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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Review Article

Vitamin D: Production, Metabolism, and Impact on Human Health

Author(s): Anushka Joshi, Sudhanshu Mishra*, Ramanathan Rajagopalan and Deepti Jain

Volume 19, Issue 8, 2023

Published on: 17 October, 2022

Page: [785 - 795] Pages: 11

DOI: 10.2174/1573401318666220822121613

Price: $65

Abstract

Background and Objective: Vitamins play an important role in maintaining proper health and wellness of the body. The deficiency of any of them may lead to serious health consequences. In the current scenario, deficiency of vitamin D has become a very prevalent and underdiagnosed health issue throughout the world. The purpose of this review is to briefly describe the importance, present market condition, and role of vitamin D supplements in COVID-19 in India, as well as how this has influenced the current situation.

Methods: Literature survey was carried out using various online search engines like Google Scholar, Science Direct, Springer, PubMed, etc. offline libraries were also used for the compilation of the data.

Results: It is evident from the study that the deficiency of vitamin D is associated with a lot of health problems, including cancer, diabetes, bone health deterioration, cardiovascular disorders, etc. This deficiency may occur due to an unhealthy lifestyle, mal-absorption, or decreased synthesis in the body. Vitamin D levels in the body can also be correlated with COVID-19 and the immunity of an individual.

Conclusion: From this study, the importance of vitamin D levels in the human body can easily be understood. Various evidence of its connection with the COVID-19 pandemic is also available, though many studies in the area are still required. Altogether, increasing instances of vitamin D deficiency is a matter of great concern.

Keywords: COVID-19, Vitamin D, Pandemic, Cholecalciferol deficiency.

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[1]
Umar M, Sastry K, Chouchane A. Role of vitamin D beyond the skeletal function: A review of the molecular and clinical studies. Int J Mol Sci 2018; 19(6): 1618.
[http://dx.doi.org/10.3390/ijms19061618] [PMID: 29849001]
[2]
Jones G, Strugnell SA. DeLUCA HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998; 78(4): 1193-231.
[http://dx.doi.org/10.1152/physrev.1998.78.4.1193] [PMID: 9790574]
[3]
Ma Y, Yu WD, Hidalgo AA, et al. Inecalcitol, an analog of 1,25D₃ displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system. Cell Cycle 2013; 12(5): 743-52.
[http://dx.doi.org/10.4161/cc.23846] [PMID: 23388458]
[4]
Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front Physiol 2014; 5: 151.
[http://dx.doi.org/10.3389/fphys.2014.00151] [PMID: 24795646]
[5]
Macdonald HM, Mavroeidi A, Fraser WD, et al. Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: A major cause for concern? Osteoporos Int 2011; 22(9): 2461-72.
[http://dx.doi.org/10.1007/s00198-010-1467-z] [PMID: 21085934]
[6]
Holick MF, MacLaughlin JA, Clark MB, et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science 1980; 210(4466): 203-5.
[http://dx.doi.org/10.1126/science.6251551] [PMID: 6251551]
[7]
Webb AR, De Costa BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. J Clin Endocrinol Metab 1980; 68(5): 882-7.
[8]
Martineau AR, Forouhi NG. Vitamin D for COVID-19: A case to answer? Lancet Diabetes Endocrinol 2020; 8(9): 735-6.
[http://dx.doi.org/10.1016/S2213-8587(20)30268-0] [PMID: 32758429]
[9]
Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 2014; 21(3): 319-29.
[http://dx.doi.org/10.1016/j.chembiol.2013.12.016] [PMID: 24529992]
[10]
Zhang R, Naughton DP. Vitamin D in health and disease: Current perspectives. Nutr J 2010; 9(1): 65.
[http://dx.doi.org/10.1186/1475-2891-9-65] [PMID: 21143872]
[11]
Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Dietary reference intakes for adequacy: Calcium and vitamin D.In: Dietary reference intakes for calcium and vitamin D. US: National Academies Press 2011; pp. 1-7.
[12]
Institute of Medicine, Food and Nutrition BoardDietary Reference Intakes for Calcium and Vitamin D. Washington: National Academy Press 2011; pp. 1-7.
[13]
Rusińska A, Płudowski P, Walczak M, et al. Vitamin D supplementationguidelines for general population and groups at risk ofvitamin d deficiency in poland—recommendations of the polish societyof pediatric endocrinology and diabetes and the expert panelwith participation of national specialist consultants and representatives of scientific societies —2018 update. Front Endocrinol (Lausanne) 2018; 9: 246.
[http://dx.doi.org/10.3389/fendo.2018.00246] [PMID: 29904370]
[14]
Charzewska J, Chlebna SD, Chybicka A, et al. Prophylaxis of vitamin D deficiency--Polish recommendation 2009. Ginekol Pol 2010; 81(2): 149-53.
[PMID: 20232716]
[15]
Płudowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol 2013; 64(4): 319-27.
[http://dx.doi.org/ 10.5603/EP.2013.0012] [PMID: 24002961 ]
[16]
Munns CF, Shaw N, Kiely M, et al. Global consensus recommendations on prevention and management of nutritional rickets. Horm Res Paediatr 2016; 85(2): 83-106.
[http://dx.doi.org/10.1159/000443136] [PMID: 26741135]
[17]
Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol 2008; 3(5): 1535-41.
[http://dx.doi.org/10.2215/CJN.01160308] [PMID: 18525006]
[18]
Nair R, Maseeh A, Vitamin D. The “sunshine” vitamin. J Pharmacol Pharmacother 2012; 3(2): 118-26.
[PMID: 22629085]
[19]
Polzonetti V, Pucciarelli S, Vincenzetti S, Polidori P. Dietary intake of vitamin D from dairy products reduces the risk of osteoporosis. Nutrients 2020; 12(6): 1743.
[http://dx.doi.org/10.3390/nu12061743] [PMID: 32532150]
[20]
Kaushal M, Magon N. Vitamin D in pregnancy: A metabolic outlook. Indian J Endocrinol Metab 2013; 17(1): 76-82.
[http://dx.doi.org/10.4103/2230-8210.107862] [PMID: 23776856]
[21]
Scientific Advisory Committee on Nutrition Vitamin D and health. 2016.
[22]
Saggese G, Vierucci F, Prodam F, et al. Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr 2018; 44(1): 51.
[http://dx.doi.org/10.1186/s13052-018-0488-7] [PMID: 29739471]
[23]
Khadgawat R, Raizada N, Goyal A, Singla R, Sreenivas V, Gupta N. Changing trend in vitamin D status from 2008 to 2016: An experience from a tertiary care institute in North India. Indian J Endocrinol Metab 2020; 24(2): 150-4.
[http://dx.doi.org/10.4103/ijem.IJEM_634_19] [PMID: 32699781]
[24]
Das S. Market for vitamin D likely to touch $2.5 billion by 2020,says report ”business standard.com 2018.
[25]
Rizzoli R. Vitamin D supplementation: Upper limit for safety revisited? Aging Clin Exp Res 2021; 33(1): 19-24.
[http://dx.doi.org/10.1007/s40520-020-01678-x] [PMID: 32857334]
[26]
Glowka E, Stasiak J, Lulek J. Drug delivery systems for vitamin D supplementation and therapy. Pharmaceutics 2019; 11(7): 347.
[http://dx.doi.org/10.3390/pharmaceutics11070347] [PMID: 31323777]
[27]
Mahor S, Chadha H, Prajapati S, Mishra S, Ojha S. An update on COVID-19 outbreak: The longest pandemic. Biol Sci 2022; 2(1): 114-26.
[http://dx.doi.org/10.55006/biolsciences.2022.2102]
[28]
Mishra S, Sharma D, Raghuvanshi A, Rajput A, Chaturvedi V, Shanno K. Potential impact of nutrition on immune system: Prevent or assist COVID-19 recovery. J Adv Med Med Res 2020; 23: 20-33.
[http://dx.doi.org/10.9734/jammr/2020/v32i2230702]
[29]
Hamulka J, Jeruszka-Bielak M, Górnicka M, Drywie ´n ME, Zielinska-Pukos MA. Dietary supplements during COVID-19 outbreak. Results of google trends analysis supported by PLifeCOVID-19 online studies. Nutrients 2021.
[PMID: 33375422]
[30]
Yisak H, Ewunetei A, Kefale B, et al. Effects of Vitamin D on COVID-19 infection and prognosis: A systematic review. Risk Manag Healthc Policy 2021; 14: 31-8.
[http://dx.doi.org/10.2147/RMHP.S291584] [PMID: 33447107]
[31]
Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, et al. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. J Steroid Biochem Mol Biol 2020; 203: 105751.
[http://dx.doi.org/10.1016/j.jsbmb.2020.105751] [PMID: 32871238]
[32]
Ye Q, Wang B, Mao J. Cytokine storm in COVID-19 and treatment. J Infect 2020; 80(6): 607-13.
[http://dx.doi.org/10.1016/j.jinf.2020.03.037] [PMID: 32283152]
[33]
Murdaca G, Pioggia G, Negrini S. Vitamin D and Covid-19: An update on evidence and potential therapeutic implications. Clin Mol Allergy 2020; 18(1): 23.
[http://dx.doi.org/10.1186/s12948-020-00139-0] [PMID: 33292313]
[34]
Schwalfenberg GK. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol Nutr Food Res 2011; 55(1): 96-108.
[http://dx.doi.org/10.1002/mnfr.201000174] [PMID: 20824663]
[35]
Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311(5768): 1770-3.
[http://dx.doi.org/10.1126/science.1123933] [PMID: 16497887]
[36]
Laaksi I. Vitamin D and respiratory infection in adults. Proc Nutr Soc 2012; 71(1): 90-7.
[http://dx.doi.org/10.1017/S0029665111003351] [PMID: 22115013]
[37]
Wacker M, Holick M. Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 2013; 5(1): 111-48.
[http://dx.doi.org/10.3390/nu5010111] [PMID: 23306192]
[38]
Veugelers P, Ekwaru J. A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients 2014; 6(10): 4472-5.
[http://dx.doi.org/10.3390/nu6104472] [PMID: 25333201]
[39]
Chao YS, Brunel L, Faris P, Veugelers P. The importance of dose, frequency and duration of vitamin D supplementation for plasma 25-hydroxyvitamin D. Nutrients 2013; 5(10): 4067-78.
[http://dx.doi.org/10.3390/nu5104067] [PMID: 24152747]
[40]
Alshahrani F, Aljohani N, Vitamin D, Vitamin D. Deficiency, sufficiency and toxicity. Nutrients 2013; 5(9): 3605-16.
[http://dx.doi.org/10.3390/nu5093605] [PMID: 24067388]
[41]
Spedding S, Vanlint S, Morris H, Scragg R. Does vitamin D sufficiency equate to a single serum 25-hydroxyvitamin D level or are different levels required for non-skeletal diseases? Nutrients 2013; 5(12): 5127-39.
[http://dx.doi.org/10.3390/nu5125127] [PMID: 24352091]
[42]
Roth D, Mahmud A, Raqib R, Akhtar E, Black R, Baqui A. Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. Nutrients 2013; 5(3): 788-810.
[http://dx.doi.org/10.3390/nu5030788] [PMID: 23482056]
[43]
Moukayed M, Grant W. Molecular link between vitamin D and cancer prevention. Nutrients 2013; 5(10): 3993-4021.
[http://dx.doi.org/10.3390/nu5103993] [PMID: 24084056]
[44]
Thyer L, Ward E, Smith R, et al. A novel role for a major component of the vitamin D axis: Vitamin D binding protein-derived macrophage activating factor induces human breast cancer cell apoptosis through stimulation of macrophages. Nutrients 2013; 5(7): 2577-89.
[http://dx.doi.org/10.3390/nu5072577] [PMID: 23857228]
[45]
Hall A, Juckett M. The role of vitamin D in hematologic disease and stem cell transplantation. Nutrients 2013; 5(6): 2206-21.
[http://dx.doi.org/10.3390/nu5062206] [PMID: 23778150]
[46]
Weyland P, Grant W, Howie-Esquivel J. Does sufficient evidence exist to support a causal association between vitamin D status and cardiovascular disease risk? An assessment using Hill’s criteria for causality. Nutrients 2014; 6(9): 3403-30.
[http://dx.doi.org/10.3390/nu6093403] [PMID: 25184368]
[47]
Mann M, Exner D, Hemmelgarn B, et al. Vitamin D levels are associated with cardiac autonomic activity in healthy humans. Nutrients 2013; 5(6): 2114-27.
[http://dx.doi.org/10.3390/nu5062114] [PMID: 23752493]
[48]
Pacini S, Morucci G, Branca J, et al. Effects of vitamin D3 and paricalcitol on immature cardiomyocytes: A novel role for vitamin D analogs in the prevention of cardiovascular diseases. Nutrients 2013; 5(6): 2076-92.
[http://dx.doi.org/10.3390/nu5062076] [PMID: 23749205]
[49]
Liu ZM, Woo J, Wu SH, Ho S. The role of vitamin D in blood pressure, endothelial and renal function in postmenopausal women. Nutrients 2013; 5(7): 2590-610.
[http://dx.doi.org/10.3390/nu5072590] [PMID: 23839167]
[50]
Dong JY, Zhang W, Chen J, et al. Vitamin D intake and risk of type 1 diabetes: A meta-analysis of observational studies. Nutrients 2013; 5(9): 3551-62.
[http://dx.doi.org/10.3390/nu5093551] [PMID: 24036529]
[51]
Hessel V. Special issue: Design and engineering of microreactor and smart-scaled flow processes. Nutrients 2013; 5: 949-56.
[52]
Spedding S. Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients 2014; 6(4): 1501-18.
[http://dx.doi.org/10.3390/nu6041501] [PMID: 24732019]
[53]
Polak M, Houghton L, Reeder A, Harper M, Conner T. Serum 25-hydroxyvitamin D concentrations and depressive symptoms among young adult men and women. Nutrients 2014; 6(11): 4720-30.
[http://dx.doi.org/10.3390/nu6114720] [PMID: 25353666]
[54]
Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008; 13(1): 6-20.
[PMID: 18377099]
[55]
Ogan D, Pritchett K. Vitamin D and the athlete: Risks, recommendations, and benefits. Nutrients 2013; 5(6): 1856-68.
[http://dx.doi.org/10.3390/nu5061856] [PMID: 23760056]
[56]
Barker T, Henriksen V, Martins T, et al. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients 2013; 5(4): 1253-75.
[http://dx.doi.org/10.3390/nu5041253] [PMID: 23595134]
[57]
Stechschulte SA, Kirsner RS, Federman DG, Vitamin D. Bone and beyond, rationale and recommendations for supplementation. Am J Med 2009; 122(9): 793-802.
[http://dx.doi.org/10.1016/j.amjmed.2009.02.029] [PMID: 19699370]
[58]
Sintzel MB, Rametta M, Reder AT. Vitamin D and multiple sclerosis: A comprehensive review. Neurol Ther 2018; 7(1): 59-85.
[http://dx.doi.org/10.1007/s40120-017-0086-4] [PMID: 29243029]
[59]
Jean G, Souberbielle J, Chazot C. Vitamin D in chronic kidney disease and dialysis patients. Nutrients 2017; 9(4): 328.
[http://dx.doi.org/10.3390/nu9040328] [PMID: 28346348]
[60]
Talib RA, Khalafalla K, Cangüven O. The role of vitamin D supplementation on erectile function. Turk J Urol 2017; 43(2): 105-11.
[http://dx.doi.org/10.5152/tud.2017.76032] [PMID: 28717531]
[61]
Jovanovich A, Ginde A, Holmen J, et al. Vitamin D level and risk of community-acquired pneumonia and sepsis. Nutrients 2014; 6(6): 2196-205.
[http://dx.doi.org/10.3390/nu6062196] [PMID: 24918697]
[62]
Valipour G, Saneei P, Esmaillzadeh A. Serum vitamin D levels in relation to schizophrenia: A systematic review and meta-analysis of observational studies. J Clin Endocrinol Metab 2014; 99(10): 3863-72.
[http://dx.doi.org/10.1210/jc.2014-1887] [PMID: 25050991]
[63]
Sabbagh Z, Markland J, Vatanparast H. Vitamin D status is associated with disease activity among rheumatology outpatients. Nutrients 2013; 5(7): 2268-75.
[http://dx.doi.org/10.3390/nu5072268] [PMID: 23803739]
[64]
Sahay M, Sahay R. Rickets-vitamin D deficiency and dependency. Indian J Endocrinol Metab 2012; 16(2): 164-76.
[http://dx.doi.org/10.4103/2230-8210.93732] [PMID: 22470851]
[65]
Littlejohns TJ, Henley WE, Lang IA, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014; 83(10): 920-8.
[http://dx.doi.org/10.1212/WNL.0000000000000755] [PMID: 25098535]
[66]
Pincikova T, Paquin PD, Sandberg JK, Flodström-Tullberg M, Hjelte L. Clinical impact of vitamin D treatment in cystic fibrosis: A pilot randomized, controlled trial. Eur J Clin Nutr 2017; 71(2): 203-5.
[http://dx.doi.org/10.1038/ejcn.2016.259] [PMID: 27966575]
[67]
Shi Y, Liu T, Yao L, et al. Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system. Sci Rep 2017; 7(1): 3312.
[http://dx.doi.org/10.1038/s41598-017-03474-6] [PMID: 28607392]
[68]
Mok CC. Vitamin D and systemic lupus erythematosus: An update. Expert Rev Clin Immunol 2013; 9(5): 453-63.
[http://dx.doi.org/10.1586/eci.13.19] [PMID: 23634739]
[69]
Almetwazi MS, Noor AO, Almasri DM, et al. The association of vitamin D deficiency and glucose control among diabetic patients. Saudi Pharm J 2017; 25(8): 1179-83.
[http://dx.doi.org/10.1016/j.jsps.2017.09.001] [PMID: 30166907]
[70]
Kočovská E, Fernell E, Billstedt E, Minnis H, Gillberg C. Vitamin D and autism: Clinical review. Res Dev Disabil 2012; 33(5): 1541-50.
[http://dx.doi.org/10.1016/j.ridd.2012.02.015] [PMID: 22522213]
[71]
Chesney RW. Interactions of vitamin D and the proximal tubule. Pediatr Nephrol 2016; 31(1): 7-14.
[http://dx.doi.org/10.1007/s00467-015-3050-5] [PMID: 25618772]

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