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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Meta-Analysis

Antibiotic Prophylaxis for Orthopaedic Implant Removal: What Does the Evidence Say?

Author(s): Imran Ibni Gani Rather, Nusrat Shafiq*, Avaneesh Kumar Pandey, Ritika Kondel Bhandari, Samir Malhotra and Devinder Kumar Chouhan

Volume 18, Issue 1, 2023

Published on: 24 June, 2022

Page: [116 - 120] Pages: 5

DOI: 10.2174/1574886317666220429081207

Price: $65

Abstract

Orthopaedic implant removal is considered a sterile procedure, but the current literature suggests it is associated with around a 20% Surgical Site Infection (SSI) rate. The use of antibiotic prophylaxis is still ambiguous and contentious. Taking into consideration this issue we conducted a meta-analysis for the use of antibiotic prophylaxis in orthopaedic implant removal surgery.

Objectives: To determine whether or not antibiotic prophylaxis benefits orthopaedic implant removal surgeries.

Methods: Electronic and printed sources were searched up to February 2021 for randomised controlled trials (RCTs) using antibiotic prophylaxis and a control group. Data from eligible studies were pooled for the following outcomes: overall, superficial, and deep surgical site infection (SSI). Pooled odds ratios with a 95% confidence interval (CI) were calculated using Mantel Haenszel fixed-effect model preferentially.

Results: Two studies, including 766 patients were included in this meta-analysis. Heterogeneity was not statistically significant between the studies. There was no significant difference in the incidence of overall SSI in cefazolin and normal saline (NS) groups (Pooled OR 0.79; 95% CI 0.53- 1.17). In subgroup analysis, antibiotic prophylaxis showed statistically significant improvement for deep SSI (Pooled OR 0.20; 95% CI 0.06-0.70).

Conclusion: Overall incidence of SSI is not reduced after the administration of antibiotic prophylaxis one hour before removal of orthopaedic implants.

Keywords: Antibiotic prophylaxis, orthopaedic implant, surgical site infection, superficial surgical site infection, deep-seated surgical site infection, fractures.

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