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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Quantitative Determination of Pitavastatin in Tablets Using FTIR and RP-HPLC Analysis: A Comparative Study

Author(s): Hourieh AlKadi*, Ali Alzier, Huda Mando, Zaynab Mando, Jamal Abdul Naser Darwicha and Abdul Wahab Allaf

Volume 22, Issue 7, 2022

Published on: 27 July, 2022

Article ID: e090522204401 Pages: 7

DOI: 10.2174/1871526522666220509055847

Price: $65

Abstract

Background: Fourier Transform Infrared (FTIR) spectroscopy and reverse phase highperformance liquid chromatography, RP-HPLC analysis have been used for the quantitative determination of local l commercially available Pitavastatin products.

Methods: The FTIR method of analysis is not widely used in pharmaceutical quality control laboratories. This technique is non-destructive, reliable, precise, and efficient, and the samples can be prepared easily. These features emphasized that the FTIR technique can be considered as a potential analytical method for quantitative analysis in pharmaceutical laboratories.

Results: It is strongly recommended that FTIR analytical method can be applied simultaneously with RP-HPLC techniques for quality control purposes of drug analysis. Both methods of analysis have shown comparable precision and good repeatability and reproducibility for analysis of Pitavastatin which can be generalized for other pharmaceutical products.

Conclusion: In addition, FTIR is not only used for the determination of vibrational modes and structure in the fingerprint region, but it can be also generally applied in quantitative analysis for many pharmaceutical products.

Keywords: FTIR, RP-HPLC, pitavastatin, qualitative, quantitative, validation.

Graphical Abstract

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