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Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Research Article

Establishment of Analyzing Method of Fenpropathrin Residue in Angelica dahurica Radix and Osterici Radix

Author(s): Hun-Ju Ham, Byung-gi Lee, Jeong-Yoon Choi, Abd Elaziz Sulieman Ahmed Ishag and Jang-Hyun Hur*

Volume 9, Issue 5, 2023

Published on: 20 October, 2022

Article ID: e010722206556 Pages: 18

DOI: 10.2174/2215083808666220701084929

Abstract

Background: Angelica dahurica Radix and Osterici Radix are perennial herbs belonging to the family Umbelliferae, which are attacked by red spiders; thus, fenpropathrin has been registered to save them from this attack. Fenpropathrin is important in improving the productivity and quality of medicinal herbs due to timely pest control. However, residue may likely remain after harvest, and therefore, the residue analysis is important to ensure pesticides’ safety management.

Objective: This study aimed to establish an analysis method for fenpropathrin residues in A. dahurica Radix and O. Radix using GLC-ECD and GC-MS/MS.

Methods: Samples were moisturized with distilled water and extracted with acetonitrile. The interferences were removed using SPE cartridges and analyzed by GLC-ECD and GC-MS/MS.

Results: Based on pre-experiment results, the analysis method was optimized using the doublecleanup method (SPE-GCB/NH2 and SPE silica cartridges). Fenpropathrin peak was confirmed by GC-MS at the same retention time and with its mass numbers. Nevertheless, the cleanup processes are laborious and require a rather long time. Thus, an additional effortless analysis method was developed using the d-SPE method that can apply to highly selective and sensitive GC-MS/MS techniques. The LOD of GC-ECD and GC-MS/MS was 0.1 and 0.01 ng, respectively. While the LOQ was 0.04 mg/kg for both. Linearity (r2) was > 0.998 (GLC-ECD) and 0.999 (GC-MS/MS). The recoveries at three spiking levels ranged from 83.6-103.1% and 89.6-98.0% for A. dahurica Radix and O. Radix, respectively.

Conclusion: The accuracy of the improved method met the standard of the Korean Ministry of Food and Drug Safety. Therefore, the developed methods are expected to be used for analyzing pesticide residues in herbal medicines in Korea and other countries.

Keywords: Analytical method, Fenpropathrin, Herbal medicine, GLC-ECD, GC-MS/MS.

Graphical Abstract

[1]
Ministry of Agriculture, Food and Rural Affairs (MAFRA). Specialty crop production results 2018; 1-233.
[2]
Rural Development Administration (RDA). Registration status of safe use of pesticides in farming 2020. The Republic of Korea. Available from: https://psis.rda.go.kr/psis/cont/contentMain.ps?menuId=PS00334 (Accessed June 3, 2022).
[3]
Mottaghipisheh J. Oxypeucedanin: Chemotaxonomy, isolation, and bioactivities. Plants 2021; 10(8): 1577.
[http://dx.doi.org/10.3390/plants10081577] [PMID: 34451622]
[4]
Kim S, Kim KY, Han CS, et al. Simultaneous analysis of six major compounds in Osterici Radix and Notopterygii rhizoma et Radix by HPLC and discrimination of their origins from chemical fingerprint analysis. Arch Pharm Res 2012; 35(4): 691-9.
[http://dx.doi.org/10.1007/s12272-012-0413-3] [PMID: 22553062]
[5]
National Crop Pest Management System, NCPMS. Special crop pest information 2020. Available from: http://www.ncpms.rda.go.kr (Accessed June 3, 2022).
[6]
Turner A. The Pesticide Manual. (17th Ed.). Alton, Hampshire, UK: British Crop Protection Council 2015; p. 1357.
[7]
Li XF, Richardson SD. 29th ASMS Asilomar Conference on Mass spectrometry in environmental chemistry, toxicology, and health. J Am Soc Mass Spectrom 2014; 25(7): 1089-92.
[http://dx.doi.org/10.1007/s13361-014-0876-1] [PMID: 24819460]
[8]
Coy SL, Krylov EV, Schneider BB, et al. Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS-MS). Int J Mass Spectrom 2010; 291(3): 108-17.
[http://dx.doi.org/10.1016/j.ijms.2010.01.013] [PMID: 20305793]
[9]
Barriada-Pereira M, Concha-Graña E, González-Castro MJ, et al. Microwave-assisted extraction versus Soxhlet extraction in the analysis of 21 organochlorine pesticides in plants. J Chromatogr A 2003; 1008(1): 115-22.
[http://dx.doi.org/10.1016/S0021-9673(03)01061-6] [PMID: 12943256]
[10]
Cai L, Xing J, Dong L, Wu C. Application of polyphenylmethylsiloxane coated fiber for solid-phase microextraction combined with microwave-assisted extraction for the determination of organochlorine pesticides in Chinese teas. J Chromatogr A 2003; 1015(1-2): 11-21.
[http://dx.doi.org/10.1016/S0021-9673(03)01328-1] [PMID: 14570315]
[11]
Lee SJ, Hur JH, Han DS, Kim SM. Residue of fenpropathrin in fruits and red pepper (Capsicum annuum L). Kangwon Agric Life Environ Res 1996; 7(1): 95-103.
[12]
Hong YS, Park HW, Choi H, et al. An improved method for multiresidue analysis of pesticides in lettuce, Chinese cabbage and green pepper by gas chromatography. Korean J Environ Agric 2004; 23(3): 158-69.
[http://dx.doi.org/10.5338/KJEA.2004.23.3.158]
[13]
Kim MJ, Jung SS, Park JS, et al. Application of the pesticide multiresidue analysis method for potatoes and carrots. Korean J Food Sci Technol 2005; 37(2): 304-7.
[14]
Kim JW, Kwon H, Hong SM, et al. Method development of multiple pesticides residues in rice straw silage. Nongyag Gwahag Hoeji 2017; 21(4): 395-416.
[http://dx.doi.org/10.7585/kjps.2017.21.4.395]
[15]
Seo KE, Kim AY, Pyo BS, Lee KI. A study on the possibility of analyzing pesticide residues in herbal medicines using QuEChERS pretreatment and GC-MS/MS. Korean J Pharmacogn 2020; 51(3): 207-16.
[http://dx.doi.org/10.22889/KJP.2020.51.3.207]
[16]
Tong Z, Wu YC, Liu QQ, et al. Multi-residue analysis of pesticide residues in crude pollens by UPLC-MS/MS. Molecules 2016; 21(12): 1652.
[http://dx.doi.org/10.3390/molecules21121652] [PMID: 27916955]
[17]
Yang X, Xu DC, Qiu JW, et al. Simultaneous determination of 118 pesticide residues in Chinese test by gas chromatography-mass spectrometry. Chem Pap 2009; 63(1): 39-46.
[http://dx.doi.org/10.2478/s11696-008-0090-3]
[18]
Ministry of Food and Drug Safety (MFDS). Analysis of pesticide residues among general test methods in the Korean Pharmacopoeia (Notice No. 2019-102). Osong, The Republic of Korea 2019; 1-4.
[19]
Ministry of Food and Drug Safety. Food and Drug Safety Research Report. The Republic of Korea, Cheongju-si: Ministry of Food and Drug Safety 2010.
[20]
Korean Ministry of Food and Drug Safety. Ministry of Food and Drug Safety Research Report 2011. The Republic of Korea, Cheongju-si.
[21]
Anastassiades M, Lehotay SJ, Štajnbaher D, Schenck FJ. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J AOAC Int 2003; 86(2): 412-31.
[http://dx.doi.org/10.1093/jaoac/86.2.412] [PMID: 12723926]
[22]
Erney D, Gillespie A, Gilvydis D, Poole C. Explanation of the matrix-induced chromatographic response enhancement of organophosphorus pesticides during open tubular column gas chromatography with splitless or hot on-column injection and flame photometric detection. J Chromatogr A 1993; 638(1): 57-63.
[http://dx.doi.org/10.1016/0021-9673(93)85007-T]
[23]
Erney DR, Pawlowski TM, Poole CF. Matrix‐induced peak enhancement of pesticides in gas chromatography: Is there a solution. J High Resolut Chromatogr 2005; 20(7): 375-8.
[http://dx.doi.org/10.1002/jhrc.1240200706]
[24]
Hajslová J, Zrostlíková J. Matrix effects in (ultra) trace analysis of pesticide residues in food and biotic matrices. J Chromatogr A 2003; 1000(1-2): 181-97.
[http://dx.doi.org/10.1016/S0021-9673(03)00539-9] [PMID: 12877171]
[25]
Kwon CH, Chang MI, Im MH, et al. Determination of mandipropamid residues in agricultural commodities using high-performance liquid chromatography with mass spectrometry. Anal Sci Technol 2008; 21(6): 518-25.
[26]
Jang J, Kim H, Ko AY, et al. Development an official analytical method for determination of imazapyr in agricultural commodities using HPLC-UVD. Nongyag Gwahag Hoeji 2015; 19(1): 5-13.
[http://dx.doi.org/10.7585/kjps.2015.19.1.5]
[27]
Choung MG. Development of analytical method for valinamide carbamate fungicide iprovalicarb residue. J Korean Soc Int Agric 2019; 31(1): 25-33.
[http://dx.doi.org/10.12719/KSIA.2019.31.1.25]
[28]
Yim JG, Jang HW, Lee KG. Rapid and simple analytical method for removing patulin from apple juice using solid phase extraction. Korean J Food Sci Technol 2010; 42(3): 257-62.
[29]
Choi JY, Lee JY, Ham JH, Ishag ASA, Hur JH. A study on improvement of the analytical method of chlorantraniliprole residue in herbal medicine (Rehmannia glutinosa Libosch) using HPLC-UVD. Nongyag Gwahag Hoeji 2021; 25(3): 196-211.
[http://dx.doi.org/10.7585/kjps.2021.25.3.196]
[30]
Choi JY, Ham JH, Kim MN, Ishag ASA, Hur JH. Development of an analytical method for kasugamycin residue in herbal medicine, Achyranthes japonica Nakai. Indones J Chem 2022; 22(1): 47-61.
[http://dx.doi.org/10.22146/ijc.65970]
[31]
Tadeo JL, Tadeo JL. Analysis of Pesticides in Food and Environmental Samples. (1st ed.), Boca Raton, USA: CRC Press 2008.
[http://dx.doi.org/10.1201/9781420007756]
[32]
Li L, Li W, Ge J, Wu Y, Jiang S, Liu F. Use of graphitic carbon black and primary secondary amine for determination of 17 organophosphorus pesticide residues in spinach. J Sep Sci 2008; 31(20): 3588-94.
[http://dx.doi.org/10.1002/jssc.200800384] [PMID: 18972520]
[33]
Kim E, Park H, Park S, Choi J, Yoon HJ, Kim JH. Simultaneous determination of multi-class veterinary drugs in fishery products with liquid chromatography-tandem mass spectrometry. Appl Biol Chem 2021; 64(1): 40.
[http://dx.doi.org/10.1186/s13765-021-00611-8]
[34]
Wang YH, Du LW, Zhou XM, et al. QuEChERS extraction for high performance liquid chromatographic determination of pyrazosulfuron-ethyl in soils. J Chem Soc Pak 2012; 34(1): 28-32.
[35]
Bierman S, Campognone MV. Simplifying solid-phase extraction method development: Exploring the use of software. LC GC 2009; 27(8): 24-6.
[36]
Łozowicka B, Rutkowska E, Jankowska M. Influence of QuEChERS modifications on recovery and matrix effect during the multi-residue pesticide analysis in soil by GC/MS/MS and GC/ECD/NPD. Environ Sci Pollut Res Int 2017; 24(8): 7124-38.
[http://dx.doi.org/10.1007/s11356-016-8334-1] [PMID: 28093672]
[37]
Smith E, Ridgway I, Coffey M. The determination of alkylphenols in aqueous samples from the Forth Estuary by SPE-HPLC-fluorescence. J Environ Monit 2001; 3(6): 616-20.
[http://dx.doi.org/10.1039/b105144j] [PMID: 11785635]
[38]
Zhou W, Yang S, Wang PG. Matrix effects and application of matrix effect factor. Bioanalysis 2017; 9(23): 1839-44.
[http://dx.doi.org/10.4155/bio-2017-0214] [PMID: 29171768]
[39]
Niessen WMA, Manini P, Andreoli R. Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry. Mass Spectrom Rev 2006; 25(6): 881-99.
[http://dx.doi.org/10.1002/mas.20097] [PMID: 16783795]
[40]
Shrivastava A, Gupta VB. Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chron Young Sci 2011; 2(1): 21-5.
[http://dx.doi.org/10.4103/2229-5186.79345]
[41]
Lee HR, Choi H, Kim BJ, et al. Establishment of analytical method for pencycuron in representative agricultural commodities by high-performance liquid chromatography. Nongyag Gwahag Hoeji 2017; 21(1): 75-83.
[http://dx.doi.org/10.7585/kjps.2017.21.1.75]
[42]
Leem SB, Lee JW, Choi JW, Choi JY, Ham HJ, Hur JH. Improvement on analytical method of residual propineb in red bean (Vigna angularis Willd.) rich in protein. Nongyag Gwahag Hoeji 2019; 23(1): 17-25.
[http://dx.doi.org/10.7585/kjps.2018.23.1.17]
[43]
Korean Ministry of Food and Drug Safety. Guideline for Pesticide Residue Analysis Practice in the Korean Food Public Code. (5th edition;.). Ministry of Food and Drug Safety: Osong, The Republic of Korea 2017; pp. 1-1302.

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      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=156) and sj.journal_id!=156 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      810μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=156) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      7.27msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=156) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      6.12msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '124936'
      1.62msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 124936
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '124936'
      2.13msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 124936
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '124936' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      4.61msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 124936
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      230μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      520μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 156 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      30.91msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 156 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      8.47msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 156 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      3.48msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 124936 limit 1
      1.5msalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 124936
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 124936 and content_type = 'article' order by status desc limit 1
      220μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 206556 limit 1
      180μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 206556
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CTM' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      280μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CTM
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '124936' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      390μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '34' and is_uploaded = 1 and issue_id = 12257 order by cast(first_page as SIGNED) desc limit 1
      470μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 34
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '51' and is_uploaded = 1 and issue_id = 12257 order by cast(first_page as SIGNED) asc limit 1
      390μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 51
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      180μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 124936 limit 1
      2.42msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 124936
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 156 and `b`.`banner_from_date` <= 1739972516 and `b`.`banner_to_date` >= 1739972516 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.1msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 156
      • 3: 1739972516
      • 4: 1739972516
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 156 and `b`.`banner_from_date` <= 1739972516 and `b`.`banner_to_date` >= 1739972516 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.4msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 156
      • 3: 1739972516
      • 4: 1739972516
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='0113f8e47148dd4173e1aaa17619453b'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        ggxuvDYCp6jfODAfVmVGbkL2xDNBP2tIZkHGPAcd
        uc_cart_id
        0113f8e47148dd4173e1aaa17619453b
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/124936" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/124936
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
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