Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Intravoxel Incoherent Motion Diffusion-weighted MRI Assessing the Effect of the Vascular Disrupting Agent CA4P on VX2 Liver Tumors in Rabbits

Author(s): Ting Qian*, Rong Yang*, Yuzhe Wang* and Qingqing Duan

Volume 20, 2024

Published on: 27 April, 2023

Article ID: e060323214365 Pages: 9

DOI: 10.2174/1573405619666230306110835

open_access

Abstract

Objective: This study aimed to assess the response of combretastatin-A4-phosphate (CA4P) in rabbit VX2 liver tumors using intravoxel incoherent motion diffusion-weighted MRI (IVIM DW-MRI).

Methods: Forty rabbits with implanted VX2 liver tumors underwent baseline MRI and were then given 10 mg/kg CA4P (n=20) or saline (n=20). After 4 h, 10 rabbits from each group underwent an MRI examination and were then sacrificed. The remaining rabbits underwent MRI after 1, 3, and 7 days and were then sacrificed. Liver samples were processed for H&E and immunohistochemical staining. IVIM parameters (D, f, D*) were compared in the treatment and control groups, and the correlations of IVIM parameters with microvascular density (MVD) were determined.

Results: At 4 h, the two treatment groups had significantly different f and D* values (p<0.001), and these values were at their minimum in the treatment group. The treatment group had moderate correlations between MVD and f at 4 h (r=0.676, p=0.032) and 7 days (r=0.656, p=0.039) and with D* at 4 h (r=0.732, p=0.016) and 7 days (r=0.748, p=0.013), but no correlation was reported between MVD and f or D* in the control group (all P>0.05).

Conclusion: IVIM DW-MRI is a sensitive imaging technique. It successfully evaluated the effect of CA4P on VX2 liver tumors in rabbits. The f and D* values correlated with MVD at 4 h and 7 days after using CA4P, indicating that these parameters have the potential to be used as indicators of tumor angiogenesis after treatment.

[1]
Öz A, Server S, Koyuncu Sökmen B, Namal E, İnan N, Balcı NC. Intravoxel incoherent motion of colon cancer liver metastases for the assessment of response to antiangiogenic treatment: Results from a pilot study. Med Princ Pract 2020; 29(5): 429-35.
[http://dx.doi.org/10.1159/000505814] [PMID: 31914438]
[2]
Abou Elkassem AM, Lo SS, Gunn AJ, et al. Role of imaging in renal cell carcinoma: A multidisciplinary perspective. Radiographics 2021; 41(5): 1387-407.
[http://dx.doi.org/10.1148/rg.2021200202] [PMID: 34270355]
[3]
Chen J, Qian T, Zhang H, Wei C, Meng F, Yin H. Combining dynamic contrast enhanced magnetic resonance imaging and microvessel density to assess the angiogenesis after PEI in a rabbit VX2 liver tumor model. Magn Reson Imaging 2016; 34(2): 177-82.
[http://dx.doi.org/10.1016/j.mri.2015.10.013] [PMID: 26518059]
[4]
Qian T, Chen M, Gao F, Meng F, Gao X, Yin H. Diffusion-weighted magnetic resonance imaging to evaluate microvascular density after transarterial embolization ablation in a rabbit VX2 liver tumor model. Magn Reson Imaging 2014; 32(8): 1052-7.
[http://dx.doi.org/10.1016/j.mri.2014.05.011] [PMID: 24970024]
[5]
Shi Y, Oeh J, Hitz A, et al. Monitoring and targeting Anti-VEGF induced hypoxia within the viable tumor by 19 F–MRI and multispectral analysis. Neoplasia 2017; 19(11): 950-9.
[http://dx.doi.org/10.1016/j.neo.2017.07.010] [PMID: 28987998]
[6]
Feraco P, Scartoni D, Porretti G, et al. Predict treatment response by magnetic resonance diffusion weighted imaging: A preliminary study on 46 meningiomas treated with proton-therapy. Diagnostics 2021; 11(9): 1684.
[http://dx.doi.org/10.3390/diagnostics11091684] [PMID: 34574025]
[7]
Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988; 168(2): 497-505.
[http://dx.doi.org/10.1148/radiology.168.2.3393671] [PMID: 3393671]
[8]
Le Bihan DJ. Differentiation of benign versus pathologic compression fractures with diffusion-weighted MR imaging: A closer step toward the "holy grail" of tissue characterization? Radiology 1998; 207(2): 305-7.
[9]
Lee HJ, Rha SY, Chung YE, et al. Tumor perfusion-related parameter of diffusion-weighted magnetic resonance imaging: Correlation with histological microvessel density. Magn Reson Med 2014; 71(4): 1554-8.
[http://dx.doi.org/10.1002/mrm.24810] [PMID: 23798038]
[10]
Dolciami M, Capuani S, Celli V, et al. Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary study on assessment of tumor aggressiveness and response to neoadjuvant chemotherapy. J Pers Med 2022; 12(4): 638.
[http://dx.doi.org/10.3390/jpm12040638] [PMID: 35455755]
[11]
Joo I, Lee JM, Han JK, Choi BI. Intravoxel incoherent motion diffusion-weighted MR imaging for monitoring the therapeutic efficacy of the vascular disrupting agent CKD-516 in rabbit VX2 liver tumors. Radiology 2014; 272(2): 417-26.
[http://dx.doi.org/10.1148/radiol.14131165] [PMID: 24697148]
[12]
Xiao-ping Y, Jing H, Fei-ping L, et al. Intravoxel incoherent motion MRI for predicting early response to induction chemotherapy and chemoradiotherapy in patients with nasopharyngeal carcinoma. J Magn Reson Imaging 2016; 43(5): 1179-90.
[http://dx.doi.org/10.1002/jmri.25075] [PMID: 26540374]
[13]
Karayama M, Yoshizawa N, Sugiyama M, et al. Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer. Lung Cancer 2020; 143: 47-54.
[http://dx.doi.org/10.1016/j.lungcan.2020.03.013] [PMID: 32203770]
[14]
Garon EB, Neidhart JD, Gabrail NY, de Oliveira MR, Balkissoon J, Kabbinavar F. A randomized Phase II trial of the tumor vascular disrupting agent CA4P (fosbretabulin tromethamine) with carboplatin, paclitaxel, and bevacizumab in advanced nonsquamous non-small-cell lung cancer. OncoTargets Ther 2016; 9: 7275-83.
[http://dx.doi.org/10.2147/OTT.S109186] [PMID: 27942221]
[15]
Zweifel M, Jayson GC, Reed NS, et al. Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol 2011; 22(9): 2036-41.
[http://dx.doi.org/10.1093/annonc/mdq708] [PMID: 21273348]
[16]
Shi C, Liu D, Xiao Z, et al. Monitoring tumor response to antivascular therapy using non-contrast intravoxel incoherent motion diffusion-weighted MRI. Cancer research 2017; 77(13): 3491-501.
[http://dx.doi.org/10.1158/0008-5472.CAN-16-2499]
[17]
Cheng J, Wang Y, Zhang CF, et al. Chemotherapy response evaluation in a mouse model of gastric cancer using intravoxel incoherent motion diffusion-weighted MRI and histopathology. World J Gastroenterol 2017; 23(11): 1990-2001.
[http://dx.doi.org/10.3748/wjg.v23.i11.1990] [PMID: 28373765]
[18]
Liu Y, De Keyzer F, Wang Y, et al. The first study on therapeutic efficacies of a vascular disrupting agent CA4P among primary hepatocellular carcinomas with a full spectrum of differentiation and vascularity: Correlation of MRI-microangiography-histopathology in rats. Int J Cancer 2018; 143(7): 1817-28.
[http://dx.doi.org/10.1002/ijc.31567] [PMID: 29707770]
[19]
Liu Y, Guan Q, Kong X, et al. Predicting therapeutic efficacy of vascular disrupting agent CA4P in rats with liver tumors by hepatobiliary contrast agent Mn-DPDP-enhanced MRI. Transl Oncol 2020; 13(1): 92-101.
[http://dx.doi.org/10.1016/j.tranon.2019.09.010] [PMID: 31810003]
[20]
Shao H, Ni Y, Zhang J, et al. Dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging noninvasive evaluation of vascular disrupting treatment on rabbit liver tumors. PLoS One 2013; 8(12): e82649.
[http://dx.doi.org/10.1371/journal.pone.0082649] [PMID: 24376560]
[21]
Shao H, Ni Y, Dai X, et al. Diffusion-weighted MR imaging allows monitoring the effect of combretastatin A4 phosphate on rabbit implanted VX2 tumor model: 12-Day dynamic results. Eur J Radiol 2012; 81(3): 578-83.
[http://dx.doi.org/10.1016/j.ejrad.2011.03.009] [PMID: 21454029]
[22]
Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 1995; 36(2): 169-80.
[http://dx.doi.org/10.1007/BF00666038] [PMID: 8534865]
[23]
Thoeny HC, De Keyzer F, Vandecaveye V, et al. Effect of vascular targeting agent in rat tumor model: Dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 2005; 237(2): 492-9.
[http://dx.doi.org/10.1148/radiol.2372041638]
[24]
Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: Application to diffusion and perfusion in neurologic disorders. Radiology 1986; 161(2): 401-7.
[http://dx.doi.org/10.1148/radiology.161.2.3763909] [PMID: 3763909]
[25]
Luo J, Zhou K, Zhang B, Luo N, Bian J. Intravoxel incoherent motion diffusion-weighted imaging for evaluation of the cell density and angiogenesis of cirrhosis-related nodules in an experimental rat model: Comparison and correlation with dynamic contrast-enhanced MRI. J Magn Reson Imaging 2020; 51(3): 812-23.
[http://dx.doi.org/10.1002/jmri.26845] [PMID: 31245888]
[26]
Li Y, Wang Z, Chen F, et al. Intravoxel incoherent motion diffusion-weighted MRI in patients with breast cancer: Correlation with tumor stroma characteristics. Eur J Radiol 2019; 120: 108686.
[http://dx.doi.org/10.1016/j.ejrad.2019.108686] [PMID: 31586850]
[27]
Noij DP, Martens RM, Marcus JT, et al. Intravoxel incoherent motion magnetic resonance imaging in head and neck cancer: A systematic review of the diagnostic and prognostic value. Oral Oncol 2017; 68: 81-91.
[http://dx.doi.org/10.1016/j.oraloncology.2017.03.016] [PMID: 28438298]
[28]
Liang CY, Chen MD, Zhao XX, Yan CG, Mei YJ, Xu YK. Multiple mathematical models of diffusion-weighted magnetic resonance imaging combined with prognostic factors for assessing the response to neoadjuvant chemotherapy and radiation therapy in locally advanced rectal cancer. Eur J Radiol 2019; 110: 249-55.
[http://dx.doi.org/10.1016/j.ejrad.2018.12.005] [PMID: 30599868]
[29]
Mürtz P, Penner AH, Pfeiffer AK, et al. Intravoxel incoherent motion model–based analysis of diffusion-weighted magnetic resonance imaging with 3 b-values for response assessment in locoregional therapy of hepatocellular carcinoma. OncoTargets Ther 2016; 9: 6425-33.
[http://dx.doi.org/10.2147/OTT.S113909] [PMID: 27799790]
[30]
Prise V, Honess D, Stratford M, Wilson J, Tozer G. The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses. Int J Oncol 2002; 21(4): 717-26.
[http://dx.doi.org/10.3892/ijo.21.4.717] [PMID: 12239609]
[31]
Kanthou C, Tozer GM. Microtubule depolymerizing vascular disrupting agents: Novel therapeutic agents for oncology and other pathologies. Int J Exp Pathol 2009; 90(3): 284-94.
[http://dx.doi.org/10.1111/j.1365-2613.2009.00651.x] [PMID: 19563611]
[32]
Wang H, Cona MM, Chen F, et al. Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers. Anticancer Drugs 2012; 23(1): 12-21.
[http://dx.doi.org/10.1097/CAD.0b013e328349dd60] [PMID: 21857503]
[33]
Le Bihan D. What can we see with IVIM MRI? Neuroimage 2019; 187: 56-67.
[http://dx.doi.org/10.1016/j.neuroimage.2017.12.062] [PMID: 29277647]
[34]
Yuan Y, Zeng D, Zhang Y, et al. Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model. Acta radiologica (Stockholm, Sweden : 1987) 2020; 61(2): 260-6.
[http://dx.doi.org/10.1177/0284185119855731]
[35]
Song X, Wang L, Ren H, Wei R, Ren JL, Niu J. Intravoxel incoherent motion imaging in differentiation borderline from malignant ovarian epithelial tumors: Correlation With histological cell proliferation and vessel characteristics. J Magn Reson Imaging 2020; 51(3): 928-35.
[http://dx.doi.org/10.1002/jmri.26885] [PMID: 31373117]
[36]
Mita MM, Sargsyan L, Mita AC, Spear M. Vascular-disrupting agents in oncology. Expert Opin Investig Drugs 2013; 22(3): 317-28.
[http://dx.doi.org/10.1517/13543784.2013.759557] [PMID: 23316880]

© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version350msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[13:39:06] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[13:39:06] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[13:39:06] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[13:39:06] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[13:39:06] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (101ms)time
  • Application (249ms)time
  • 1 x Application (71.06%)
    249ms
    1 x Booting (28.94%)
    101ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    33 statements were executed, 4 of which were duplicates, 29 unique. Show only duplicated162ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51399716','',1,1739972346,1739972346) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739972346
      1.34msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51399716','/article/130009',1,1739972346,1739972346)
      250μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51399716 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51399716) limit 1
      51.17msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51399716
      • 1: 51399716
      • 2: 51399716
      • 3: 51399716
      • 4: 51399716
      • 5: 51399716
      • 6: 51399716
      • 7: 51399716
      • 8: 51399716
      • 9: 51399716
      • 10: 51399716
      • 11: 51399716
      • 12: 51399716
      • 13: 51399716
      • 14: 51399716
      • 15: 51399716
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=130009
      1.01msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 33 limit 1
      1.2msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 33
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=33) and sj.journal_id!=33 group by `j`.`nid`) as `aggregate_table`
      540μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=33) and sj.journal_id!=33 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      440μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=33) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      610μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=33) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      550μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '130009'
      220μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 130009
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '130009'
      5.42msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 130009
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '130009' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.67msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 130009
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      240μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 33 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      26.99msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 33 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      30.57msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 33 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      16.53msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 130009 limit 1
      320μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 130009
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 130009 and content_type = 'article' order by status desc limit 1
      330μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 214365 limit 1
      300μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 214365
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      290μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CMIM' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      420μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CMIM
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '130009' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      690μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12622' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      450μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3427' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      490μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '1' and is_uploaded = 1 and issue_id = 12622 order by cast(first_page as SIGNED) desc limit 1
      5.23msalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 1
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '9' and is_uploaded = 1 and issue_id = 12622 order by cast(first_page as SIGNED) asc limit 1
      5msalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 9
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      250μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      310μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 130009 limit 1
      4.02msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 130009
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 33 and `b`.`banner_from_date` <= 1739972346 and `b`.`banner_to_date` >= 1739972346 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.63msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 33
      • 3: 1739972346
      • 4: 1739972346
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 33 and `b`.`banner_from_date` <= 1739972346 and `b`.`banner_to_date` >= 1739972346 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.55msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 33
      • 3: 1739972346
      • 4: 1739972346
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='b916a7b025e7d6d726bfa3fc70886eb9'
      300μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        IGiUjKZiqpODXn1fJB5wdzLoyYic9martsCpALd0
        uc_cart_id
        b916a7b025e7d6d726bfa3fc70886eb9
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/130009" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/130009
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 13:39:06 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InU4QzlqeGhMOWwrMkR0UGR5Z0dtaEE9PSIsInZhbHVlIjoiaDVCeTB1blljdHZjQzdEYUpYUTdBdjlCZjdIbk9XSFhWNDgyRTR5cjFPQkhFWGN0MUx0VVFGNE95anBBQ1lsSVJIREJzbU9ZaUUrWkRTd1I4Y0N4RnNmR09xY04xUjNjUFo0N29YUG51MjVqVG5ONkFXbWkzc0tKakV2RFFKbWsiLCJtYWMiOiIyNWU3MDUxZDYwZGM2MzdhM2U0ODEwMmYwOTBmMTRkYjNhZTg2MDI0MjRlNTMwMTkwNjM1N2YyYjFkZmY4OGU0IiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 01:39:06 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InU4QzlqeGhMOWwrMkR0UGR5Z0dtaEE9PSIsInZhbHVlIjoiaDVCeTB1blljdHZjQzdEYUpYUTdBdjlCZjdIbk9XSFhWNDgyRTR5cjFPQkhFWGN0MUx0VVFGNE95anBBQ1lsSVJIREJzb" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjV6dXNEN0luenhwR3MvYWhaS3ZKaHc9PSIsInZhbHVlIjoiUndRWTIzUDVQVnlveDRVTEdLUGNiNjdMTTlnd1hEenhtR0p1aTBBM0NMckltVyt3M3kvK21kNjdiRWwrL1E1Qk93Z0lLZnN3SXVTSE5obDZxV2hhckNxTlVkS1RSalhVSDlqQ3k2QTJrMVBESU9XTVZDeGhJLzNYcnlsNzB0cUciLCJtYWMiOiJkYmZmMzk3Yzk0YjFiODg1ZTFmZjVkYzhlN2FlNDNkMDU0ZGEyNzg5MDk5YmM5NWZkNmE0MDIyYmRjNTUyNTJmIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjV6dXNEN0luenhwR3MvYWhaS3ZKaHc9PSIsInZhbHVlIjoiUndRWTIzUDVQVnlveDRVTEdLUGNiNjdMTTlnd1hEenhtR0p1aTBBM0NMckltVyt3M3kvK21kNjd" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InU4QzlqeGhMOWwrMkR0UGR5Z0dtaEE9PSIsInZhbHVlIjoiaDVCeTB1blljdHZjQzdEYUpYUTdBdjlCZjdIbk9XSFhWNDgyRTR5cjFPQkhFWGN0MUx0VVFGNE95anBBQ1lsSVJIREJzbU9ZaUUrWkRTd1I4Y0N4RnNmR09xY04xUjNjUFo0N29YUG51MjVqVG5ONkFXbWkzc0tKakV2RFFKbWsiLCJtYWMiOiIyNWU3MDUxZDYwZGM2MzdhM2U0ODEwMmYwOTBmMTRkYjNhZTg2MDI0MjRlNTMwMTkwNjM1N2YyYjFkZmY4OGU0IiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 01:39:06 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InU4QzlqeGhMOWwrMkR0UGR5Z0dtaEE9PSIsInZhbHVlIjoiaDVCeTB1blljdHZjQzdEYUpYUTdBdjlCZjdIbk9XSFhWNDgyRTR5cjFPQkhFWGN0MUx0VVFGNE95anBBQ1lsSVJIREJzb" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjV6dXNEN0luenhwR3MvYWhaS3ZKaHc9PSIsInZhbHVlIjoiUndRWTIzUDVQVnlveDRVTEdLUGNiNjdMTTlnd1hEenhtR0p1aTBBM0NMckltVyt3M3kvK21kNjdiRWwrL1E1Qk93Z0lLZnN3SXVTSE5obDZxV2hhckNxTlVkS1RSalhVSDlqQ3k2QTJrMVBESU9XTVZDeGhJLzNYcnlsNzB0cUciLCJtYWMiOiJkYmZmMzk3Yzk0YjFiODg1ZTFmZjVkYzhlN2FlNDNkMDU0ZGEyNzg5MDk5YmM5NWZkNmE0MDIyYmRjNTUyNTJmIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjV6dXNEN0luenhwR3MvYWhaS3ZKaHc9PSIsInZhbHVlIjoiUndRWTIzUDVQVnlveDRVTEdLUGNiNjdMTTlnd1hEenhtR0p1aTBBM0NMckltVyt3M3kvK21kNjd" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "IGiUjKZiqpODXn1fJB5wdzLoyYic9martsCpALd0" "uc_cart_id" => "b916a7b025e7d6d726bfa3fc70886eb9" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/130009" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 13:39:06GET/article/130009514331