Chlorpheniramine Maleate by fusion method. Marmara Pharmaceut J 2017; 21(1): 67-77.
[37]
Gaur PK, Mishra S, Purohit S. Solid lipid nanoparticles of guggul lipid as drug carrier for transdermal drug delivery. Bio Med Res Int 2013; 2013: 750690.
[http://dx.doi.org/10.1155/2013/750690] [PMID: 24058913]
[38]
Kaur MT, Bhise KS. Formulation design and evaluation of anti-inflammatory activity of Commiphora mukul loaded emulgel. J Res Educ Indian Med 2014; 20(2): 75-87.

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