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Review Article

肿瘤靶向治疗中放射性标记肽和抗体片段的改进策略

卷 29, 期 29, 2022

发表于: 17 June, 2022

页: [4923 - 4957] 页: 35

弟呕挨: 10.2174/0929867329666220420131836

价格: $65

摘要

一个同源的放射性配体由多个相同的配体连接到连接体和放射性核素组成，用于检测癌细胞上的各种过表达受体。多聚体策略在分子成像和治疗中引入基于肽和单克隆抗体（mAb）衍生物的新型放射性示踪剂方面具有巨大的潜力。它为制备具有不同亲和性和药代动力学的生物靶向药物提供了一个可靠的程序。在此背景下，我们提供了一个有用的总结和解释的主要结果。因此，我们将解释其策略机制和影响生物分布结果的主要变量。讨论之后是最近在针对各种类型的受体方面的工作的重点。在每个相关部分中比较单体和多聚物之间的一些参数来表示结果。

关键词: 放射性标记肽，肿瘤靶向，同多聚体，PET，SPECT，RGD。

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