Baclofen-induced Encephalopathy in Patients with End-stage Kidney Disease –
A Case Series

Nahla      Kharraz; Hebah      Al Jaghoub; Hamzeh      Alsubbah; Dhanya      Mohan; Fakhriya      Alalawi; Amna      Alhadari

doi:10.2174/03666220909092340

Abstract

Introduction/Background: Baclofen is a centrally acting GABA B receptor agonist, widely used for the treatment of neurological diseases ranging from hiccups to multiple sclerosis. As the drug is renally excreted, intoxication can rapidly develop in those patients with a reduced glomerular filtration rate. A strong index of clinical suspicion is essential to correctly diagnose the condition.

Case Presentation: We report a case series of patients with advanced kidney disease and baclofen-induced encephalopathy that settled with discontinuation of the drug and hemodialysis sessions.

Conclusion: We report this cluster of patients with baclofen toxicity to highlight the common occurrence of neurotoxicity after its use in patients with end-stage renal disease and its resolution after cessation of the drug and hemodialysis sessions.

Keywords: Baclofen, Encephalopathy, Hemodialysis, ESKD: End-Stage Kidney Disease

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