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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Systematic Review Article

Native Iranian Medicinal Plants with Anti-Vaginal Infection Properties: A Systematic Review

Author(s): Marzieh Rashidipour, Pegah Shakib*, Gholamreza Goudarzi, Yadollah Pournia, Maryam Karimi and Maryam Sarlak

Volume 22, Issue 6, 2022

Published on: 06 June, 2022

Article ID: e010522204326 Pages: 7

DOI: 10.2174/1871526522666220501171551

Price: $65

Abstract

Background: The use of herbs has recently been considered an effective method in the treatment of infections. The purpose of this study was to introduce Iranian medicinal plants with an effect on vaginal infections.

Methods: In our systematic review study, keywords including ‘medicinal plants’, ‘Iranian medicinal plants’, ‘vaginal infection’, ‘essential oils’, and ‘extracts’ were searched in PubMed, Web of Science Direct, Scopus, Scientific Information Database, and Google Scholar. This study focused on the articles published from 2000 to 2019.

Results and Discussion: According to our investigation, Stachys lavandulifolia, Thymus vulgaris L., Origanum vulgare L., Allium jesdianum, Cichorium intybus, Trigonella foenum-graecum, Azadirachta Indica, Stachys lavandulifolia, Coriandrum sativum L., Rosmarinus officinalis, Ferula gummosa L., Origanum syriacum, Eucalyptus globulus, Myrtus communis, Zingiber officinale, Punica granatum, Vitex agnus-castus, Mentha suaveolens, Quercus Brantii Lindl, Zataria multiflora, Berberis vulgaris, Thymus vulgaris L., Echinophora platyloba, Stachys lavandulifolia, Viola odorata, Menthe piperita, Eucalyptus camaldulensis, Ziziphus mauritiana, Quercus infectoria, Hypericum perforatum, Glycyrrhiza glabra L., Calendula officinalis, Origanum vulgare, Ziziphus nummularia, Satureja Bachtiarica, Foeniculum vulgare, Nigella sativa, Anethum graveolens, Salvia officinalis, and Calendula officinalis are used to treat vaginal infections.

Conclusion: Therefore, native plants of Iran have been reported to have antimicrobial properties for the treatment of vaginal infections and can be used as a suitable and effective alternative to antibiotics in future research.

Keywords: Bacteria, vaginal infection, medicinal plants, systematic review, Iranian medicinal plants, essential oils, extracts.

Graphical Abstract

[1]
Jonathan SB. Berek and Novak's Gynocology 14th ed Philadelphia, PA: Lippincott Williams & Wilkins 2012.
[2]
McGregor JA, French JI. Chlamydia trachomatis infection dur-ing pregnancy. Am J Obstet Gynecol 1991; 164(6 Pt 2): 1782-9.
[http://dx.doi.org/10.1016/0002-9378(91)90560-E ] [PMID: 2039032]
[3]
Schwebke JR, Burgess D. Trichomoniasis. Clin Microbiol Rev 2004; 17(4): 794-803.
[http://dx.doi.org/10.1128/CMR.17.4.794-803.2004 ] [PMID: 15489349]
[4]
Perumal P, Mekala S, Chaffin WL. Role for cell density in anti-fungal drug resistance in Candida albicans biofilms. Antimicrob Agents Chemother 2007; 51(7): 2454-63.
[http://dx.doi.org/10.1128/AAC.01237-06 ] [PMID: 17502416]
[5]
Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4: 177.
[http://dx.doi.org/10.3389/fphar.2013.00177 ] [PMID: 24454289]
[6]
Fisher C, Adams J, Hickman L, Sibbritt D. The use of comple-mentary and alternative medicine by 7427 Australian women with cyclic perimenstrual pain and discomfort: A cross-sectional study. BMC Complement Altern Med 2016; 16: 129.
[http://dx.doi.org/10.1186/s12906-016-1119-8 ] [PMID: 27189381]
[7]
Rafieian-Kopaei M. Medicinal plants and the human needs. J HerbMed Pharmacol 2012; 1(1): 1-2.
[8]
Arab F, Afzalaghayi M, Vakilzade AK, Ghorbanzade A. Evalua-tion of the reasons behind the use of traditional medicine from the perspective of Mashhad medical students. Avicenna J Phytomed 2015; 5: 46-7.
[9]
Masoudi M, Rafieian Kopaei M, Miraj S. A comparison of the efficacy of metronidazole vaginal gel and Myrtus (Myrtus com-munis) extract combination and metronidazole vaginal gel alone in the treatment of recurrent bacterial vaginosis. Avicenna J Phytomed 2017; 7(2): 129-36.
[PMID: 28348968]
[10]
Masoudi M, Miraj S, Rafieian-Kopaei M. Comparison of the effects of Myrtus communis L, Berberis vulgaris and metronida-zole vaginal gel alone for the treatment of bacterial vaginosis. J Clin Diagn Res 2016; 10(3): QC04-7.
[http://dx.doi.org/10.7860/JCDR/2016/17211.7392 ] [PMID: 27134945]
[11]
Arbabi M, Delavari M, Fakhrieh Kashan Z, Taghizadeh M, Hooshyar H. Ginger (Zingiber officinale) induces apoptosis in Trichomonas vaginalis in vitro. Int J Reprod Biomed (Yazd) 2016; 14(11): 691-8.
[http://dx.doi.org/10.29252/ijrm.14.11.691 ] [PMID: 27981254]
[12]
Shabanian S, Khalili S, Lorigooini Z, Malekpour A, Heidari-Soureshjani S. The effect of vaginal cream containing ginger in users of clotrimazole vaginal cream on vaginal candidiasis. J Adv Pharm Technol Res 2017; 8(2): 80-4.
[PMID: 28516061]
[13]
El-Sherbiny GM, El Sherbiny ET. The effect of Commiphora molmol (myrrh) in treatment of trichomoniasis vaginalis infec-tion. Iran Red Crescent Med J 2011; 13(7): 480-6.
[PMID: 22737515]
[14]
Keikha N, Shafaghat M, Mousavia SM, Moudi M, Keshavarzi F. Antifungal effects of ethanolic and aqueous extracts of Vitexag-nus-castus against vaginal isolates of Candida albicans. Curr Med Mycol 2018; 4(1): 1-5.
[http://dx.doi.org/10.18502/cmm.4.1.26 ] [PMID: 30186986]
[15]
Pietrella D, Angiolella L, Vavala E, et al. Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal can-didiasis assessed by real-time monitoring of infection. BMC Complement Altern Med 2011; 11: 18.
[http://dx.doi.org/10.1186/1472-6882-11-18 ] [PMID: 21356078]
[16]
Moshfeghy Z, Asadi K, Akbarzadeh M, et al. Quercus brantii Lindl. Vaginal douche versus clotrimazole on vaginal candidia-sis: A randomized clinical trial. J Pharmacopuncture 2018; 21(3): 185-94.
[PMID: 30283706]
[17]
Abdali K, Jahed L, Amooee S, Zarshenas M, Tabatabaee H, Bekhradi R. Comparison of the effect of vaginal Zataria multi-flora cream and oral metronidazole pill on results of treatments for vaginal infections including trichomoniasis and bacterial vaginosis in women of reproductive age. BioMed Res Int 2015; 2015: 683640.
[http://dx.doi.org/10.1155/2015/683640 ] [PMID: 26266260]
[18]
Bogavac M, Karaman M. Janjušević Lj, et al. Alternative treat-ment of vaginal infections – in vitro antimicrobial and toxic ef-fects of Coriandrum sativum L. and Thymus vulgaris L. essential oils. J Appl Microbiol 2015; 119(3): 697-710.
[http://dx.doi.org/10.1111/jam.12883 ] [PMID: 26109513]
[19]
Avijgan M, Mirzadeh F, Nia EA. The comparative study of anti-fungal effect of pharmaceutical product containing hydroalco-holic extract of Echinophora platyloba DC and fluconazole in women with chronic recurrent vaginitis caused by Candida al-binicans. J Res Med Sci 2012; 1: S103-7.
[20]
Youse HA, Kazemian A, Sereshti M, et al. Effect of Echinopho-ra platyloba, Stachys lavandulifolia, and Eucalyptus camaldu-lensis plants on Trichomonas vaginalis growth in vitro. Adv Biomed Res 2012; 1: 79.
[http://dx.doi.org/10.4103/2277-9175.102987 ] [PMID: 23326809]
[21]
Aslani A, Asghari G, Darani HY, Ghanadian M, Hosseini F. Design, formulation, and physicochemical evaluation of vaginal cream containing Eucalyptus camaldulensis, Viola odorata, and Mentha piperita extracts for prevention and treatment of trich-omoniasis. Int J Prev Med 2019; 10: 179.
[http://dx.doi.org/10.4103/ijpvm.IJPVM_525_17 ] [PMID: 32133097]
[22]
Dubey R, Dubey K, Sridhar C, Jayaveera K. Human vaginal pathogen inhibition studies on aqueous, methanolic and sapo-nins extracts of stem barks of Ziziphus mauritiana. Int J Pharm Sci Res 2011; 2(22): 659-3.
[http://dx.doi.org/10.13040/IJPSR.0975-8232.2(3).659-63]
[23]
Ardestani MM, Aliahmadi A, Toliat T, Dalimi A, Momeni Z, Rahimi R. Antimicrobial activity of Quercus infectoria gall and its active constituent, gallic acid, against vaginal pathogens. Trad Integr Med 2019; 4(1): 1664.
[http://dx.doi.org/10.18502/tim.v4i1.1664]
[24]
Mohammadzadeh Z, Mohammadalizadeh CS, Farshbaf KA, Javadzadeh Y. The effect of Hypericum perforatum vaginal gel in treatment of bacterial vaginosis. Majallah-i Zanan, Mamai va Nazai-i Iran 2013; 16: 17-27.
[25]
Mahmoudabadi AZ, Iravani M, Khazrei A. Anti-fungal activity of Glycyrrhiza glabra (Licorice) against vaginal isolates of Can-dida. Biotechnology (Rajkot) 2009; 3: 75-7.
[26]
Saffari E, Mohammad-Alizadeh-Charandabi S, Adibpour M, Mirghafourvand M, Javadzadeh Y. Comparing the effects of Ca-lendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial. Women Health 2017; 57(10): 1145-60.
[http://dx.doi.org/10.1080/03630242.2016.1263272 ] [PMID: 27880086]
[27]
Karaman M, Bogavac M. Radovanović B, Sudji J, Tešanović K, Janjušević L. Origanum vulgare essential oil affects pathogens causing vaginal infections. J Appl Microbiol 2017; 122(5): 1177-85.
[http://dx.doi.org/10.1111/jam.13413 ] [PMID: 28176439]
[28]
Raghvendra D, Kushagra D, Janapati Y, Sridhar C, Jayaveera K. Comparative anti microbial studies of aqueous, methanolic and saponins extract of stem barks of Ziziphus nummularia on hu-man vaginal pathogens causing UTI infection. Recent Adv Pro-spects Potential Med Plants 2009; pp. 19-24.
[29]
Jafarzadeh L, Separdar A, Lori GZ, Rafiean M, Deris F, Shahin-fard N. Effect of clotrimazole-satureja bachtiarica vaginal cream and clotrimazole vaginal cream in patients with vaginal candidi-asis. Majallah-i Zanan, Mamai va Nazai-i Iran 2019; 21: 14-22.
[30]
Saghafi N, Karjalian M, Ghazanfarpour M, et al. The effect of a vaginal suppository formulation of dill (Anethum graveolens) in comparison to clotrimazole vaginal tablet on the treatment of vulvovaginal candidiasis. J Obstet Gynaecol 2018; 38(7): 985-8.
[http://dx.doi.org/10.1080/01443615.2018.1432578 ] [PMID: 29553834]
[31]
Jasim RM, Abd Al-Khaliq IM. Inhibitory effect of aqueous Salvia officinalis’s leaves in the growth of Candida albicans from infected women with vaginal candidiasis. Al-Kindy Col-lege Med J 2011; 6(2): 47-9.
[32]
Bogavac MA, Karaman MA. Suđi JJ, et al. Antimicrobial poten-tial of Rosmarinus officinalis commercial essential oil in the treatment of vaginal infections in pregnant women. Nat Prod Commun 2017; 12(1): 127-30.
[http://dx.doi.org/10.1177/1934578X1701200136 ] [PMID: 30549845]
[33]
Mazandarani M, Zeinali Z, Ghafourian M. Autecology essential oil composition, antibacterial, anti candidacies and ethnophar-macological survey of Ferula gummosa L. as anti infection to treat of vaginal infections in traditional medicine of Razavi Khorasan province. North East of Iran CJMB 2015; 2(2): 42-7.
[34]
Kassaify Z, Gerges DD, Jaber LS, et al. Bioactivity of Origanum syriacum essential oil against Candida albicans. J Herbs Spices Med Plants 2008; 14: 185-99.
[http://dx.doi.org/10.1080/10496470802598818]
[35]
Bogavac M. Tešanović K, Marić J, Jovanović M, Karaman M. Antimicrobial activity and toxicity of Eucalyptus globulus La-bill. Essential oil against vaginal microorganisms. Trends Phy-tochem Res 2019; 3(3): 201-6.
[36]
Sereshti M, Yousofi Darani H, Zebardast N, Rafieian-Kopaei M, Naeini M, Yousofi HA. Effect of ethanolic and watery extract of aerial parts of Stachys lavandulifolia on Trichomonas vaginalis, in vitro. Faslnamah-i Giyahan-i Daruyi 2012; 11: 159-65.
[37]
Mane RS. Studies on Azadirachta Indica against fever, wound infection and vaginal infection. Int J Sci Res 2017; 6(10): 217-9.
[38]
Yadav SK, Jain GK, Mazumder A, Khar RK. Antimicrobial activity of a novel polyherbal combination for the treatment of vaginal infection. J Adv Pharm Technol Res 2019; 10(4): 190-4.
[http://dx.doi.org/10.4103/japtr.JAPTR_3_19 ] [PMID: 31742120]
[39]
Shahrokh S, Vahedi G, Khosravi A-R, et al. In vitro antifungal activity of aqueous-ethanolic extract of Allium jesdianum against fluconazole-susceptible and-resistant human vaginal Candida glabrata isolates. J Herbmed Pharmacol 2017; 6(4): 165-70.
[40]
Kaambo E, Africa C, Chambuso R, Passmore JS. Vaginal mi-crobiomes associated with aerobic vaginitis and bacterial vagi-nosis. Front Public Health 2018; 6: 78.
[http://dx.doi.org/10.3389/fpubh.2018.00078 ] [PMID: 29632854]
[41]
Paladine HL, Desai UA. Vaginitis: Diagnosis and treatment. Am Fam Physician 2018; 97(5): 321-9.
[PMID: 29671516]

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