Login Register Cart 0
Generic placeholder image

Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Therapeutic Role of Desmodium Species on its Isolated Flavonoids

Author(s): Vedpal Singh*, Rohit Singh, Manish Pal Singh and Archita Katrolia

Volume 24, Issue 1, 2024

Published on: 02 January, 2023

Page: [74 - 84] Pages: 11

DOI: 10.2174/1566524023666221213111851

Price: $65

conference banner
Abstract

Secondary metabolites are an important part to play a major role in society and it was isolated from plant flavonoids and useful in the treatment of various kinds of diseases in the human race. They are widely used as food and nutrition supplements as well as antioxidants. Traditionally, the Desmodium species are an important tool for the secondary metabolites to treat various diseases. Desmodium triquetrum (Fabaceae) one of the Indian medicinal plants is widely used in the treatment of asthma and inflammation. Three flavonoids isolated from Desmodium triquetrum Linn namely Baicalein, Naringin and Neohesperidin are useful as antioxidants, food and nutrition supplements, that help the body to function efficiently while protecting it against toxins as well stressors. The role of flavonoids may be due to the presence of the phenolic compound. Similarly, the flavonoids such as gangetin, gangetinin, desmocarpin and desmodin isolated from the species Desmodium gangeticum are responsible for antileishmanial, antioxidant, anti-arthritic, and immunomodulatory activities. Additionally, isolated flavanoids from the species Desmodium triflorum show antibacterial, antiepileptic, antifungal, and radioprotective activities. So, the aim of the present study, based on the literature miming from the desmodium species is to acknowledge the importance of flavonoids in human health as dietary food supplements and therapeutic uses.

« Previous Next »
[1]
Egert S, Rimbach G. Which sources of flavonoids: Complex diets or dietary supplements? Adv Nutr 2011; 2(1): 8-14.
[http://dx.doi.org/10.3945/an.110.000026] [PMID: 22211185]
[2]
Kozłowska A, Szostak-Wegierek D. Flavonoids-food sources and health benefits. Rocz Panstw Zakl Hig 2014; 65(2): 79-85.
[PMID: 25272572]
[3]
Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. J Nutr Sci 2016; 5: e47.
[http://dx.doi.org/10.1017/jns.2016.41] [PMID: 28620474]
[4]
Ma X, Zheng C, Hu C, Rahman K, Qin L. The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. J Ethnopharmacol 2011; 138(2): 314-32.
[http://dx.doi.org/10.1016/j.jep.2011.09.053] [PMID: 22004895]
[5]
Bodhare A. Dashmularishta: Uses, benefits, side effects & more. Available from: https://pharmeasy.in/blog/ayurveda-uses-benefits-side-effects-of-dashmularishta/
[6]
Dhanabal SP, Dhamodaran P, Chaitnya M, Duraiswamy BUJ, Srivastava N. Ethnopharmacological and Phytochemical profile of three potent Desmodium species: Desmodium gangeticum (L.) DC, Desmodium triflorum Linn and Desmodium triquetrum Linn. J Chem Pharm Res 2016; 395-402.
[7]
Tatli Cankaya II, Somuncuoglu EI. Potential and prophylactic use of plants containing saponin-type compounds as antibiofilm agents against respiratory tract infections. Evid Based Complement Alternat Med 2021; 2021: 1-14.
[http://dx.doi.org/10.1155/2021/6814215] [PMID: 34349828]
[8]
DeFelice SL. Nutraceuticals – opportunities in an emerging market. Available from: https://fimdefelice.org/library/nutraceuticals-opportunities-in-an-emerging-market/
[9]
Dillard CJ, German JB. Phytochemicals: nutraceuticals and human health. J Sci Food Agric 2000; 80(12): 1744-56.
[http://dx.doi.org/10.1002/1097-0010(20000915)80:12<1744:AID-JSFA725>3.0.CO;2-W]
[10]
Ohashi H, Ohashi K. Grona, a genus separated from desmodium (Leguminosae Tribe Desmodieae). Shokubutsu Kenkyu Zasshi 2018; 93(2): 104-20.
[11]
Kajita T, Ohashi H, Tateishi Y, Bailey CD, Doyle JJ. RBCL and legume phylogeny, with particular reference to phaseoleae, millettieae, and allies. Syst Bot 2001; 26(3): 515-36.
[12]
Mishra PK, Singh N, Ahmad G, Dube A, Maurya R. Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities. Bioorg Med Chem Lett 2005; 15(20): 4543-6.
[http://dx.doi.org/10.1016/j.bmcl.2005.07.020] [PMID: 16099649]
[13]
Govindarajan R, Vijayakumar M, Shirwaikar A, Rawat AK, Mehrotra S, Pushpangadan P. Antioxidant activity of Desmodium gangeticum and its phenolics in arthritic rats. Acta Pharm 2006; 56(4): 489-96.
[PMID: 19839141]
[14]
Adinarayana D, Syamasundar KV. Occurrence of a rare diholosylflavone, 2”-o-glucosylvitexin in Desmodium triflorum. Curr Sci 1982; 51(19): 936-7.
[15]
Zhang G, Chen Y, Tariq K, et al. Optimization of ultrasound assisted extraction method for polyphenols from Desmodium triquetrum (L.) DC. with Response Surface Methodology (RSM) and in vitro determination of its antioxidant properties. Czech J Food Sci 2020; 38(2): 115-22.
[http://dx.doi.org/10.17221/230/2019-CJFS]
[16]
Prayagadatta S, Sharangadhra S. Chowkhamba Sanskrita Academy. 1966; p. 1192-4.
[17]
Harborne JB. Indian Medicinal Plants A Compendium of 500 Species. 1994; 1: p. 935-5.
[18]
Yadava RN, Tripathi P. A novel flavone glycoside from the stem of Desmodium gangeticum. Fitoterapia 1998; 69(5): 443-4.
[19]
Mohan PK, Adarsh Krishna TP, Senthil Kumar T, Ranjitha Kumari BD. Pharmaco-chemical profiling of Desmodium gangeticum (L.) DC. with special reference to soil chemistry. Fut J Pharm Sci 2021; 7(1): 210.
[http://dx.doi.org/10.1186/s43094-021-00356-7] [PMID: 34692854]
[20]
Vijaya Vara Prasad M, Balakrishna K, Sukumar E, Patra A. Gangetial, a new pterocarpan from the roots of Desmodium gangeticum. ChemInform 2010; 41(9)
[21]
Singh N, Mishra PK, Kapil A, Arya KR, Maurya R, Dube A. Efficacy of Desmodium gangeticum extract and its fractions against experimental visceral leishmaniasis. J Ethnopharmacol 2005; 98(1-2): 83-8.
[http://dx.doi.org/10.1016/j.jep.2004.12.032] [PMID: 15763367]
[22]
Latha P, Govindasamy S, Balakrishna K. Effect of gangetin on fertility of male rats. Phytother Res 1997; 11(5): 372-5.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199708)11:5<372:AID-PTR111>3.0.CO;2-9]
[23]
Kurian GA, Philip S, Varghese T. Effect of aqueous extract of the Desmodium gangeticum DC root in the severity of myocardial infarction. J Ethnopharmacol 2005; 97(3): 457-61.
[http://dx.doi.org/10.1016/j.jep.2004.11.028] [PMID: 15740881]
[24]
Vijaya Vara Prasad M, Balakrishna K, Carey MW. Hepatoprotective activity of roots of Desmodium gangeticum (Linn.) DC. Asian J Chem 2005; 17: 2847-9.
[25]
N’gouemo P, Baldy-Moulinier M, Nguemby-Bina C. Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents. J Ethnopharmacol 1996; 52(2): 77-83.
[http://dx.doi.org/10.1016/0378-8741(96)01389-X] [PMID: 8735451]
[26]
Jabbar S, Khan MT, Choudhuri MS. The effects of aqueous extracts of Desmodium gangeticum DC. (Leguminosae) on the central nervous system. Pharmazie 2001; 56(6): 506-8.
[PMID: 11446174]
[27]
K Yadav A. Agrawal J, Pal A, Gupta MM. Novel anti-inflammatory phytoconstituents from Desmodium gangeticum. Nat Prod Res 2013; 27(18): 1639-45.
[http://dx.doi.org/10.1080/14786419.2012.761620] [PMID: 23336435]
[28]
Singh A, Singh PK. An ethnobotanical study of medicinal plants in Chandauli District of Uttar Pradesh, India. J Ethnopharmacol 2009; 121(2): 324-9.
[http://dx.doi.org/10.1016/j.jep.2008.10.018] [PMID: 19022368]
[29]
Joshi H, Parle M. Antiamnesic effects of Desmodium gangeticum in mice. Yakugaku Zasshi 2006; 126(9): 795-804.
[http://dx.doi.org/10.1248/yakushi.126.795] [PMID: 16946593]
[30]
Kritika M, Deepak K, Suresh K. Journal of Pharmaceutical Technology. Res Manage 2015; 3(1): 67-77.
[31]
Venkatachalam U, Muthukrishnan S. Free radical scavenging activity of ethanolic extract of Desmodium gangeticum. J Acute Med 2012; 2(2): 36-42.
[http://dx.doi.org/10.1016/j.jacme.2012.04.002]
[32]
Adhikari A, Dey A, Kanjilal S, et al. Gastroprotective and digestive potential of an Ayurvedic asava–arishta preparation. Orient Pharm Exp Med 2018; 18(4): 391-401.
[http://dx.doi.org/10.1007/s13596-018-0325-y]
[33]
Chen YF, Lu YH, Tsai HY. Crude extract of Desmodium gangeticum process anticancer activity via arresting cell cycle in G1 and modulating cell cycle-related protein expression in A549 human lung carcinoma cells. Biomedicine 2022; 12(2): 31-9.
[http://dx.doi.org/10.37796/2211-8039.1362] [PMID: 35836974]
[34]
Rajendrakurup AA, Nair VPK, Mohanan A, Venkatesha RN. Ayurvedic milk powder as a health drink—an innovative approach in antenatal health care—a research proposal. Biol Life Sci Forum 6(1): 16.
[35]
Deshpande DJ. A Handbook of Herbal Remedies: A Source Book Of Medicinal Herbs Chemical Constituents Biological Activities And Usage. India: Agrobios 2002.
[36]
Bhosle V. Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion. Rev Bras Farmacogn 2013; 23(4): 692-8.
[http://dx.doi.org/10.1590/S0102-695X2013005000047]
[37]
Lai SC, Ho YL, Huang SC, et al. Antioxidant and antiproliferative activities of Desmodium triflorum (L.) DC. Am J Chin Med 2010; 38(2): 329-42.
[http://dx.doi.org/10.1142/S0192415X10007889] [PMID: 20387229]
[38]
Xu C, Han X, Staehelin C, Zhang J. First report of Meloidogyne arenaria on roots of Grona triflora in Guangdong Province, China. Plant Dis 2021; 105(11): 3763.
[http://dx.doi.org/10.1094/PDIS-01-21-0002-PDN] [PMID: 34058840]
[39]
Nassiri-Asl M, Shariati-Rad S, Zamansoltani F. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complement Altern Med 2007; 7(1): 26.
[http://dx.doi.org/10.1186/1472-6882-7-26] [PMID: 17686156]
[40]
Lai SC, Peng WH, Huang SC, et al. Analgesic and anti-inflammatory activities of methanol extract from Desmodium triflorum DC in mice. Am J Chin Med 2009; 37(3): 573-88.
[http://dx.doi.org/10.1142/S0192415X09007065] [PMID: 19606516]
[41]
Sharma R, Parashar B, Kabra A. Efficacy of aqueous and methanolic extracts of plant Desmodium triflorum for potential antibacterial activity. Int J Pharm Sci Res 2013; 4(5): 1975-81.
[42]
Ratnasooriya W, Jayakody A, Chatura R, Tissa D, Weerasekera K. Antinociceptive activity of cold water extract of Desmodium triflorum in rats. Int Res J Pharm 2011; 2(7): 120-3.
[43]
Nguyen-Ngoc H, Nguyen-Thi-Thu T, Vo-Thi KA, et al. Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi. Z Naturforsch C J Biosci 2022; 0(0): C.
[http://dx.doi.org/10.1515/znc-2022-0048] [PMID: 35768067]
[44]
Karim R, Begum MM, Jui Y, et al. In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits. Clinical Phytoscience 2021; 7(1): 36.
[http://dx.doi.org/10.1186/s40816-021-00272-6]
[45]
Vedpal Jayaram U, Wadhwani A, Dhanabal SP. Isolation and characterization of flavonoids from the roots of medicinal plant Tadehagi triquetrum (L.) H. Ohashi. Nat Prod Res 2020; 34(13): 1913-8.
[http://dx.doi.org/10.1080/14786419.2018.1561679] [PMID: 30698030]
[46]
Qi-wen Y, Xi-hui L, Ya-ping W. Studies on the constituents of Desmodium triquetrum (L.) DC. J Integr Plant Biol 1989; 31(2)
[47]
Kubatka P, Mazurakova A, Samec M, et al. Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways. EPMA J 2021; 12(4): 559-87.
[http://dx.doi.org/10.1007/s13167-021-00257-y] [PMID: 34950252]
[48]
Gaskins AJ, Rovner AJ, Mumford SL, et al. Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women. Am J Clin Nutr 2010; 92(6): 1461-7.
[http://dx.doi.org/10.3945/ajcn.110.000026] [PMID: 20943796]
[49]
Kalyani GA, Ramesh CK, Krishna V. Hepatoprotective and antioxidant activities of desmodium triquetrum DC. Indian J Pharm Sci 2011; 73(4): 463-6.
[PMID: 22707836]
[50]
Libman A, Bouamanivong S, Southavong B, Sydara K, Soejarto DD. Medicinal plants: An important asset to health care in a region of Central Laos. J Ethnopharmacol 2006; 106(3): 303-11.
[http://dx.doi.org/10.1016/j.jep.2005.11.034] [PMID: 16473485]
[51]
Joshi H, Cs C, Alkanad MA. Neuroprotective potentials of ayurvedic rasayana Desmodium triquetrum on brain aging and chemically induced amnesia in animal models relevant to dementia. J Trad Med Clinical Naturop 2018; 7(2): 272.
[http://dx.doi.org/10.4172/2573-4555.1000272]
[52]
Bahmani M, Mozaffari Nejad AS, Shah NA, Shah SA, Rafieian-Kopaei M, Mahmoodnia L. Survey on ethnobotanical uses of anti-cancer herbs in Southern region of Ilam, West Iran. J Biol Res 2017; 90(1): 851.
[53]
Gao X, Wang B, Wei X, et al. Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale 2012; 4(22): 7021-30.
[http://dx.doi.org/10.1039/c2nr32181e] [PMID: 23044718]
[54]
Palpu P, Venkateswara RC, Raghavan G, et al. Anti-arthritic herbal composition and method thereof. United States patent US 7,338,674, 2008.
[55]
Shetty MV. Herbo-mineral formulation for the treatment of cardio vascular diseases and method of preparation thereof. United States patent US 10,653,741, 2020.
[56]
Bandyopadhyay P, Bansal V, Gadgil VR, Shariff R, Shukla RK. Personal care composition. United States patent US 9,283,170, 2016.
[57]
Chen JNH. adehagi triquetrum-containing weight-reducing tea and preparation method thereof. Chinese patent 104431057A, 2015.
[58]
Shibazaki S, Ochiai N, Kobayashi K, Chin D. Antioxidant and external preparation for skin. Japanese patent JP2008001634A, 2008.
[59]
Li Y. Chinese herbal medicine preparation for treating prostatic swelling or hypertrophy in middle-aged and elderly people. Chinese patent CN102205043A, 2011.
[60]
Slika H, Mansour H, Wehbe N, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomed Pharmacother 2022; 146: 112442.
[http://dx.doi.org/10.1016/j.biopha.2021.112442] [PMID: 35062053]
[61]
Tiwari P, Mishra R, Mazumder A, Mazumder R, Singh A. An insight into diverse activities and targets of flavonoids. Curr Drug Targets 2022; 23: 1-1.
[PMID: 36111764]
[62]
Lv Y, Liu Z, Jia H, Xiu Y, Liu Z, Deng L. Properties of flavonoids in the treatment of bladder cancer. Exp Ther Med 2022; 24(5): 676.
[http://dx.doi.org/10.3892/etm.2022.11612] [PMID: 36185766]
[63]
Ma EZ, Khachemoune A. Flavonoids and their therapeutic applications in skin diseases. Arch Dermatol Res 2022.
[http://dx.doi.org/10.1007/s00403-022-02395-3] [PMID: 36129522]
[64]
Fardoun MM, Maaliki D, Halabi N, et al. Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets. Clin Sci 2020; 134(12): 1403-32.
[http://dx.doi.org/10.1042/CS20200356]
[65]
Li T, Zhao Y, Yuan L, et al. Total dietary flavonoid intake and risk of cardiometabolic diseases: A dose-response meta-analysis of prospective cohort studies. Crit Rev Food Sci Nutr 2022; 1-13.
[http://dx.doi.org/10.1080/10408398.2022.2126427] [PMID: 36148848]
[66]
Popiolek-Kalisz J, Fornal E. The impact of flavonols on cardiovascular risk. Nutrients 2022; 14(9): 1973.
[http://dx.doi.org/10.3390/nu14091973] [PMID: 35565940]
[67]
Cao Y, Xie L, Liu K, et al. The antihypertensive potential of flavonoids from chinese herbal medicine: A review. Pharmacol Res 2021; 174: 105919.
[http://dx.doi.org/10.1016/j.phrs.2021.105919] [PMID: 34601080]
[68]
Maaliki D, Shaito AA, Pintus G, El-Yazbi A, Eid AH. Flavonoids in hypertension: A brief review of the underlying mechanisms. Curr Opin Pharmacol 2019; 45: 57-65.
[http://dx.doi.org/10.1016/j.coph.2019.04.014] [PMID: 31102958]
[69]
Tan P, Jin L, Qin X, He B. Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease. Front Pharmacol 2022; 13: 1005312.
[http://dx.doi.org/10.3389/fphar.2022.1005312] [PMID: 36188561]
[70]
Magni G, Riboldi B, Petroni K, Ceruti S. Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration. Biochem Pharmacol 2022; 205: 115257.
[http://dx.doi.org/10.1016/j.bcp.2022.115257] [PMID: 36179933]
[71]
Pereira-Wilson C. Can dietary flavonoids be useful in the personalized treatment of colorectal cancer? World J Gastrointest Oncol 2022; 14(6): 1115-23.
[http://dx.doi.org/10.4251/wjgo.v14.i6.1115] [PMID: 35949218]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy