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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Advances in Metal-organic Frameworks (MOFs) based Biosensors for Diagnosis: An Update

Author(s): Ghazala Ashraf*, Tauqir Ahmad, Muhammad Zeeshan Ahmed, Murtaza and Yousef Rasmi*

Volume 22, Issue 27, 2022

Published on: 05 September, 2022

Page: [2222 - 2240] Pages: 19

DOI: 10.2174/1568026622666220829125548

Price: $65

Abstract

Metal-organic frameworks (MOFs) have significant advantages over other candidate classes of chemo-sensory materials owing to their extraordinary structural tunability and characteristics. MOF-based biosensing is a simple and convenient method for identifying various species. Biomarkers are molecular or cellular processes that link environmental exposure to a health outcome. Biomarkers are important in understanding the links between environmental chemical exposure and the development of chronic diseases, as well as in identifying disease-prone subgroups. Until now, several species, including nanoparticles (NPs) and their nanocomposites, small molecules, and unique complex systems, have been used for the chemical sensing of biomarkers. Following the overview of the field, we discussed the various fabrication methods for MOFs development in this review. We provide a thorough overview of the previous five years of progress to broaden the scope of analytes for future research. Several enzymatic and non-enzymatic sensors are offered, together with a mandatory measuring method that includes detection range and dynamic range. In addition, we reviewed the comparison of enzymatic and non-enzymatic biosensors, inventive edges, and the difficulties that need to be solved. This work might open up new possibilities for material production, sensor development, medical diagnostics, and other sensing fields.

Keywords: Metal-organic frameworks, biomarkers, protein, dopamine, metabolites, disease diagnosis.

Graphical Abstract

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