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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

Synthesis and Anti-Cancer Applications of Benzimidazole Derivatives - Recent Studies

Author(s): Yogesh K. Tyagi, Geetan jali and Ram Singh*

Volume 22, Issue 19, 2022

Published on: 17 August, 2022

Page: [3280 - 3290] Pages: 11

DOI: 10.2174/1871520622666220429134818

Price: $65

Abstract

Background: Cancer is a life-threatening disease. Anti-cancer drugs are the focus of research. The heterocyclic molecules like benzimidazole occupy a central position in searching for novel and effective anti-cancer drugs. The medicinal chemists designed and synthesized several benzimidazole derivatives and conjugates to evaluate them as potential anti-cancer agents.

Objective: The purpose of this compilation of literature is to cover the progress of benzimidazole-based anti-cancer agents, their synthesis, and their evaluation for cancer disease treatment.

Methods: The recent literatures have been collected from various search engines and peer-reviewed journals.

Results: The compounds like benzimidazole derivatives of dehydroabietic acid, piperidyl benzimidazole carboxamide, benzimidazole-quinazolinone hybrids, benzimidazole-thiazole conjugate, and benzimidazole pendant cyanopyrimidine derivatives have been discussed in detail.

Conclusion: This review article will help the medicinal chemists to design and synthesize benzimidazole-based molecules and evaluate them as anti-cancer agents.

Keywords: Cancer, anticancer agents, benzimidazole, heterocyclic molecules, bicyclic molecules, medicinal applications.

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