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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Assessment of Thyroid Function in Patients with Rheumatoid Arthritis in Kunming, China: A Case-control Study

Author(s): Fang He, Fayou Li, Dachen Zuo, Sha Ma, Yang Chen, Jihui Ying and Lixuan Zhu*

Volume 20, 2024

Published on: 24 May, 2023

Article ID: e050423215448 Pages: 6

DOI: 10.2174/1573405620666230405092350

Price: $65

Abstract

Introduction: The present study aimed to analyze the prevalence of hypothyroidism in patients with rheumatoid arthritis (RA). In addition, the study aimed to elucidate the correlation of hypothyroidism with RA activity and to investigate the relationship between RA and thyroid dysfunction.

Materials and Methods: A total of 314 patients were categorized into two groups according to thyroid stimulating hormone (TSH) level: RA without hypothyroidism and RA with hypothyroidism. All patients underwent routine laboratory investigation, including thyroid function testing, and complete clinical assessment. These included the determination of the erythrocyte sedimentation rate as well as the level of TSH, free triiodothyronine, free thyroxine, total triiodothyronine level, total thyroxine level, C-reactive protein, rheumatoid factor immunoglobulin (RF-Ig), RF-IgA, RF-IgG, RFIgM, cyclic citrullinated peptide immunoglobulin G (CCP IgG), complement component 3, and complement component 4. Based on these data, thyroid function, and rheumatoid factor levels were analyzed.

Results and Discussion: Curve estimation using linear regression revealed that CCP Ig level was significantly correlated with the TSH level (r = 0.122, P = 0.031).

Conclusion: TSH level may be used as an auxiliary test to assess disease severity in patients with RA and to evaluate thyroid function. This evaluation parameter may be considered for determining clinical prognosis in patients with RA.

[1]
Arthritis HoHR.. National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2014.
[2]
Majithia V, Geraci SA. Rheumatoid arthritis: Diagnosis and management. Am J Med 2007; 120(11): 936-9.
[http://dx.doi.org/10.1016/j.amjmed.2007.04.005] [PMID: 17976416]
[3]
Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet 2010; 376(9746): 1094-108.
[http://dx.doi.org/10.1016/S0140-6736(10)60826-4] [PMID: 20870100]
[4]
Fang L. Their Mutual 2010 American College of Rheumatology classification criteria of rheumatoid arthritis joint European League Against Rheumatism Interpretation. Diagnosis Theory and Practice 2010; 9(4): 307-10.
[5]
O’Dell JR. Therapeutic strategies for rheumatoid arthritis. N Engl J Med 2004; 350(25): 2591-602.
[http://dx.doi.org/10.1056/NEJMra040226] [PMID: 15201416]
[6]
Tunbridge WMG, Vanderpump MPJ. Population screening for autoimmune thyroid disease. Endocrinol Metab Clin North Am 2000; 29(2): 239-53.
[http://dx.doi.org/10.1016/S0889-8529(05)70129-8] [PMID: 10874527]
[7]
Porkodi RRS, Maheshk A, Kanakarani P, Rukmangathrajan S, Rajedran C. Thyroid dysfunction in systemic lupus erythematosus and rheumatoid arthritis. Indian J Rheumatol 2004; 12: 88-97.
[8]
Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: An american college of rheumatology/european league against rheumatism collaborative initiative. Ann Rheum Dis 2010; 69(9): 1580-8.
[http://dx.doi.org/10.1136/ard.2010.138461] [PMID: 20699241]
[9]
Handout on Health: Rheumatoid Arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases 2014.
[10]
Conigliaro P, D’Antonio A, Pinto S, et al. Autoimmune thyroid disorders and rheumatoid arthritis: A bidirectional interplay. Autoimmun Rev 2020; 19(6): 102529.
[http://dx.doi.org/10.1016/j.autrev.2020.102529] [PMID: 32234405]
[11]
Andonopoulos AP, Siambi V, Makri M, Christofidou M, Markou C, Vagenakis AG. Thyroid function and immune profile in rheumatoid arthritis. A controlled study. Clin Rheumatol 1996; 15(6): 599-603.
[http://dx.doi.org/10.1007/BF02238551] [PMID: 8973871]
[12]
Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis 2002; 61(1): 70-2.
[http://dx.doi.org/10.1136/ard.61.1.70] [PMID: 11779764]
[13]
de Carvalho JF, Pereira RM, Shoenfeld Y. The mosaic of autoimmunity: The role of environmental factors. Front Biosci 2009; 1(2): 501-9.
[PMID: 19482664]
[14]
Xu Y, Graves PN, Tomer Y, Davies TF. CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4. Cell Immunol 2002; 215(2): 133-40.
[http://dx.doi.org/10.1016/S0008-8749(02)00018-7] [PMID: 12202150]
[15]
Tagoe CE, Zezon A, Khattri S, Castellanos P. Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients. Rheumatol Int 2013; 33(7): 1745-52.
[http://dx.doi.org/10.1007/s00296-012-2616-9] [PMID: 23292189]
[16]
Raterman HG, van Halm VP, Voskuyl AE, Simsek S, Dijkmans B A C, Nurmohamed MT. Rheumatoid arthritis is associated with a high prevalence of hypothyroidism that amplifies its cardiovascular risk. Ann Rheum Dis 2008; 67(2): 229-32.
[http://dx.doi.org/10.1136/ard.2006.068130] [PMID: 17557891]
[17]
Elmaadawy SA, Ghitany MK, Soliman EA, Bondok ME. Autoimmune thyroid disorders in seropositive versus seronegative rheumatoid arthritis. Egypt J Obes Diabetes Endocrinol 2015; 1(1): 53-63.
[http://dx.doi.org/10.4103/2356-8062.159997]
[18]
Staykova ND. Rheumatoid arthritis and thyroid abnormalities. Folia Med 2007; 49(3-4): 5-12.
[PMID: 18504927]
[19]
Shiroky JB, Cohen M, Ballachey ML, Neville C. Thyroid dysfunction in rheumatoid arthritis: A controlled prospective survey. Ann Rheum Dis 1993; 52(6): 454-6.
[http://dx.doi.org/10.1136/ard.52.6.454] [PMID: 8323398]
[20]
Atzeni F, Atzeni F, Doria A, et al. Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value. Autoimmunity 2008; 41(1): 111-5.
[http://dx.doi.org/10.1080/08916930701620100] [PMID: 18176873]
[21]
Han S, Li Y, Mao Y, Xie Y. Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis. Hum Genet 2005; 118(1): 123-32.
[http://dx.doi.org/10.1007/s00439-005-0033-9] [PMID: 16133179]
[22]
Anoop J, Geetha F, Jyothi I, Rekha P, Shobha V. Unravelling thyroid dysfunction in rheumatoid arthritis: History matters. Int J Rheum Dis 2018; 21(3): 688-92.
[http://dx.doi.org/10.1111/1756-185X.13040] [PMID: 28217973]
[23]
Kochi Y, Suzuki A, Yamada R, Yamamoto K. Ethnogenetic heterogeneity of rheumatoid arthritis—implications for pathogenesis. Nat Rev Rheumatol 2010; 6(5): 290-5.
[http://dx.doi.org/10.1038/nrrheum.2010.23] [PMID: 20234359]
[24]
Mäurer M, Loserth S, Kolb-Mäurer A, et al. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics 2002; 54(1): 1-8.
[http://dx.doi.org/10.1007/s00251-002-0429-9] [PMID: 11976786]
[25]
Anjos S, Nguyen A, Ounissi-Benkalha H, Tessier MC, Polychronakos C. A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J Biol Chem 2002; 277(48): 46478-86.
[http://dx.doi.org/10.1074/jbc.M206894200] [PMID: 12244107]

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