Recent Advances in the Synthesis of Nitrogen Heterocycles Using β-Nitrostyrenes as
Substrates

Chunmei      Li; Xiang      Zhou; Furen      Zhang; Zhenlu      Shen
doi:10.2174/1385272827666230329104528
Abstract

The exploration of synthetic methodologies that allow rapid access to a wide variety of N-heterocycles is of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space and drives more efficient drug discovery programs. β-Nitrostyrenes, as unique active intermediates, have been widely applied in synthetic organic chemistry because of their versatile utility as pharmaceutical agents and agrochemicals. In this review, we summarize the recent development and application of the elegant and efficient methods that enable the concise synthesis of N-heterocycles from β-nitrostyrenes and various partners in a step- and atom-economic manner, including cascade reactions, C-H activation, regio- and stereoselective syntheses, as well as other novel syntheses, which will potentially provide useful insights for further exploring and designing novel reactions.
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DOI https://dx.doi.org/10.2174/1385272827666230329104528	Print ISSN 1385-2728
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Current Organic Chemistry

Recent Advances in the Synthesis of Nitrogen Heterocycles Using β-Nitrostyrenes as Substrates

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

Recent Advances in the Synthesis of Nitrogen Heterocycles Using β-Nitrostyrenes as Substrates

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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