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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

An Improved Synthesis of Disubstituted 2H-indazoles using Microwaves

Author(s): Sushovan Jena and Kaushik Chanda*

Volume 20, Issue 9, 2023

Published on: 11 April, 2023

Page: [858 - 863] Pages: 6

DOI: 10.2174/1570178620666230222100449

Price: $65

Abstract

Microwaves have been used to produce a practical, high-yielding, and scalable synthesis method for producing disubstituted 2H-indazoles. With this technique, a large class of 2H-indazoles can be effectively produced from substituted 2-bromobenzaldehyde, aromatic amine and NaN3 using [Cu(phen)(PPh3)2]NO3 as catalysts. With outstanding purity and yields, the current one-pot synthetic sequence enables the addition of two structural diversity points to broaden the chemical space.

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