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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Targeting the Transforming Growth Factor-beta Signaling Pathway in the Treatment of Gynecologic Cancer

Author(s): Sadaf Ghanaatgar-Kasbi, Farzaneh Pouya, Negar Khoshghamat, Ghazaleh Ghorbannezhad, Majid Khazaei, Malihe Hasanzadeh, Gordon A. Ferns and Amir Avan*

Volume 23, Issue 1, 2023

Published on: 05 September, 2022

Page: [15 - 24] Pages: 10

DOI: 10.2174/1568009622666220623115614

Price: $65

Abstract

The transforming growth factor-beta (TGF-β) signaling pathway has been reported to be dysregulated in the pathogenesis of several malignancies, including gynecologic cancers. This provides proof of concept of its potential value as a therapeutic target and prognostic biomarker in cervical cancer. Here we provide an overview of the biological role and clinical impact of TGF-β inhibitors either as a single agent or as a combinatorial therapy in gynecological cancers, concentrating on phase I to phase II/III clinical trials. Aberrant TGF-β signaling may lead to carcinogenesis. Inhibition of TGF-β represents an interesting area of focus for the treatment of gynecological cancer. Several TGF-β inhibitors are potential anticancer agents and are undergoing clinical trials in cancer, including galunisertib, dalantercept, and vigil. There is a growing body of data showing the potential therapeutic impact of targeting the TGF-β pathway in different cancer types, although further studies are still warranted to explore the value of this strategy and finding the most appropriate patients who could most benefit from therapy.

Keywords: TGF-β pathway, TGF-β inhibitors, gynecologic cancer, target therapy, anticancer agents, malignancies.

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