Login Register Cart 0
Generic placeholder image

Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Systematic Review Article

Colostrum Antibodies and Cytokines in Puerperal Women with Diabetes Before and During the COVID-19 Pandemic: A Systematic Review

Author(s): Rosane Nassar Meireles Guerra*, Cláudia Regina Silva dos Santos Cunha, Marcela Patrícia Macêdo Belo Fort, Eremita Val Rafael, Rebeca Aranha Arrais e Silva Santos, Mônica Virginia Viegas Lima-Aragão, Mayara Cristina Pinto Silva and Flávia Raquel Fernandes Nascimento

Volume 19, Issue 3, 2023

Published on: 22 August, 2022

Article ID: e260422204030 Pages: 7

DOI: 10.2174/1573399818666220426084902

Price: $65

Abstract

Background: Breastfeeding maintains the maternal-fetal immune link after birth, favors the transmission of immunological competence, and is considered an important contributing factor to the development of the babies’ immune system.

Objective: This study aimed to obtain data related to the effects of gestational diabetes on immunoglobulin A (IgA) and cytokines levels in the colostrum, before and during the pandemic of the new coronavirus, in order to study the possible outcomes regarding the immunological characteristics of human milk.

Methods: This systematic review was registered in PROSPERO CRD42020212397, and the question elaborated using the PICO strategy was: does maternal hyperglycemia associated or not with Covid-19 influence the immunological composition of colostrum? Electronic searching and reference lists of published reports were used to identify studies that reported the influence of gestational diabetes on colostrum and milk composition.

Results: Seven studies were selected from the 51 found, six of them were cross-sectional and one was a case report. Six studies included Brazilian groups and only one was conducted in USA. The mothers with gestational diabetes presented a reduced level of IgA and other immunoreactive proteins in colostrum. Those alterations could be related to changes in macronutrient metabolism and cellular oxidative metabolism.

Conclusion: It was possible to conclude that diabetes changes the immunological composition of breast milk; however, data on the impact of the association between gestational diabetes and Covid-19 infection on the composition of antibodies and cytokines present in human milk are still scarce and inconclusive.

Keywords: Breast milk, gestational diabetes, IgA, cytokines, SARS-CoV-2, Covid-19.

[1]
Chirico G, Marzollo R, Cortinovis S, Fonte C, Gasparoni A. Anti-infective properties of human milk. J Nutrition 2008; 138(9): 1801S-6S.
[2]
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde Departamento de Atenção Básica. Saúde da criança: Nutrição Infantil, aleitamento Materno e alimentação Complementar. Brasília, 2015. Available from https://bvsms.saude.gov.br/bvs/publicacoes/saude_ crianca_nutricao_aleitamento_alimentacao.pdf Access October 10, 2020
[3]
WHO. World Health Organization. Levels and trends in child mortality. Geneve, 2017. Available from: https://www.unicef.org/publications/index_101071.html Accessed on October 13, 2020.
[4]
Edmond KM, Zandoh C, Quigley MA, Amenga-Etego S, Owusu-Agyei S, Kirkwood BR. Delayed breastfeeding initiation increases risk of neonatal mortality. Pediatrics 2006; 117(3): e380-6.
[http://dx.doi.org/10.1542/peds.2005-1496] [PMID: 16510618]
[5]
Passanha A, Cervato-Mancuso AM, Silva MEMP. Elementos protetores do leite materno na prevenção de doenças gastrintestinais e respiratórias. Rev Bras Cresc Desenv Hum 2010; 20: 351-60.
[http://dx.doi.org/10.7322/jhgd.19972]
[6]
Brandtzaeg P. Secretory IgA: Designed for anti-microbial defense. Front Immunol 2013; 4(222): 222.
[PMID: 23964273]
[7]
Ballard O, Morrow AL. Human milk composition: Nutrients and bioactive factors. Pediatr Clin North Am 2013; 60(1): 49-74.
[http://dx.doi.org/10.1016/j.pcl.2012.10.002] [PMID: 23178060]
[8]
Agarwal S, Karmaus W, Davis S, Gangur V. Immune markers in breast milk and fetal and maternal body fluids: A systematic review of perinatal concentrations. J Hum Lact 2011; 27(2): 171-86.
[http://dx.doi.org/10.1177/0890334410395761] [PMID: 21678611]
[9]
Oliveira AMM, Cunha CC, Penha-Silva N, Abdallah VOS, Jorge PT. Interference of the blood glucose control in the transition between phases I and II of lactogenesis in patients with type 1 diabetes mellitus. Braz Arq Bras Endocrinol Metab 2008; 52(3): 473-81.
[http://dx.doi.org/10.1590/S0004-27302008000300007]
[10]
Lima-Aragão MVV, de Oliveira-Junior JJ, Maciel MC, Silva LA, do Nascimento FRF, Guerra RNM. Salivary profile in diabetic patients: Biochemical and immunological evaluation. BMC Res Notes 2016; 9(103): 103.
[http://dx.doi.org/10.1186/s13104-016-1881-1] [PMID: 26879274]
[11]
Eisenbarth GS. Insulin autoimmunity: Immunogenetics/immunopathogenesis of type 1A diabetes. Ann N Y Acad Sci 2003; 1005(1): 109-18.
[http://dx.doi.org/10.1196/annals.1288.012] [PMID: 14679045]
[12]
Guiliani C. Volsi Pl, Brun E, Chiambretti A, Giandalia A, Tonutti L, Bartolo P, Napoli A. Breastfeeding during the COVID-19 pandemic: Suggestions on behalf of woman study group of AMD. Diabetes Res Clin Pract 2020; 165(108239)108239
[http://dx.doi.org/10.1016/j.diabres.2020.108239]
[13]
Brasil. Ministério da Educação. Empresa Brasileira de Serviços Hospitalares. Diretoria de Atenção à Saúde. Coordenadoria de Gestão Clínica. Serviço de Gestão do Cuidado Assistencial. Nota Técnica Covid-19: Orientações aos hospitais universitários federais da rede EBSERH a respeito da ocorrência de Diabetes Mellitus (DM) em pacientes com Covid-19, durante e após a resolução da doença. Brasília, 2020. Available from: http://www2.ebserh.gov.br/web/husmufsm/orientacoes-covid-19 (Accessed on: October 28, 2020).
[14]
University of York. Centre for reviews and dissemination. International Prospective Register of Systematic Reviews (PROSPERO). York: University of York; 2015. Available from: http://www.crd.york.ac.uk/PROSPERO (Accessed on: October 2, 2020).
[15]
Stone PW. Popping the (PICO) question in research and evidence-based practice. Appl Nurs Res 2002; 15(3): 197-8.
[http://dx.doi.org/10.1053/apnr.2002.34181] [PMID: 12173172]
[16]
Strobe Statement. Strengthening the reporting of observational studies in Epidemiology. Strobe checklists: version 4. Berna: University of Bern; 2007. Available from: http://www.strobe-statement.org/index.php?id=available-checklists (Accessed on: October 15, 2020).
[17]
Effective public health practice project -EPHPP. Quality assessment tool for quantitative studies. 2009. Available from: http://www.ephpp.ca/tools.html (Accessed on: October 10, 2020).
[18]
Moher D, Liberati A, Tetzlaff J, Altman DG. Reprint--preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Phys Ther 2009; 89(9): 873-80.
[http://dx.doi.org/10.1093/ptj/89.9.873] [PMID: 19723669]
[19]
França EL, Morceli G, Fagundes DLG, Rudge MVC, Calderon I de MP, Honorio-França AC. Secretory IgA-Fcα receptor interaction modulating phagocytosis and microbicidal activity by phagocytes in human colostrum of diabetics. APMIS 2011; 119(10): 710-9.
[http://dx.doi.org/10.1111/j.1600-0463.2011.02789.x] [PMID: 21917008]
[20]
Morceli G, França EL, Magalhães VB, Damasceno DC, Calderon IMP, Honorio-França AC. Diabetes induced immunological and biochemical changes in human colostrum. Acta Paediatr 2011; 100(4): 550-6.
[http://dx.doi.org/10.1111/j.1651-2227.2010.02070.x] [PMID: 20969623]
[21]
França EL, Calderon IMP, Vieira EL, Morceli G, Honorio-França AC. Transfer of maternal immunity to newborns of diabetic mothers. J Immunol Res 2012; 2012928187
[http://dx.doi.org/10.1155/2012/928187]
[22]
Fagundes DL, França EL, Morceli G, Rudge MV, Calderon IM, Honorio-França AC. The role of cytokines in the functional activity of phagocytes in blood and colostrum of diabetic mothers. Clin Dev Immunol 2013; 2013590190
[http://dx.doi.org/10.1155/2013/590190] [PMID: 24489577]
[23]
Smilowitz JT, Totten SM, Huang J, et al. Human milk secretory immunoglobulin A and lactoferrin N-glycans are altered in women with gestational diabetes mellitus. J Nutr 2013; 143(12): 1906-12.
[http://dx.doi.org/10.3945/jn.113.180695] [PMID: 24047700]
[24]
Fagundes DLG, França EL, Gonzatti MB, Rugde MVC, Calderon IMP, Honorio-França AC. The modulatory role of cytokines IL-4 and IL-17 in the functional activity of phagocytes in diabetic pregnant women. APMIS 2018; 126(1): 56-64.
[http://dx.doi.org/10.1111/apm.12772] [PMID: 29135055]
[25]
Lebrão CW, Cruz MN, Silva MHD, et al. Early identification of IgA anti-SARSCoV-2 in milk of mother with COVID-19 infection. J Hum Lact 2020; 36(4): 609-13.
[http://dx.doi.org/10.1177/0890334420960433] [PMID: 32985922]
[26]
WHO. World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: Report of a WHO/IDF consultation. Geneve, 2006. Available from: https://www.who.int/diabetes/publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf Access October 5, 2020.
[27]
Padoan A, Sciacovelli L, Basso D, et al. IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study. Clin Chim Acta 2020; 507(1): 164-6.
[http://dx.doi.org/10.1016/j.cca.2020.04.026] [PMID: 32343948]
[28]
Victora CG, Bahl R, Barros AJ, et al. Breastfeeding in the 21st century: Epidemiology, mechanisms, and lifelong effect. Lancet 2016; 387(10017): 475-90.
[29]
Guerra R. Specific antibodies in mouse milk after ovalbumin ingestion. Braz J Med Biol Res 1991; 24(1): 107-9.
[PMID: 1823210]
[30]
Kumar N, Arthur CP, Ciferri C, Matsumoto ML. Structure of the secretory immunoglobulin A core. Science 2020; 367(6481): 1008-14.
[http://dx.doi.org/10.1126/science.aaz5807] [PMID: 32029686]
[31]
Neville MC, McFadden TB, Forsyth I. Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia 2002; 7(1): 49-66.
[http://dx.doi.org/10.1023/A:1015770423167] [PMID: 12160086]
[32]
Narayanaswamy V, Pentecost B, Alfandari D, et al. Humoral and cell-mediated immune response in colostrum from women diagnosed positive for SARS-CoV-2. Breastfeed Med 2021; 16(12): 987-94.
[http://dx.doi.org/10.1089/bfm.2021.0082] [PMID: 34382820]
[33]
Sly LM, Braun P, Woodcock BG. COVID-19: Cytokine storm modulation/blockade with oral polyvalent immunoglobulins (PVIG, KMP01D): A potential and safe therapeutic agent (Primum nil nocere). Int J Clin Pharmacol Ther 2020; 58(12): 678-86.
[http://dx.doi.org/10.5414/CP203890] [PMID: 33141018]
[34]
Chao YX, Rötzschke O, Tan EK. The role of IgA in COVID-19. Brain Behav Immun 2020; 87(1): 182-3.
[http://dx.doi.org/10.1016/j.bbi.2020.05.057] [PMID: 32454136]
[35]
Zhao FQ, Miller PJ, Wall EH, et al. Bovine glucose transporter GLUT8: Cloning, expression, and developmental regulation in mammary gland. Biochim Biophys Acta 2004; 1680(2): 103-13.
[http://dx.doi.org/10.1016/j.bbaexp.2004.09.001] [PMID: 15488990]
[36]
Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 1994; 43(5): 613-21.
[http://dx.doi.org/10.2337/diab.43.5.613] [PMID: 8168635]
[37]
Pennline KJ, Roque-Gaffney E, Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 1994; 71(2): 169-75.
[http://dx.doi.org/10.1006/clin.1994.1068] [PMID: 8181185]
[38]
Moreli JB, Morceli G, De Luca AK, et al. Influence of maternal hyperglycemia on IL-10 and TNF-α production: The relationship with perinatal outcomes. J Clin Immunol 2012; 32(3): 604-10.
[http://dx.doi.org/10.1007/s10875-011-9634-3] [PMID: 22205204]
[39]
França EL, Bitencourt RV, Fujimori MT, Morais C, Calderon IMP, Honorio-França AC. Human colostral phagocytes eliminate enterotoxigenic Escherichia coli opsonized by colostrum supernatant. J Microbiol Immunol Infect 2011; 44(1): 1-7.

Rights & Permissions Print Cite
Article Metrics
1
© 2024 Bentham Science Publishers | Privacy Policy