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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Phenol Derivatives With Antiviral Activities from the Arctic Fungus Phoma muscivora CPCC 401424

Author(s): Yan Tang, Jing Wang, Zhe Guo, Guowei Gu, Tao Zhang, Shan Cen, Liyan Yu, Shengjun Dai* and Dewu Zhang*

Volume 20, Issue 9, 2023

Published on: 16 March, 2023

Page: [853 - 857] Pages: 5

DOI: 10.2174/1570178620666230221090132

Price: $65

Abstract

A new phenol derivative, 3-butyryl-2,6-dihydroxy-4-methoxyphenethyl acetate (1) and seven known phenol analogs (2-8) have been isolated from Arctic fungus Phoma muscivora CPCC 401424. Their structures were elucidated by means of extensive spectroscopic analyses (HRMS, NMR, and IR), and comparison with reported data. All compounds were obtained from Phoma muscivora CPCC 401424 for the first time. Compounds 1 and 5 displayed excellent anti-influenza A virus activities with IC50 values of 2.20 and 2.17 μM, respectively. Compounds 1, 2, 5, and 7 showed moderate cytotoxic activities against Hela and H460 cancer cell lines.

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