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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Mini-Review Article

Lemon Nutraceuticals for Management of Metabolic Syndrome Disorders: Recent Advances

Author(s): Bababode Adesegun Kehinde*, Shafiya Rafiq and Adetokunbo Adekoya

Volume 19, Issue 5, 2023

Published on: 14 October, 2022

Page: [499 - 508] Pages: 10

DOI: 10.2174/1573401318666220827091649

Price: $65

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Abstract

The modern industrial application of lemon is significantly associated with their juicy materials obtained from the pulpy region, leaving behind a remarkable mass of by-products that are often discarded as waste. Several studies have shown that materials obtained from all handling and processing operations have substantial biological benefits based on their concomitant phytochemistry. In addition, these materials have been found suitable as raw substrates for the syntheses and manufacturing of various food-based additives. This research briefly delineates these concepts and offers a comprehensive framework of its etymology, rich history, and overall pomology. More importantly, recently studied underlying biochemical mechanisms for the actions of lemon and its by-products for metabolic disorders such as diabetes, cancer and hypertension are technically delineated. These materials have been appraised as natural sources for nutraceuticals studied to be potential alternatives to typical synthetic pharmaceutics.

Keywords: Lemon, D-limonene, Antidiabetic, Anticancer, Antihypertension, Nutraceuticals

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[1]
Kehinde BA, Sharma P, Kaur S, Panghal A. Effects of drying temperature on the drying kinetics, engineering, microstructural and phytochemical profile of cassava. Think India J 2019; 22(16): 636-64.
[2]
Li X, Xie R, Lu Z, Zhou Z. The origin of cultivated citrus as inferred from internal transcribed spacer and chloroplast DNA sequence and amplified fragment length polymorphism fingerprints. J Am Soc Hortic Sci 2010; 135(4): 341-50.
[http://dx.doi.org/10.21273/JASHS.135.4.341]
[3]
Wu GA, Terol J, Ibanez V, et al. Genomics of the origin and evolution of Citrus. Nature 2018; 554(7692): 311-6.
[http://dx.doi.org/10.1038/nature25447] [PMID: 29414943]
[4]
Langgut D. The citrus route revealed: From southeast asia into the mediterranean. HortScience 2017; 52(6): 814-22.
[http://dx.doi.org/10.21273/HORTSCI11023-16]
[5]
Morton J. Lemon. In: Morton JF, Ed. Fruits of warm climates. Miami, FL 1987.[https://www.cabi.org/isc/abstract/19876763104
[6]
Giuffrè AM, Zappia C, Capocasale M. Physicochemical stability of blood orange juice during frozen storage. Int J Food Prop 2017; 20: 1930-43.
[http://dx.doi.org/10.1080/10942912.2017.1359184]
[7]
Giuffrè A. Bergamot (Citrus bergamia, Risso): The effects of cultivar and harvest date on functional properties of juice and cloudy juice. Antioxidants 2019; 8(7): 221.
[http://dx.doi.org/10.3390/antiox8070221] [PMID: 31336933]
[8]
Zhang H, Yang Y, Zhou Z. Phenolic and flavonoid contents of mandarin (Citrus reticulata Blanco) fruit tissues and their antioxidant capacity as evaluated by DPPH and ABTS methods. J Integr Agric 2018; 17(1): 256-63.
[http://dx.doi.org/10.1016/S2095-3119(17)61664-2]
[9]
Barreca D, Bellocco E, Caristi C, Leuzzi U, Gattuso G. Kumquat (Fortunella japonica Swingle) juice: Flavonoid distribution and antioxidant properties. Food Res Int 2011; 44(7): 2190-7.
[http://dx.doi.org/10.1016/j.foodres.2010.11.031]
[10]
United States Department of Agriculture, Foreign agricultural service Citrus: World markets and trade Available from: https://apps.fas.usda.gov/psdonline/circulars/citrus.pdf (Accessed on: June 4, 2022).
[11]
California Citrus Manual USDA releases biannual world markets and trade report on 2021-22 citrus season 2022. Available from: https://www.cacitrusmutual.com/2022/01/27/usda-releases-biannual-world-markets-and-trade-report-on-2021-22-citrus-season/ (Accessed on: June 5, 2022).
[12]
Lawore O. Diaspora and syncretism: Marriage rites in yorùbá homeland and abroad. Yoruba Stud Rev 2021; 4(1): 1-17.
[http://dx.doi.org/10.32473/ysr.v4i1.130026]
[13]
Yashvantha R, Pinto S, Patel D, Paul P. Manufacture; evaluation of paneer using lemon rinds as a value added ingredient. Int Res J Pure Appl Chem 2020; 1-12.
[http://dx.doi.org/10.9734/irjpac/2020/v21i1930272]
[14]
Sharma P, Kehinde BA, Kaur S, Vyas P. Application of edible coatings on fresh and minimally processed fruits: A review. Nutr Food Sci 2019; 49(4): 713-38.
[http://dx.doi.org/10.1108/NFS-08-2018-0246]
[15]
Sharma P, Kehinde BA, Chhikara N, Panghal A. Development of whey and turmeric based functional synbiotic product. Enviro Sustain 2021; 4(4): 861-72.
[http://dx.doi.org/10.1007/s42398-021-00211-8]
[16]
Kaur N, Sharma P, Jaimni S, Kehinde BA, Kaur S. Recent developments in purification techniques and industrial applications for whey valorization: A review. Chem Eng Commun 2020; 207(1): 123-38.
[http://dx.doi.org/10.1080/00986445.2019.1573169]
[17]
Adjuik T, Rodjom AM, Miller KE, Reza MTM, Davis SC. Application of hydrochar, digestate, and synthetic fertilizer to a Miscanthus x giganteus crop: Implications for biomass and greenhouse gas emissions. Appl Sci 2020; 10(24): 8953.
[http://dx.doi.org/10.3390/app10248953]
[18]
Petracek PD, Montalvo L, Dou H, Davis C. Postharvest pitting of Fallglo tangerine. J Am Soc Hortic Sci 1998; 123(1): 130-5.
[http://dx.doi.org/10.21273/JASHS.123.1.130]
[19]
Escobedo AZ, Gutiérrez UJ, Valdez FA, Torres JA, Welti CJ. Phytochemicals and antioxidant activity of juice, flavedo, albedo and comminuted orange. J Funct Foods 2014; 6: 470-81.
[http://dx.doi.org/10.1016/j.jff.2013.11.013]
[20]
Lu SY, Chu YL, Sridhar K, Tsai PJ. Effect of ultrasound, high pressure processing, and enzymatic hydrolysis on carbohydrate hydrolyzing enzymes and antioxidant activity of lemon (Citrus limon) flavedo. Lebensm Wiss Technol 2020; 138(14): 110511.
[http://dx.doi.org/10.1016/j.lwt.2020.110511]
[21]
Chappalwar AM, Pathak V, Goswami M, Verma AK, Rajkumar V. Efficacy of lemon albedo as fat replacer for development of ultra low fat chicken patties. J Food Process Preserv 2021; 45(7): e15587.
[http://dx.doi.org/10.1111/jfpp.15587]
[22]
Sar çoban C, Unal K. Influence of pre treated bitter orange albedo on the physicochemical, textural and sensory properties of fermented sausages (sucuk). J Food Sci Technol 2022; 59(4): 1478-86.
[http://dx.doi.org/10.1007/s13197-021-05158-6] [PMID: 35250071]
[23]
Aleson CL, Fernández LJ, Pérez AJA, Kuri V. Characteristics of beef burger as influenced by various types of lemon albedo. Innov Food Sci Emerg Technol 2005; 6(2): 247-55.
[http://dx.doi.org/10.1016/j.ifset.2005.01.002]
[24]
Albergamo A, Costa R, Dugo G. Cold pressed lemon (Citrus limon) seed oil. Cold Pressed Oils 2020; pp. 159-80.
[http://dx.doi.org/10.1016/B978-0-12-818188-1.00014-1]
[25]
Karaman E, Karabiber EB. Y lmaz E. Physicochemical and functional properties of the cold press lemon, orange, and grapefruit seed meals. Qual Assur Saf Crops Foods 2018; 10(3): 233-43.
[http://dx.doi.org/10.3920/QAS2017.1218]
[26]
Kehinde BA, Sharma P, Kaur S. Recent nano, micro and macrotechnological applications of ultrasonication in food based systems. Crit Rev Food Sci Nutr 2021; 61(4): 599-621.
[http://dx.doi.org/10.1080/10408398.2020.1740646] [PMID: 32208850]
[27]
Kehinde BA, Majid I, Hussain S, Nanda V. Innovations and future trends in product development and packaging technologies. In: Prakash B, Ed. Functional and Preservative Properties of Phytochemicals. Cambridge: Academic Press 2020; pp. 377-409.
[http://dx.doi.org/10.1016/B978-0-12-818593-3.00013-0]
[28]
Rajapaksha P, Ojo I, Yang L, Pandeya A, Abeywansha T, Wei Y. Insight into the AcrAB-TolC complex assembly process learned from competition studies. Antibiotics 2021; 10(7): 830.
[http://dx.doi.org/10.3390/antibiotics10070830] [PMID: 34356751]
[29]
Abu OD, Onoagbe IO, Ojo I. Dose response study of aqueous extract of Dialium guineense stem bark. Am J Biomed Sci Res 2022; 15(2)
[http://dx.doi.org/10.34297/AJBSR.2022.15.002099]
[30]
Pandeya A, Ojo I, Alegun O, Wei Y. Periplasmic targets for the development of effective antimicrobials against gram negative bacteria. ACS Infect Dis 2020; 6(9): 2337-54.
[http://dx.doi.org/10.1021/acsinfecdis.0c00384] [PMID: 32786281]
[31]
Kehinde BA, Panghal A, Garg MK, Sharma P, Chhikara N. Vegetable milk as probiotic and prebiotic foods. In: Gomes da Cruz A, Prudencio ES, Esmerino EA, Cristina da Silva M, Eds. Advances in Food and Nutrition Research. Cambridge: Academic Press 2020; 94: pp. 115-60.
[http://dx.doi.org/10.1016/bs.afnr.2020.06.003]
[32]
Kehinde BA, Chhikara N, Sharma P, Garg MK, Panghal A. Application of polymer nanocomposites in food and bioprocessing industries. In: Hussain CM, Ed. Micro and nano technologies, handbook of polymer nanocomposites for industrial applications. Amsterdam: Elsevier 2021; pp. 201-36.
[http://dx.doi.org/10.1016/B978-0-12-821497-8.00006-X]
[33]
Food and Agriculture Organization of the United Nations. Major tropical fruits preliminary market results 2019. Available from: https://www.fao.org/3/ca7566en/CA7566EN.pdf(Accessed on: January, 2022).
[34]
Kehinde BA, Sharma P. Recently isolated bioactive hydrolysates and peptides from multiple food sources: A review. Crit Rev Food Sci Nutr 2020; 60(2): 322-40.
[http://dx.doi.org/10.1080/10408398.2018.1528206] [PMID: 30463420]
[35]
Laganà V, Giuffrè AM, De Bruno A, Poiana M. Formulation of biscuits fortified with a flour obtained from bergamot by products (Citrus bergamia, Risso). Foods 2022; 11(8): 1137.
[http://dx.doi.org/10.3390/foods11081137] [PMID: 35454727]
[36]
Al-Saab AH, Gadallah MGE. Phytochemicals, antioxidant activity and quality properties of fibre enriched cookies incorporated with orange peel powder. Food Res 2021; 5(4): 72-9.
[http://dx.doi.org/10.26656/fr.2017.5(4).698]
[37]
Sosalagere C, Kehinde BA, Sharma P. Isolation and functionalities of bioactive peptides from fruits and vegetables: A review. Food Chem 2020; 366: 130494.
[http://dx.doi.org/10.1016/j.foodchem.2021.130494] [PMID: 34293544]
[38]
Rafique S, Hassan SM, Mughal SS, Hassan SK, Shabbir N. Biological attributes of lemon: A review. J Addict Med Ther Sci 2020; 6(1): 30-4.
[http://dx.doi.org/10.17352/2455-3484.000034]
[39]
Klimek SM, Szopa A, Ekiert H. Citrus limon (Lemon) Phenomenon—A Review of the chemistry, pharmacological properties, applications in the modern pharmaceutical, food; cosmetics industries; biotechnological studies. Plants 2020; 9(1): 119.
[http://dx.doi.org/10.3390/plants9010119] [PMID: 31963590]
[40]
Freitas D, Le Feunteun S. Inhibitory effect of black tea, lemon juice; other beverages on salivary and pancreatic amylases: What impact on bread starch digestion? A dynamic in vitro study. Food Chem 2019; 297: 124885.
[http://dx.doi.org/10.1016/j.foodchem.2019.05.159]
[41]
Freitas D, Boué F, Benallaoua M, Airinei G, Benamouzig R, Le Feunteun S. Lemon juice, but not tea, reduces the glycemic response to bread in healthy volunteers: A randomized crossover trial. Eur J Nutr 2021; 60(1): 113-22.
[http://dx.doi.org/10.1007/s00394-020-02228-x] [PMID: 32201919]
[42]
Murali R, Saravanan R. Antidiabetic effect of d-limonene, a monoterpene in streptozotocin induced diabetic rats. Biomedicine & Preventive Nutrition 2012; 2(4): 269-75.
[http://dx.doi.org/10.1016/j.bionut.2012.08.008]
[43]
Afkhami-Ardekani M, Shojaoddiny-Ardekani A. Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients. Indian J Med Res 2007; 126(5): 471-4.
[PMID: 18160753]
[44]
Zhou C, Na L, Shan R, et al. Dietary vitamin C intake reduces the risk of type 2 diabetes in chinese adults: HOMA-IR and T-AOC as potential mediators. PLoS One 2016; 11(9): e0163571.
[http://dx.doi.org/10.1371/journal.pone.0163571] [PMID: 27685994]
[45]
Kaur A, Kehinde BA, Sharma P, Sharma D, Kaur S. Recently isolated food derived antihypertensive hydrolysates and peptides: A review. Food Chem 2021; 346: 128719.
[http://dx.doi.org/10.1016/j.foodchem.2020.128719] [PMID: 33339686]
[46]
Sharma P, Kaur G, Kehinde BA, Chhikara N, Panghal A, Kaur H. Pharmacological and biomedical uses of extracts of pumpkin and its relatives and applications in the food industry: A review. Int J Veg Sci 2019; 26(1): 79-95.
[http://dx.doi.org/10.1080/19315260.2019.1606130]
[47]
Toprak D, Demir S. Treatment choices of hypertensive patients in Turkey. Behav Med 2007; 33(1): 5-10.
[http://dx.doi.org/10.3200/BMED.33.1.5-10] [PMID: 17517540]
[48]
Morin B, Nichols LA, Zalasky KM, Davis JW, Manthey JA, Holland LJ. The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. J Nutr 2008; 138(7): 1274-81.
[http://dx.doi.org/10.1093/jn/138.7.1274] [PMID: 18567747]
[49]
Miyake Y, Suzuki E, Ohya S, et al. Lipid lowering effect of eriocitrin, the main flavonoid in lemon fruit, in rats on a high fat and high cholesterol diet. J Food Sci 2006; 71(9): S633-7.
[http://dx.doi.org/10.1111/j.1750-3841.2006.00192.x]
[50]
Özünal ZG, Tahirbegolli IA, Üresin AY. 2017, Evaluation of the effect of citrus lemon l. “enter” on blood pressure in hypertensive patients. J Pharm Pharmacol 2017; 5(10): 742-5.
[http://dx.doi.org/10.17265/2328-2150/2017.10.006]
[51]
Adibelli Z, Dilek M, Akpolat T. Lemon juice as an alternative therapy in hypertension in Turkey. Int J Cardiol 2009; 1352: e58-9.
[http://dx.doi.org/10.1016/j.ijcard.2008.03.085]
[52]
Sharma P, Kaur H, Kehinde BA, Chhikara N, Sharma D, Panghal A. Food derived anticancer peptides: A review. Int J Pept Res Ther 2021; 27(1): 55-70.
[http://dx.doi.org/10.1007/s10989-020-10063-1]
[53]
Kehinde BA, Rafiq S, Nayik GA, Pala SA. Phalsa (Grewia asiatica L.). In: Nayik GA, Gull A, Eds. Antioxidants in Fruits: Properties and health benefits. Singapore: Springer 2020; vol. 1: pp. 55-66.
[http://dx.doi.org/10.1007/978-981-15-7285-2_3]
[54]
Kehinde BA, Nayik GA, Rafiq S. Muntingia calabura. In: Nayik GA, Gull A, Eds. Antioxidants in Fruits: Properties and health benefits. Singapore: Springer 2020; vol.1: pp. 251-70.
[http://dx.doi.org/10.1007/978-981-15-7285-2_13]
[55]
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100(1): 57-70.
[http://dx.doi.org/10.1016/S0092-8674(00)81683-9] [PMID: 10647931]
[56]
Diab KA. In vitro studies on phytochemical content, antioxidant, anticancer, immunomodulatory; antigenotoxic activities of Lemon, Grapefruit; Mandarin Citrus peels. Asian Pac J Cancer Prev 2016; 17(7): 3559-67.
[PMID: 27510009]
[57]
Alshatwi AA, Shafi G, Hasan TN, et al. Apoptosis mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pac J Cancer Prev 2011; 12(6): 1555-9.
[PMID: 22126498]
[58]
González ME, Domínguez PR, Moreno DA, García VC. Natural bioactive compounds of Citrus limon for food and health. J Pharm Biomed Anal 2010; 51(2): 327-45.
[http://dx.doi.org/10.1016/j.jpba.2009.07.027] [PMID: 19748198]
[59]
Kehinde BA, Panghal A, Kumar S, Adedeji AA, Garg MK, Chhikara N. Nanocapsules as potential antimicrobial agents in food. In: Dhull SB, Chawla P, Kaushik R, Eds. Nanotechnological Approaches in Food Microbiology. Boca Raton: CRC Press 2020; vol. 1: pp. 331-52.
[http://dx.doi.org/10.1201/9780429342776-14]
[60]
Garg A, Garg S, Zaneveld LJD, Singla AK. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 2001; 15(8): 655-69.
[http://dx.doi.org/10.1002/ptr.1074] [PMID: 11746857]
[61]
Al-Qudah T, Zahra U, Rehman R, et al. Lemon as a source of functional and medicinal ingredient: A review. Int J Chem Biochem Sci 2019; 14: 55-61.
[62]
Kehinde BA, Morgan M, Sharma P. Microbial technologies for sustainable food additives production. In: Singh J, Sharma D, Eds. Microbial Resource Technologies for Sustainable Development. Amsterdam: Elsevier 2022; Vol. 1: pp. 289-98.
[http://dx.doi.org/10.1016/B978-0-323-90590-9.00018-3]
[63]
Kehinde BA, Joy OS, Ishrat M, Kehinde O, Ashaolu TJ. Use of biopolymers for packaging of functional foods. In: Chhikara N, Panghal A, Chaudhary G, Eds. Functional Foods. 2022.
[http://dx.doi.org/10.1002/9781119776345.ch14]
[64]
Rafiq S, Kehinde BA, Suthar P, Bhat S, Nayik G, Jagdale Y. Onion oleoresin: Extraction, characterization, and application. In: Nayik GA, Gull A, Ganaie TA, Eds. Handbook of Oleoresins Extraction, Characterization, and Applications. New York: CRC Press 2022; vol. 1: pp. 292-302.
[http://dx.doi.org/10.1201/9781003186205-15]
[65]
Arthur G, Osborn JL, Yiannikouris FB. (Pro)renin receptor in the kidney: Function and significance. Am J Physiol Regul Integr Comp Physiol 2021; 320(4): R377-83.
[http://dx.doi.org/10.1152/ajpregu.00259.2020] [PMID: 33470188]
[66]
Dhanavade MJ, Jalkute CB, Ghosh JS, Sonawane KD. Study antimicrobial activity of lemon (Citrus lemon L.) peel extract. Br J Pharmacol Toxicol 2011; 2: 119-22.
[67]
Viuda MM, Ruiz NY, Fernández LJ, Pérez ÁJ. Antifungal activity of lemon (Citrus lemon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils. Food Control 2008; 19(12): 1130-8.
[http://dx.doi.org/10.1016/j.foodcont.2007.12.003]
[68]
Ben HA, Ben HN, Smaoui S, Hamdi N. Citrus lemon essential oil: Chemical composition, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in minced beef meat. Lipids Health Dis 2017; 16(1): 146.
[http://dx.doi.org/10.1186/s12944-017-0487-5] [PMID: 28774297]
[69]
Rozza AL, Moraes TM, Kushima H, et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat shock protein- 70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2 Chem Biol Interact 2011; 189(1-2): 82-9. 82-89
[http://dx.doi.org/10.1016/j.cbi.2010.09.031] [PMID: 20934418]
[70]
Liu Y, Liu P, Wang L, et al. Inhibitory effects of Citrus lemon oil and limonene on Streptococcus sobrinus - Induced dental caries in rats. Arch Oral Biol 2020; 118: 104851.
[http://dx.doi.org/10.1016/j.archoralbio.2020.104851] [PMID: 32739630]
[71]
Chen YJL, Chou PC, Hsu CL, Hung JF, Wu YC, Lin JG. Fermented Citrus lemon reduces liver injury induced by carbon tetrachloride in rats. Evid Based Complement Alternat Med 2018; 2018: 1-10.
[http://dx.doi.org/10.1155/2018/6546808] [PMID: 29887908]
[72]
Khan Y, Khan R, Afroz S, Siddiq A. Evaluation of hypolipidemic effect of Citrus lemon. J Basic Appl Sci 2010; 6: 39-43.
[73]
Kim J, Jayaprakasha GK, Uckoo RM, Patil BS. Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cells. Food Chem Toxicol 2012; 50(2): 423-30.
[http://dx.doi.org/10.1016/j.fct.2011.10.057] [PMID: 22056335]
[74]
Guneser BA, Yilmaz E. Bioactives, aromatics and sensory properties of cold pressed and hexane extracted lemon (Citrus Limon L.) seed oils. J Am Oil Chem Soc 2017; 94(5): 723-31.
[http://dx.doi.org/10.1007/s11746-017-2977-z]
[75]
Demir A, Celik I. Investigation of healing effects of lemon (Citrus limonum) seeds lyophilized extracts on experimental diabetic rats. Arch Physiol Biochem 2019; 1-8.
[http://dx.doi.org/10.1080/13813455.2019.170206] [PMID: 31829746]

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