Research Progress of Pectin Methylesterase and its Inhibitors

Title:Research Progress of Pectin Methylesterase and its Inhibitors

Volume: 23 Issue: 10

Author(s): Yueteng Wang, Derong Zhang, Lifen Huang, Zelan Zhang, Jiaxing Gao, Wei Liu, Gan He, Xiaoqiang Guo*, Shan Chang*Jianping Hu*

Affiliation:

• Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu 610106, China

• Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China

• Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu 610106, China

Keywords: Molecular recognition, Pectin methylesterase, Pectin methylesterase inhibitors, Inhibition mechanism, Semi-rational design

Abstract: As an important pectin enzyme, pectin methylesterase (PME) can hydrolyze methyl esters, release methanol and reduce esterification. It is essential in regulating pollen tube development, root extension, and fruit ripening. Pectin methylesterase inhibitors (PMEI) can specifically bind PME and inhibit its activity, which jointly determines the esterification degree of pectin. PMEI has important application prospects in plant pest control, fruits and vegetable processing fields. In this paper, the gene families, crystal structures, molecular recognition, and applications in plants and industry are reviewed for the PME and PMEI systems. Finally, the semi-rational design of PMEI is discussed and discussed prospected.

Cite this article as:

Wang Yueteng, Zhang Derong, Huang Lifen, Zhang Zelan, Gao Jiaxing, Liu Wei, He Gan, Guo Xiaoqiang*, Chang Shan*, Hu Jianping*, Research Progress of Pectin Methylesterase and its Inhibitors, Current Protein & Peptide Science 2022; 23 (10) . https://dx.doi.org/10.2174/1389203723666220919092428