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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Patent News

Novel Proline Derivatives for Treating COVID-19

Author(s): Surya K. De*

Volume 30, Issue 12, 2023

Published on: 27 October, 2022

Page: [1458 - 1461] Pages: 4

DOI: 10.2174/0929867329666220922095343

Price: $65

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Abstract

COVID-19 is a contagious disease. Paxlovid, a combination of Nirmatrelvir and Ritonavir, was granted emergency use authorization by the United States Food and Drug Administration (FDA) for the treatment of COVID-19 on December 22, 2021. These are peptidomimetic coronavirus main protease inhibitors. Nirmatrelvir is a proline derivative. The present patent describes similar proline- like compounds, their preparation, use, pharmaceutical composition, and treatment.

Keywords: COVID-19, Proline derivatives, Protease inhibitors, Picornavirus, Norovirus, Single-stranded RNA virus

« Previous
[1]
Banerjee, R.; Perera, L.; Tillekeratne, L.M.V. Potential SARS-CoV-2 main protease inhibitors. Drug Discov. Today, 2021, 26(3), 804-816.
[http://dx.doi.org/10.1016/j.drudis.2020.12.005] [PMID: 33309533]
[2]
Chia, C.S.B. Novel nitrile peptidomimetics for treating COVID-19. ACS Med. Chem. Lett., 2022, 13(3), 330-331.
[http://dx.doi.org/10.1021/acsmedchemlett.2c00030] [PMID: 35291756]
[3]
Beckerman, R.; Gori, A.; Jeyakumar, S.; Malin, J.J.; Paredes, R.; Póvoa, P.; Smith, N.J.; Teixeira-Pinto, A. Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis. Sci. Rep., 2022, 12(1), 9622.
[http://dx.doi.org/10.1038/s41598-022-13680-6] [PMID: 35688854]
[4]
Talic, S.; Shah, S.; Wild, H.; Gasevic, D.; Maharaj, A.; Ademi, Z.; Li, X.; Xu, W.; Mesa-Eguiagaray, I.; Rostron, J.; Theodoratou, E.; Zhang, X.; Motee, A.; Liew, D.; Ilic, D. Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis. BMJ, 2021, 375, e068302.
[http://dx.doi.org/10.1136/bmj-2021-068302] [PMID: 34789505]
[5]
Chan, J.F.W.; Yuan, S.; Kok, K.H.; To, K.K.W.; Chu, H.; Yang, J.; Xing, F.; Liu, J.; Yip, C.C.Y.; Poon, R.W.S.; Tsoi, H.W.; Lo, S.K.F.; Chan, K.H.; Poon, V.K.M.; Chan, W.M.; Ip, J.D.; Cai, J.P.; Cheng, V.C.C.; Chen, H.; Hui, C.K.M.; Yuen, K.Y. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet, 2020, 395(10223), 514-523.
[http://dx.doi.org/10.1016/S0140-6736(20)30154-9] [PMID: 31986261]
[6]
Wiersinga, W.J.; Rhodes, A.; Cheng, A.C.; Peacock, S.J.; Prescott, H.C. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19). JAMA, 2020, 324(8), 782-793.
[http://dx.doi.org/10.1001/jama.2020.12839] [PMID: 32648899]
[7]
Zhu, N.; Zhang, D.; Wang, W.; Li, X.; Yang, B.; Song, J.; Zhao, X.; Huang, B.; Shi, W.; Lu, R.; Niu, P.; Zhan, F.; Ma, X.; Wang, D.; Xu, W.; Wu, G.; Gao, G.F.; Tan, W. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med., 2020, 382(8), 727-733.
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945]
[8]
Kashani, N.R.; Azadbakht, J.; Ehteram, H.; Kashani, H.H.; Rajabi-Moghadam, H.; Ahmad, E.; Nikzad, H.; Hosseini, E.S. Molecular and clinical investigation of COVID-19: From pathogenesis and immune responses to novel diagnosis and treatment. Front. Mol. Biosci., 2022, 9, 770775.
[http://dx.doi.org/10.3389/fmolb.2022.770775] [PMID: 35664675]
[9]
Alagheband Bahrami, A.; Azargoonjahromi, A.; Sadraei, S.; Aarabi, A.; Payandeh, Z.; Rajabibazl, M. An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19). Cell. Mol. Biol. Lett., 2022, 27(1), 38.
[http://dx.doi.org/10.1186/s11658-022-00339-3] [PMID: 35562685]
[10]
Yang, K.S.; Leeuwon, S.Z.; Xu, S.; Liu, W.R. Evolutionary and structural insights about potential sars-cov-2 evasion of nirmatrelvir. J. Med. Chem., 2022.
[http://dx.doi.org/10.1021/acs.jmedchem.2c00404]
[11]
Rajashekar Reddy, C.B.; Rajasekhara Reddy, S.; Suthindhiran, K.; Sivakumar, A. HDAC and NF-κB mediated cytotoxicity induced by novel N-Chloro β-lactams and benzisoxazole derivatives. Chem. Biol. Interact., 2016, 246, 69-76.
[http://dx.doi.org/10.1016/j.cbi.2016.01.010] [PMID: 26776669]
[12]
Manohara, C.S.; Manikundan, A.; Sridhar, P.; Sivakumar, A.; Reddy, A.R. Design and synthesis of substituted nitroimidazo pyridazine-triazoles as protein Tyrosine Kinase inhibitors: An approach to develop anticancer drugs. J. Mol. Struct., 2018, 1154, 437-444.
[http://dx.doi.org/10.1016/j.molstruc.2017.10.075]

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