Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Phytochemical and Pharmacological Profile of Desmodium styracifolium (Osbeck) Merr: Updated Review

Author(s): Acharya Balkrishna, Ankita Semwal, Nidhi Sharma* and Vedpriya Arya

Volume 9, Issue 5, 2023

Published on: 09 January, 2023

Article ID: e091222211797 Pages: 19

DOI: 10.2174/2215083809666221209085439

Price: $65

Abstract

Desmodium styracifolium (Osbeck) Merr. is an important traditional medicinal herb documented in the indigenous medicinal systems and used in many folk medicines to treat various ailments. D. styracifolium belongs to the legume family Fabaceae (Leguminosae) and is preferably abundantly found worldwide. The plant possesses various phytochemical and pharmacological activities. Plant’s phytochemical accouter confers significant therapeutic properties and has been used traditionally for treating ailments like pyrexia, stranguria, renal calculi, dysuria, and oliguria. Here, we provide a comprehensive review of scientific findings of D. styracifolium phytoconstituents and their related anti-hypertensive, anti-oxidant, anti-urolithic and hepatoprotective activities in nonclinical in-vitro and in-vivo studies. More than 50 chemical compounds have been reported from D. styracifolium, including flavonoids, terpenoids, glycosides, phenols, and phytosterols. This paper presents a comprehensive analysis of the chemical constituents, pharmacological activities, and ethnomedicinal uses of D. styracifolium, providing scientific evidence for ethnomedicinal claims and opening perspectives for future research.

Graphical Abstract

[1]
Macêdo MJF, Ribeiro DA, Santos MO, et al. Fabaceae medicinal flora with therapeutic potential in Savanna areas in the Chapada do Araripe, Northeastern Brazil. Rev Bras Farmacogn 2018; 28(6): 738-50.
[http://dx.doi.org/10.1016/j.bjp.2018.06.010]
[2]
Ji CH, Tang CW, Feng WM, Bao Y, Yao LQ. A Chinese herbal decoction, Huoxue Qingyi decoction, promotes rehabilitation of patients with severe acute pancreatitis: A retrospective study. evid Based Complement Alternat Med 2016; 2016: 1-5.
[http://dx.doi.org/10.1155/2016/3456510] [PMID: 27110265]
[3]
Das S, Vasudeva N, Sharma S. Kidney disorders and management through herbs: A review. J Phytopharmacol 2019; 8(1): 21-7.
[http://dx.doi.org/10.31254/phyto.2019.8106]
[4]
The State Pharmacopoeia Committee of China. Pharmacopoeia Commission of the People’s Republic of China. Beijing: Chemical Industry Press 2005; Vol. 1.
[5]
Ho CS, Wong YH, Chiu KW. The hypotensive action of Desmodium styracifolium and Clematis chinensis. Am J Chin Med 1989; 17(4): 189-202.
[6]
Eflora: Desmodium styracifolium Available from: http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200012110
[7]
Zhang YQ, Luo JG, Han C, Xu JF, Kong LY. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal 2015; 102: 276-81.
[http://dx.doi.org/10.1016/j.jpba.2014.09.027] [PMID: 25459924]
[8]
Giang PM, Son PT, Matsunami K, Otsuka H. Flavonoid compounds from Desmodium styracifolium of Vietnamese origin. Chem Nat Compd 2010; 46(5): 797-8.
[http://dx.doi.org/10.1007/s10600-010-9746-7]
[9]
Zhou J, Jin J, Li X, et al. Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-l-proline-induced calcium oxalate urolithiasis in rats. Urolithiasis 2018; 46(3): 231-41.
[http://dx.doi.org/10.1007/s00240-017-0985-y] [PMID: 28567512]
[10]
Hirayama H, Wang Z, Nishi K, et al. Effect of Desmodium styracifolium-triterpenoid on calcium oxalate renal stones. Br J Urol 1993; 71(2): 143-7.
[http://dx.doi.org/10.1111/j.1464-410X.1993.tb15906.x] [PMID: 8461944]
[11]
a) Ma X, Zheng C, Hu C, Rahman K, Qin L. The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. J Ethnopharmacol 2011; 138(2): 314-32.
[http://dx.doi.org/10.1016/j.jep.2011.09.053] [PMID: 22004895];
b) Polat R, Güner B, Babacan EY, Çakılcıoğlu U. Survey of wild food plants for human consumption in Bingöl (Turkey). Indian J Tradit Knowl 2017; 16(3): 378-84.
[12]
Rodgers AL, Webber D, Ramsout R, Gohel MDI. Herbal preparations affect the kinetic factors of calcium oxalate crystallization in synthetic urine: Implications for kidney stone therapy. Urolithiasis 2014; 42(3): 221-5.
[http://dx.doi.org/10.1007/s00240-014-0654-3] [PMID: 24648109]
[13]
Cheng X, Guo C, Yang Q, Tang X, Zhang C. Isolation and identification of radical scavenging components of seeds of Desmodium styracifolium. Chem Nat Compd 2017; 53(1): 36-9.
[http://dx.doi.org/10.1007/s10600-017-1905-7]
[14]
Zhao M, Duan JA, Che CT. Isoflavanones and their O-glycosides from Desmodium styracifolium. Phytochemistry 2007; 68(10): 1471-9.
[http://dx.doi.org/10.1016/j.phytochem.2007.02.015] [PMID: 17434190]
[15]
Su W, Liu Q, Yang Q, Yu J, Chen X. Separation and purification of four compounds from Desmodium styracifolium using off-line two-dimensional high-speed counter-current chromatography. J Sep Sci 2013; 36(20): 3338-44.
[http://dx.doi.org/10.1002/jssc.201300653] [PMID: 23939907]
[16]
Liu X, Fan X, Wang X, Liu R, Meng C, Wang C. Structural characterization and screening of chemical markers of flavonoids in Lysimachiae Herba and Desmodii Styracifolii Herba by ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry based metabolomics approach. J Pharm Biomed Anal Elsevier BV 2019; 171: 52-64.
[17]
Chen L, Tang X, Yang Q, Cheng X. Quantitative and chemical fingerprint analysis of Desmodium styracifolium by high-performance liquid chromatography combined with chemometrics. J Chromatogr Sci 2020; 58(4): 294-302.
[http://dx.doi.org/10.1093/chromsci/bmz112] [PMID: 31879757]
[18]
Sun X, Tang X, Yang Q. An effective quantitative fingerprint method for evaluating the quality consistency of Desmodium styracifolium. Pharmazie 2018; 73(10): 579-84.
[PMID: 30223921]
[19]
Hansen K, Nyman U, Smitt UW, et al. In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE). J Ethnopharmacol 1995; 48(1): 43-51.
[http://dx.doi.org/10.1016/0378-8741(95)01286-M] [PMID: 8569246]
[20]
Cheng X, Tang X, Guo C, Zhang C, Yang Q. New flavonol glycosides from the seeds of Desmodium styracifolium. Chem Nat Compd 2018; 54(5): 846-50.
[http://dx.doi.org/10.1007/s10600-018-2496-7]
[21]
Xiang S, Zhou J, Li J, et al. Antilithic effects of extracts from different polarity fractions of Desmodium styracifolium on experimentally induced urolithiasis in rats. Urolithiasis 2015; 43(5): 433-9.
[http://dx.doi.org/10.1007/s00240-015-0795-z] [PMID: 26123751]
[22]
Mi J, Duan J, Zhang J, Lu J, Wang H, Wang Z. Evaluation of antiurolithic effect and the possible mechanisms of Desmodium styracifolium and Pyrrosiae petiolosa in rats. Urol Res 2012; 40(2): 151-61.
[http://dx.doi.org/10.1007/s00240-011-0401-y] [PMID: 21822640]
[23]
Liu M, Zhang G, Song M, et al. Activation of farnesoid x receptor by schaftoside ameliorates acetaminophen-induced hepatotoxicity by modulating oxidative stress and inflammation. Antioxid Redox Signal 2020; 33(2): 87-116.
[http://dx.doi.org/10.1089/ars.2019.7791] [PMID: 32037847]
[24]
Liu Z, Dong Y, Wang N, Wang N, Wang JH, Li X. Chemical studies on the constituents of Desmodium styracifolium (Osb.) Merr. J Shenyang Pharm Univ 2005; 6.
[25]
Li D, Zheng X, Duan L, et al. Ethnobotanical survey of herbal tea plants from the traditional markets in Chaoshan, China. J Ethnopharmacol 2017; 205: 195-206.
[http://dx.doi.org/10.1016/j.jep.2017.02.040] [PMID: 28249822]
[26]
Zhou C, Luo JG, Kong LY. Quality evaluation of Desmodium styracifolium using high-performance liquid chromatography with photodiode array detection and electrospray ionisation tandem mass spectrometry. Phytochem Anal 2012; 23(3): 240-7.
[http://dx.doi.org/10.1002/pca.1349] [PMID: 21853495]
[27]
Evan AP, Worcester EM, Coe FL, Williams J Jr, Lingeman JE. Mechanisms of human kidney stone formation. Urolithiasis 2015; 43(S1): 19-32.
[http://dx.doi.org/10.1007/s00240-014-0701-0] [PMID: 25108546]
[28]
Wang Z, Gong H, Xu X, Wei X, Wang Y, Zeng S. Transcriptome and small RNAome facilitate to study schaftoside in Desmodium styracifolium Merr. Ind Crops Prod Elsevier 2019; 2020(149): 112352.
[29]
Su D, Shan Y, Guang H, et al. Chinese medicinal herb formula for treating urinary calculus. CN Patent 103071071A, 2021.
[30]
Yasukawa K. Studies on the constituents in the water extracts of crude drugs. V. On the leaves of Desmodium styracifolium. Yakugaku Zasshi J Pharm Soc Japan 2017; 106(6): 517-9.
[31]
Liu L, Chen M, Chen X. Analysis of alcohol dehydrogenase inhibitors from Desmodium styracifolium using centrifugal ultrafiltration coupled with HPLC-MS. J Serb Chem Soc 2015; 80(8): 1051-9.
[http://dx.doi.org/10.2298/JSC140919023L]
[32]
Tran TD, Bui TQ, Le TA, et al. Styracifoline from the vietnamese plant Desmodium styracifolium: A potential inhibitor of diabetes-related and thrombosis-based proteins. ACS Omega 2021; 6(36): 23211-21.
[http://dx.doi.org/10.1021/acsomega.1c02840] [PMID: 34549122]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy