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Current Organic Synthesis

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ISSN (Online): 1875-6271

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Review Article

Recent Updates on Synthesis, Biological Activity, and Structure-activity Relationship of 1,3,4-Oxadiazole-quinoline Hybrids: A Review

Author(s): Abhishek Shankar Sharma, Salahuddin*, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km Shabana, Sonakshi Tyagi, Mohammad Shahar Yar and Mohamed Jawed Ahsan

Volume 20, Issue 7, 2023

Published on: 29 December, 2022

Page: [758 - 787] Pages: 30

DOI: 10.2174/1570179420666221004142659

Price: $65

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Abstract

Due to their diverse applications in industrial and synthetic organic chemistry, quinoline and 1,3,4-oxadiazole have become important heterocyclic compounds. Quinoline and 1,3,4- oxadiazole compounds have been developed for various medical conditions such as anti-cancer, anti-bacterial, anti-fungal, antimalarial, antioxidants, anti-HIV, anticonvulsant, antiviral, etc. The current review includes synthetic protocols for biologically active 1,3,4-oxadiazole incorporating quinoline hybrids with their structure-activity relationship to explore work (Mainly from 2010 to 2021) based on 1,3,4-oxadiazole-quinoline hybrids to the medicinal chemist for further research in the development of the molecule.

Keywords: Oxadiazole, Quinoline, Oxadiazole-quinoline hybrids, Synthetic Approaches, Biological Activity, Structure-Activity Relationship

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