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Current Organocatalysis

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ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

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Review Article

Recent Advances in Polymer-supported Proline-derived Catalysts for Asymmetric Reactions

Author(s): Rubina Shajahan, Rithwik Sarang, Roopak Ramakrishnan and Anas Saithalavi*

Volume 10, Issue 2, 2023

Published on: 17 April, 2023

Page: [81 - 112] Pages: 32

DOI: 10.2174/2213337210666230224115814

Price: $65

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Abstract

The last two decades have witnessed tremendous growth in organocatalysis, especially using proline and related catalysts in a wide range of organic processes. Along with this, the heterogenization of organocatalysts over suitable support systems also emerged as an effective approach for addressing some of the major drawbacks associated with classical organocatalysts. Polymer-immobilized catalysts, in particular, are extremely stable under reaction conditions with excellent recyclability and reusability. Moreover, this approach offers green chemistry standards and is, thereby, supportive of large-scale industrial manufacturing processes. This article summarises the developments using polymer immobilized prolinederived systems as efficient organocatalysts for various asymmetric transformations in Aldol, Michael, Mannich, cyclization reactions, etc.

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