Generic placeholder image

Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

An Easy and Straight Forward Approach Towards the Synthesis of N-Benzyl-5(S)-Substituted Pyrrolidin-2-ones from N-Benzyl-5(S)-pyroglutaminol through Mitsunobu Reaction

Author(s): Sharad Kumar Panday* and Munish Kumar

Volume 19, Issue 6, 2023

Published on: 21 November, 2022

Article ID: e290822208125 Pages: 5

DOI: 10.2174/1573407218666220829104307

Abstract

Background: Pyroglutamic acid is one of the cheapest chiral synthon for the synthesis of a variety of bioactive molecules ranging from synthetic to natural origin. Derived from glutamic acid by internal cyclization pyroglutamic acid can serve easily as a precursor for prolines or pyroglutaminols by the selective reduction of lactam carbonyl or carboxylic group, respectively. Pyroglutamic acid has two differential carbonyls and a lactam NH group. All these can differentially be modified to get a variety of compounds. These applications coupled with the easy availability of pyroglutamic acid have made it a choice of interest for various research groups in recent years to get a range of bioactive compounds both of natural as well as synthetic origins. In our ongoing research programme, we were interested to develop an easy route for the synthesis of 5-substituted pyrrolidin-2-ones exploiting the chemistry of pyroglutamates, whose synthetic potential is well established.

Objective: To develop a simple and efficient methodology for the synthesis of 5-sustituted- pyrrolidin-2-ones as bioactive molecules/intermediate to bioactive molecules.

Methods: N-Benzyl-5(S)-pyroglutaminol 1, (0.96 g, 5.0 mmol) was taken in THF (15 mL) and diethylazodicarboxylate (DEAD) (1.21 g, 1.4 eq) and triphenylphosphine (Ph3P) (1.72 g, 1.4 eq), were added to it and the reaction mixture was stirred at RT for 30 min. After 30 min a solution of the substituted pyrazole/imidazole derivative (1.2 eq) in THF (10 mL) was added and the reaction mixture was stirred again at RT for 7 hr. The progress of the reaction was monitored by thin layer chromatography (TLC). At the completion of the reaction, the solvents were evaporated under a vacuum to give a liquid which was poured into water (15 mL) and extracted twice with ethyl acetate (2 x 20 mL). The combined organic layer was washed with brine solution (15 mL), dried over sodium sulfate, concentrated and purified by column chromatography on silica gel using 20% EtOAc-hexane as eluent to give pure compounds 2 a-d, 3 and 4, respectively in satisfactory yields.

Results: Herein, we wish to describe the synthesis of new 5(S)-substituted pyrrolidin-2- one derivatives through Mitsunobu reaction of N-benzyl-5(S)- pyroglutaminol with substituted pyrazole and imidazole derivatives.

Conclusion: An easy and straightforward approach towards the synthesis of enantiomerically pure N-benzyl- (S)-5-substituted pyrrolidin-2-ones from N-benzyl-5(S)- pyroglutaminol through Mitsunobu reaction has been developed. These N-benzyl-(S)-5-substituted pyrrolidin-2-ones could be useful for the synthesis of bioactive natural products requiring pyrazole/imidazole moiety attached at C-5 position of native pyrrolidin-2- one moiety.

Keywords: Optically pure, pyroglutaminol, piracetam, Doxapram, Mitsunobu reaction, 5-substituted pyrrolidin-2-ones

Graphical Abstract

[1]
Panday, S.K.; Prasad, J.; Dikshit, D.K. Pyroglutamic acid: A unique chiral. Synthon. Tetrahedron: Asymmetry, 2009, 20, 1581-1631.
[2]
Stefanucci, A.; Novellino, E.; Costante, R.; Mollica, A. Pyroglutamic acid derivatives: Building blocks for drug discovery. Heterocycles, 2014, 89(8), 1801-1825.
[http://dx.doi.org/10.3987/REV-14-800]
[3]
Panday, S.K. Pyroglutamic acid and its derivatives: The privileged precursors for the asymmetric synthesis of bioactive natural products. Mini Rev. Org. Chem., 2020, 17(6), 1-21.
[http://dx.doi.org/10.2174/1570193X16666190917142814]
[4]
Panday, S.K.; Dikshit, M.; Dikshit, D.K. Synthesis of N-3′-(acetylthio)alkanoyl and N-[3′-mercaptoalkanoyl]-4-α(s)-(phenylme-thyl) pyroglutamic acids and prolines as potent ACE inhibitors. Med. Chem. Res., 2009, 18(7), 566-578.
[http://dx.doi.org/10.1007/s00044-008-9150-z]
[5]
Dikshit, D.K.; Panday, S.K. Aldol reactions of pyroglutamates: Chiral synthesis of 4α(S)- and 4β(R)-(arylmethyl)pyroglutamates. J. Org. Chem., 1992, 57(6), 1920-1924.
[http://dx.doi.org/10.1021/jo00032a056]
[6]
Panday, S.K.; Brunet, D-G.; Langlois, N. A short and efficient synthesis of (S)-4-methylene proline benzyl ester from (S)-pyroglutamic acid. Tetrahedron Lett., 1994, 35(36), 6673-6376.
[http://dx.doi.org/10.1016/S0040-4039(00)73465-4]
[7]
Panday, S.K.; Langlois, N. An efficient straightforward synthesis of (-)-bulgecinine. Synth. Commun., 1997, 27(8), 1373-1384.
[http://dx.doi.org/10.1080/00397919708006067]
[8]
Ohfune, Y.; Tomita, M. Total synthesis of (-)-domoic acid. A revision of the original structure. J. Am. Chem. Soc., 1982, 104(12), 3511-3513.
[http://dx.doi.org/10.1021/ja00376a048]
[9]
a) Cossy, J.; Cases, M.; Pardo, D.G. Approaches to a synthesis of α- kainic acid. Tetrahedron, 1999, 55, 6153-6166.;
b) Hanessian, S.; Ninkovic, S. Stereoselective synthesis of (−)-α-kainic acid and (+)-α-allokainic acid via trimethylstannyl-mediated radical carbocyclization and oxidative destannylation. J. Org. Chem.,, 1996, 61, 5418-5424.;
c) Baldwin, J.E.; Moloney, M.G.; Parsous, A.F. Enantioselective kainoid synthesis by cobalt-mediated cyclisation of an amino acid derivative. Tetrahedron, 1990, 46, 7263-7282.
[10]
Peterson, J.S.; Fels, G.; Rapoport, H. Chirospecific syntheses of (+)- and (-)-anatoxin a. J. Am. Chem. Soc., 1984, 106(16), 4539-4547.
[http://dx.doi.org/10.1021/ja00328a040]
[11]
Panday, S.K.; Prasad, J.; Pathak, M.B. A straight forward and facile approach towards the N- derivatization of pyroglutamates through mitsunobu reaction: Synthesis of N-alkyl/N-acyl pyroglutamates. Synth. Commun., 2011, 41(24), 3654-3661.
[http://dx.doi.org/10.1080/00397911.2010.519844]
[12]
Wierzejska, J.; Motogoe, S.; Makino, Y.; Sengoku, T.; Takahashi, M.; Yoda, H. A new approach toward the total synthesis of (+)-batzellaside B. Beilstein J. Org. Chem., 2012, 8, 1831-1838.
[http://dx.doi.org/10.3762/bjoc.8.210] [PMID: 23209519]
[13]
Toyooka, N.; Zhou, D.; Nemoto, H.; Tezuka, Y.; Kadota, S.; Jones, T.H.; Garraffo, H.M.; Spande, T.F.; Daly, J.W. First enantioselective synthesis of a hydroxyindolizidine alkaloid from the ant myrmicaria melanogaster. Synlett, 2008, 12(12), 1894-1896.
[http://dx.doi.org/10.1055/s-2008-1078502]
[14]
a) Moutevelis-Minakakis, P.; Papavassilopoulou, E.; Mavromoustakos, T. Synthesis of new optically active 2-pyrrolidinones. Molecules, 2012, 18(1), 50-73.
[http://dx.doi.org/10.3390/molecules18010050] [PMID: 23344188];
b) Winblad, B. Piracetam: A review of pharmacological properties and clinical uses. CNS Drug Rev., 2005, 11(2), 169-182.
[http://dx.doi.org/10.1111/j.1527-3458.2005.tb00268.x] [PMID: 16007238]
[15]
Singh, P.; Dimitriou, V.; Mahajan, R.P.; Crossley, A.W. Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. Br. J. Anaesth., 1993, 71(5), 685-688.
[http://dx.doi.org/10.1093/bja/71.5.685] [PMID: 8251281]
[16]
Volkhard, A.; Eisert, W.; Himmelsbach, F.; Linz, G.; Mueller, T.; Pieper, H.; Weisenberger, J.U.S. Patent 5455348, 1995.
[17]
Siddiqui, N.; Ahsan, W.; Alam, M.S.; Ali, R.; Srivastava, K. Design, synthesis and evaluation of anticonvulsant activity of pyridinyl-pyrrolidones: A pharmacophore hybrid approach. Arch. Pharm. (Weinheim), 2012, 345(3), 185-194.
[http://dx.doi.org/10.1002/ardp.201100140] [PMID: 21997797]
[18]
Zhongli, G.; Ryan, H.; David, S. Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof. U.S. Patent 20120238757, 2012.
[19]
Hughes, D.L. The Mitsunobu reaction. Org. React., 1992, 42, 335-656.
[20]
But, T.Y.S.; Toy, P.H. Organocatalytic mitsunobu reactions, h. organocatalytic mitsunobu reactions. J. Am. Chem. Soc., 2006, 128(30), 9636-9637.
[http://dx.doi.org/10.1021/ja063141v] [PMID: 16866510]
[21]
Lepore, S.D.; He, Y. Use of sonication for the coupling of sterically hindered substrates in the phenolic Mitsunobu reaction. J. Org. Chem., 2003, 68(21), 8261-8263.
[http://dx.doi.org/10.1021/jo0345751] [PMID: 14535815]
[22]
Olofsson, B.; Wijtmans, R.; Somfai, P. Synthesis of N–H vinylaziridines: A comparative study. Tetrahedron, 2002, 58(30), 5979-5982.
[http://dx.doi.org/10.1016/S0040-4020(02)00610-5]
[23]
Swamy, K.C.; Kumar, N.N.; Balaraman, E.; Kumar, K.V. Mitsunobu and related reactions: Advances and applications. Chem. Rev., 2009, 109(6), 2551-2651.
[http://dx.doi.org/10.1021/cr800278z] [PMID: 19382806]
[24]
Panday, S.K.; Prasad, J.; Pathak, M.B. Straightforward and facile approach toward the N-derivatization of pyroglutamates through mitsunobu reaction: Synthesis of N-Alkyl/N-Acyl pyroglutamates. Synth. Commun., 2011, 41(24), 3654-3661.
[http://dx.doi.org/10.1080/00397911.2010.519844]
[25]
Panday, S.K. Advances in the mitsunobu reaction: An excellent organic protocol with versatile applications. Mini Rev. Org. Chem., 2019, 16(2), 1-14.
[http://dx.doi.org/10.2174/1570193X15666180612090313]
[26]
Prasad, J.; Pathak, M.B.; Panday, S.K. An efficient and straight forward synthesis of (5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone (MM1): A novel antihypertensive agent. Med. Chem. Res., 2012, 21(3), 321-324.
[http://dx.doi.org/10.1007/s00044-010-9536-6]
[27]
Panday, S.K.; Pathak, M.B.; Prasad, J. An efficient and straight forward strategy for the synthesis of enantiomerically pure(S)-1- Benzyl-5-((Alkyl/Aryl amino-methyl)-Pyrrolidin-2-ones. Indian J. Chem.,, 2015, 54(B), 936-39.

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version18.99sRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[20:45:35] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[20:45:54] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[20:45:54] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[20:45:54] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (283ms)time
  • Application (18.71s)time
  • 1 x Application (98.51%)
    18.71s
    1 x Booting (1.49%)
    283ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    31 statements were executed, 4 of which were duplicates, 27 unique. Show only duplicated7.94s
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316381173','',1,1740775545,1740775545) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740775545
      2.99salphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316381173','/article/125950',1,1740775545,1740775545)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316381173 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316381173) limit 1
      640msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316381173
      • 1: 316381173
      • 2: 316381173
      • 3: 316381173
      • 4: 316381173
      • 5: 316381173
      • 6: 316381173
      • 7: 316381173
      • 8: 316381173
      • 9: 316381173
      • 10: 316381173
      • 11: 316381173
      • 12: 316381173
      • 13: 316381173
      • 14: 316381173
      • 15: 316381173
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=125950
      11.45msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 6 limit 1
      1.21msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 6
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=6) and sj.journal_id!=6 group by `j`.`nid`) as `aggregate_table`
      1.34salphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=6) and sj.journal_id!=6 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      3.94msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=6) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.52salphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=6) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      526msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '125950'
      24.25msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 125950
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '125950'
      27msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 125950
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '125950' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      12.3msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 125950
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      710μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      720μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 6 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      588msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 6 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      139msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 6 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      47.26msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 125950 limit 1
      1.04msalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 125950
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 125950 and content_type = 'article' order by status desc limit 1
      500μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 208125 limit 1
      370μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 208125
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      390μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CBC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      43.6msalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CBC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '125950' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      2.11msalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '49' and is_uploaded = 1 and issue_id = 12312 order by cast(first_page as SIGNED) desc limit 1
      790μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 49
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '53' and is_uploaded = 1 and issue_id = 12312 order by cast(first_page as SIGNED) asc limit 1
      1.37msalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 53
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      220μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      370μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 125950 limit 1
      5.25msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 125950
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 6 and `b`.`banner_from_date` <= 1740775554 and `b`.`banner_to_date` >= 1740775554 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      2.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 6
      • 3: 1740775554
      • 4: 1740775554
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 6 and `b`.`banner_from_date` <= 1740775554 and `b`.`banner_to_date` >= 1740775554 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.81msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 6
      • 3: 1740775554
      • 4: 1740775554
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='ff12f1fd962db8d782b1f6a01b8ded84'
      430μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:291
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        eQI4zeAiMJU3ojXPkV0ayE3HrUq9cxQGyhUaJcCq
        uc_cart_id
        ff12f1fd962db8d782b1f6a01b8ded84
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/125950" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/125950
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Fri, 28 Feb 2025 20:45:54 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InEvZVBJcDNtRko4SXBmcGNvczg3N2c9PSIsInZhbHVlIjoiK3dYNHlzRHlDcnpCKzFEQngzanJqMjdoRjlzTDRUQ0VXbDBGRFlpblJsOUUxb0g3am9rTys4a0RNOHNyQ1dITCtMMStUWTNzWFlZMnhHQWtPOVhHdXpUYVJNOVBDODBSNm92YTZEMnpjcGVYWUdYd21HT0JyS2NEU01tK2xiWWUiLCJtYWMiOiJlMGNjNTlmZmExNGQyYjE0ZTc4Zjg1YzkyYzkwMWFiMTAyYmZjZDI2MDU0YTU1YzJlYzA4ZGVmOTA5OWNiNzkxIiwidGFnIjoiIn0%3D; expires=Mon, 03 Mar 2025 08:45:54 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InEvZVBJcDNtRko4SXBmcGNvczg3N2c9PSIsInZhbHVlIjoiK3dYNHlzRHlDcnpCKzFEQngzanJqMjdoRjlzTDRUQ0VXbDBGRFlpblJsOUUxb0g3am9rTys4a0RNOHNyQ1dITCtMMStUW" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlhTakhENllYa01KZThDQXI0bkNmRXc9PSIsInZhbHVlIjoiSTVKMWpQZTEwTGxtR2t2d0xMa0I5OE1xLzh2Sjl5R0VBODhYNjgwTWoxQVprcW5OZjJDNHIzbjFYS0x4UXpiQnY1VmZzNW1qZmNOK2xBWkxxVzYzSU1RU0YyNzloOFNRK3pyS283Y2RTbEFLb0xZUFRNUDlEOGdwQ0tSazNvZDMiLCJtYWMiOiJmZWVjZGQyM2NkOWIwMzMxZGYwYjU2NjFhMTYyNmUyYmRlNzY5NzJlZTQ0ZDBmZDI3NjM0YjcyN2JiZWZjZDI4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlhTakhENllYa01KZThDQXI0bkNmRXc9PSIsInZhbHVlIjoiSTVKMWpQZTEwTGxtR2t2d0xMa0I5OE1xLzh2Sjl5R0VBODhYNjgwTWoxQVprcW5OZjJDNHIzbjF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InEvZVBJcDNtRko4SXBmcGNvczg3N2c9PSIsInZhbHVlIjoiK3dYNHlzRHlDcnpCKzFEQngzanJqMjdoRjlzTDRUQ0VXbDBGRFlpblJsOUUxb0g3am9rTys4a0RNOHNyQ1dITCtMMStUWTNzWFlZMnhHQWtPOVhHdXpUYVJNOVBDODBSNm92YTZEMnpjcGVYWUdYd21HT0JyS2NEU01tK2xiWWUiLCJtYWMiOiJlMGNjNTlmZmExNGQyYjE0ZTc4Zjg1YzkyYzkwMWFiMTAyYmZjZDI2MDU0YTU1YzJlYzA4ZGVmOTA5OWNiNzkxIiwidGFnIjoiIn0%3D; expires=Mon, 03-Mar-2025 08:45:54 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InEvZVBJcDNtRko4SXBmcGNvczg3N2c9PSIsInZhbHVlIjoiK3dYNHlzRHlDcnpCKzFEQngzanJqMjdoRjlzTDRUQ0VXbDBGRFlpblJsOUUxb0g3am9rTys4a0RNOHNyQ1dITCtMMStUW" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlhTakhENllYa01KZThDQXI0bkNmRXc9PSIsInZhbHVlIjoiSTVKMWpQZTEwTGxtR2t2d0xMa0I5OE1xLzh2Sjl5R0VBODhYNjgwTWoxQVprcW5OZjJDNHIzbjFYS0x4UXpiQnY1VmZzNW1qZmNOK2xBWkxxVzYzSU1RU0YyNzloOFNRK3pyS283Y2RTbEFLb0xZUFRNUDlEOGdwQ0tSazNvZDMiLCJtYWMiOiJmZWVjZGQyM2NkOWIwMzMxZGYwYjU2NjFhMTYyNmUyYmRlNzY5NzJlZTQ0ZDBmZDI3NjM0YjcyN2JiZWZjZDI4IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlhTakhENllYa01KZThDQXI0bkNmRXc9PSIsInZhbHVlIjoiSTVKMWpQZTEwTGxtR2t2d0xMa0I5OE1xLzh2Sjl5R0VBODhYNjgwTWoxQVprcW5OZjJDNHIzbjF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "eQI4zeAiMJU3ojXPkV0ayE3HrUq9cxQGyhUaJcCq" "uc_cart_id" => "ff12f1fd962db8d782b1f6a01b8ded84" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/125950" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-28 20:45:54GET/article/125950414311