Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

The Role of Gut Microbiota in Inflammatory Bowel Disease-Current State of the Art

Author(s): Hassan Askari, Sara Shojaei-Zarghani, Ehsan Raeis-Abdollahi, Hossein Kargar Jahromi, ‪Payman Raise Abdullahi, Karim Daliri, Amir Tajbakhsh, Leila Rahmati and Ali Reza Safarpour*

Volume 23, Issue 13, 2023

Published on: 21 October, 2022

Page: [1376 - 1389] Pages: 14

DOI: 10.2174/1389557522666220914093331

Price: $65

Abstract

The human microbiome comprises the genomes of the microbiota that live on and within humans, such as protozoa, archaea, eukaryotes, viruses, and most bacteria. Gastrointestinal disorders such as inflammatory bowel disease, colon cancer, celiac disease, and irritable bowel syndrome can all be triggered by a change in gut flora. The alteration of the gut microbiota (also known as "gut dysbiosis") is affected by host genetics, nutrition, antibiotics, and inflammation, and it is associated with the development of inflammatory bowel disease (IBD). Also, intestinal epithelial dysfunction, altered autophagy, and immune hyperactivation are frequently detected in individuals with severe IBD, which may be attributed to impaired miRNA expression functions. While the exact mechanisms of how Gut Microbiota may cause IBD and intestinal epithelial dysfunction are still debated, recent data point toward the possibility that hormones, gender and miRNAs expression are modifiable contributors to IBD. This review summarizes the current evidence for an association between hormones, gender and miRNAs and Gut Microbiota in IBD and discusses potential mechanisms by which gut microbiota may impact IBD. The study also outlines critical unanswered topics that need to be solved to enhance IBD prevention and treatment in people with gut dysbiosis.

Keywords: Inflammatory bowel disease, Ulcerative colitis, Crohn's disease, Gut, Microbiota, Pathogenesis

« Previous Next »
Graphical Abstract

[1]
Mulder, D.J.; Noble, A.J.; Justinich, C.J.; Duffin, J.M. A tale of two diseases: The history of inflammatory bowel disease. J. Crohn’s Colitis, 2014, 8(5), 341-348.
[http://dx.doi.org/10.1016/j.crohns.2013.09.009] [PMID: 24094598]
[2]
Wijmenga, C. Expressing the differences between Crohn disease and ulcerative colitis. PLoS Med., 2005, 2(8), e230.
[http://dx.doi.org/10.1371/journal.pmed.0020230] [PMID: 16120009]
[3]
Hammer, T.; Nielsen, K.R.; Munkholm, P.; Burisch, J.; Lynge, E. The Faroese IBD study: Incidence of inflammatory bowel diseases across 54 years of population-based data. J. Crohn’s Colitis, 2016, 10(8), 934-942.
[http://dx.doi.org/10.1093/ecco-jcc/jjw050] [PMID: 26933031]
[4]
Kaplan, G.G. The global burden of IBD: From 2015 to 2025. Nat. Rev. Gastroenterol. Hepatol., 2015, 12(12), 720-727.
[http://dx.doi.org/10.1038/nrgastro.2015.150] [PMID: 26323879]
[5]
Victoria, C.R.; Sassak, L.Y.; Nunes, H.R.C. Incidence and prevalence rates of inflammatory bowel diseases, in Midwestern of São Paulo State, Brazil. Arq. Gastroenterol., 2009, 46(1), 20-25.
[http://dx.doi.org/10.1590/S0004-28032009000100009] [PMID: 19466305]
[6]
Ouyang, Q.; Tandon, R.; Goh, K.L.; Pan, G.Z.; Fock, K.M.; Fiocchi, C.; Lam, S.K.; Xiao, S.D. Management consensus of inflammatory bowel disease for the Asia-Pacific region. J. Gastroenterol. Hepatol., 2006, 21(12), 1772-1782.
[http://dx.doi.org/10.1111/j.1440-1746.2006.04674.x] [PMID: 17074013]
[7]
Olfatifar, M.; Zali, M.R.; Pourhoseingholi, M.A.; Balaii, H.; Ghavami, S.B.; Ivanchuk, M.; Ivanchuk, P.; Nazari, S. shahrokh, S.; Sabour, S.; Khodakarim, S.; Aghdaei, H.A.; Rohani, P.; Mehralian, G. The emerging epidemic of inflammatory bowel disease in Asia and Iran by 2035: A modeling study. BMC Gastroenterol., 2021, 21(1), 204.
[http://dx.doi.org/10.1186/s12876-021-01745-1] [PMID: 33957874]
[8]
Rosen, C.E.; Palm, N.W. Navigating the microbiota seas: Triangulation finds a way forward. Cell Host Microbe, 2018, 23(1), 1-3.
[http://dx.doi.org/10.1016/j.chom.2017.12.015] [PMID: 29324223]
[9]
Nanda, K.; Moss, A.C. Update on the management of ulcerative colitis: Treatment and maintenance approaches focused on MMX(®) mesalamine. Clin. Pharmacol., 2012, 4, 41-50.
[PMID: 22888278]
[10]
Baumgart, D.C.; Sandborn, W.J. Inflammatory bowel disease: Clinical aspects and established and evolving therapies. Lancet, 2007, 369(9573), 1641-1657.
[http://dx.doi.org/10.1016/S0140-6736(07)60751-X] [PMID: 17499606]
[11]
Shah, S.C.; Khalili, H.; Chen, C.Y.; Ahn, H.S.; Ng, S.C.; Burisch, J.; Colombel, J.F. Sex-based differences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region. Aliment. Pharmacol. Ther., 2019, 49(7), 904-911.
[http://dx.doi.org/10.1111/apt.15178] [PMID: 30773656]
[12]
Rustgi, S.D.; Kayal, M.; Shah, S.C. Sex-based differences in inflammatory bowel diseases: A review. Therap. Adv. Gastroenterol., 2020, 13.
[http://dx.doi.org/10.1177/1756284820915043] [PMID: 32523620]
[13]
Whitacre, C.C.; Reingold, S.C.; O’Looney, P.A.; Blankenhorn, E.; Brinley, F.; Collier, E.; Duquette, P.; Fox, H.; Giesser, B.; Gilmore, W.; Lahita, R.; Nelson, J.L.; Reiss, C.; Riskind, P.; Voskuhl, R. A gender gap in autoimmunity. Science, 1999, 283(5406), 1277-1278.
[http://dx.doi.org/10.1126/science.283.5406.1277] [PMID: 10084932]
[14]
Shah, S.C.; Khalili, H.; Gower-Rousseau, C.; Olen, O.; Benchimol, E.I.; Lynge, E.; Nielsen, K.R.; Brassard, P.; Vutcovici, M.; Bitton, A.; Bernstein, C.N.; Leddin, D.; Tamim, H.; Stefansson, T.; Loftus, E.V., Jr; Moum, B.; Tang, W.; Ng, S.C.; Gearry, R.; Sincic, B.; Bell, S.; Sands, B.E.; Lakatos, P.L.; Végh, Z.; Ott, C.; Kaplan, G.G.; Burisch, J.; Colombel, J.F. Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from western countries. Gastroenterology, 2018, 155(4), 1079-1089.e3.
[http://dx.doi.org/10.1053/j.gastro.2018.06.043] [PMID: 29958857]
[15]
Beeson, P.B. Age and sex associations of 40 autoimmune diseases. Am. J. Med., 1994, 96(5), 457-462.
[http://dx.doi.org/10.1016/0002-9343(94)90173-2] [PMID: 8192178]
[16]
O’Toole, A.; Winter, D.; Friedman, S. Review article: The psychosexual impact of inflammatory bowel disease in male patients. Aliment. Pharmacol. Ther., 2014, 39(10), 1085-1094.
[http://dx.doi.org/10.1111/apt.12720] [PMID: 24654697]
[17]
Rosenblatt, E.; Kane, S. Sex-specific issues in inflammatory bowel disease. Gastroenterol. Hepatol. (N. Y.), 2015, 11(9), 592-601.
[PMID: 27482181]
[18]
Clarke, G.; Stilling, R.M.; Kennedy, P.J.; Stanton, C.; Cryan, J.F.; Dinan, T.G. Minireview: Gut microbiota: The neglected endocrine organ. Mol. Endocrinol., 2014, 28(8), 1221-1238.
[http://dx.doi.org/10.1210/me.2014-1108] [PMID: 24892638]
[19]
Flak, M.B.; Neves, J.F.; Blumberg, R.S. Welcome to the microgenderome. Science, 2013, 339(6123), 1044-1045.
[http://dx.doi.org/10.1126/science.1236226] [PMID: 23449586]
[20]
Vemuri, R.; Sylvia, K.E.; Klein, S.L.; Forster, S.C.; Plebanski, M.; Eri, R.; Flanagan, K.L. The microgenderome revealed: Sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility. Semin. Immunopathol., 2019, 41(2), 265-275.
[http://dx.doi.org/10.1007/s00281-018-0716-7] [PMID: 30298433]
[21]
Holingue, C.; Budavari, A.C.; Rodriguez, K.M.; Zisman, C.R.; Windheim, G.; Fallin, M.D. Sex differences in the gut-brain axis: Implications for mental health. Curr. Psychiatry Rep., 2020, 22(12), 83.
[http://dx.doi.org/10.1007/s11920-020-01202-y] [PMID: 33216233]
[22]
Christian, L.M.; Galley, J.D.; Hade, E.M.; Schoppe-Sullivan, S.; Kamp Dush, C.; Bailey, M.T. Gut microbiome composition is associated with temperament during early childhood. Brain Behav. Immun., 2015, 45, 118-127.
[http://dx.doi.org/10.1016/j.bbi.2014.10.018] [PMID: 25449582]
[23]
Minter, M.R.; Zhang, C.; Leone, V.; Ringus, D.L.; Zhang, X.; Oyler-Castrillo, P.; Musch, M.W.; Liao, F.; Ward, J.F.; Holtzman, D.M.; Chang, E.B.; Tanzi, R.E.; Sisodia, S.S. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease. Sci. Rep., 2016, 6(1), 30028.
[http://dx.doi.org/10.1038/srep30028] [PMID: 27443609]
[24]
Goodman, W.A.; Erkkila, I.P.; Pizarro, T.T. Sex matters: Impact on pathogenesis, presentation and treatment of inflammatory bowel disease. Nat. Rev. Gastroenterol. Hepatol., 2020, 17(12), 740-754.
[http://dx.doi.org/10.1038/s41575-020-0354-0] [PMID: 32901108]
[25]
Ye, Y.; Manne, S.; Treem, W.R.; Bennett, D. Prevalence of inflammatory bowel disease in pediatric and adult populations: Recent estimates from large national databases in the United States, 2007-2016. Inflamm. Bowel Dis., 2020, 26(4), 619-625.
[PMID: 31504515]
[26]
Bernstein, C.N.; Wajda, A.; Svenson, L.W.; MacKenzie, A.; Koehoorn, M.; Jackson, M.; Fedorak, R.; Israel, D.; Blanchard, J.F. The epidemiology of inflammatory bowel disease in Canada: A population-based study. Am. J. Gastroenterol., 2006, 101(7), 1559-1568.
[http://dx.doi.org/10.1111/j.1572-0241.2006.00603.x] [PMID: 16863561]
[27]
Abramson, O.; Durant, M.; Mow, W.; Finley, A.; Kodali, P.; Wong, A.; Tavares, V.; McCroskey, E.; Liu, L.; Lewis, J.D.; Allison, J.E.; Flowers, N.; Hutfless, S.; Velayos, F.S.; Perry, G.S.; Cannon, R.; Herrinton, L.J. Incidence, prevalence, and time trends of pediatric inflammatory bowel disease in Northern California, 1996 to 2006. J. Pediatr., 2010, 157(2), 233-239.e1.
[http://dx.doi.org/10.1016/j.jpeds.2010.02.024] [PMID: 20400099]
[28]
Gearry, R.B.; Richardson, A.; Frampton, C.M.A.; Collett, J.A.; Burt, M.J.; Chapman, B.A.; Barclay, M.L. High incidence of Crohnʼs disease in Canterbury, New Zealand: Results of an epidemiologic study. Inflamm. Bowel Dis., 2006, 12(10), 936-943.
[http://dx.doi.org/10.1097/01.mib.0000231572.88806.b9] [PMID: 17012964]
[29]
Molinié, F.; Gower-Rousseau, C.; Yzet, T.; Merle, V.; Grandbastien, B.; Marti, R.; Lerebours, E.; Dupas, J.L.; Colombel, J.F.; Salomez, J.L.; Cortot, A. Opposite evolution in incidence of Crohn’s disease and ulcerative colitis in Northern France (1988-1999). Gut, 2004, 53(6), 843-848.
[http://dx.doi.org/10.1136/gut.2003.025346] [PMID: 15138211]
[30]
Fumery, M.; Kohut, M.; Gower-Rousseau, C.; Duhamel, A.; Brazier, F.; Thelu, F.; Nagorniewicz, F.; Lamarche, F.; Nguyen-Khac, E.; Sabbagh, C.; Loreau, J.; Colombel, J.F.; Savoye, G.; Chatelain, D.; Dupas, J.L. Incidence, clinical presentation, and associated factors of microscopic colitis in Northern France: A population-based study. Dig. Dis. Sci., 2017, 62(6), 1571-1579.
[http://dx.doi.org/10.1007/s10620-016-4306-z] [PMID: 27659673]
[31]
Ciocîrlan, M.; Ciocîrlan, M.; Iacob, R.; Tanțău, A.; Gheorghe, L.; Gheorghe, C.; Dobru, D.; Constantinescu, G.; Cijevschi, C.; Trifan, A.; Goldiș, A.; Diculescu, M. Malnutrition prevalence in newly diagnosed patients with inflammatory bowel disease - data from the national Romanian database. J. Gastrointestin. Liver Dis., 2019, 28, 163-168.
[http://dx.doi.org/10.15403/jgld-176] [PMID: 31204412]
[32]
Lakatos, L.; Kiss, L.S.; David, G.; Pandur, T.; Erdelyi, Z.; Mester, G.; Balogh, M.; Szipocs, I.; Molnar, C.; Komaromi, E.; Laszlo Lakatos, P. Incidence, disease phenotype at diagnosis, and early disease course in inflammatory bowel diseases in Western Hungary, 2002-2006. Inflamm. Bowel Dis., 2011, 17(12), 2558-2565.
[http://dx.doi.org/10.1002/ibd.21607] [PMID: 22072315]
[33]
Sinčić, B.M.; Vucelić, B.; Peršić, M.; Brnčić, N.; Eržen, D.J.; Radaković, B.; Mićović, V.; Štimac, D. Incidence of inflammatory bowel disease in Primorsko-goranska County, Croatia, 2000–2004: A prospective population-based study. Scand. J. Gastroenterol., 2006, 41(4), 437-444.
[http://dx.doi.org/10.1080/00365520500320094] [PMID: 16635912]
[34]
Wiercinska-Drapalo, A.; Jaroszewicz, J.; Flisiak, R.; Prokopowicz, D. Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland. World J. Gastroenterol., 2005, 11(17), 2630-2633.
[http://dx.doi.org/10.3748/wjg.v11.i17.2630] [PMID: 15849823]
[35]
Park, S.H.; Kim, Y.J.; Rhee, K.H.; Kim, Y.H.; Hong, S.N.; Kim, K.H.; Seo, S.I.; Cha, J.M.; Park, S.Y.; Jeong, S.K.; Lee, J.H.; Park, H.; Kim, J.S. Im, J.P.; Yoon, H.; Kim, S.H.; Jang, J.; Kim, J.H.; Suh, S.O.; Kim, Y.K.; Ye, B.D.; Yang, S.K. A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986–2015. J. Crohn’s Colitis, 2019, 13(11), 1410-1417.
[http://dx.doi.org/10.1093/ecco-jcc/jjz081] [PMID: 30989166]
[36]
Yao, T.; Matsui, T.; Hiwatashi, N. Crohn’s disease in Japan. Dis. Colon Rectum, 2000, 43(10)(Suppl.), S85-S93.
[http://dx.doi.org/10.1007/BF02237231] [PMID: 11052483]
[37]
Yen, H.H.; Hsu, T.C.; Chen, M.W.; Su, P.Y.; Chen, Y.Y. Clinical features and treatment of inflammatory bowel disease in a low-incidence area. Medicine (Baltimore), 2021, 100(10), e25090.
[http://dx.doi.org/10.1097/MD.0000000000025090] [PMID: 33725901]
[38]
Li, X.; Song, P.; Li, J.; Tao, Y.; Li, G.; Li, X.; Yu, Z. The disease burden and clinical characteristics of inflammatory bowel disease in the Chinese population: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health, 2017, 14(3), 238.
[http://dx.doi.org/10.3390/ijerph14030238] [PMID: 28264519]
[39]
Fucilini, L.M.P.; Genaro, L.M.; Sousa, D.C.; Coy, C.S.R.; Leal, R.F.; Ayrizono, M.L.S. Epidemiological profile and clinical characteristics of inflammatory bowel diseases in a Brazilian referral center. Arq. Gastroenterol., 2021, 58(4), 483-490.
[http://dx.doi.org/10.1590/s0004-2803.202100000-87] [PMID: 34909854]
[40]
Sarmiento-Aguilar, A.; Ríos-Blancas, M.J.; Yamamoto-Furusho, J.K. Mortality and hospitalizations in Mexican patients with inflammatory bowel disease: Results from a nationwide health registry. Can. J. Gastroenterol. Hepatol., 2020, 2020, 1-8.
[http://dx.doi.org/10.1155/2020/8825330] [PMID: 32832489]
[41]
Shi, H.Y.; Levy, A.N.; Trivedi, H.D.; Chan, F.K.L.; Ng, S.C.; Ananthakrishnan, A.N. Ethnicity influences phenotype and outcomes in inflammatory bowel disease: A systematic review and meta-analysis of population-based studies. Clin. Gastroenterol. Hepatol., 2018, 16(2), 190-197.e11.
[http://dx.doi.org/10.1016/j.cgh.2017.05.047] [PMID: 28603049]
[42]
Ng, S.C.; Bernstein, C.N.; Vatn, M.H.; Lakatos, P.L.; Loftus, E.V., Jr; Tysk, C.; O’Morain, C.; Moum, B.; Colombel, J.F. Geographical variability and environmental risk factors in inflammatory bowel disease. Gut, 2013, 62(4), 630-649.
[http://dx.doi.org/10.1136/gutjnl-2012-303661] [PMID: 23335431]
[43]
Kim, Y.S.; Unno, T.; Kim, B.Y.; Park, M.S. Sex differences in gut microbiota. World J. Mens Health, 2020, 38(1), 48-60.
[http://dx.doi.org/10.5534/wjmh.190009] [PMID: 30929328]
[44]
Jašarević, E.; Morrison, K.E.; Bale, T.L. Sex differences in the gut microbiome–brain axis across the lifespan. Philos. Trans. R. Soc. Lond. B Biol. Sci., 2016, 371(1688), 20150122.
[http://dx.doi.org/10.1098/rstb.2015.0122] [PMID: 26833840]
[45]
Mulak, A.; Taché, Y.; Larauche, M. Sex hormones in the modulation of irritable bowel syndrome. World J. Gastroenterol., 2014, 20(10), 2433-2448.
[http://dx.doi.org/10.3748/wjg.v20.i10.2433] [PMID: 24627581]
[46]
Son, H.J.; Kim, N.; Song, C.H.; Nam, R.H.; Choi, S.I.; Kim, J.S.; Lee, D.H. Sex-related alterations of gut microbiota in the C57BL/6 mouse model of inflammatory bowel disease. J. Cancer Prev., 2019, 24(3), 173-182.
[http://dx.doi.org/10.15430/JCP.2019.24.3.173] [PMID: 31624723]
[47]
Zhang, Z.; Hyun, J.E.; Thiesen, A.; Park, H.; Hotte, N.; Watanabe, H.; Higashiyama, T.; Madsen, K.L. Sex-specific differences in the gut microbiome in response to dietary fiber supplementation in IL-10-deficient mice. Nutrients, 2020, 12(7), 2088.
[http://dx.doi.org/10.3390/nu12072088] [PMID: 32679670]
[48]
Harrison, C.A.; Laubitz, D.; Midura-Kiela, M.T.; Jamwal, D.R.; Besselsen, D.G.; Ghishan, F.K.; Kiela, P.R. Sexual dimorphism in the response to broad-spectrum antibiotics during t cell-mediated colitis. J. Crohn’s Colitis, 2019, 13(1), 115-126.
[http://dx.doi.org/10.1093/ecco-jcc/jjy144] [PMID: 30252029]
[49]
Kozik, A.J.; Nakatsu, C.H.; Chun, H.; Jones-Hall, Y.L. Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis. PLoS One, 2019, 14(11), e0225079.
[http://dx.doi.org/10.1371/journal.pone.0225079] [PMID: 31703107]
[50]
Fransen, F.; van Beek, A.A.; Borghuis, T.; Meijer, B.; Hugenholtz, F.; van der Gaast-de Jongh, C.; Savelkoul, H.F.; de Jonge, M.I.; Faas, M.M.; Boekschoten, M.V.; Smidt, H.; El Aidy, S.; de Vos, P. The impact of gut microbiota on gender-specific differences in immunity. Front. Immunol., 2017, 8, 754.
[http://dx.doi.org/10.3389/fimmu.2017.00754] [PMID: 28713378]
[51]
Org, E.; Mehrabian, M.; Parks, B.W.; Shipkova, P.; Liu, X.; Drake, T.A.; Lusis, A.J. Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes, 2016, 7(4), 313-322.
[http://dx.doi.org/10.1080/19490976.2016.1203502] [PMID: 27355107]
[52]
Lovell, R.M.; Ford, A.C. Effect of gender on prevalence of irritable bowel syndrome in the community: Systematic review and meta-analysis. Am. J. Gastroenterol., 2012, 107(7), 991-1000.
[http://dx.doi.org/10.1038/ajg.2012.131] [PMID: 22613905]
[53]
Khalili, H.; Higuchi, L.M.; Ananthakrishnan, A.N.; Manson, J.E.; Feskanich, D.; Richter, J.M.; Fuchs, C.S.; Chan, A.T. Hormone therapy increases risk of ulcerative colitis but not Crohn’s disease. Gastroenterology, 2012, 143(5), 1199-1206.
[http://dx.doi.org/10.1053/j.gastro.2012.07.096] [PMID: 22841783]
[54]
Khalili, H.; Higuchi, L.M.; Ananthakrishnan, A.N.; Richter, J.M.; Feskanich, D.; Fuchs, C.S.; Chan, A.T. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut, 2013, 62(8), 1153-1159.
[http://dx.doi.org/10.1136/gutjnl-2012-302362] [PMID: 22619368]
[55]
Sender, R.; Fuchs, S.; Milo, R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol., 2016, 14(8), e1002533.
[http://dx.doi.org/10.1371/journal.pbio.1002533] [PMID: 27541692]
[56]
Ghoshal, U.C.; Yadav, A.; Fatima, B.; Agrahari, A.P.; Misra, A. Small intestinal bacterial overgrowth in patients with inflammatory bowel disease: A case-control study. Indian J. Gastroenterol., 2022, 41(1), 96-103.
[PMID: 34390471]
[57]
Chen, K.L.; Madak-Erdogan, Z. Estrogen and microbiota crosstalk: Should we pay attention? Trends Endocrinol. Metab., 2016, 27(11), 752-755.
[http://dx.doi.org/10.1016/j.tem.2016.08.001] [PMID: 27553057]
[58]
Cox-York, K.A.; Sheflin, A.M.; Foster, M.T.; Gentile, C.L.; Kahl, A.; Koch, L.G.; Britton, S.L.; Weir, T.L. Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. Physiol. Rep., 2015, 3(8), e12488.
[http://dx.doi.org/10.14814/phy2.12488] [PMID: 26265751]
[59]
Sinha, T.; Vich Vila, A.; Garmaeva, S.; Jankipersadsing, S.A.; Imhann, F.; Collij, V.; Bonder, M.J.; Jiang, X.; Gurry, T.; Alm, E.J.; D’Amato, M.; Weersma, R.K.; Scherjon, S.; Wijmenga, C.; Fu, J.; Kurilshikov, A.; Zhernakova, A. Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles. Gut Microbes, 2019, 10(3), 358-366.
[http://dx.doi.org/10.1080/19490976.2018.1528822] [PMID: 30373468]
[60]
Yoon, K.; Kim, N. Roles of sex hormones and gender in the gut microbiota. J. Neurogastroenterol. Motil., 2021, 27(3), 314-325.
[http://dx.doi.org/10.5056/jnm20208] [PMID: 33762473]
[61]
Heitkemper, M.; Jarrett, M.; Bond, E.F.; Chang, L. Impact of sex and gender on irritable bowel syndrome. Biol. Res. Nurs., 2003, 5(1), 56-65.
[http://dx.doi.org/10.1177/1099800403005001006] [PMID: 12886671]
[62]
Shin, J.H.; Park, Y.H.; Sim, M.; Kim, S.A.; Joung, H.; Shin, D.M. Serum level of sex steroid hormone is associated with diversity and profiles of human gut microbiome. Res. Microbiol., 2019, 170(4-5), 192-201.
[http://dx.doi.org/10.1016/j.resmic.2019.03.003] [PMID: 30940469]
[63]
Flores, R.; Shi, J.; Fuhrman, B.; Xu, X.; Veenstra, T.D.; Gail, M.H.; Gajer, P.; Ravel, J.; Goedert, J.J. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: A cross-sectional study. J. Transl. Med., 2012, 10(1), 253.
[http://dx.doi.org/10.1186/1479-5876-10-253] [PMID: 23259758]
[64]
Baker, J.M.; Al-Nakkash, L.; Herbst-Kralovetz, M.M. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas, 2017, 103, 45-53.
[http://dx.doi.org/10.1016/j.maturitas.2017.06.025] [PMID: 28778332]
[65]
Menon, R.; Watson, S.E.; Thomas, L.N.; Allred, C.D.; Dabney, A.; Azcarate-Peril, M.A.; Sturino, J.M. Diet complexity and estrogen receptor β status affect the composition of the murine intestinal microbiota. Appl. Environ. Microbiol., 2013, 79(18), 5763-5773.
[http://dx.doi.org/10.1128/AEM.01182-13] [PMID: 23872567]
[66]
Colldén, H.; Landin, A.; Wallenius, V.; Elebring, E.; Fändriks, L.; Nilsson, M.E.; Ryberg, H.; Poutanen, M.; Sjögren, K.; Vandenput, L.; Ohlsson, C. The gut microbiota is a major regulator of androgen metabolism in intestinal contents. Am. J. Physiol. Endocrinol. Metab., 2019, 317(6), E1182-E1192.
[http://dx.doi.org/10.1152/ajpendo.00338.2019] [PMID: 31689143]
[67]
Soory, M. Bacterial steroidogenesis by periodontal pathogens and the effect of bacterial enzymes on steroid conversions by human gingival fibroblasts in culture. J. Periodontal Res., 1995, 30(2), 124-131.
[http://dx.doi.org/10.1111/j.1600-0765.1995.tb01261.x] [PMID: 7776153]
[68]
Li, X.; Cheng, W.; Shang, H.; Wei, H.; Deng, C. The interplay between androgen and gut microbiota: Is there a microbiota-gut-testis axis. Reprod. Sci., 2022, 29(6), 1674-1684.
[PMID: 34037957]
[69]
Chen, J.Q.; Papp, G.; Szodoray, P.; Zeher, M. The role of microRNAs in the pathogenesis of autoimmune diseases. Autoimmun. Rev., 2016, 15(12), 1171-1180.
[http://dx.doi.org/10.1016/j.autrev.2016.09.003] [PMID: 27639156]
[70]
Askari, H.; Raeis-Abdollahi, E.; Abazari, M.F.; Akrami, H.; Vakili, S.; Savardashtaki, A.; Tajbakhsh, A.; Sanadgol, N.; Azarnezhad, A.; Rahmati, L.; Abdullahi, P.R.; Zare Karizi, S.; Safarpour, A.R. Recent findings on the role of microRNAs in genetic kidney diseases. Mol. Biol. Rep., 2022, 49(7), 7039-7056.
[http://dx.doi.org/10.1007/s11033-022-07620-w] [PMID: 35717474]
[71]
Ghafouri-Fard, S.; Shirvani-Farsani, Z.; Taheri, M. The role of microRNAs in the pathogenesis of thyroid cancer. Noncoding RNA Res., 2020, 5(3), 88-98.
[http://dx.doi.org/10.1016/j.ncrna.2020.06.001] [PMID: 32637757]
[72]
Babashah, S.; Sadeghizadeh, M.; Tavirani, M.R.; Farivar, S.; Soleimani, M. Aberrant microRNA expression and its implications in the pathogenesis of leukemias. Cell Oncol. (Dordr.), 2012, 35(5), 317-334.
[http://dx.doi.org/10.1007/s13402-012-0095-3] [PMID: 22956261]
[73]
Asghari, M.; Abazari, M.F.; Bokharaei, H.; Aleagha, M.N.; Poortahmasebi, V.; Askari, H.; Torabinejad, S.; Ardalan, A.; Negaresh, N.; Ataei, A.; Pazooki, P.; Poorebrahim, M. Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer. Future Sci. OA, 2018, 4(3), FSO278.
[http://dx.doi.org/10.4155/fsoa-2017-0108] [PMID: 29568567]
[74]
Hashimoto, N.; Tanaka, T. Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus. J. Hum. Genet., 2017, 62(2), 141-150.
[http://dx.doi.org/10.1038/jhg.2016.150] [PMID: 27928162]
[75]
Gorabi, A.M.; Ghanbari, M.; Sathyapalan, T.; Jamialahmadi, T.; Sahebkar, A. Implications of microRNAs in the pathogenesis of atherosclerosis and prospects for therapy. Curr. Drug Targets, 2021, 22(15), 1738-1749.
[http://dx.doi.org/10.2174/1389450122666210120143450] [PMID: 33494668]
[76]
Feng, Y.Y.; Xu, X.Q.; Ji, C.B.; Shi, C.M.; Guo, X.R.; Fu, J.F. Aberrant hepatic microRNA expression in nonalcoholic fatty liver disease. Cell. Physiol. Biochem., 2014, 34(6), 1983-1997.
[http://dx.doi.org/10.1159/000366394] [PMID: 25562147]
[77]
Coskun, M.; Bjerrum, J.T.; Seidelin, J.B.; Nielsen, O.H. MicroRNAs in inflammatory bowel disease-pathogenesis, diagnostics and therapeutics. World J. Gastroenterol., 2012, 18(34), 4629.
[http://dx.doi.org/10.3748/wjg.v18.i34.4629]
[78]
Turchinovich, A.; Cho, W.C. The origin, function and diagnostic potential of extracellular microRNA in human body fluids. Front. Genet., 2014, 5, 30.
[http://dx.doi.org/10.3389/fgene.2014.00030] [PMID: 24575125]
[79]
Rashid, H.; Hossain, B.; Siddiqua, T.; Kabir, M.; Noor, Z.; Ahmed, M.; Haque, R. Fecal microRNAs as potential biomarkers for screening and diagnosis of intestinal diseases. Front. Mol. Biosci., 2020, 7, 181.
[http://dx.doi.org/10.3389/fmolb.2020.00181] [PMID: 32850969]
[80]
Liu, S.; da Cunha, A.P.; Rezende, R.M.; Cialic, R.; Wei, Z.; Bry, L.; Comstock, L.E.; Gandhi, R.; Weiner, H.L. Microbe, The host shapes the gut microbiota via fecal. Cell Host Microbe, 2016, 19(1), 32-43.
[http://dx.doi.org/10.1016/j.chom.2015.12.005] [PMID: 26764595]
[81]
Saini, V.; Dawar, R.; Suneja, S.; Gangopadhyay, S.; Kaur, C. Can microRNA become next-generation tools in molecular diagnostics and therapeutics? A systematic review. Egypt. J. Med. Hum. Genet., 2021, 22(1), 1-9.
[82]
Wu, F.; Zikusoka, M.; Trindade, A.; Dassopoulos, T.; Harris, M.L.; Bayless, T.M.; Brant, S.R.; Chakravarti, S.; Kwon, J.H. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2α. Gastroenterology, 2008, 135(5), 1624-1635.
[http://dx.doi.org/10.1053/j.gastro.2008.07.068]
[83]
James, J.P.; Riis, L.B.; Malham, M.; Høgdall, E.; Langholz, E.; Nielsen, B.S. MicroRNA biomarkers in IBD-Differential diagnosis and prediction of Colitis-Associated cancer. Int. J. Mol. Sci., 2020, 21(21), 7893.
[84]
Yan, H.; Zhang, X.; Xu, Y. Aberrant expression of miR-21 in patients with inflammatory bowel disease. Medicine (Baltimore), 2020, 99(17), e19693.
[http://dx.doi.org/10.1097/MD.0000000000019693] [PMID: 32332611]
[85]
Jung, H.; Kim, J.S.; Lee, K.H.; Tizaoui, K.; Terrazzino, S.; Cargnin, S.; Smith, L.; Koyanagi, A.; Jacob, L.; Li, H.; Hong, S.H.; Yon, D.K.; Lee, S.W.; Kim, M.S.; Wasuwanich, P.; Karnsakul, W.; Shin, J.I.; Kronbichler, A. Roles of microRNAs in inflammatory bowel disease. Int. J. Biol. Sci., 2021, 17(8), 2112-2123.
[http://dx.doi.org/10.7150/ijbs.59904] [PMID: 34131410]
[86]
Stiegeler, S.; Mercurio, K.; Iancu, M.A.; Corr, S.C. The impact of microRNAs during inflammatory bowel disease: Effects on the mucus layer and intercellular junctions for gut permeability. Cells, 2021, 10(12), 3358.
[http://dx.doi.org/10.3390/cells10123358] [PMID: 34943865]
[87]
Dai, X.; Chen, X.; Chen, Q.; Shi, L.; Liang, H.; Zhou, Z.; Liu, Q.; Pang, W.; Hou, D.; Wang, C.; Zen, K.; Yuan, Y.; Zhang, C.Y.; Xia, L. MicroRNA-193a-3p reduces intestinal inflammation in response to microbiota via down-regulation of colonic PepT1. J. Biol. Chem., 2015, 290(26), 16099-16115.
[http://dx.doi.org/10.1074/jbc.M115.659318] [PMID: 25931122]
[88]
Zhao, S.; Zhu, L.; Feng, W.; Zhang, L.; Chen, D.D.; Hu, Y.C.; Shen, H. MicroRNA 602 prevents the development of inflammatory bowel diseases in a microbiota dependent manner. Exp. Ther. Med., 2021, 22(6), 1373.
[http://dx.doi.org/10.3892/etm.2021.10808] [PMID: 34659519]
[89]
He, L.; Zhou, X.; Liu, Y.; Zhou, L.; Li, F. Fecal miR-142a-3p from dextran sulfate sodium-challenge recovered mice prevents colitis by promoting the growth of Lactobacillus reuteri. Mol. Ther., 2022, 30(1), 388-399.
[http://dx.doi.org/10.1016/j.ymthe.2021.08.025] [PMID: 34450255]
[90]
Johnston, D.G.W.; Williams, M.A.; Thaiss, C.A.; Cabrera-Rubio, R.; Raverdeau, M.; McEntee, C.; Cotter, P.D.; Elinav, E.; O’Neill, L.A.J.; Corr, S.C. Loss of microRNA-21 influences the gut microbiota, causing reduced susceptibility in a murine model of colitis. J. Crohn’s Colitis, 2018, 12(7), 835-848.
[http://dx.doi.org/10.1093/ecco-jcc/jjy038] [PMID: 29608690]
[91]
Viennois, E.; Chassaing, B.; Tahsin, A.; Pujada, A.; Wang, L.; Gewirtz, A.T.; Merlin, D. Host-derived fecal microRNAs can indicate gut microbiota healthiness and ability to induce inflammation. Theranostics, 2019, 9(15), 4542-4557.
[http://dx.doi.org/10.7150/thno.35282] [PMID: 31285778]
[92]
Baldelli, V.; Scaldaferri, F.; Putignani, L.; Del Chierico, F. The role of enterobacteriaceae in gut microbiota dysbiosis in inflammatory bowel diseases. Microorganisms, 2021, 9(4), 697.
[http://dx.doi.org/10.3390/microorganisms9040697] [PMID: 33801755]
[93]
Ji, Y.; Li, X.; Zhu, Y.; Li, N.; Zhang, N.; Niu, M. Faecal microRNA as a biomarker of the activity and prognosis of inflammatory bowel diseases. Biochem. Biophys. Res. Commun., 2018, 503(4), 2443-2450.
[http://dx.doi.org/10.1016/j.bbrc.2018.06.174] [PMID: 29969632]
[94]
Miles, D.R.; Shen, J.; Chuang, A.Y.; Dong, F.; Wu, F.; Kwon, J. Alpha-defensin 5 expression is regulated by microRNAs in the Caco-2 intestinal epithelial cell line. J. Inflamm. Bowel Dis. Disord., 2016, 1(1), 105.
[95]
Salzman, N.H.; Hung, K.; Haribhai, D.; Chu, H.; Karlsson-Sjöberg, J.; Amir, E.; Teggatz, P.; Barman, M.; Hayward, M.; Eastwood, D.; Stoel, M.; Zhou, Y.; Sodergren, E.; Weinstock, G.M.; Bevins, C.L.; Williams, C.B.; Bos, N.A. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol., 2010, 11(1), 76-82.
[http://dx.doi.org/10.1038/ni.1825] [PMID: 19855381]
[96]
Runtsch, M.C.; Hu, R.; Alexander, M.; Wallace, J.; Kagele, D.; Petersen, C.; Valentine, J.F.; Welker, N.C.; Bronner, M.P.; Chen, X.; Smith, D.P.; Ajami, N.J.; Petrosino, J.F.; Round, J.L.; O’Connell, R.M. MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. Oncotarget, 2015, 6(30), 28556-28572.
[http://dx.doi.org/10.18632/oncotarget.5597] [PMID: 26456940]
[97]
Filip, A.T.; Balacescu, O.; Marian, C.; Anghel, A. Microbiota small RNAs in inflammatory bowel disease. J. Gastrointestin. Liver Dis., 2016, 25(4), 509-516.
[http://dx.doi.org/10.15403/jgld.2014.1121.254.lip] [PMID: 27981307]
[98]
Khan, I.; Ullah, N.; Zha, L.; Bai, Y.; Khan, A.; Zhao, T.; Che, T.; Zhang, C. Alteration of gut microbiota in Inflammatory Bowel Disease (IBD): Cause or consequence? IBD treatment targeting the gut microbiome. Pathogens, 2019, 8(3), 126.
[http://dx.doi.org/10.3390/pathogens8030126] [PMID: 31412603]
[99]
Yang, L.; Liu, C.; Zhao, W.; He, C.; Ding, J.; Dai, R.; Xu, K.; Xiao, L.; Luo, L.; Liu, S.; Li, W.; Meng, H. Impaired autophagy in intestinal epithelial cells alters gut microbiota and host immune responses. Appl. Environ. Microbiol., 2018, 84(18), e00880-18.
[http://dx.doi.org/10.1128/AEM.00880-18] [PMID: 30006408]
[100]
Poorebrahim, M.; Asghari, M.; Abazari, M.F.; Askari, H.; Sadeghi, S.; Taheri-Kafrani, A.; Nasr-Esfahani, M.H.; Ghoraeian, P.; Aleagha, M.N.; Arab, S.S.; Kennedy, D.; Montaseri, A.; Mehranfar, M.; Sanadgol, N. Immunomodulatory effects of a rationally designed peptide mimetic of human IFNβ in EAE model of multiple sclerosis. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2018, 82, 49-61.
[http://dx.doi.org/10.1016/j.pnpbp.2017.11.028] [PMID: 29203302]
[101]
Li, Y.; Dong, J.; Xiao, H.; Zhang, S.; Wang, B.; Cui, M.; Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes, 2020, 11(4), 789-806.
[http://dx.doi.org/10.1080/19490976.2019.1709387] [PMID: 31931652]
[102]
Gao, B.; Chi, L.; Zhu, Y.; Shi, X.; Tu, P.; Li, B.; Yin, J.; Gao, N.; Shen, W.; Schnabl, B. An introduction to next generation sequencing bioinformatic analysis in gut microbiome studies. Biomolecules, 2021, 11(4), 530.
[http://dx.doi.org/10.3390/biom11040530] [PMID: 33918473]
[103]
Xia, R.; Shi, Y.; Wang, X.; Wu, Y.; Sun, M.; Hu, F. Metagenomic sequencing reveals that the assembly of functional genes and taxa varied highly and lacked redundancy in the earthworm gut compared with soil under vanadium stress. mSystems, 2022, 7(1), e01253-e21.
[http://dx.doi.org/10.1128/mSystems.01253-21] [PMID: 35089099]
[104]
Chiu, C.Y.; Miller, S.A. Clinical metagenomics. Nat. Rev. Genet., 2019, 20(6), 341-355.
[http://dx.doi.org/10.1038/s41576-019-0113-7] [PMID: 30918369]
[105]
Mack, A.; Bobardt, J.S.; Haß, A.; Nichols, K.B.; Schmid, R.M.; Stein-Thoeringer, C.K. Changes in gut microbial metagenomic pathways associated with clinical outcomes after the elimination of malabsorbed sugars in an IBS cohort. Gut Microbes, 2020, 11(3), 620-631.
[http://dx.doi.org/10.1080/19490976.2019.1686322] [PMID: 31809634]
[106]
Stevens, E.J.; Bates, K.A.; King, K.C. Host microbiota can facilitate pathogen infection. PLoS Pathog., 2021, 17(5), e1009514.
[http://dx.doi.org/10.1371/journal.ppat.1009514] [PMID: 33984069]
[107]
Trindade, B.C.; Chen, G.Y. NOD1 and NOD2 in inflammatory and infectious diseases. Immunol. Rev., 2020, 297(1), 139-161.
[http://dx.doi.org/10.1111/imr.12902] [PMID: 32677123]
[108]
Goethel, A.; Turpin, W.; Rouquier, S.; Zanello, G.; Robertson, S.J.; Streutker, C.J.; Philpott, D.J.; Croitoru, K. Nod2 influences microbial resilience and susceptibility to colitis following antibiotic exposure. Mucosal Immunol., 2019, 12(3), 720-732.
[http://dx.doi.org/10.1038/s41385-018-0128-y] [PMID: 30651577]
[109]
Bryant, S.S. The Influence of Genetic Background on Experimentally-Induced Colitis in Murine Models of Inflammatory Bowel Disease; North Carolina State University, 2019.
[110]
Caron, B.; Jouzeau, J.Y.; Miossec, P.; Petitpain, N.; Gillet, P.; Netter, P.; Peyrin-Biroulet, L. Gastroenterological safety of IL-17 inhibitors: A systematic literature review. Expert Opin. Drug Saf., 2022, 21(2), 223-239.
[http://dx.doi.org/10.1080/14740338.2021.1960981] [PMID: 34304684]
[111]
Abazari, M.F.; Nasiri, N.; Karizi, S.Z.; Nejati, F.; Haghi-Aminjan, H.; Norouzi, S.; Piri, P.; Estakhr, L.; Faradonbeh, D.R.; Kohandani, M.; Daliri, K.; Sanadgol, N.; Askari, H. An updated review of various medicinal applications of p-Co umaric acid: From antioxidative and anti-inflammatory properties to effects on cell cycle and proliferation. Mini Rev. Med. Chem., 2021, 21(15), 2187-2201.
[http://dx.doi.org/10.2174/1389557521666210114163024] [PMID: 33459233]
[112]
Caruso, R.; Mathes, T.; Martens, E.C.; Kamada, N.; Nusrat, A.; Inohara, N.; Núñez, G. A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice. Sci. Immunol., 2019, 4(34), eaaw4341.
[http://dx.doi.org/10.1126/sciimmunol.aaw4341] [PMID: 31004013]
[113]
Shan, Y.; Lee, M.; Chang, E.B. The gut microbiome and inflammatory bowel diseases. Annu. Rev. Med., 2022, 73(1), 455-468.
[http://dx.doi.org/10.1146/annurev-med-042320-021020] [PMID: 34555295]
[114]
Shirazi, T.; Longman, R.J.; Corfield, A.P.; Probert, C.S. Mucins and inflammatory bowel disease. Postgrad. Med. J., 2000, 76(898), 473-478.
[http://dx.doi.org/10.1136/pmj.76.898.473] [PMID: 10908374]
[115]
Wu, M.; Wu, Y.; Li, J.; Bao, Y.; Guo, Y.; Yang, W. The dynamic changes of gut microbiota in Muc2 deficient mice. Int. J. Mol. Sci., 2018, 19(9), 2809.
[http://dx.doi.org/10.3390/ijms19092809] [PMID: 30231491]
[116]
Liang, C.; Zhao, J.; Lu, J.; Zhang, Y.; Ma, X.; Shang, X.; Li, Y.; Ma, X.; Liu, M.; Wang, X. Development and characterization of MDR1 (Mdr1a/b) CRISPR/Cas9 knockout rat model. Drug Metab. Dispos., 2019, 47(2), 71-79.
[http://dx.doi.org/10.1124/dmd.118.084277] [PMID: 30478157]
[117]
Cui, Y.J.; Cheng, X.; Weaver, Y.M.; Klaassen, C.D. Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metab. Dispos., 2009, 37(1), 203-210.
[http://dx.doi.org/10.1124/dmd.108.023721] [PMID: 18854377]
[118]
Surawicz, C.M.; Brandt, L.J.; Binion, D.G.; Ananthakrishnan, A.N.; Curry, S.R.; Gilligan, P.H.; McFarland, L.V.; Mellow, M.; Zuckerbraun, B.S. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am. J. Gastroenterol., 2013, 108(4), 478-498.
[119]
Chen, M.; Liu, X.L.; Zhang, Y.J.; Nie, Y.Z.; Wu, K.C.; Shi, Y.Q. Efficacy and safety of fecal microbiota transplantation by washed preparation in patients with moderate to severely active ulcerative colitis. J. Dig. Dis., 2020, 21(11), 621-628.
[http://dx.doi.org/10.1111/1751-2980.12938] [PMID: 32909356]
[120]
Pai, N.; Popov, J.; Hill, L.; Hartung, E. Protocol for a double-blind, randomised, placebo-controlled pilot study for assessing the feasibility and efficacy of faecal microbiota transplant in a paediatric Crohn’s disease population: PediCRaFT Trial. BMJ Open, 2019, 9(11), e030120.
[PMID: 31784432]
[121]
Kunde, S.; Pham, A.; Bonczyk, S.; Crumb, T.; Duba, M.; Conrad, H., Jr; Cloney, D.; Kugathasan, S. Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis. J. Pediatr. Gastroenterol. Nutr., 2013, 56(6), 597-601.
[http://dx.doi.org/10.1097/MPG.0b013e318292fa0d] [PMID: 23542823]
[122]
Karolewska-Bochenek, K.; Lazowska-Przeorek, I.; Grzesiowski, P.; Dziekiewicz, M.; Dembinski, L.; Albrecht, P.; Radzikowski, A.; Banaszkiewicz, A. Faecal microbiota transfer - a new concept for treating cytomegalovirus colitis in children with ulcerative colitis. Ann. Agric. Environ. Med., 2021, 28(1), 56-60.
[PMID: 33775068]
[123]
Xiang, L.; Ding, X.; Li, Q.; Wu, X.; Dai, M.; Long, C.; He, Z.; Cui, B.; Zhang, F. Efficacy of faecal microbiota transplantation in Crohn’s disease: A new target treatment? Microb. Biotechnol., 2020, 13(3), 760-769.
[http://dx.doi.org/10.1111/1751-7915.13536] [PMID: 31958884]
[124]
Wang, Y.; Ren, R.; Sun, G.; Peng, L.; Tian, Y.; Yang, Y. Pilot study of cytokine changes evaluation after fecal microbiota transplantation in patients with ulcerative colitis. Int. Immunopharmacol., 2020, 85, 106661.
[http://dx.doi.org/10.1016/j.intimp.2020.106661] [PMID: 32563025]
[125]
Nahidi, L.; Corley, S.M.; Wilkins, M.R.; Wei, J.; Alhagamhmad, M.; Day, A.S.; Lemberg, D.A.; Leach, S.T. The major pathway by which polymeric formula reduces inflammation in intestinal epithelial cells: A microarray-based analysis. Genes Nutr., 2015, 10(5), 29.
[http://dx.doi.org/10.1007/s12263-015-0479-x] [PMID: 26183161]
[126]
Moayyedi, P.; Surette, M.G.; Kim, P.T.; Libertucci, J.; Wolfe, M.; Onischi, C.; Armstrong, D.; Marshall, J.K.; Kassam, Z.; Reinisch, W.; Lee, C.H. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology, 2015, 149(1), 102-109.e6.
[http://dx.doi.org/10.1053/j.gastro.2015.04.001] [PMID: 25857665]
[127]
Hamilton, A.L.; Kamm, M.A.; De Cruz, P.; Wright, E.K.; Feng, H.; Wagner, J.; Sung, J.J.Y.; Kirkwood, C.D.; Inouye, M.; Teo, S.M. Luminal microbiota related to Crohn’s disease recurrence after surgery. Gut Microbes, 2020, 11(6), 1713-1728.
[http://dx.doi.org/10.1080/19490976.2020.1778262] [PMID: 32564657]
[128]
Feng, L.; Zhou, N.; Li, Z.; Fu, D.; Guo, Y.; Gao, X.; Liu, X. Co‐occurrence of gut microbiota dysbiosis and bile acid metabolism alteration is associated with psychological disorders in Crohn’s disease. FASEB J., 2022, 36(1), e22100.
[http://dx.doi.org/10.1096/fj.202101088RRR] [PMID: 34939244]
[129]
Lee, T.; Clavel, T.; Smirnov, K.; Schmidt, A.; Lagkouvardos, I.; Walker, A.; Lucio, M.; Michalke, B.; Schmitt-Kopplin, P.; Fedorak, R.; Haller, D. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut, 2017, 66(5), 863-871.
[http://dx.doi.org/10.1136/gutjnl-2015-309940] [PMID: 26848182]
[130]
Sprockett, D.; Fischer, N.; Boneh, R.S.; Turner, D.; Kierkus, J.; Sladek, M.; Escher, J.C.; Wine, E.; Yerushalmi, B.; Dias, J.A.; Shaoul, R.; Kori, M.; Snapper, S.B.; Holmes, S.; Bousvaros, A.; Levine, A.; Relman, D.A. Treatment-specific composition of the gut microbiota is associated with disease remission in a pediatric Crohn’s disease cohort. Inflamm. Bowel Dis., 2019, 25(12), 1927-1938.
[http://dx.doi.org/10.1093/ibd/izz130] [PMID: 31276165]
[131]
Wellington, V.N.A.; Sundaram, V.L.; Singh, S.; Sundaram, U. Dietary supplementation with vitamin D, fish oil or resveratrol modulates the gut microbiome in inflammatory bowel disease. Int. J. Mol. Sci., 2021, 23(1), 206.
[http://dx.doi.org/10.3390/ijms23010206] [PMID: 35008631]
[132]
Hart, L.; Verburgt, C.M.; Wine, E.; Zachos, M.; Poppen, A.; Chavannes, M.; Van Limbergen, J.; Pai, N. Nutritional therapies and their influence on the intestinal microbiome in pediatric inflammatory bowel disease. Nutrients, 2021, 14(1), 4.
[http://dx.doi.org/10.3390/nu14010004] [PMID: 35010879]
[133]
Facchin, S.; Vitulo, N.; Calgaro, M.; Buda, A.; Romualdi, C.; Pohl, D.; Perini, B.; Lorenzon, G.; Marinelli, C.; D’Incà, R.; Sturniolo, G.C.; Savarino, E.V. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterol. Motil., 2020, 32(10), e13914.
[http://dx.doi.org/10.1111/nmo.13914] [PMID: 32476236]
[134]
Peter, I.; Maldonado-Contreras, A.; Eisele, C.; Frisard, C.; Simpson, S.; Nair, N.; Rendon, A.; Hawkins, K.; Cawley, C.; Debebe, A.; Tarassishin, L.; White, S.; Dubinsky, M.; Stone, J.; Clemente, J.C.; Sabino, J.; Torres, J.; Hu, J.; Colombel, J.F.; Olendzki, B. A dietary intervention to improve the microbiome composition of pregnant women with Crohn’s disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design. Contemp. Clin. Trials Commun., 2020, 18, 100573.
[http://dx.doi.org/10.1016/j.conctc.2020.100573] [PMID: 32617430]
[135]
Xu, L.; Lochhead, P.; Ko, Y.; Claggett, B.; Leong, R.W.; Ananthakrishnan, A.N. Systematic review with meta-analysis: Breastfeeding and the risk of Crohn’s disease and ulcerative colitis. Aliment. Pharmacol. Ther., 2017, 46(9), 780-789.
[http://dx.doi.org/10.1111/apt.14291] [PMID: 28892171]
[136]
Yilmaz, I.; Dolar, M.E.; Özpınar, H. Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial. Turk. J. Gastroenterol., 2020, 30(3), 242-253.
[http://dx.doi.org/10.5152/tjg.2018.18227] [PMID: 30662004]
[137]
Shadnoush, M.; Hosseini, R.S.; Khalilnezhad, A.; Navai, L.; Goudarzi, H.; Vaezjalali, M. Effects of probiotics on gut microbiota in patients with inflammatory bowel disease: A double-blind, placebo-controlled clinical trial. Korean J. Gastroenterol., 2015, 65(4), 215-221.
[138]
Chu, N.D.; Crothers, J.W.; Nguyen, L.T.T.; Kearney, S.M.; Smith, M.B.; Kassam, Z.; Collins, C.; Xavier, R.; Moses, P.L.; Alm, E.J. Dynamic colonization of microbes and their functions after fecal microbiota transplantation for inflammatory bowel disease. MBio, 2021, 12(4), e00975-21.
[http://dx.doi.org/10.1128/mBio.00975-21] [PMID: 34281401]
[139]
Bashir, M.; Prietl, B.; Tauschmann, M.; Mautner, S.I.; Kump, P.K.; Treiber, G.; Wurm, P.; Gorkiewicz, G.; Högenauer, C.; Pieber, T.R. Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. Eur. J. Nutr., 2016, 55(4), 1479-1489.
[http://dx.doi.org/10.1007/s00394-015-0966-2] [PMID: 26130323]
[140]
Noriega, B.S.; Sanchez-Gonzalez, M.A.; Salyakina, D.; Coffman, J. Understanding the impact of omega-3 rich diet on the gut microbiota. Case Rep. Med., 2016, 2016, 3089303.
[http://dx.doi.org/10.1155/2016/3089303] [PMID: 27065349]
[141]
Perri, M.R.; Romano, C.; Marrelli, M.; Zicarelli, L.; Toma, C.C.; Basta, D.; Conforti, F.; Statti, G. Beneficial role of fruits, their juices, and freeze-dried powders on inflammatory bowel disease and related dysbiosis. Plants (Basel, Switzerland), 2021, 11(1), 4.
[142]
Luo, S.; Zhu, H.; Zhang, J.; Wan, D. The pivotal role of microbiota in modulating the neuronal-glial-epithelial unit. Infect. Drug Resist., 2021, 14, 5613-5628.
[http://dx.doi.org/10.2147/IDR.S342782] [PMID: 34992388]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy