Tandem Mass Analysis of Amino Acids and Acylcarnitine Profiles in Neonates
with Congenital Hypothyroidism

Jabar      Lotfi; Mohammad      Taghikhani; Ali      Rabbani; Shohreh      Khatami; Mohammad   Javad   Rasaee

doi:10.2174/1871530322666220816105828

Abstract

Background: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder. This study aimed to investigate whether disturbances in amino acid metabolism and fatty acid oxidation existed in neonates with CH compared to healthy neonates.

Methods: In this case-control study, we evaluated the metabolomics of neonates with newly diagnosed CH and healthy neonates. Forty-three metabolites, including 13 amino acids and 30 acylcarnitines, were investigated.

Results: Two hundred neonates with CH and 209 healthy children were enrolled. The mean age of males and females was 4.8 ± 2.4 and 5.52 ± 3.2 days in the case group and 5.1 ± 2.6 and 4.7 ± 3.6 days in the control group, respectively. Of the metabolites, 34 were significantly different between the two groups. Five amino acids and four acylcarnitines did not differ significantly between groups.

Conclusion: These findings pave the way for a better understanding of the relationship between alterations and the clinical manifestation of CH, which has the potential for identifying novel therapeutics.

Keywords: Amino acid, acylcarnitine, congenital hypothyroidism, tandem mass, fatty acid oxidation, acylcarnitines

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DOI https://dx.doi.org/10.2174/1871530322666220816105828	Print ISSN 1871-5303
Publisher Name Bentham Science Publisher	Online ISSN 2212-3873

Endocrine, Metabolic & Immune Disorders - Drug Targets

Tandem Mass Analysis of Amino Acids and Acylcarnitine Profiles in Neonates with Congenital Hypothyroidism

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