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Current Cancer Drug Targets

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ISSN (Online): 1873-5576

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Review Article

Characteristic Hallmarks of Aging and the Impact on Carcinogenesis

Author(s): Sergio Terracina, Giampiero Ferraguti, Carla Petrella, Sabina Maria Bruno, Giovanna Blaconà, Maria Grazia Di Certo, Antonio Minni, Antonio Greco, Angela Musacchio, Massimo Ralli, Luigi Tarani, Mauro Ceccanti, Antonella Polimeni, Viviana Triaca and Marco Fiore*

Volume 23, Issue 2, 2023

Published on: 07 September, 2022

Page: [87 - 102] Pages: 16

DOI: 10.2174/1568009622666220816120353

Price: $65

Abstract

Evidence shows that there is a synergistic, bidirectional association between cancer and aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while evidence suggests that cancer and its treatments might accelerate aging by causing genotoxic and cytotoxic insults. Aging has been associated with a series of alterations that can be linked to cancer: i) genomic instability caused by DNA damage or epigenetic alterations coupled with repair errors, which lead to progressive accumulation of mutations; ii) telomere attrition with possible impairment of telomerase, shelterin complex, or the trimeric complex (Cdc13, Stn1 and Ten1 - CST) activities associated with abnormalities in DNA replication and repair; iii) altered proteostasis, especially when leading to an augmented proteasome, chaperon and autophagy-lysosome activity; iv) mitochondrial dysfunction causing oxidative stress; v) cellular senescence; vi) stem cells exhaustion, intercellular altered communication and deregulated nutrient sensing which are associated with microenvironmental modifications which may facilitate the subsequential role of cancer stem cells. Nowadays, anti-growth factor agents and epigenetic therapies seem to assume an increasing role in fighting aging-related diseases, especially cancer. This report aims to discuss the impact of age on cancer growth.

Keywords: aging, cancer, epigenetic, genomic instability, microenvironment, oxidative stress.

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