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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Systematic Review Article

Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies

Author(s): Hamed Kalani, Pegah Shakib, Roghiyeh Faridnia, Jeffery Ho, Omid Mardanshah, Mehrdad Dolatshah, Asghar Sepahvand, Kourosh Cheraghipour* and Masoomeh Zivdaria

Volume 23, Issue 2, 2023

Published on: 20 October, 2022

Article ID: e200822207821 Pages: 5

DOI: 10.2174/1871526522666220820185637

Price: $65

Abstract

Objective: This study has focused on anti-Toxoplasma gondii activity of curcumin.

Methods: In this systematic review, anti-parasitic activity of Curcuma longa on Toxoplasma gondii was assessed. Therefore, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar, were searched from 2010 to 2020.

Results: Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%).

Conclusion: Curcumin and nanoparticles formulated with curcumin are new and useful agents for the treatment of parasitic diseases and reduction of drug resistance. The success of this therapeutic approach stems from the specific action of Curcuma longa against parasites and pathogens.

Keywords: Toxoplasma gondii, Curcuma longa, Parasitic activity, Pre-clinical studies, Curcumin, Systematic review.

Graphical Abstract

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