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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

The Effects of Vitamin Therapy on ASD and ADHD: A Narrative Review

Author(s): Mohadeseh Poudineh, Sadaf Parvin, Mehrnia Omidali, Farhad Nikzad, Fatemeh Mohammadyari, Fatemeh Sadeghi Poor Ranjbar, Fayaz Rasouli, Sepehr Nanbakhsh and Sepehr Olangian-Tehrani*

Volume 22, Issue 5, 2023

Published on: 11 August, 2022

Page: [711 - 735] Pages: 25

DOI: 10.2174/1871527321666220517205813

open access plus

Abstract

The effects of a sufficient amount of vitamins and nutrients on the proper function of the nervous system have always been regarded by scientists. In recent years, many studies have been done on controlling or improving the symptoms of neurological and behavioral disorders created by changes in the level of vitamins and other nutrition, such as omega-3 and iron supplements. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that disrupts individual communication, especially in social interactions. Its symptoms include anxiety, violence, depression, self-injury, trouble with social contact and pervasive, stereotyped, and repetitive behavior. ASD is most noticeable in early childhood. Attention Deficit Hyperactivity Disorder (ADHD) is a lasting pattern of inattention with or without hyperactivity that causes functional disruption in daily life. ADHD symptoms included; impulsivity, hyperactivity, inattention, restlessness, talkativeness, excessive fidgeting in situations such as sitting, meetings, lectures, or at the movies, boredom, inability to make decisions, and procrastination. The exact etiology of ADHD has not yet been found, but several observations have assumed the reduced function of the brain leads to deficits in motor planning and cognitive processing. It has been shown that Pro-inflammatory cytokines and oxidative stress biomarkers could be increased in both ASD and ADHD. Several studies have been done to illustrate if vitamins and other dietary supplements are effective in treating and preventing ASD and ADHD. In this review, we aim to evaluate the effects of vitamins and other dietary supplements (e.g., melatonin, zinc supplements, magnesium supplements) on ASD and ADHD.

Keywords: Autism spectrum disorder, attention deficit hyperactivity disorder, vitamin, omega-3, iron supplements, zinc supplements.

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