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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Review Article

Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms

Author(s): Seyyed Mohammad Matin Alavi Dana, Tahereh Farkhondeh, Michael Aschner, Majid Darroudi, Helia Samini and Saeed Samarghandian*

Volume 16, Issue 7, 2023

Published on: 03 March, 2023

Article ID: e030123212340 Pages: 5

DOI: 10.2174/1874467216666230103105725

Price: $65

Abstract

Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic modalities have been used for its treatment, but all exhibit severe side effects, establishing the need for novel approaches. Chrysin is a phytomedicine compound belonging to the flavonoid group. It is found in honey and many plants. Its antitumor effects have been documented against gastric cancer cell lines in vitro, establishing its effects are mediated via different pathways and the expression of miRNA. In this review, we summarize the available literature on chrysin and its effects on gastric cancer, focusing on the cellular mechanisms it targets.

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