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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

COVID-19-associated Coagulopathy: Role of Vitamins D and K

Author(s): Bruk Getachew, Harold E. Landis, Kebreten F. Manaye and Yousef Tizabi*

Volume 24, Issue 3, 2023

Published on: 26 August, 2022

Page: [401 - 410] Pages: 10

DOI: 10.2174/1389201023666220527110455

Price: $65

Abstract

Recent reports show coagulopathy as a potential complication and poorer outcome of coronavirus disease 2019 (COVID-19), especially in those with comorbid conditions such as diabetes and hypertension as thrombosis could result in stroke and heart attacks. Indeed, cardiovascular complications in COVID-19 account for 40% of mortality. Although there is no standard treatment protocol or guidelines for COVID-19, it is a common practice to use anti-inflammatory corticosteroids and anti-coagulants, especially for severe COVID-19 patients. It has also been confirmed that deficiencies of vitamin D and/or vitamin K can exacerbate premorbid cardiovascular and diabetes conditions associated with COVID-19, at least partially due to a higher incidence of coagulopathy. Here, we discuss the roles of vitamins D and K in general and in COVID-19-related coagulopathy. Moreover, the suggestion for proper supplementations of these vitamins in countering COVID-19 is provided.

Keywords: Thrombosis, phylloquinone, menaquinone, vitamin D, SARS-CoV-2, COVID-19.

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