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Current Nanoscience

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ISSN (Online): 1875-6786

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Review Article

Polymeric Nanoparticles: Prospective on the Synthesis, Characterization and Applications in Nose-to-Brain Drug Delivery

Author(s): Prakash N. Kendre*, Dhiraj R. Kayande, Shirish P. Jain, Tejaswini G. Malge, Namrata N. Zadpe and Bhupendra G. Prajapati

Volume 19, Issue 5, 2023

Published on: 20 October, 2022

Page: [663 - 676] Pages: 14

DOI: 10.2174/1573413718666220929102013

Price: $65

Abstract

For the treatment of brain illnesses, there is growing interest in nose-to-brain drug administration. Other, more traditional methods of crossing the blood–brain barrier (BBB) are ineffective. As a result, the therapeutic concentration in the brain cannot be achieved, and the reaction is inadequate. Intranasal medication delivery is one intriguing technique for avoiding first-pass metabolism and bypassing the blood-brain barrier. It lowers medicine doses while reducing systemic side effects. Compared to conventional drug delivery platforms, a nanoparticulate drug delivery method allows for greater penetration via the nasal route. It is better to make the nanoparticles for nose-to-brain administration when a good carrier (polymers) is used. This review focuses on the many processes for creating polymeric nanoparticles, strategies and tactics for improving nose-tobrain drug delivery efficiency, and nanoparticle characterization. The use of the nose-to-brain drug delivery platform is being explored using a variety of nanoparticles created by researchers for the treatment of brain illnesses.

Keywords: Polymeric nanoparticles, synthesis, blood-brain-barrier, brain diseases, techniques

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