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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Chitosan: Applications in Drug Delivery System

Author(s): Suresh Kumar, Ruby Dhiman, Carlos R. Prudencio, Antonio Charlys da Costa, Arpana Vibhuti, Elcio Leal, Chung-Ming Chang, Vethakkani Samuel Raj and Ramendra Pati Pandey*

Volume 23, Issue 2, 2023

Published on: 22 August, 2022

Page: [187 - 191] Pages: 5

DOI: 10.2174/1389557522666220609102010

Price: $65

Abstract

Chitin and chitosan have unique structures with significant functional groups carrying useful chemical capabilities. Chitin and chitosan are acknowledged as novel biomaterials with advantageous biocompatibility and biodegradability. Chitosan is a polysaccharide that is made from chitin. There have been several attempts to employ this biopolymer in the biomedical area. This material's application in the production of artificial skin, drug targeting, and other areas is explored. The most prevalent strategies for recovering chitin from sea organisms are described and various pharmacological and biological uses are discussed. This review article targets drug delivery with the help of chitosan derived nanomaterial. The drug delivery system applications through nonmaterial have encountered a considerable role in the pharmaceutical, medical, biological, and other sectors in recent years. Nanomaterials have advanced applications as novel drug delivery systems in many fields, especially in industry, biology, and medicine. In the biomedical and pharmaceutical arena, the natural polymer-based nanoparticulate method has now been widely studied as particulate vehicles. By mixing alginate with other biopolymers, by immobilizing specific molecules such as sugar molecules and peptides by chemical or physical cross-linking, different properties and structures such as biodegradability, gelling properties, mechanical strength, and cell affinity can be obtained. Owing to their inherent ability to deliver both hydrophilic and hydrophobic drug molecules, increase stability, decrease toxicity, and enhance commonly formulated medications, these particles are now widely used in imaging and molecular diagnostics, cosmetics, household chemicals, sunscreens, radiation safety, and novel drug delivery.

Keywords: Biopolymers, physicochemical properties, biological properties, nanomaterials, nanotoxicity, pharmaceutical nanotechnology, toxicological effect.

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[1]
Crini, G. Historical review on chitin and chitosan biopolymers. Environ. Chem. Lett., 2019, 17(4), 1623-1643.
[http://dx.doi.org/10.1007/s10311-019-00901-0]
[2]
Kumar, M.N. A review of chitin and chitosan applications. React. Funct. Polym., 2000, 46(1), 1-27.
[http://dx.doi.org/10.1016/S1381-5148(00)00038-9]
[3]
Rinaudo, M. Chitin and chitosan: Properties and applications. Prog. Polym. Sci., 2006, 31(7), 603-632.
[http://dx.doi.org/10.1016/j.progpolymsci.2006.06.001]
[4]
van den Broek, L.A.M.; Boeriu, C.G. Chitin and Chitosan: Properties and Applications, 1st ed; John Wiley & Sons: Hoboken, New Jersey, 2019.
[http://dx.doi.org/10.1002/9781119450467]
[5]
Morin-Crini, N.; Lichtfouse, E.; Torri, G.; Crini, G. Applications of Chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry. Environ. Chem. Lett., 2010, 17(4), 1667-1692.
[http://dx.doi.org/10.1007/s10311-019-00904-x]
[6]
Tsurkan, M.V.; Voronkina, A.; Khrunyk, Y.; Wysokowski, M.; Petrenko, I.; Ehrlich, H. Progress in chitin analytics. Carbohydr. Polym., 2021, 252, 117204.
[http://dx.doi.org/10.1016/j.carbpol.2020.117204] [PMID: 33183639]
[7]
Pillai, C.K.; Paul, W.; Sharma, C.P. Chitin and chitosan polymers: Chemistry, solubility and fiber formation. Prog. Polym. Sci., 2009, 34(7), 641-678.
[http://dx.doi.org/10.1016/j.progpolymsci.2009.04.001]
[8]
Bashir, S.; Teo, Y.Y.; Ramesh, S.; Ramesh, K.; Khan, A.A. N-succinyl chitosan preparation, characterization, properties and biomedical applications: A state of the art review. Rev. Chem. Eng., 2015, 0(0)
[9]
Satoh, T.; Vladimirov, L.; Johmen, M.; Sakairi, N. Preparation and thermal dehydration of (Carboxy) acyl chitosan derivatives with high stereoregularity. Chem. Lett., 2003, 32(4), 318-319.
[http://dx.doi.org/10.1246/cl.2003.318]
[10]
Nel, A.; Xia, T.; Mädler, L.; Li, N. Toxic potential of materials at the nanolevel. Science, 2006, 311(5761), 622-627.
[http://dx.doi.org/10.1126/science.1114397] [PMID: 16456071]
[11]
Kurita, K. Chitin and chitosan: Functional biopolymers from marine crustaceans. Mar. Biotechnol. (NY), 2006, 8(3), 203-226.
[http://dx.doi.org/10.1007/s10126-005-0097-5] [PMID: 16532368]
[12]
Younes, I.; Rinaudo, M. Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar. Drugs, 2015, 13(3), 1133-1174.
[http://dx.doi.org/10.3390/md13031133] [PMID: 25738328]
[13]
Toan, N.V. Production of Chitin and Chitosan from partially autolyzed shrimp shell materials. TOBIOMTJ, 2009, 1(1), 21-24.
[http://dx.doi.org/10.2174/1876502500901010021]
[14]
Kumirska, J.; Weinhold, M.X.; Thöming, J.; Stepnowski, P. Biomedical activity of chitin/chitosan-based materials-influence of physico-chemical properties apart from molecular weight and degree of N-acetylation. Polymers (Basel), 2011, 3(4), 1875-1901.
[http://dx.doi.org/10.3390/polym3041875]
[15]
Ibitoye, E.B.; Lokman, I.H.; Hezmee, M.N.M.; Goh, Y.M.; Zuki, A.B.Z.; Jimoh, A.A. Extraction and physicochemical characterization of chitin and chitosan isolated from house cricket. Biomed. Mater., 2018, 13(2), 025009.
[http://dx.doi.org/10.1088/1748-605X/aa9dde] [PMID: 29182521]
[16]
Hafdani, F.N.; Sadeghinia, N. A review on application of chitosan as a natural antimicrobial. World Acad. Sci. Eng. Technol., 2011, 50, 252-256.
[17]
Ahmed, S.; Ahmad, M.; Ikram, S. Chitosan: A natural antimicrobial agent-a review. J. Appl. Chem., 2014, 3(2), 493-503.
[18]
Benhabiles, M.S.; Salah, R.; Lounici, H.; Drouiche, N.; Goosen, M.F.; Mameri, N. Antibacterial activity of chitin, chitosan and its oligo-mers prepared from shrimp shell waste. Food Hydrocoll., 2012, 29(1), 48-56.
[http://dx.doi.org/10.1016/j.foodhyd.2012.02.013]
[19]
Ji, J.H.; Bae, G.N.; Yun, S.H.; Jung, J.H.; Noh, H.S.; Kim, S.S. Evaluation of a silver nanoparticle generator using a small ceramic heater for inactivation of S. epidermidis bioaerosols. Aerosol Sci. Technol., 2007, 41, 786-793.
[http://dx.doi.org/10.1080/02786820701459932]
[20]
Ampollini, L.; Sonvico, F.; Barocelli, E.; Cavazzoni, A.; Bilancia, R.; Mucchino, C.; Cantoni, A.M.; Carbognani, P. Intrapleural polymeric films containing cisplatin for malignant pleural mesothelioma in a rat tumour model: A preliminary study. Eur. J. Cardiothorac. Surg., 2010, 37(3), 557-565.
[http://dx.doi.org/10.1016/j.ejcts.2009.08.012]
[21]
Kim, Choi. H.S.; Song, M.K.; Youk, D.Y.; Kim, J.H.; Ryu, J.C. Genotoxicity of aluminum oxide (Al2O3) nanoparticle in mammalian cell lines. Mol. Cell. Toxicol., 2009, 5, 172-178.
[22]
Pradeep, H.M.B.; Suresh, S.; Thadathil, A.; Periyat, P. Recent trends and advances in polyindole-based nanocomposites as potential antimicrobial agents: A mini review. RSC Adv, 2022, 12(13), 8211-8227.
[http://dx.doi.org/10.1039/D1RA09317G] [PMID: 35424771]
[23]
Maliki, S.; Sharma, G.; Kumar, A.; Moral-Zamorano, M.; Moradi, O.; Baselga, J.; Stadler, F.J.; García-Peñas, A. Chitosan as a tool for sustainable development: A mini review. Polymers (Basel), 2022, 14(7), 1475.
[http://dx.doi.org/10.3390/polym14071475] [PMID: 35406347]

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